PPR repeat/Pentatricopeptide repeat domain/PPR repeat family, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pentatricopeptide repeat domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ22_LEIDO

TriTrypDb:

LdBPK_365040.1 , LdCL_360057600 , LDHU3_36.6760

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.404
CLV_NRD_NRD_1	166	168	PF00675	0.338
CLV_NRD_NRD_1	47	49	PF00675	0.310
CLV_PCSK_KEX2_1	166	168	PF00082	0.338
CLV_PCSK_KEX2_1	47	49	PF00082	0.310
CLV_PCSK_SKI1_1	121	125	PF00082	0.279
CLV_PCSK_SKI1_1	15	19	PF00082	0.250
CLV_PCSK_SKI1_1	209	213	PF00082	0.315
CLV_PCSK_SKI1_1	230	234	PF00082	0.344
CLV_PCSK_SKI1_1	48	52	PF00082	0.417
CLV_PCSK_SKI1_1	74	78	PF00082	0.390
CLV_Separin_Metazoa	231	235	PF03568	0.370
DEG_APCC_DBOX_1	229	237	PF00400	0.419
DOC_ANK_TNKS_1	216	223	PF00023	0.390
DOC_CKS1_1	170	175	PF01111	0.367
DOC_CYCLIN_RxL_1	227	235	PF00134	0.397
DOC_MAPK_gen_1	206	214	PF00069	0.266
DOC_MAPK_gen_1	99	107	PF00069	0.334
DOC_MAPK_MEF2A_6	99	107	PF00069	0.262
DOC_MAPK_NFAT4_5	100	108	PF00069	0.372
DOC_PP4_FxxP_1	150	153	PF00568	0.390
DOC_USP7_UBL2_3	250	254	PF12436	0.286
DOC_WW_Pin1_4	169	174	PF00397	0.371
LIG_14-3-3_CanoR_1	11	17	PF00244	0.396
LIG_14-3-3_CanoR_1	181	185	PF00244	0.448
LIG_14-3-3_CanoR_1	217	225	PF00244	0.189
LIG_14-3-3_CanoR_1	238	243	PF00244	0.508
LIG_14-3-3_CanoR_1	252	261	PF00244	0.489
LIG_APCC_ABBA_1	105	110	PF00400	0.390
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_DLG_GKlike_1	238	245	PF00625	0.444
LIG_eIF4E_1	86	92	PF01652	0.260
LIG_FHA_1	122	128	PF00498	0.260
LIG_FHA_1	16	22	PF00498	0.245
LIG_FHA_1	170	176	PF00498	0.454
LIG_FHA_1	227	233	PF00498	0.357
LIG_FHA_1	52	58	PF00498	0.262
LIG_FHA_1	87	93	PF00498	0.254
LIG_FHA_2	238	244	PF00498	0.429
LIG_GBD_Chelix_1	103	111	PF00786	0.390
LIG_LIR_Apic_2	147	153	PF02991	0.416
LIG_LIR_Gen_1	192	203	PF02991	0.246
LIG_LIR_Gen_1	87	96	PF02991	0.324
LIG_LIR_Nem_3	192	198	PF02991	0.246
LIG_LIR_Nem_3	221	226	PF02991	0.262
LIG_LIR_Nem_3	255	261	PF02991	0.633
LIG_LIR_Nem_3	87	91	PF02991	0.259
LIG_Pex14_2	12	16	PF04695	0.510
LIG_SH2_CRK	195	199	PF00017	0.245
LIG_SH2_CRK	53	57	PF00017	0.293
LIG_SH2_CRK	88	92	PF00017	0.277
LIG_SH2_NCK_1	223	227	PF00017	0.366
LIG_SH2_SRC	223	226	PF00017	0.339
LIG_SH2_STAP1	158	162	PF00017	0.246
LIG_SH2_STAP1	228	232	PF00017	0.365
LIG_SH2_STAP1	53	57	PF00017	0.245
LIG_SH2_STAP1	88	92	PF00017	0.316
LIG_SH2_STAT5	158	161	PF00017	0.263
LIG_SH2_STAT5	228	231	PF00017	0.377
LIG_SH2_STAT5	261	264	PF00017	0.667
LIG_SH2_STAT5	53	56	PF00017	0.245
LIG_SH2_STAT5	86	89	PF00017	0.245
LIG_SH3_3	111	117	PF00018	0.269
LIG_SH3_3	167	173	PF00018	0.351
LIG_SUMO_SIM_par_1	124	131	PF11976	0.310
LIG_TRAF2_1	273	276	PF00917	0.536
LIG_TYR_ITIM	193	198	PF00017	0.245
LIG_WRC_WIRS_1	21	26	PF05994	0.352
MOD_CK1_1	128	134	PF00069	0.359
MOD_CK2_1	253	259	PF00069	0.517
MOD_GlcNHglycan	26	29	PF01048	0.328
MOD_GlcNHglycan	4	7	PF01048	0.549
MOD_GSK3_1	11	18	PF00069	0.422
MOD_GSK3_1	121	128	PF00069	0.339
MOD_GSK3_1	20	27	PF00069	0.291
MOD_GSK3_1	262	269	PF00069	0.543
MOD_GSK3_1	51	58	PF00069	0.308
MOD_N-GLC_2	93	95	PF02516	0.304
MOD_NEK2_1	156	161	PF00069	0.260
MOD_NEK2_1	237	242	PF00069	0.380
MOD_NEK2_1	24	29	PF00069	0.363
MOD_NEK2_1	40	45	PF00069	0.243
MOD_NEK2_1	51	56	PF00069	0.184
MOD_PIKK_1	183	189	PF00454	0.556
MOD_PKA_2	10	16	PF00069	0.463
MOD_PKA_2	180	186	PF00069	0.542
MOD_PKA_2	216	222	PF00069	0.189
MOD_PKA_2	237	243	PF00069	0.481
MOD_Plk_1	191	197	PF00069	0.260
MOD_Plk_4	194	200	PF00069	0.297
MOD_Plk_4	41	47	PF00069	0.290
MOD_Plk_4	52	58	PF00069	0.184
MOD_Plk_4	87	93	PF00069	0.356
MOD_ProDKin_1	169	175	PF00069	0.368
TRG_ENDOCYTIC_2	195	198	PF00928	0.245
TRG_ENDOCYTIC_2	215	218	PF00928	0.267
TRG_ENDOCYTIC_2	223	226	PF00928	0.249
TRG_ENDOCYTIC_2	53	56	PF00928	0.293
TRG_ENDOCYTIC_2	88	91	PF00928	0.277
TRG_ER_diArg_1	46	48	PF00400	0.310
TRG_NES_CRM1_1	102	115	PF08389	0.390
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J7	Leptomonas seymouri	82%	100%
A0A0S4IYI9	Bodo saltans	47%	100%
A0A1X0P0D8	Trypanosomatidae	60%	88%
A0A3Q8IF22	Leishmania donovani	24%	100%
A0A3R7KPI7	Trypanosoma rangeli	57%	99%
A4HPZ8	Leishmania braziliensis	90%	100%
A4I129	Leishmania infantum	25%	100%
A4IDQ9	Leishmania infantum	99%	100%
C9ZW80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
D0A4F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	71%
E9ATR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AX66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4Q0T2	Leishmania major	95%	100%
Q4QAB0	Leishmania major	23%	100%
Q5BIV3	Arabidopsis thaliana	25%	76%
Q940Z1	Arabidopsis thaliana	25%	88%
Q9FFZ2	Arabidopsis thaliana	22%	84%
Q9LG23	Arabidopsis thaliana	22%	70%
Q9SAB4	Arabidopsis thaliana	22%	69%
V5DLI8	Trypanosoma cruzi	58%	91%