START domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ21_LEIDO

TriTrypDb:

LdBPK_292840.1 , LdCL_290034500 , LDHU3_29.4160

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ21

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	19
GO:0008289	lipid binding	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.469
CLV_NRD_NRD_1	360	362	PF00675	0.488
CLV_PCSK_KEX2_1	360	362	PF00082	0.428
CLV_PCSK_SKI1_1	15	19	PF00082	0.419
CLV_PCSK_SKI1_1	162	166	PF00082	0.305
CLV_PCSK_SKI1_1	207	211	PF00082	0.412
CLV_PCSK_SKI1_1	334	338	PF00082	0.487
CLV_PCSK_SKI1_1	68	72	PF00082	0.375
DEG_APCC_DBOX_1	14	22	PF00400	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.628
DEG_SIAH_1	302	310	PF03145	0.516
DOC_CKS1_1	236	241	PF01111	0.331
DOC_MAPK_gen_1	12	21	PF00069	0.476
DOC_MAPK_gen_1	25	32	PF00069	0.419
DOC_MAPK_gen_1	360	366	PF00069	0.379
DOC_PP4_FxxP_1	117	120	PF00568	0.274
DOC_USP7_MATH_1	189	193	PF00917	0.259
DOC_USP7_MATH_1	268	272	PF00917	0.701
DOC_USP7_MATH_1	31	35	PF00917	0.260
DOC_USP7_UBL2_3	48	52	PF12436	0.258
DOC_WW_Pin1_4	235	240	PF00397	0.411
DOC_WW_Pin1_4	242	247	PF00397	0.422
LIG_14-3-3_CanoR_1	311	318	PF00244	0.630
LIG_14-3-3_CanoR_1	360	365	PF00244	0.477
LIG_14-3-3_CanoR_1	88	92	PF00244	0.359
LIG_Actin_WH2_2	325	340	PF00022	0.558
LIG_EH1_1	309	317	PF00400	0.508
LIG_eIF4E_1	310	316	PF01652	0.622
LIG_FHA_1	177	183	PF00498	0.388
LIG_FHA_1	311	317	PF00498	0.544
LIG_FHA_1	91	97	PF00498	0.336
LIG_FHA_2	134	140	PF00498	0.272
LIG_FHA_2	342	348	PF00498	0.503
LIG_FHA_2	360	366	PF00498	0.528
LIG_HCF-1_HBM_1	231	234	PF13415	0.403
LIG_LIR_Apic_2	166	172	PF02991	0.362
LIG_LIR_Apic_2	244	250	PF02991	0.377
LIG_LIR_Gen_1	125	133	PF02991	0.279
LIG_LIR_Gen_1	139	148	PF02991	0.311
LIG_LIR_Gen_1	14	24	PF02991	0.508
LIG_LIR_Gen_1	97	104	PF02991	0.367
LIG_LIR_Nem_3	109	115	PF02991	0.238
LIG_LIR_Nem_3	131	135	PF02991	0.295
LIG_LIR_Nem_3	139	143	PF02991	0.307
LIG_LIR_Nem_3	217	223	PF02991	0.380
LIG_LIR_Nem_3	97	102	PF02991	0.376
LIG_MYND_1	246	250	PF01753	0.503
LIG_PDZ_Class_2	361	366	PF00595	0.614
LIG_Pex14_1	243	247	PF04695	0.399
LIG_Pex14_1	38	42	PF04695	0.274
LIG_PTB_Apo_2	120	127	PF02174	0.303
LIG_PTB_Apo_2	134	141	PF02174	0.308
LIG_PTB_Phospho_1	134	140	PF10480	0.411
LIG_SH2_CRK	321	325	PF00017	0.435
LIG_SH2_CRK	79	83	PF00017	0.305
LIG_SH2_CRK	99	103	PF00017	0.125
LIG_SH2_NCK_1	99	103	PF00017	0.300
LIG_SH2_PTP2	169	172	PF00017	0.362
LIG_SH2_SRC	247	250	PF00017	0.505
LIG_SH2_STAP1	113	117	PF00017	0.290
LIG_SH2_STAP1	216	220	PF00017	0.474
LIG_SH2_STAP1	42	46	PF00017	0.384
LIG_SH2_STAT5	140	143	PF00017	0.433
LIG_SH2_STAT5	169	172	PF00017	0.282
LIG_SH2_STAT5	183	186	PF00017	0.367
LIG_SH2_STAT5	223	226	PF00017	0.421
LIG_SH2_STAT5	247	250	PF00017	0.504
LIG_SH2_STAT5	348	351	PF00017	0.441
LIG_SH2_STAT5	8	11	PF00017	0.473
LIG_SH3_2	150	155	PF14604	0.367
LIG_SH3_2	306	311	PF14604	0.652
LIG_SH3_3	112	118	PF00018	0.396
LIG_SH3_3	147	153	PF00018	0.372
LIG_SH3_3	300	306	PF00018	0.600
LIG_TRAF2_1	282	285	PF00917	0.578
LIG_TYR_ITIM	110	115	PF00017	0.396
LIG_TYR_ITIM	77	82	PF00017	0.367
LIG_UBA3_1	18	26	PF00899	0.345
MOD_CDK_SPK_2	235	240	PF00069	0.359
MOD_CK1_1	163	169	PF00069	0.315
MOD_CK1_1	33	39	PF00069	0.344
MOD_CK2_1	128	134	PF00069	0.274
MOD_CK2_1	268	274	PF00069	0.634
MOD_CK2_1	279	285	PF00069	0.761
MOD_CK2_1	341	347	PF00069	0.537
MOD_GlcNHglycan	173	176	PF01048	0.466
MOD_GlcNHglycan	270	273	PF01048	0.718
MOD_GlcNHglycan	280	284	PF01048	0.760
MOD_GlcNHglycan	35	38	PF01048	0.238
MOD_GSK3_1	189	196	PF00069	0.274
MOD_GSK3_1	254	261	PF00069	0.600
MOD_GSK3_1	310	317	PF00069	0.574
MOD_GSK3_1	328	335	PF00069	0.296
MOD_GSK3_1	33	40	PF00069	0.303
MOD_N-GLC_1	143	148	PF02516	0.305
MOD_NEK2_1	133	138	PF00069	0.253
MOD_NEK2_1	200	205	PF00069	0.274
MOD_NEK2_1	290	295	PF00069	0.645
MOD_NEK2_1	297	302	PF00069	0.569
MOD_PIKK_1	176	182	PF00454	0.355
MOD_PK_1	160	166	PF00069	0.274
MOD_PKA_1	360	366	PF00069	0.379
MOD_PKA_2	176	182	PF00069	0.392
MOD_PKA_2	310	316	PF00069	0.657
MOD_PKA_2	359	365	PF00069	0.467
MOD_PKA_2	64	70	PF00069	0.396
MOD_PKA_2	87	93	PF00069	0.342
MOD_Plk_1	332	338	PF00069	0.481
MOD_Plk_4	193	199	PF00069	0.359
MOD_Plk_4	42	48	PF00069	0.319
MOD_ProDKin_1	235	241	PF00069	0.403
MOD_ProDKin_1	242	248	PF00069	0.420
MOD_SUMO_for_1	47	50	PF00179	0.415
MOD_SUMO_rev_2	280	288	PF00179	0.524
MOD_SUMO_rev_2	4	14	PF00179	0.406
MOD_SUMO_rev_2	44	54	PF00179	0.415
TRG_ENDOCYTIC_2	112	115	PF00928	0.249
TRG_ENDOCYTIC_2	140	143	PF00928	0.390
TRG_ENDOCYTIC_2	16	19	PF00928	0.379
TRG_ENDOCYTIC_2	321	324	PF00928	0.424
TRG_ENDOCYTIC_2	79	82	PF00928	0.314
TRG_ENDOCYTIC_2	99	102	PF00928	0.125
TRG_ER_diArg_1	159	162	PF00400	0.290
TRG_ER_diArg_1	359	361	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J9	Leptomonas seymouri	74%	99%
A0A0S4KH88	Bodo saltans	48%	93%
A0A1X0P910	Trypanosomatidae	51%	97%
A0A3Q8IBA5	Leishmania donovani	34%	100%
A0A3R7KCX0	Trypanosoma rangeli	48%	100%
A4H6L4	Leishmania braziliensis	35%	100%
A4HHT0	Leishmania braziliensis	82%	100%
A4HUZ7	Leishmania infantum	34%	89%
A4I4Z0	Leishmania infantum	100%	100%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AED5	Leishmania major	95%	100%
E9ALF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9ANN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4QGZ1	Leishmania major	36%	100%
Q9Y365	Homo sapiens	30%	100%
V5BC62	Trypanosoma cruzi	50%	100%
V5DT41	Trypanosoma cruzi	35%	100%