Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ19_LEIDO

TriTrypDb:

LdBPK_352290.1 , LdCL_350027800 , LDHU3_35.2920

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IJ19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.682
CLV_C14_Caspase3-7	278	282	PF00656	0.496
CLV_C14_Caspase3-7	403	407	PF00656	0.706
CLV_NRD_NRD_1	139	141	PF00675	0.523
CLV_NRD_NRD_1	25	27	PF00675	0.750
CLV_NRD_NRD_1	308	310	PF00675	0.572
CLV_NRD_NRD_1	333	335	PF00675	0.414
CLV_NRD_NRD_1	35	37	PF00675	0.727
CLV_NRD_NRD_1	434	436	PF00675	0.537
CLV_NRD_NRD_1	46	48	PF00675	0.718
CLV_NRD_NRD_1	520	522	PF00675	0.573
CLV_PCSK_FUR_1	432	436	PF00082	0.690
CLV_PCSK_FUR_1	44	48	PF00082	0.721
CLV_PCSK_KEX2_1	25	27	PF00082	0.687
CLV_PCSK_KEX2_1	308	310	PF00082	0.530
CLV_PCSK_KEX2_1	332	334	PF00082	0.406
CLV_PCSK_KEX2_1	35	37	PF00082	0.731
CLV_PCSK_KEX2_1	432	434	PF00082	0.568
CLV_PCSK_KEX2_1	46	48	PF00082	0.718
CLV_PCSK_KEX2_1	520	522	PF00082	0.573
CLV_PCSK_KEX2_1	62	64	PF00082	0.677
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.584
CLV_PCSK_SKI1_1	13	17	PF00082	0.775
CLV_PCSK_SKI1_1	334	338	PF00082	0.462
CLV_PCSK_SKI1_1	494	498	PF00082	0.566
CLV_PCSK_SKI1_1	63	67	PF00082	0.584
DEG_APCC_DBOX_1	493	501	PF00400	0.719
DEG_SCF_FBW7_2	480	487	PF00400	0.584
DOC_CYCLIN_yClb5_NLxxxL_5	494	500	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.746
DOC_MAPK_FxFP_2	326	329	PF00069	0.453
DOC_MAPK_gen_1	242	252	PF00069	0.447
DOC_MAPK_gen_1	25	33	PF00069	0.563
DOC_MAPK_gen_1	305	313	PF00069	0.542
DOC_MAPK_HePTP_8	431	448	PF00069	0.463
DOC_MAPK_MEF2A_6	461	468	PF00069	0.561
DOC_PP2B_LxvP_1	157	160	PF13499	0.761
DOC_PP4_FxxP_1	20	23	PF00568	0.679
DOC_PP4_FxxP_1	231	234	PF00568	0.565
DOC_PP4_FxxP_1	326	329	PF00568	0.453
DOC_PP4_FxxP_1	84	87	PF00568	0.482
DOC_USP7_MATH_1	178	182	PF00917	0.718
DOC_USP7_MATH_1	327	331	PF00917	0.404
DOC_USP7_MATH_1	363	367	PF00917	0.545
DOC_USP7_MATH_1	57	61	PF00917	0.699
DOC_WW_Pin1_4	135	140	PF00397	0.558
DOC_WW_Pin1_4	202	207	PF00397	0.441
DOC_WW_Pin1_4	208	213	PF00397	0.455
DOC_WW_Pin1_4	351	356	PF00397	0.475
DOC_WW_Pin1_4	36	41	PF00397	0.735
DOC_WW_Pin1_4	424	429	PF00397	0.662
DOC_WW_Pin1_4	480	485	PF00397	0.567
DOC_WW_Pin1_4	64	69	PF00397	0.716
LIG_14-3-3_CanoR_1	13	20	PF00244	0.718
LIG_14-3-3_CanoR_1	26	32	PF00244	0.673
LIG_14-3-3_CanoR_1	287	297	PF00244	0.648
LIG_14-3-3_CanoR_1	333	342	PF00244	0.441
LIG_14-3-3_CanoR_1	38	44	PF00244	0.722
LIG_14-3-3_CanoR_1	381	389	PF00244	0.607
LIG_14-3-3_CanoR_1	505	509	PF00244	0.719
LIG_14-3-3_CanoR_1	513	522	PF00244	0.616
LIG_Actin_WH2_2	304	320	PF00022	0.540
LIG_BRCT_BRCA1_1	221	225	PF00533	0.484
LIG_BRCT_BRCA1_1	97	101	PF00533	0.541
LIG_BRCT_BRCA1_2	97	103	PF00533	0.518
LIG_CSL_BTD_1	425	428	PF09270	0.654
LIG_EH1_1	246	254	PF00400	0.388
LIG_FHA_1	195	201	PF00498	0.628
LIG_FHA_1	28	34	PF00498	0.751
LIG_FHA_1	283	289	PF00498	0.595
LIG_FHA_1	362	368	PF00498	0.574
LIG_FHA_1	406	412	PF00498	0.761
LIG_FHA_1	450	456	PF00498	0.443
LIG_FHA_2	110	116	PF00498	0.538
LIG_FHA_2	146	152	PF00498	0.606
LIG_FHA_2	276	282	PF00498	0.504
LIG_FHA_2	297	303	PF00498	0.672
LIG_FHA_2	401	407	PF00498	0.585
LIG_Integrin_RGD_1	390	392	PF01839	0.505
LIG_LIR_Apic_2	228	234	PF02991	0.517
LIG_LIR_Apic_2	323	329	PF02991	0.464
LIG_LIR_Gen_1	354	363	PF02991	0.455
LIG_LIR_Gen_1	366	376	PF02991	0.492
LIG_LIR_Gen_1	394	405	PF02991	0.691
LIG_LIR_Gen_1	89	99	PF02991	0.422
LIG_LIR_Nem_3	202	207	PF02991	0.577
LIG_LIR_Nem_3	323	328	PF02991	0.384
LIG_LIR_Nem_3	354	360	PF02991	0.422
LIG_LIR_Nem_3	394	400	PF02991	0.689
LIG_LIR_Nem_3	67	72	PF02991	0.672
LIG_LIR_Nem_3	89	94	PF02991	0.418
LIG_PCNA_yPIPBox_3	461	472	PF02747	0.520
LIG_PCNA_yPIPBox_3	489	500	PF02747	0.564
LIG_Pex14_2	231	235	PF04695	0.567
LIG_SH2_CRK	357	361	PF00017	0.427
LIG_SH2_SRC	274	277	PF00017	0.576
LIG_SH2_STAT3	340	343	PF00017	0.574
LIG_SH2_STAT5	274	277	PF00017	0.544
LIG_SH3_3	104	110	PF00018	0.419
LIG_SH3_3	258	264	PF00018	0.425
LIG_SH3_3	321	327	PF00018	0.533
LIG_SH3_3	434	440	PF00018	0.647
LIG_SH3_3	519	525	PF00018	0.686
LIG_SH3_4	461	468	PF00018	0.537
LIG_SUMO_SIM_anti_2	214	219	PF11976	0.410
LIG_SUMO_SIM_anti_2	30	35	PF11976	0.550
LIG_SUMO_SIM_par_1	133	138	PF11976	0.383
LIG_SUMO_SIM_par_1	216	222	PF11976	0.490
LIG_TRFH_1	340	344	PF08558	0.534
MOD_CDK_SPK_2	135	140	PF00069	0.533
MOD_CDK_SPxK_1	135	141	PF00069	0.546
MOD_CK1_1	111	117	PF00069	0.459
MOD_CK1_1	194	200	PF00069	0.659
MOD_CK1_1	202	208	PF00069	0.496
MOD_CK1_1	211	217	PF00069	0.494
MOD_CK1_1	39	45	PF00069	0.750
MOD_CK1_1	476	482	PF00069	0.463
MOD_CK1_1	511	517	PF00069	0.720
MOD_CK1_1	58	64	PF00069	0.692
MOD_CK2_1	202	208	PF00069	0.431
MOD_CK2_1	296	302	PF00069	0.683
MOD_CK2_1	414	420	PF00069	0.550
MOD_Cter_Amidation	44	47	PF01082	0.723
MOD_GlcNHglycan	193	196	PF01048	0.710
MOD_GlcNHglycan	318	321	PF01048	0.482
MOD_GlcNHglycan	386	389	PF01048	0.645
MOD_GlcNHglycan	457	460	PF01048	0.654
MOD_GlcNHglycan	475	478	PF01048	0.466
MOD_GlcNHglycan	57	60	PF01048	0.701
MOD_GSK3_1	161	168	PF00069	0.725
MOD_GSK3_1	190	197	PF00069	0.651
MOD_GSK3_1	401	408	PF00069	0.671
MOD_GSK3_1	451	458	PF00069	0.551
MOD_GSK3_1	476	483	PF00069	0.568
MOD_GSK3_1	504	511	PF00069	0.758
MOD_N-GLC_1	160	165	PF02516	0.710
MOD_N-GLC_1	455	460	PF02516	0.592
MOD_N-GLC_1	480	485	PF02516	0.721
MOD_N-GLC_2	123	125	PF02516	0.522
MOD_NEK2_1	3	8	PF00069	0.680
MOD_NEK2_1	405	410	PF00069	0.763
MOD_NEK2_1	471	476	PF00069	0.378
MOD_NEK2_1	73	78	PF00069	0.651
MOD_NEK2_1	95	100	PF00069	0.473
MOD_NEK2_2	282	287	PF00069	0.489
MOD_PIKK_1	13	19	PF00454	0.756
MOD_PKA_1	46	52	PF00069	0.739
MOD_PKA_1	520	526	PF00069	0.564
MOD_PKA_2	282	288	PF00069	0.576
MOD_PKA_2	46	52	PF00069	0.718
MOD_PKA_2	504	510	PF00069	0.683
MOD_PKA_2	514	520	PF00069	0.568
MOD_PKB_1	332	340	PF00069	0.528
MOD_PKB_1	36	44	PF00069	0.690
MOD_Plk_1	275	281	PF00069	0.510
MOD_Plk_1	392	398	PF00069	0.620
MOD_Plk_4	152	158	PF00069	0.718
MOD_Plk_4	178	184	PF00069	0.705
MOD_Plk_4	199	205	PF00069	0.584
MOD_Plk_4	29	35	PF00069	0.550
MOD_Plk_4	363	369	PF00069	0.553
MOD_Plk_4	392	398	PF00069	0.660
MOD_Plk_4	90	96	PF00069	0.502
MOD_ProDKin_1	135	141	PF00069	0.571
MOD_ProDKin_1	202	208	PF00069	0.439
MOD_ProDKin_1	351	357	PF00069	0.473
MOD_ProDKin_1	36	42	PF00069	0.737
MOD_ProDKin_1	424	430	PF00069	0.665
MOD_ProDKin_1	480	486	PF00069	0.576
MOD_ProDKin_1	64	70	PF00069	0.710
TRG_DiLeu_BaEn_2	392	398	PF01217	0.660
TRG_ENDOCYTIC_2	204	207	PF00928	0.559
TRG_ENDOCYTIC_2	357	360	PF00928	0.426
TRG_ER_diArg_1	307	309	PF00400	0.570
TRG_ER_diArg_1	331	334	PF00400	0.407
TRG_ER_diArg_1	34	36	PF00400	0.742
TRG_ER_diArg_1	43	46	PF00400	0.707
TRG_ER_diArg_1	431	434	PF00400	0.589
TRG_ER_diArg_1	519	521	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L8	Leptomonas seymouri	47%	98%
A0A1X0P5V1	Trypanosomatidae	37%	100%
A0A422NLY6	Trypanosoma rangeli	37%	100%
A4HMP7	Leishmania braziliensis	75%	100%
A4IBB6	Leishmania infantum	100%	100%
C9ZZD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AF48	Leishmania major	92%	100%
E9B6A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DKB8	Trypanosoma cruzi	37%	100%