Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ18_LEIDO

TriTrypDb:

LdBPK_350250.1 , LdCL_350007500 , LDHU3_35.0340

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJ18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.649
CLV_NRD_NRD_1	333	335	PF00675	0.707
CLV_NRD_NRD_1	386	388	PF00675	0.739
CLV_NRD_NRD_1	6	8	PF00675	0.443
CLV_NRD_NRD_1	673	675	PF00675	0.604
CLV_NRD_NRD_1	684	686	PF00675	0.570
CLV_PCSK_KEX2_1	333	335	PF00082	0.707
CLV_PCSK_KEX2_1	386	388	PF00082	0.688
CLV_PCSK_KEX2_1	431	433	PF00082	0.788
CLV_PCSK_KEX2_1	6	8	PF00082	0.452
CLV_PCSK_KEX2_1	683	685	PF00082	0.590
CLV_PCSK_KEX2_1	707	709	PF00082	0.675
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.579
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.542
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.675
CLV_PCSK_SKI1_1	140	144	PF00082	0.607
CLV_PCSK_SKI1_1	239	243	PF00082	0.522
CLV_PCSK_SKI1_1	334	338	PF00082	0.713
CLV_Separin_Metazoa	95	99	PF03568	0.546
DEG_APCC_DBOX_1	69	77	PF00400	0.602
DEG_SPOP_SBC_1	497	501	PF00917	0.741
DOC_CDC14_PxL_1	598	606	PF14671	0.626
DOC_CYCLIN_yClb3_PxF_3	132	140	PF00134	0.592
DOC_CYCLIN_yClb5_NLxxxL_5	349	358	PF00134	0.703
DOC_CYCLIN_yCln2_LP_2	604	610	PF00134	0.637
DOC_PP2B_LxvP_1	583	586	PF13499	0.671
DOC_PP2B_LxvP_1	604	607	PF13499	0.672
DOC_PP2B_LxvP_1	615	618	PF13499	0.579
DOC_PP4_FxxP_1	193	196	PF00568	0.588
DOC_USP7_MATH_1	155	159	PF00917	0.723
DOC_USP7_MATH_1	258	262	PF00917	0.517
DOC_USP7_MATH_1	406	410	PF00917	0.741
DOC_USP7_MATH_1	419	423	PF00917	0.527
DOC_USP7_MATH_1	497	501	PF00917	0.748
DOC_WW_Pin1_4	128	133	PF00397	0.654
DOC_WW_Pin1_4	151	156	PF00397	0.709
DOC_WW_Pin1_4	192	197	PF00397	0.593
DOC_WW_Pin1_4	361	366	PF00397	0.788
DOC_WW_Pin1_4	552	557	PF00397	0.768
DOC_WW_Pin1_4	589	594	PF00397	0.700
LIG_14-3-3_CanoR_1	101	109	PF00244	0.527
LIG_14-3-3_CanoR_1	147	155	PF00244	0.774
LIG_14-3-3_CanoR_1	180	187	PF00244	0.503
LIG_14-3-3_CanoR_1	323	330	PF00244	0.698
LIG_14-3-3_CanoR_1	333	337	PF00244	0.718
LIG_14-3-3_CanoR_1	377	385	PF00244	0.780
LIG_14-3-3_CanoR_1	6	11	PF00244	0.500
LIG_14-3-3_CanoR_1	611	615	PF00244	0.693
LIG_14-3-3_CanoR_1	674	682	PF00244	0.632
LIG_Actin_WH2_2	529	547	PF00022	0.664
LIG_Actin_WH2_2	82	100	PF00022	0.594
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BRCT_BRCA1_1	421	425	PF00533	0.659
LIG_BRCT_BRCA1_1	591	595	PF00533	0.659
LIG_Clathr_ClatBox_1	460	464	PF01394	0.656
LIG_eIF4E_1	594	600	PF01652	0.709
LIG_FHA_1	101	107	PF00498	0.508
LIG_FHA_1	110	116	PF00498	0.522
LIG_FHA_1	129	135	PF00498	0.601
LIG_FHA_1	261	267	PF00498	0.541
LIG_FHA_1	279	285	PF00498	0.545
LIG_FHA_1	286	292	PF00498	0.527
LIG_FHA_1	3	9	PF00498	0.493
LIG_FHA_1	349	355	PF00498	0.688
LIG_FHA_1	45	51	PF00498	0.554
LIG_FHA_1	506	512	PF00498	0.730
LIG_FHA_1	611	617	PF00498	0.572
LIG_FHA_1	674	680	PF00498	0.612
LIG_FHA_1	85	91	PF00498	0.488
LIG_FHA_2	134	140	PF00498	0.571
LIG_FHA_2	308	314	PF00498	0.644
LIG_FHA_2	553	559	PF00498	0.728
LIG_LIR_Gen_1	261	272	PF02991	0.536
LIG_LIR_Gen_1	288	295	PF02991	0.550
LIG_LIR_Gen_1	508	516	PF02991	0.647
LIG_LIR_Nem_3	261	267	PF02991	0.538
LIG_LIR_Nem_3	288	293	PF02991	0.549
LIG_LIR_Nem_3	35	39	PF02991	0.420
LIG_LIR_Nem_3	422	428	PF02991	0.667
LIG_LIR_Nem_3	508	512	PF02991	0.624
LIG_LIR_Nem_3	592	598	PF02991	0.598
LIG_LYPXL_S_1	600	604	PF13949	0.631
LIG_LYPXL_yS_3	601	604	PF13949	0.630
LIG_MAD2	696	704	PF02301	0.596
LIG_MLH1_MIPbox_1	591	595	PF16413	0.731
LIG_SH2_CRK	187	191	PF00017	0.439
LIG_SH2_CRK	456	460	PF00017	0.679
LIG_SH2_CRK	484	488	PF00017	0.671
LIG_SH2_CRK	651	655	PF00017	0.591
LIG_SH2_NCK_1	240	244	PF00017	0.337
LIG_SH2_SRC	217	220	PF00017	0.467
LIG_SH2_STAP1	217	221	PF00017	0.453
LIG_SH2_STAP1	456	460	PF00017	0.679
LIG_SH2_STAP1	651	655	PF00017	0.537
LIG_SH2_STAT5	187	190	PF00017	0.482
LIG_SH2_STAT5	255	258	PF00017	0.547
LIG_SH2_STAT5	264	267	PF00017	0.499
LIG_SH2_STAT5	594	597	PF00017	0.610
LIG_SH3_1	129	135	PF00018	0.524
LIG_SH3_3	129	135	PF00018	0.660
LIG_SH3_3	228	234	PF00018	0.519
LIG_SH3_3	362	368	PF00018	0.745
LIG_SH3_3	485	491	PF00018	0.624
LIG_SH3_3	590	596	PF00018	0.730
LIG_SH3_3	650	656	PF00018	0.570
LIG_SUMO_SIM_anti_2	613	621	PF11976	0.700
LIG_SUMO_SIM_par_1	613	621	PF11976	0.408
LIG_TRAF2_1	136	139	PF00917	0.572
LIG_TRAF2_1	162	165	PF00917	0.627
LIG_TRAF2_1	669	672	PF00917	0.516
LIG_TRFH_1	598	602	PF08558	0.700
LIG_TYR_ITIM	599	604	PF00017	0.627
LIG_UBA3_1	424	431	PF00899	0.586
LIG_WRC_WIRS_1	134	139	PF05994	0.560
MOD_CDK_SPK_2	192	197	PF00069	0.379
MOD_CK1_1	120	126	PF00069	0.746
MOD_CK1_1	133	139	PF00069	0.546
MOD_CK1_1	148	154	PF00069	0.710
MOD_CK1_1	158	164	PF00069	0.620
MOD_CK1_1	2	8	PF00069	0.594
MOD_CK1_1	279	285	PF00069	0.567
MOD_CK1_1	328	334	PF00069	0.652
MOD_CK1_1	529	535	PF00069	0.657
MOD_CK1_1	9	15	PF00069	0.515
MOD_CK2_1	133	139	PF00069	0.637
MOD_CK2_1	167	173	PF00069	0.575
MOD_CK2_1	307	313	PF00069	0.641
MOD_CK2_1	535	541	PF00069	0.675
MOD_CK2_1	89	95	PF00069	0.567
MOD_GlcNHglycan	169	172	PF01048	0.617
MOD_GlcNHglycan	25	28	PF01048	0.479
MOD_GlcNHglycan	273	276	PF01048	0.591
MOD_GlcNHglycan	303	306	PF01048	0.589
MOD_GlcNHglycan	325	328	PF01048	0.608
MOD_GlcNHglycan	373	376	PF01048	0.835
MOD_GlcNHglycan	433	436	PF01048	0.647
MOD_GlcNHglycan	441	444	PF01048	0.774
MOD_GlcNHglycan	528	531	PF01048	0.641
MOD_GlcNHglycan	578	581	PF01048	0.646
MOD_GlcNHglycan	58	61	PF01048	0.487
MOD_GlcNHglycan	91	94	PF01048	0.561
MOD_GSK3_1	115	122	PF00069	0.620
MOD_GSK3_1	124	131	PF00069	0.708
MOD_GSK3_1	146	153	PF00069	0.769
MOD_GSK3_1	154	161	PF00069	0.627
MOD_GSK3_1	2	9	PF00069	0.560
MOD_GSK3_1	279	286	PF00069	0.533
MOD_GSK3_1	303	310	PF00069	0.554
MOD_GSK3_1	325	332	PF00069	0.642
MOD_GSK3_1	341	348	PF00069	0.713
MOD_GSK3_1	431	438	PF00069	0.681
MOD_GSK3_1	562	569	PF00069	0.648
MOD_GSK3_1	606	613	PF00069	0.665
MOD_GSK3_1	617	624	PF00069	0.585
MOD_GSK3_1	629	636	PF00069	0.548
MOD_N-GLC_1	120	125	PF02516	0.691
MOD_N-GLC_1	394	399	PF02516	0.782
MOD_N-GLC_1	45	50	PF02516	0.562
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	109	114	PF00069	0.600
MOD_NEK2_1	259	264	PF00069	0.649
MOD_NEK2_1	283	288	PF00069	0.508
MOD_NEK2_1	291	296	PF00069	0.602
MOD_NEK2_1	303	308	PF00069	0.629
MOD_NEK2_1	322	327	PF00069	0.508
MOD_NEK2_1	349	354	PF00069	0.686
MOD_NEK2_1	424	429	PF00069	0.664
MOD_NEK2_1	571	576	PF00069	0.577
MOD_NEK2_1	610	615	PF00069	0.622
MOD_NEK2_2	345	350	PF00069	0.706
MOD_PK_1	6	12	PF00069	0.527
MOD_PKA_1	386	392	PF00069	0.815
MOD_PKA_1	431	437	PF00069	0.708
MOD_PKA_1	6	12	PF00069	0.527
MOD_PKA_2	100	106	PF00069	0.552
MOD_PKA_2	146	152	PF00069	0.695
MOD_PKA_2	179	185	PF00069	0.506
MOD_PKA_2	322	328	PF00069	0.674
MOD_PKA_2	332	338	PF00069	0.718
MOD_PKA_2	349	355	PF00069	0.718
MOD_PKA_2	376	382	PF00069	0.762
MOD_PKA_2	386	392	PF00069	0.733
MOD_PKA_2	431	437	PF00069	0.714
MOD_PKA_2	6	12	PF00069	0.527
MOD_PKA_2	610	616	PF00069	0.696
MOD_PKA_2	673	679	PF00069	0.642
MOD_Plk_1	138	144	PF00069	0.600
MOD_Plk_1	394	400	PF00069	0.737
MOD_Plk_1	45	51	PF00069	0.554
MOD_Plk_2-3	621	627	PF00069	0.735
MOD_Plk_4	138	144	PF00069	0.600
MOD_Plk_4	212	218	PF00069	0.579
MOD_Plk_4	279	285	PF00069	0.573
MOD_Plk_4	566	572	PF00069	0.567
MOD_Plk_4	610	616	PF00069	0.624
MOD_Plk_4	633	639	PF00069	0.580
MOD_ProDKin_1	128	134	PF00069	0.642
MOD_ProDKin_1	151	157	PF00069	0.710
MOD_ProDKin_1	192	198	PF00069	0.593
MOD_ProDKin_1	361	367	PF00069	0.790
MOD_ProDKin_1	552	558	PF00069	0.770
MOD_ProDKin_1	589	595	PF00069	0.698
MOD_SUMO_rev_2	133	142	PF00179	0.594
TRG_DiLeu_BaEn_1	139	144	PF01217	0.606
TRG_DiLeu_BaEn_2	137	143	PF01217	0.591
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.676
TRG_ENDOCYTIC_2	187	190	PF00928	0.444
TRG_ENDOCYTIC_2	264	267	PF00928	0.515
TRG_ENDOCYTIC_2	31	34	PF00928	0.427
TRG_ENDOCYTIC_2	456	459	PF00928	0.683
TRG_ENDOCYTIC_2	601	604	PF00928	0.629
TRG_ENDOCYTIC_2	651	654	PF00928	0.545
TRG_ER_diArg_1	385	387	PF00400	0.731
TRG_ER_diArg_1	6	8	PF00400	0.451
TRG_ER_diArg_1	684	686	PF00400	0.571
TRG_ER_diArg_1	70	73	PF00400	0.640
TRG_NLS_MonoCore_2	706	711	PF00514	0.748
TRG_NLS_MonoExtN_4	704	711	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L9	Leptomonas seymouri	65%	97%
A4HM64	Leishmania braziliensis	82%	100%
A4IAS6	Leishmania infantum	100%	100%
D0A2D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AEK2	Leishmania major	94%	100%
E9B5R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%