t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ09_LEIDO

TriTrypDb:

LdBPK_364840.1 , LdCL_360055500 , LDHU3_36.6500

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IJ09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.724
CLV_C14_Caspase3-7	290	294	PF00656	0.702
CLV_C14_Caspase3-7	386	390	PF00656	0.651
CLV_NRD_NRD_1	119	121	PF00675	0.450
CLV_NRD_NRD_1	15	17	PF00675	0.505
CLV_NRD_NRD_1	171	173	PF00675	0.452
CLV_NRD_NRD_1	215	217	PF00675	0.523
CLV_NRD_NRD_1	252	254	PF00675	0.619
CLV_NRD_NRD_1	329	331	PF00675	0.525
CLV_PCSK_KEX2_1	119	121	PF00082	0.485
CLV_PCSK_KEX2_1	15	17	PF00082	0.505
CLV_PCSK_KEX2_1	171	173	PF00082	0.432
CLV_PCSK_KEX2_1	176	178	PF00082	0.414
CLV_PCSK_KEX2_1	215	217	PF00082	0.515
CLV_PCSK_KEX2_1	252	254	PF00082	0.597
CLV_PCSK_KEX2_1	329	331	PF00082	0.514
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.418
CLV_PCSK_PC7_1	172	178	PF00082	0.427
CLV_PCSK_SKI1_1	103	107	PF00082	0.307
CLV_PCSK_SKI1_1	308	312	PF00082	0.494
CLV_PCSK_SKI1_1	376	380	PF00082	0.468
DEG_Nend_UBRbox_2	1	3	PF02207	0.680
DOC_CYCLIN_RxL_1	304	315	PF00134	0.702
DOC_CYCLIN_RxL_1	372	380	PF00134	0.644
DOC_MAPK_gen_1	176	182	PF00069	0.549
DOC_PP2B_LxvP_1	336	339	PF13499	0.776
DOC_PP4_FxxP_1	446	449	PF00568	0.646
DOC_USP7_MATH_1	14	18	PF00917	0.696
DOC_USP7_MATH_1	287	291	PF00917	0.741
DOC_USP7_MATH_1	40	44	PF00917	0.656
DOC_WW_Pin1_4	257	262	PF00397	0.758
DOC_WW_Pin1_4	74	79	PF00397	0.636
LIG_14-3-3_CanoR_1	15	21	PF00244	0.756
LIG_14-3-3_CanoR_1	163	173	PF00244	0.621
LIG_14-3-3_CanoR_1	24	28	PF00244	0.748
LIG_14-3-3_CanoR_1	252	261	PF00244	0.810
LIG_14-3-3_CanoR_1	61	69	PF00244	0.580
LIG_CaM_NSCaTE_8	121	128	PF13499	0.600
LIG_eIF4E_1	5	11	PF01652	0.707
LIG_FHA_1	104	110	PF00498	0.573
LIG_FHA_1	268	274	PF00498	0.705
LIG_FHA_1	313	319	PF00498	0.706
LIG_FHA_1	39	45	PF00498	0.667
LIG_FHA_1	448	454	PF00498	0.575
LIG_FHA_1	61	67	PF00498	0.651
LIG_FHA_2	131	137	PF00498	0.774
LIG_FHA_2	218	224	PF00498	0.652
LIG_FHA_2	32	38	PF00498	0.693
LIG_FHA_2	362	368	PF00498	0.655
LIG_GBD_Chelix_1	209	217	PF00786	0.366
LIG_GBD_Chelix_1	453	461	PF00786	0.484
LIG_LIR_Apic_2	444	449	PF02991	0.673
LIG_LIR_Gen_1	415	422	PF02991	0.581
LIG_LIR_Nem_3	269	274	PF02991	0.713
LIG_LIR_Nem_3	415	421	PF02991	0.566
LIG_MYND_1	356	360	PF01753	0.731
LIG_Pex14_2	267	271	PF04695	0.743
LIG_SH2_STAT5	370	373	PF00017	0.682
LIG_SH3_3	141	147	PF00018	0.788
LIG_SH3_3	350	356	PF00018	0.754
LIG_SH3_3	436	442	PF00018	0.630
LIG_SH3_4	146	153	PF00018	0.722
LIG_SUMO_SIM_par_1	94	101	PF11976	0.609
LIG_TRAF2_1	183	186	PF00917	0.614
LIG_TRAF2_1	364	367	PF00917	0.603
MOD_CK1_1	130	136	PF00069	0.769
MOD_CK1_1	257	263	PF00069	0.744
MOD_CK1_1	401	407	PF00069	0.574
MOD_CK1_1	97	103	PF00069	0.599
MOD_CK2_1	217	223	PF00069	0.709
MOD_CK2_1	31	37	PF00069	0.688
MOD_CK2_1	314	320	PF00069	0.714
MOD_CK2_1	361	367	PF00069	0.611
MOD_CK2_1	434	440	PF00069	0.569
MOD_CK2_1	6	12	PF00069	0.648
MOD_CK2_1	88	94	PF00069	0.562
MOD_GlcNHglycan	155	158	PF01048	0.471
MOD_GlcNHglycan	293	296	PF01048	0.440
MOD_GlcNHglycan	385	388	PF01048	0.379
MOD_GlcNHglycan	443	446	PF01048	0.471
MOD_GlcNHglycan	66	69	PF01048	0.424
MOD_GSK3_1	103	110	PF00069	0.497
MOD_GSK3_1	123	130	PF00069	0.661
MOD_GSK3_1	253	260	PF00069	0.800
MOD_GSK3_1	287	294	PF00069	0.676
MOD_GSK3_1	31	38	PF00069	0.669
MOD_GSK3_1	398	405	PF00069	0.571
MOD_GSK3_1	40	47	PF00069	0.607
MOD_GSK3_1	412	419	PF00069	0.573
MOD_GSK3_1	60	67	PF00069	0.413
MOD_GSK3_1	84	91	PF00069	0.582
MOD_GSK3_1	94	101	PF00069	0.531
MOD_N-GLC_1	334	339	PF02516	0.537
MOD_NEK2_1	1	6	PF00069	0.667
MOD_NEK2_1	105	110	PF00069	0.517
MOD_NEK2_1	217	222	PF00069	0.637
MOD_NEK2_1	267	272	PF00069	0.741
MOD_NEK2_1	344	349	PF00069	0.736
MOD_NEK2_1	44	49	PF00069	0.605
MOD_NEK2_1	84	89	PF00069	0.567
MOD_NEK2_1	96	101	PF00069	0.527
MOD_NEK2_2	281	286	PF00069	0.692
MOD_PIKK_1	35	41	PF00454	0.641
MOD_PIKK_1	398	404	PF00454	0.571
MOD_PIKK_1	45	51	PF00454	0.552
MOD_PKA_1	15	21	PF00069	0.638
MOD_PKA_2	123	129	PF00069	0.612
MOD_PKA_2	14	20	PF00069	0.748
MOD_PKA_2	23	29	PF00069	0.732
MOD_PKA_2	60	66	PF00069	0.553
MOD_Plk_1	1	7	PF00069	0.732
MOD_Plk_1	334	340	PF00069	0.663
MOD_Plk_1	398	404	PF00069	0.586
MOD_Plk_4	40	46	PF00069	0.635
MOD_Plk_4	402	408	PF00069	0.572
MOD_Plk_4	84	90	PF00069	0.577
MOD_ProDKin_1	257	263	PF00069	0.757
MOD_ProDKin_1	74	80	PF00069	0.632
MOD_SUMO_for_1	183	186	PF00179	0.609
MOD_SUMO_rev_2	145	154	PF00179	0.692
MOD_SUMO_rev_2	386	393	PF00179	0.581
TRG_DiLeu_BaEn_1	416	421	PF01217	0.635
TRG_DiLeu_BaEn_4	366	372	PF01217	0.588
TRG_ER_diArg_1	119	121	PF00400	0.705
TRG_ER_diArg_1	122	125	PF00400	0.711
TRG_ER_diArg_1	171	173	PF00400	0.557
TRG_ER_diArg_1	215	217	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ6	Leptomonas seymouri	52%	100%
A0A422P578	Trypanosoma rangeli	30%	100%
A4HPX8	Leishmania braziliensis	72%	100%
A4IDP0	Leishmania infantum	100%	100%
D0A4C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ATP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0V3	Leishmania major	89%	100%
V5BUS9	Trypanosoma cruzi	35%	100%