NOL1/NOP2/sun family/FtsJ-like methyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IJ07_LEIDO

TriTrypDb:

LdBPK_292650.1 , LdCL_290032600 , LDHU3_29.3920

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IJ07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IJ07

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.469
CLV_C14_Caspase3-7	415	419	PF00656	0.507
CLV_C14_Caspase3-7	73	77	PF00656	0.446
CLV_NRD_NRD_1	111	113	PF00675	0.546
CLV_NRD_NRD_1	243	245	PF00675	0.202
CLV_NRD_NRD_1	357	359	PF00675	0.261
CLV_NRD_NRD_1	382	384	PF00675	0.269
CLV_NRD_NRD_1	6	8	PF00675	0.575
CLV_PCSK_FUR_1	380	384	PF00082	0.249
CLV_PCSK_KEX2_1	111	113	PF00082	0.410
CLV_PCSK_KEX2_1	12	14	PF00082	0.576
CLV_PCSK_KEX2_1	120	122	PF00082	0.402
CLV_PCSK_KEX2_1	357	359	PF00082	0.293
CLV_PCSK_KEX2_1	382	384	PF00082	0.227
CLV_PCSK_KEX2_1	90	92	PF00082	0.377
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.381
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.572
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.328
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.434
CLV_PCSK_PC7_1	107	113	PF00082	0.359
CLV_PCSK_SKI1_1	117	121	PF00082	0.391
CLV_PCSK_SKI1_1	267	271	PF00082	0.228
CLV_PCSK_SKI1_1	335	339	PF00082	0.245
CLV_PCSK_SKI1_1	382	386	PF00082	0.242
CLV_PCSK_SKI1_1	595	599	PF00082	0.455
DEG_APCC_DBOX_1	266	274	PF00400	0.428
DEG_SPOP_SBC_1	558	562	PF00917	0.429
DOC_CYCLIN_RxL_1	434	446	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	221	224	PF00134	0.479
DOC_MAPK_MEF2A_6	164	173	PF00069	0.417
DOC_MAPK_MEF2A_6	595	602	PF00069	0.411
DOC_MAPK_NFAT4_5	595	603	PF00069	0.463
DOC_PP1_RVXF_1	498	504	PF00149	0.324
DOC_PP1_RVXF_1	97	104	PF00149	0.434
DOC_PP2B_LxvP_1	221	224	PF13499	0.479
DOC_PP2B_LxvP_1	441	444	PF13499	0.295
DOC_PP2B_LxvP_1	598	601	PF13499	0.436
DOC_PP4_MxPP_1	140	143	PF00568	0.289
DOC_USP7_MATH_1	296	300	PF00917	0.427
DOC_USP7_MATH_1	573	577	PF00917	0.476
DOC_USP7_UBL2_3	8	12	PF12436	0.618
DOC_WW_Pin1_4	312	317	PF00397	0.490
DOC_WW_Pin1_4	321	326	PF00397	0.451
DOC_WW_Pin1_4	521	526	PF00397	0.390
DOC_WW_Pin1_4	532	537	PF00397	0.431
LIG_14-3-3_CanoR_1	271	281	PF00244	0.550
LIG_14-3-3_CanoR_1	357	361	PF00244	0.472
LIG_14-3-3_CanoR_1	434	438	PF00244	0.390
LIG_14-3-3_CanoR_1	502	511	PF00244	0.297
LIG_Actin_WH2_2	228	246	PF00022	0.402
LIG_Actin_WH2_2	482	497	PF00022	0.405
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BIR_III_4	418	422	PF00653	0.491
LIG_BRCT_BRCA1_1	486	490	PF00533	0.320
LIG_BRCT_BRCA1_1	61	65	PF00533	0.334
LIG_BRCT_BRCA1_1	83	87	PF00533	0.407
LIG_deltaCOP1_diTrp_1	248	253	PF00928	0.402
LIG_deltaCOP1_diTrp_1	47	51	PF00928	0.323
LIG_FHA_1	163	169	PF00498	0.402
LIG_FHA_1	284	290	PF00498	0.417
LIG_FHA_1	306	312	PF00498	0.439
LIG_FHA_1	313	319	PF00498	0.412
LIG_FHA_1	332	338	PF00498	0.413
LIG_FHA_1	368	374	PF00498	0.460
LIG_FHA_1	379	385	PF00498	0.389
LIG_FHA_1	503	509	PF00498	0.476
LIG_FHA_1	522	528	PF00498	0.367
LIG_FHA_1	544	550	PF00498	0.565
LIG_FHA_1	78	84	PF00498	0.446
LIG_FHA_2	131	137	PF00498	0.297
LIG_FHA_2	210	216	PF00498	0.402
LIG_FHA_2	30	36	PF00498	0.352
LIG_FHA_2	331	337	PF00498	0.453
LIG_FHA_2	617	623	PF00498	0.525
LIG_Integrin_RGD_1	107	109	PF01839	0.412
LIG_LIR_Gen_1	226	236	PF02991	0.412
LIG_LIR_Gen_1	308	317	PF02991	0.537
LIG_LIR_Gen_1	446	454	PF02991	0.398
LIG_LIR_Gen_1	46	55	PF02991	0.319
LIG_LIR_Gen_1	487	496	PF02991	0.387
LIG_LIR_Nem_3	217	222	PF02991	0.432
LIG_LIR_Nem_3	226	231	PF02991	0.421
LIG_LIR_Nem_3	308	312	PF02991	0.440
LIG_LIR_Nem_3	32	37	PF02991	0.358
LIG_LIR_Nem_3	446	452	PF02991	0.405
LIG_LIR_Nem_3	46	51	PF02991	0.275
LIG_LIR_Nem_3	487	493	PF02991	0.325
LIG_MAD2	153	161	PF02301	0.413
LIG_MYND_1	220	224	PF01753	0.479
LIG_NRBOX	167	173	PF00104	0.470
LIG_PTB_Apo_2	28	35	PF02174	0.344
LIG_SH2_GRB2like	496	499	PF00017	0.428
LIG_SH2_SRC	344	347	PF00017	0.495
LIG_SH2_SRC	362	365	PF00017	0.543
LIG_SH2_STAT5	131	134	PF00017	0.316
LIG_SH2_STAT5	465	468	PF00017	0.305
LIG_SH2_STAT5	570	573	PF00017	0.340
LIG_SH3_1	90	96	PF00018	0.321
LIG_SH3_3	217	223	PF00018	0.430
LIG_SH3_3	422	428	PF00018	0.443
LIG_SH3_3	510	516	PF00018	0.309
LIG_SH3_3	562	568	PF00018	0.499
LIG_SH3_3	90	96	PF00018	0.377
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.416
LIG_SUMO_SIM_par_1	519	524	PF11976	0.359
LIG_TRAF2_1	133	136	PF00917	0.305
LIG_TRAF2_1	605	608	PF00917	0.671
LIG_TRAF2_1	613	616	PF00917	0.681
LIG_TRFH_1	219	223	PF08558	0.402
LIG_UBA3_1	269	277	PF00899	0.445
MOD_CK1_1	11	17	PF00069	0.665
MOD_CK1_1	163	169	PF00069	0.402
MOD_CK1_1	275	281	PF00069	0.445
MOD_CK1_1	285	291	PF00069	0.368
MOD_CK1_1	543	549	PF00069	0.564
MOD_CK2_1	130	136	PF00069	0.299
MOD_CK2_1	29	35	PF00069	0.498
MOD_CK2_1	43	49	PF00069	0.289
MOD_CK2_1	602	608	PF00069	0.596
MOD_CK2_1	616	622	PF00069	0.573
MOD_CMANNOS	250	253	PF00535	0.202
MOD_GlcNHglycan	123	126	PF01048	0.382
MOD_GlcNHglycan	237	240	PF01048	0.205
MOD_GlcNHglycan	277	280	PF01048	0.249
MOD_GlcNHglycan	298	301	PF01048	0.249
MOD_GlcNHglycan	414	417	PF01048	0.559
MOD_GlcNHglycan	429	432	PF01048	0.531
MOD_GlcNHglycan	541	545	PF01048	0.481
MOD_GlcNHglycan	624	627	PF01048	0.502
MOD_GSK3_1	130	137	PF00069	0.328
MOD_GSK3_1	235	242	PF00069	0.402
MOD_GSK3_1	321	328	PF00069	0.437
MOD_GSK3_1	331	338	PF00069	0.402
MOD_GSK3_1	352	359	PF00069	0.457
MOD_GSK3_1	466	473	PF00069	0.443
MOD_GSK3_1	519	526	PF00069	0.435
MOD_GSK3_1	553	560	PF00069	0.427
MOD_GSK3_1	77	84	PF00069	0.346
MOD_N-GLC_1	115	120	PF02516	0.387
MOD_N-GLC_1	3	8	PF02516	0.517
MOD_N-GLC_1	622	627	PF02516	0.656
MOD_NEK2_1	103	108	PF00069	0.364
MOD_NEK2_1	209	214	PF00069	0.442
MOD_NEK2_1	261	266	PF00069	0.413
MOD_NEK2_1	29	34	PF00069	0.343
MOD_NEK2_1	302	307	PF00069	0.448
MOD_NEK2_1	433	438	PF00069	0.492
MOD_NEK2_1	519	524	PF00069	0.376
MOD_NEK2_1	557	562	PF00069	0.341
MOD_NEK2_2	115	120	PF00069	0.343
MOD_NEK2_2	239	244	PF00069	0.402
MOD_NEK2_2	272	277	PF00069	0.506
MOD_PIKK_1	163	169	PF00454	0.402
MOD_PIKK_1	261	267	PF00454	0.413
MOD_PIKK_1	385	391	PF00454	0.519
MOD_PIKK_1	472	478	PF00454	0.441
MOD_PIKK_1	77	83	PF00454	0.490
MOD_PIKK_1	94	100	PF00454	0.310
MOD_PKA_2	243	249	PF00069	0.402
MOD_PKA_2	356	362	PF00069	0.464
MOD_PKA_2	433	439	PF00069	0.394
MOD_PKB_1	410	418	PF00069	0.499
MOD_Plk_1	115	121	PF00069	0.386
MOD_Plk_1	214	220	PF00069	0.427
MOD_Plk_1	573	579	PF00069	0.327
MOD_Plk_1	622	628	PF00069	0.504
MOD_Plk_4	136	142	PF00069	0.284
MOD_Plk_4	362	368	PF00069	0.401
MOD_Plk_4	489	495	PF00069	0.416
MOD_Plk_4	523	529	PF00069	0.336
MOD_Plk_4	553	559	PF00069	0.349
MOD_Plk_4	574	580	PF00069	0.479
MOD_ProDKin_1	312	318	PF00069	0.490
MOD_ProDKin_1	321	327	PF00069	0.451
MOD_ProDKin_1	521	527	PF00069	0.386
MOD_ProDKin_1	532	538	PF00069	0.427
MOD_SUMO_rev_2	345	350	PF00179	0.523
MOD_SUMO_rev_2	414	422	PF00179	0.652
MOD_SUMO_rev_2	457	464	PF00179	0.288
MOD_SUMO_rev_2	84	92	PF00179	0.442
TRG_DiLeu_BaEn_2	46	52	PF01217	0.364
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.422
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.413
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.445
TRG_ENDOCYTIC_2	539	542	PF00928	0.465
TRG_ER_diArg_1	380	383	PF00400	0.451
TRG_NLS_MonoCore_2	110	115	PF00514	0.435
TRG_NLS_MonoExtC_3	11	17	PF00514	0.604
TRG_NLS_MonoExtN_4	111	116	PF00514	0.435
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.202

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y2	Leptomonas seymouri	72%	99%
A0A0S4IKI3	Bodo saltans	51%	94%
A0A1X0P924	Trypanosomatidae	54%	92%
A0A3Q8INR5	Leishmania donovani	32%	83%
A0A3S5IQZ3	Trypanosoma rangeli	57%	100%
A4HIZ4	Leishmania braziliensis	27%	100%
A4IDJ1	Leishmania infantum	32%	83%
C9ZKZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	97%
D0A386	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
E9AEB6	Leishmania major	95%	100%
E9AHJ5	Leishmania infantum	99%	100%
E9AIT8	Leishmania braziliensis	86%	100%
E9ALH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ASZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	83%
O13935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	93%
P38205	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	93%
Q08J23	Homo sapiens	35%	83%
Q1HFZ0	Mus musculus	37%	84%
Q4Q1K4	Leishmania major	32%	83%
Q4Q6P5	Leishmania major	28%	100%
Q4V7N2	Xenopus laevis	36%	91%
Q9HGQ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	92%
Q9W4M9	Drosophila melanogaster	35%	85%
V5BSK4	Trypanosoma cruzi	53%	100%