Leucine Rich Repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIZ4_LEIDO

TriTrypDb:

LdBPK_320310.1 , LdCL_320008000 , LDHU3_32.0390

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005634	nucleus	5	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IIZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIZ4

Function

Biological processes
Term	Name	Level	Count
GO:0009314	response to radiation	3	7
GO:0009628	response to abiotic stimulus	2	7
GO:0010165	response to X-ray	5	7
GO:0010212	response to ionizing radiation	4	7
GO:0050896	response to stimulus	1	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.336
CLV_C14_Caspase3-7	34	38	PF00656	0.716
CLV_C14_Caspase3-7	663	667	PF00656	0.581
CLV_NRD_NRD_1	138	140	PF00675	0.518
CLV_NRD_NRD_1	141	143	PF00675	0.531
CLV_NRD_NRD_1	356	358	PF00675	0.538
CLV_NRD_NRD_1	390	392	PF00675	0.594
CLV_NRD_NRD_1	402	404	PF00675	0.449
CLV_NRD_NRD_1	587	589	PF00675	0.613
CLV_NRD_NRD_1	600	602	PF00675	0.663
CLV_NRD_NRD_1	606	608	PF00675	0.531
CLV_NRD_NRD_1	683	685	PF00675	0.678
CLV_NRD_NRD_1	743	745	PF00675	0.496
CLV_PCSK_FUR_1	139	143	PF00082	0.570
CLV_PCSK_KEX2_1	137	139	PF00082	0.586
CLV_PCSK_KEX2_1	141	143	PF00082	0.537
CLV_PCSK_KEX2_1	356	358	PF00082	0.538
CLV_PCSK_KEX2_1	390	392	PF00082	0.594
CLV_PCSK_KEX2_1	402	404	PF00082	0.449
CLV_PCSK_KEX2_1	586	588	PF00082	0.603
CLV_PCSK_KEX2_1	600	602	PF00082	0.653
CLV_PCSK_KEX2_1	606	608	PF00082	0.522
CLV_PCSK_PC7_1	134	140	PF00082	0.575
CLV_PCSK_PC7_1	582	588	PF00082	0.573
CLV_PCSK_SKI1_1	107	111	PF00082	0.523
CLV_PCSK_SKI1_1	519	523	PF00082	0.392
CLV_PCSK_SKI1_1	658	662	PF00082	0.664
CLV_PCSK_SKI1_1	684	688	PF00082	0.691
CLV_PCSK_SKI1_1	740	744	PF00082	0.649
DEG_APCC_DBOX_1	140	148	PF00400	0.551
DEG_APCC_DBOX_1	334	342	PF00400	0.401
DEG_APCC_DBOX_1	743	751	PF00400	0.521
DEG_Nend_UBRbox_2	1	3	PF02207	0.651
DEG_SCF_FBW7_1	532	538	PF00400	0.560
DEG_SCF_FBW7_1	627	633	PF00400	0.647
DEG_SPOP_SBC_1	246	250	PF00917	0.379
DOC_CDC14_PxL_1	338	346	PF14671	0.563
DOC_CKS1_1	532	537	PF01111	0.542
DOC_CKS1_1	627	632	PF01111	0.563
DOC_CYCLIN_yCln2_LP_2	94	97	PF00134	0.658
DOC_MAPK_gen_1	50	57	PF00069	0.641
DOC_MAPK_MEF2A_6	356	365	PF00069	0.531
DOC_PP2B_LxvP_1	224	227	PF13499	0.377
DOC_PP2B_LxvP_1	94	97	PF13499	0.658
DOC_PP4_FxxP_1	123	126	PF00568	0.538
DOC_USP7_MATH_1	188	192	PF00917	0.438
DOC_USP7_MATH_1	246	250	PF00917	0.399
DOC_USP7_MATH_1	307	311	PF00917	0.312
DOC_USP7_MATH_1	35	39	PF00917	0.598
DOC_USP7_MATH_1	359	363	PF00917	0.390
DOC_USP7_MATH_1	462	466	PF00917	0.553
DOC_USP7_MATH_1	477	481	PF00917	0.591
DOC_USP7_MATH_1	489	493	PF00917	0.578
DOC_USP7_MATH_1	673	677	PF00917	0.676
DOC_USP7_MATH_1	746	750	PF00917	0.525
DOC_WW_Pin1_4	19	24	PF00397	0.576
DOC_WW_Pin1_4	312	317	PF00397	0.360
DOC_WW_Pin1_4	480	485	PF00397	0.606
DOC_WW_Pin1_4	512	517	PF00397	0.587
DOC_WW_Pin1_4	531	536	PF00397	0.382
DOC_WW_Pin1_4	626	631	PF00397	0.643
DOC_WW_Pin1_4	633	638	PF00397	0.585
DOC_WW_Pin1_4	723	728	PF00397	0.596
LIG_14-3-3_CanoR_1	117	123	PF00244	0.585
LIG_14-3-3_CanoR_1	139	145	PF00244	0.469
LIG_14-3-3_CanoR_1	302	308	PF00244	0.255
LIG_14-3-3_CanoR_1	335	344	PF00244	0.408
LIG_14-3-3_CanoR_1	448	452	PF00244	0.491
LIG_14-3-3_CanoR_1	606	614	PF00244	0.646
LIG_14-3-3_CanoR_1	684	693	PF00244	0.713
LIG_14-3-3_CanoR_1	702	707	PF00244	0.512
LIG_14-3-3_CanoR_1	719	725	PF00244	0.697
LIG_Actin_WH2_2	195	211	PF00022	0.371
LIG_APCC_ABBA_1	13	18	PF00400	0.615
LIG_APCC_ABBA_1	571	576	PF00400	0.542
LIG_BRCT_BRCA1_1	514	518	PF00533	0.533
LIG_BRCT_BRCA1_1	551	555	PF00533	0.660
LIG_deltaCOP1_diTrp_1	444	451	PF00928	0.469
LIG_FHA_1	208	214	PF00498	0.406
LIG_FHA_1	465	471	PF00498	0.551
LIG_FHA_1	563	569	PF00498	0.598
LIG_FHA_1	727	733	PF00498	0.572
LIG_FHA_2	131	137	PF00498	0.500
LIG_FHA_2	436	442	PF00498	0.560
LIG_FHA_2	518	524	PF00498	0.440
LIG_FHA_2	661	667	PF00498	0.662
LIG_FHA_2	708	714	PF00498	0.732
LIG_LIR_Apic_2	121	126	PF02991	0.614
LIG_LIR_Gen_1	168	178	PF02991	0.399
LIG_LIR_Gen_1	260	271	PF02991	0.342
LIG_LIR_Gen_1	420	428	PF02991	0.513
LIG_LIR_Gen_1	576	584	PF02991	0.540
LIG_LIR_Gen_1	67	78	PF02991	0.653
LIG_LIR_Nem_3	121	125	PF02991	0.664
LIG_LIR_Nem_3	168	173	PF02991	0.382
LIG_LIR_Nem_3	260	266	PF02991	0.298
LIG_LIR_Nem_3	317	322	PF02991	0.448
LIG_LIR_Nem_3	420	426	PF02991	0.502
LIG_LIR_Nem_3	450	454	PF02991	0.508
LIG_LIR_Nem_3	515	521	PF02991	0.504
LIG_LIR_Nem_3	523	528	PF02991	0.387
LIG_LIR_Nem_3	576	580	PF02991	0.526
LIG_LIR_Nem_3	67	73	PF02991	0.657
LIG_MYND_1	614	618	PF01753	0.528
LIG_MYND_3	226	230	PF01753	0.380
LIG_NRBOX	409	415	PF00104	0.345
LIG_PTAP_UEV_1	483	488	PF05743	0.637
LIG_PTB_Apo_2	234	241	PF02174	0.391
LIG_SH2_CRK	423	427	PF00017	0.519
LIG_SH2_CRK	581	585	PF00017	0.615
LIG_SH2_NCK_1	263	267	PF00017	0.312
LIG_SH2_NCK_1	551	555	PF00017	0.563
LIG_SH2_STAP1	423	427	PF00017	0.434
LIG_SH2_STAP1	551	555	PF00017	0.584
LIG_SH2_STAT5	122	125	PF00017	0.574
LIG_SH2_STAT5	204	207	PF00017	0.472
LIG_SH2_STAT5	454	457	PF00017	0.509
LIG_SH2_STAT5	524	527	PF00017	0.413
LIG_SH2_STAT5	549	552	PF00017	0.574
LIG_SH3_1	497	503	PF00018	0.616
LIG_SH3_1	745	751	PF00018	0.531
LIG_SH3_2	543	548	PF14604	0.605
LIG_SH3_2	615	620	PF14604	0.561
LIG_SH3_3	355	361	PF00018	0.441
LIG_SH3_3	398	404	PF00018	0.401
LIG_SH3_3	481	487	PF00018	0.630
LIG_SH3_3	497	503	PF00018	0.486
LIG_SH3_3	511	517	PF00018	0.654
LIG_SH3_3	529	535	PF00018	0.308
LIG_SH3_3	537	543	PF00018	0.563
LIG_SH3_3	566	572	PF00018	0.595
LIG_SH3_3	596	602	PF00018	0.614
LIG_SH3_3	612	618	PF00018	0.599
LIG_SH3_3	619	625	PF00018	0.577
LIG_SH3_3	70	76	PF00018	0.602
LIG_SH3_3	708	714	PF00018	0.677
LIG_SH3_3	721	727	PF00018	0.546
LIG_SH3_3	745	751	PF00018	0.531
LIG_SH3_4	43	50	PF00018	0.648
LIG_SUMO_SIM_par_1	209	215	PF11976	0.308
LIG_SUMO_SIM_par_1	255	260	PF11976	0.341
LIG_TRAF2_1	133	136	PF00917	0.567
LIG_TRAF2_1	643	646	PF00917	0.672
LIG_TRAF2_1	710	713	PF00917	0.661
LIG_TYR_ITIM	261	266	PF00017	0.312
LIG_WW_2	540	543	PF00397	0.680
LIG_WW_3	629	633	PF00397	0.676
MOD_CDK_SPK_2	531	536	PF00069	0.520
MOD_CDK_SPxK_1	626	632	PF00069	0.649
MOD_CDK_SPxxK_3	512	519	PF00069	0.490
MOD_CK1_1	192	198	PF00069	0.403
MOD_CK1_1	248	254	PF00069	0.465
MOD_CK1_1	286	292	PF00069	0.353
MOD_CK1_1	38	44	PF00069	0.583
MOD_CK1_1	480	486	PF00069	0.593
MOD_CK1_1	636	642	PF00069	0.698
MOD_CK1_1	723	729	PF00069	0.670
MOD_CK2_1	110	116	PF00069	0.500
MOD_CK2_1	130	136	PF00069	0.369
MOD_CK2_1	171	177	PF00069	0.404
MOD_CK2_1	194	200	PF00069	0.401
MOD_CK2_1	238	244	PF00069	0.454
MOD_CK2_1	426	432	PF00069	0.484
MOD_CK2_1	435	441	PF00069	0.520
MOD_CK2_1	462	468	PF00069	0.610
MOD_CK2_1	517	523	PF00069	0.537
MOD_CK2_1	640	646	PF00069	0.680
MOD_CK2_1	707	713	PF00069	0.733
MOD_Cter_Amidation	584	587	PF01082	0.580
MOD_GlcNHglycan	112	115	PF01048	0.662
MOD_GlcNHglycan	173	176	PF01048	0.408
MOD_GlcNHglycan	296	300	PF01048	0.481
MOD_GlcNHglycan	352	355	PF01048	0.623
MOD_GlcNHglycan	484	487	PF01048	0.681
MOD_GlcNHglycan	552	555	PF01048	0.559
MOD_GlcNHglycan	704	707	PF01048	0.656
MOD_GSK3_1	188	195	PF00069	0.444
MOD_GSK3_1	19	26	PF00069	0.631
MOD_GSK3_1	203	210	PF00069	0.452
MOD_GSK3_1	245	252	PF00069	0.407
MOD_GSK3_1	307	314	PF00069	0.388
MOD_GSK3_1	426	433	PF00069	0.459
MOD_GSK3_1	471	478	PF00069	0.602
MOD_GSK3_1	531	538	PF00069	0.552
MOD_GSK3_1	626	633	PF00069	0.720
MOD_GSK3_1	636	643	PF00069	0.593
MOD_GSK3_1	85	92	PF00069	0.611
MOD_N-GLC_1	110	115	PF02516	0.510
MOD_N-GLC_1	331	336	PF02516	0.347
MOD_NEK2_1	140	145	PF00069	0.465
MOD_NEK2_1	171	176	PF00069	0.432
MOD_NEK2_1	189	194	PF00069	0.477
MOD_NEK2_1	283	288	PF00069	0.381
MOD_NEK2_1	366	371	PF00069	0.371
MOD_NEK2_1	385	390	PF00069	0.409
MOD_NEK2_1	442	447	PF00069	0.532
MOD_NEK2_1	550	555	PF00069	0.583
MOD_NEK2_1	660	665	PF00069	0.662
MOD_NEK2_1	86	91	PF00069	0.607
MOD_NEK2_2	517	522	PF00069	0.471
MOD_PIKK_1	189	195	PF00454	0.410
MOD_PIKK_1	402	408	PF00454	0.400
MOD_PIKK_1	426	432	PF00454	0.450
MOD_PIKK_1	673	679	PF00454	0.631
MOD_PIKK_1	692	698	PF00454	0.702
MOD_PKA_1	402	408	PF00069	0.404
MOD_PKA_1	586	592	PF00069	0.622
MOD_PKA_1	684	690	PF00069	0.716
MOD_PKA_2	140	146	PF00069	0.606
MOD_PKA_2	301	307	PF00069	0.255
MOD_PKA_2	38	44	PF00069	0.598
MOD_PKA_2	402	408	PF00069	0.404
MOD_PKA_2	447	453	PF00069	0.542
MOD_PKA_2	586	592	PF00069	0.611
MOD_PKA_2	605	611	PF00069	0.518
MOD_Plk_1	110	116	PF00069	0.500
MOD_Plk_1	182	188	PF00069	0.427
MOD_Plk_4	252	258	PF00069	0.366
MOD_Plk_4	90	96	PF00069	0.673
MOD_ProDKin_1	19	25	PF00069	0.576
MOD_ProDKin_1	312	318	PF00069	0.355
MOD_ProDKin_1	480	486	PF00069	0.608
MOD_ProDKin_1	512	518	PF00069	0.571
MOD_ProDKin_1	531	537	PF00069	0.399
MOD_ProDKin_1	626	632	PF00069	0.648
MOD_ProDKin_1	633	639	PF00069	0.585
MOD_ProDKin_1	723	729	PF00069	0.591
TRG_DiLeu_BaEn_1	230	235	PF01217	0.330
TRG_DiLeu_BaEn_1	396	401	PF01217	0.374
TRG_DiLeu_BaEn_1	409	414	PF01217	0.299
TRG_DiLeu_BaEn_3	648	654	PF01217	0.559
TRG_DiLeu_BaEn_4	135	141	PF01217	0.574
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.418
TRG_DiLeu_LyEn_5	409	414	PF01217	0.349
TRG_ENDOCYTIC_2	122	125	PF00928	0.536
TRG_ENDOCYTIC_2	263	266	PF00928	0.312
TRG_ENDOCYTIC_2	423	426	PF00928	0.520
TRG_ENDOCYTIC_2	574	577	PF00928	0.528
TRG_ENDOCYTIC_2	581	584	PF00928	0.559
TRG_ER_diArg_1	137	139	PF00400	0.586
TRG_ER_diArg_1	140	142	PF00400	0.537
TRG_ER_diArg_1	355	357	PF00400	0.557
TRG_ER_diArg_1	389	391	PF00400	0.479
TRG_ER_diArg_1	401	403	PF00400	0.457
TRG_ER_diArg_1	586	588	PF00400	0.627
TRG_ER_diArg_1	591	594	PF00400	0.610
TRG_ER_diArg_1	599	601	PF00400	0.613
TRG_ER_diArg_1	716	719	PF00400	0.684
TRG_NES_CRM1_1	215	230	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F9	Leptomonas seymouri	44%	96%
A4HK10	Leishmania braziliensis	68%	100%
A4I7J4	Leishmania infantum	99%	100%
E9B2F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q5Q5	Leishmania major	88%	100%