Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IIZ2_LEIDO

TriTrypDb:

LdBPK_160510.1 , LdCL_160010000 , LDHU3_16.0610

Length:

222

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin: surface protein with roles in host adhesion, especially at the amastigote stage.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 17
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

A0A3Q8IIZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIZ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.599
CLV_NRD_NRD_1	28	30	PF00675	0.663
CLV_NRD_NRD_1	40	42	PF00675	0.568
CLV_PCSK_KEX2_1	40	42	PF00082	0.626
CLV_PCSK_SKI1_1	40	44	PF00082	0.634
CLV_PCSK_SKI1_1	5	9	PF00082	0.358
CLV_PCSK_SKI1_1	67	71	PF00082	0.715
CLV_PCSK_SKI1_1	75	79	PF00082	0.632
DEG_APCC_DBOX_1	4	12	PF00400	0.524
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DOC_CYCLIN_RxL_1	72	82	PF00134	0.374
DOC_MAPK_MEF2A_6	5	13	PF00069	0.616
DOC_MAPK_MEF2A_6	73	81	PF00069	0.373
DOC_PP1_RVXF_1	38	45	PF00149	0.389
DOC_PP2B_LxvP_1	150	153	PF13499	0.394
DOC_USP7_MATH_1	218	222	PF00917	0.880
DOC_WW_Pin1_4	52	57	PF00397	0.498
LIG_14-3-3_CanoR_1	190	195	PF00244	0.649
LIG_14-3-3_CanoR_1	202	210	PF00244	0.740
LIG_14-3-3_CanoR_1	51	57	PF00244	0.620
LIG_FHA_1	112	118	PF00498	0.411
LIG_FHA_1	14	20	PF00498	0.526
LIG_FHA_1	178	184	PF00498	0.447
LIG_FHA_1	64	70	PF00498	0.542
LIG_GBD_Chelix_1	116	124	PF00786	0.572
LIG_LIR_Gen_1	119	129	PF02991	0.449
LIG_LIR_LC3C_4	180	183	PF02991	0.334
LIG_LIR_Nem_3	119	124	PF02991	0.443
LIG_LIR_Nem_3	162	167	PF02991	0.396
LIG_Pex14_2	121	125	PF04695	0.414
LIG_Pex14_2	137	141	PF04695	0.376
LIG_Pex14_2	174	178	PF04695	0.509
LIG_SH2_STAP1	107	111	PF00017	0.794
LIG_SH2_STAP1	65	69	PF00017	0.512
LIG_SH2_STAT5	149	152	PF00017	0.479
LIG_SH2_STAT5	215	218	PF00017	0.881
LIG_SH2_STAT5	65	68	PF00017	0.515
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.334
LIG_UBA3_1	23	30	PF00899	0.527
LIG_UBA3_1	69	73	PF00899	0.397
MOD_CK1_1	112	118	PF00069	0.575
MOD_CK1_1	32	38	PF00069	0.616
MOD_CK1_1	82	88	PF00069	0.381
MOD_CK2_1	52	58	PF00069	0.641
MOD_Cter_Amidation	200	203	PF01082	0.496
MOD_GlcNHglycan	211	214	PF01048	0.654
MOD_GlcNHglycan	216	219	PF01048	0.591
MOD_GlcNHglycan	81	84	PF01048	0.440
MOD_GSK3_1	101	108	PF00069	0.572
MOD_GSK3_1	112	119	PF00069	0.460
MOD_GSK3_1	214	221	PF00069	0.799
MOD_GSK3_1	46	53	PF00069	0.478
MOD_N-GLC_1	143	148	PF02516	0.695
MOD_N-GLC_1	32	37	PF02516	0.709
MOD_N-GLC_1	46	51	PF02516	0.687
MOD_NEK2_1	116	121	PF00069	0.427
MOD_NEK2_1	123	128	PF00069	0.426
MOD_NEK2_1	130	135	PF00069	0.424
MOD_NEK2_1	177	182	PF00069	0.384
MOD_NEK2_1	216	221	PF00069	0.773
MOD_NEK2_1	79	84	PF00069	0.371
MOD_NEK2_2	46	51	PF00069	0.384
MOD_PIKK_1	190	196	PF00454	0.793
MOD_PKA_1	29	35	PF00069	0.436
MOD_PKA_2	201	207	PF00069	0.788
MOD_PKA_2	50	56	PF00069	0.535
MOD_Plk_1	46	52	PF00069	0.493
MOD_Plk_4	112	118	PF00069	0.460
MOD_Plk_4	131	137	PF00069	0.399
MOD_Plk_4	19	25	PF00069	0.506
MOD_Plk_4	82	88	PF00069	0.477
MOD_ProDKin_1	52	58	PF00069	0.500
TRG_DiLeu_BaEn_1	162	167	PF01217	0.379
TRG_ENDOCYTIC_2	158	161	PF00928	0.433
TRG_ER_diArg_1	39	41	PF00400	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z4	Leptomonas seymouri	32%	100%
A0A0N0P3Z6	Leptomonas seymouri	28%	98%
A0A0N0P4D5	Leptomonas seymouri	33%	100%
A0A0N1HU04	Leptomonas seymouri	27%	71%
A0A3R7KFR8	Trypanosoma rangeli	27%	100%
A0A3S5H6X1	Leishmania donovani	33%	100%
A0A3S7WTU4	Leishmania donovani	30%	100%
A4H8H3	Leishmania braziliensis	34%	100%
A4H8H5	Leishmania braziliensis	31%	100%
A4H8H6	Leishmania braziliensis	46%	100%
A4HWU5	Leishmania infantum	30%	99%
A4HWU7	Leishmania infantum	33%	100%
A4HWU8	Leishmania infantum	99%	100%
E9AQK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AQK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	96%
E9AQK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QEX0	Leishmania major	78%	100%
Q4QEX1	Leishmania major	33%	97%
Q4QEX3	Leishmania major	33%	99%