Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIY8_LEIDO

TriTrypDb:

LdBPK_360290.1 , LdCL_360007900 , LDHU3_36.0410

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	222	224	PF00675	0.641
CLV_NRD_NRD_1	237	239	PF00675	0.701
CLV_NRD_NRD_1	253	255	PF00675	0.583
CLV_NRD_NRD_1	264	266	PF00675	0.408
CLV_NRD_NRD_1	32	34	PF00675	0.710
CLV_NRD_NRD_1	497	499	PF00675	0.458
CLV_NRD_NRD_1	5	7	PF00675	0.591
CLV_NRD_NRD_1	643	645	PF00675	0.763
CLV_NRD_NRD_1	672	674	PF00675	0.742
CLV_NRD_NRD_1	740	742	PF00675	0.456
CLV_NRD_NRD_1	762	764	PF00675	0.371
CLV_NRD_NRD_1	801	803	PF00675	0.593
CLV_NRD_NRD_1	810	812	PF00675	0.602
CLV_NRD_NRD_1	92	94	PF00675	0.547
CLV_PCSK_KEX2_1	222	224	PF00082	0.683
CLV_PCSK_KEX2_1	237	239	PF00082	0.509
CLV_PCSK_KEX2_1	252	254	PF00082	0.742
CLV_PCSK_KEX2_1	264	266	PF00082	0.399
CLV_PCSK_KEX2_1	32	34	PF00082	0.603
CLV_PCSK_KEX2_1	497	499	PF00082	0.458
CLV_PCSK_KEX2_1	5	7	PF00082	0.591
CLV_PCSK_KEX2_1	643	645	PF00082	0.769
CLV_PCSK_KEX2_1	672	674	PF00082	0.622
CLV_PCSK_KEX2_1	739	741	PF00082	0.469
CLV_PCSK_KEX2_1	762	764	PF00082	0.393
CLV_PCSK_KEX2_1	801	803	PF00082	0.457
CLV_PCSK_KEX2_1	810	812	PF00082	0.544
CLV_PCSK_KEX2_1	92	94	PF00082	0.547
CLV_PCSK_PC7_1	736	742	PF00082	0.424
CLV_PCSK_SKI1_1	157	161	PF00082	0.640
CLV_PCSK_SKI1_1	222	226	PF00082	0.602
CLV_PCSK_SKI1_1	639	643	PF00082	0.678
CLV_PCSK_SKI1_1	69	73	PF00082	0.644
CLV_PCSK_SKI1_1	754	758	PF00082	0.520
DEG_APCC_DBOX_1	24	32	PF00400	0.590
DEG_APCC_DBOX_1	267	275	PF00400	0.379
DEG_APCC_DBOX_1	761	769	PF00400	0.440
DEG_COP1_1	475	482	PF00400	0.411
DEG_MDM2_SWIB_1	430	437	PF02201	0.405
DEG_SPOP_SBC_1	129	133	PF00917	0.539
DEG_SPOP_SBC_1	508	512	PF00917	0.465
DEG_SPOP_SBC_1	664	668	PF00917	0.699
DOC_ANK_TNKS_1	574	581	PF00023	0.414
DOC_MAPK_gen_1	325	335	PF00069	0.416
DOC_MAPK_gen_1	544	550	PF00069	0.458
DOC_MAPK_gen_1	561	570	PF00069	0.379
DOC_MAPK_gen_1	762	770	PF00069	0.422
DOC_MAPK_MEF2A_6	564	572	PF00069	0.334
DOC_PP1_RVXF_1	245	252	PF00149	0.518
DOC_PP1_RVXF_1	761	768	PF00149	0.363
DOC_PP1_RVXF_1	82	88	PF00149	0.545
DOC_PP1_SILK_1	668	673	PF00149	0.594
DOC_PP2B_LxvP_1	388	391	PF13499	0.450
DOC_PP2B_LxvP_1	477	480	PF13499	0.255
DOC_PP4_FxxP_1	518	521	PF00568	0.565
DOC_PP4_FxxP_1	776	779	PF00568	0.357
DOC_USP7_MATH_1	152	156	PF00917	0.687
DOC_USP7_MATH_1	193	197	PF00917	0.729
DOC_USP7_MATH_1	243	247	PF00917	0.586
DOC_USP7_MATH_1	343	347	PF00917	0.434
DOC_USP7_MATH_1	4	8	PF00917	0.490
DOC_USP7_MATH_1	438	442	PF00917	0.576
DOC_USP7_MATH_1	496	500	PF00917	0.450
DOC_USP7_MATH_1	508	512	PF00917	0.570
DOC_USP7_MATH_1	534	538	PF00917	0.436
DOC_USP7_MATH_1	626	630	PF00917	0.640
DOC_USP7_MATH_1	651	655	PF00917	0.777
DOC_USP7_MATH_1	662	666	PF00917	0.554
DOC_USP7_MATH_1	704	708	PF00917	0.413
DOC_USP7_UBL2_3	753	757	PF12436	0.482
DOC_WW_Pin1_4	110	115	PF00397	0.700
DOC_WW_Pin1_4	161	166	PF00397	0.670
DOC_WW_Pin1_4	222	227	PF00397	0.574
DOC_WW_Pin1_4	31	36	PF00397	0.636
DOC_WW_Pin1_4	344	349	PF00397	0.514
DOC_WW_Pin1_4	360	365	PF00397	0.318
DOC_WW_Pin1_4	369	374	PF00397	0.618
DOC_WW_Pin1_4	578	583	PF00397	0.528
DOC_WW_Pin1_4	600	605	PF00397	0.672
DOC_WW_Pin1_4	630	635	PF00397	0.744
DOC_WW_Pin1_4	646	651	PF00397	0.639
DOC_WW_Pin1_4	653	658	PF00397	0.561
LIG_14-3-3_CanoR_1	121	125	PF00244	0.703
LIG_14-3-3_CanoR_1	325	331	PF00244	0.496
LIG_14-3-3_CanoR_1	357	363	PF00244	0.626
LIG_14-3-3_CanoR_1	40	49	PF00244	0.540
LIG_14-3-3_CanoR_1	5	13	PF00244	0.572
LIG_14-3-3_CanoR_1	588	592	PF00244	0.508
LIG_14-3-3_CanoR_1	643	647	PF00244	0.732
LIG_14-3-3_CanoR_1	700	708	PF00244	0.455
LIG_14-3-3_CanoR_1	739	745	PF00244	0.490
LIG_Actin_WH2_2	17	34	PF00022	0.591
LIG_Actin_WH2_2	332	347	PF00022	0.478
LIG_BRCT_BRCA1_1	706	710	PF00533	0.370
LIG_BRCT_BRCA1_1	87	91	PF00533	0.607
LIG_FHA_1	130	136	PF00498	0.706
LIG_FHA_1	137	143	PF00498	0.733
LIG_FHA_1	372	378	PF00498	0.462
LIG_FHA_1	530	536	PF00498	0.489
LIG_FHA_1	541	547	PF00498	0.395
LIG_FHA_1	80	86	PF00498	0.601
LIG_FHA_2	182	188	PF00498	0.586
LIG_FHA_2	307	313	PF00498	0.530
LIG_FHA_2	327	333	PF00498	0.469
LIG_FHA_2	348	354	PF00498	0.531
LIG_FHA_2	361	367	PF00498	0.604
LIG_FHA_2	7	13	PF00498	0.633
LIG_FHA_2	700	706	PF00498	0.398
LIG_FHA_2	81	87	PF00498	0.574
LIG_FHA_2	97	103	PF00498	0.765
LIG_GBD_Chelix_1	16	24	PF00786	0.550
LIG_GBD_Chelix_1	227	235	PF00786	0.581
LIG_Integrin_RGD_1	561	563	PF01839	0.443
LIG_LIR_Apic_2	204	210	PF02991	0.582
LIG_LIR_Apic_2	441	446	PF02991	0.465
LIG_LIR_Apic_2	714	720	PF02991	0.412
LIG_LIR_Gen_1	378	388	PF02991	0.439
LIG_LIR_Gen_1	766	775	PF02991	0.495
LIG_LIR_Nem_3	378	383	PF02991	0.423
LIG_LIR_Nem_3	409	415	PF02991	0.572
LIG_LIR_Nem_3	481	486	PF02991	0.333
LIG_LIR_Nem_3	766	770	PF02991	0.481
LIG_NRBOX	567	573	PF00104	0.407
LIG_Pex14_1	207	211	PF04695	0.584
LIG_Pex14_2	430	434	PF04695	0.414
LIG_Pex14_2	87	91	PF04695	0.678
LIG_SH2_CRK	412	416	PF00017	0.490
LIG_SH2_CRK	443	447	PF00017	0.520
LIG_SH2_NCK_1	14	18	PF00017	0.564
LIG_SH2_NCK_1	412	416	PF00017	0.539
LIG_SH2_NCK_1	701	705	PF00017	0.444
LIG_SH2_SRC	387	390	PF00017	0.468
LIG_SH2_SRC	412	415	PF00017	0.561
LIG_SH2_SRC	732	735	PF00017	0.353
LIG_SH2_STAP1	337	341	PF00017	0.461
LIG_SH2_STAT5	232	235	PF00017	0.529
LIG_SH2_STAT5	270	273	PF00017	0.339
LIG_SH2_STAT5	368	371	PF00017	0.661
LIG_SH2_STAT5	387	390	PF00017	0.260
LIG_SH2_STAT5	602	605	PF00017	0.758
LIG_SH2_STAT5	701	704	PF00017	0.357
LIG_SH2_STAT5	732	735	PF00017	0.419
LIG_SH2_STAT5	804	807	PF00017	0.500
LIG_SH3_1	644	650	PF00018	0.584
LIG_SH3_3	156	162	PF00018	0.580
LIG_SH3_3	284	290	PF00018	0.545
LIG_SH3_3	411	417	PF00018	0.540
LIG_SH3_3	579	585	PF00018	0.622
LIG_SH3_3	644	650	PF00018	0.584
LIG_SUMO_SIM_par_1	275	281	PF11976	0.450
LIG_TRAF2_1	350	353	PF00917	0.575
LIG_TRAF2_1	363	366	PF00917	0.494
LIG_TRAF2_1	390	393	PF00917	0.499
LIG_WRC_WIRS_1	535	540	PF05994	0.450
MOD_CDK_SPK_2	653	658	PF00069	0.588
MOD_CDK_SPxK_1	600	606	PF00069	0.654
MOD_CDK_SPxxK_3	110	117	PF00069	0.633
MOD_CDK_SPxxK_3	222	229	PF00069	0.585
MOD_CDK_SPxxK_3	646	653	PF00069	0.690
MOD_CK1_1	120	126	PF00069	0.717
MOD_CK1_1	133	139	PF00069	0.555
MOD_CK1_1	202	208	PF00069	0.615
MOD_CK1_1	212	218	PF00069	0.599
MOD_CK1_1	346	352	PF00069	0.522
MOD_CK1_1	475	481	PF00069	0.471
MOD_CK1_1	537	543	PF00069	0.487
MOD_CK1_1	549	555	PF00069	0.519
MOD_CK1_1	620	626	PF00069	0.646
MOD_CK1_1	665	671	PF00069	0.700
MOD_CK2_1	275	281	PF00069	0.433
MOD_CK2_1	306	312	PF00069	0.471
MOD_CK2_1	326	332	PF00069	0.494
MOD_CK2_1	347	353	PF00069	0.518
MOD_CK2_1	360	366	PF00069	0.381
MOD_CK2_1	496	502	PF00069	0.448
MOD_CK2_1	62	68	PF00069	0.554
MOD_CK2_1	80	86	PF00069	0.628
MOD_DYRK1A_RPxSP_1	653	657	PF00069	0.586
MOD_GlcNHglycan	201	204	PF01048	0.646
MOD_GlcNHglycan	211	214	PF01048	0.555
MOD_GlcNHglycan	312	315	PF01048	0.620
MOD_GlcNHglycan	464	467	PF01048	0.426
MOD_GlcNHglycan	498	501	PF01048	0.456
MOD_GlcNHglycan	511	514	PF01048	0.586
MOD_GlcNHglycan	532	535	PF01048	0.436
MOD_GlcNHglycan	539	542	PF01048	0.498
MOD_GlcNHglycan	626	629	PF01048	0.624
MOD_GlcNHglycan	644	647	PF01048	0.685
MOD_GlcNHglycan	667	670	PF01048	0.724
MOD_GSK3_1	105	112	PF00069	0.768
MOD_GSK3_1	113	120	PF00069	0.733
MOD_GSK3_1	129	136	PF00069	0.605
MOD_GSK3_1	181	188	PF00069	0.678
MOD_GSK3_1	189	196	PF00069	0.643
MOD_GSK3_1	197	204	PF00069	0.582
MOD_GSK3_1	306	313	PF00069	0.352
MOD_GSK3_1	343	350	PF00069	0.482
MOD_GSK3_1	371	378	PF00069	0.479
MOD_GSK3_1	468	475	PF00069	0.457
MOD_GSK3_1	530	537	PF00069	0.398
MOD_GSK3_1	586	593	PF00069	0.615
MOD_GSK3_1	617	624	PF00069	0.624
MOD_GSK3_1	626	633	PF00069	0.592
MOD_GSK3_1	642	649	PF00069	0.631
MOD_GSK3_1	75	82	PF00069	0.579
MOD_N-GLC_1	136	141	PF02516	0.688
MOD_N-GLC_1	298	303	PF02516	0.428
MOD_N-GLC_1	529	534	PF02516	0.406
MOD_NEK2_1	130	135	PF00069	0.496
MOD_NEK2_1	298	303	PF00069	0.393
MOD_NEK2_1	306	311	PF00069	0.421
MOD_NEK2_1	383	388	PF00069	0.486
MOD_NEK2_1	41	46	PF00069	0.507
MOD_NEK2_1	621	626	PF00069	0.585
MOD_NEK2_1	642	647	PF00069	0.599
MOD_NEK2_2	152	157	PF00069	0.611
MOD_NEK2_2	375	380	PF00069	0.418
MOD_NEK2_2	438	443	PF00069	0.442
MOD_PIKK_1	150	156	PF00454	0.654
MOD_PKA_1	252	258	PF00069	0.649
MOD_PKA_1	740	746	PF00069	0.485
MOD_PKA_2	120	126	PF00069	0.672
MOD_PKA_2	252	258	PF00069	0.608
MOD_PKA_2	310	316	PF00069	0.456
MOD_PKA_2	4	10	PF00069	0.533
MOD_PKA_2	496	502	PF00069	0.441
MOD_PKA_2	587	593	PF00069	0.511
MOD_PKA_2	642	648	PF00069	0.732
MOD_PKA_2	699	705	PF00069	0.485
MOD_PKA_2	740	746	PF00069	0.485
MOD_PKA_2	809	815	PF00069	0.591
MOD_PKA_2	91	97	PF00069	0.616
MOD_Plk_1	136	142	PF00069	0.524
MOD_Plk_1	282	288	PF00069	0.566
MOD_Plk_1	552	558	PF00069	0.473
MOD_Plk_1	704	710	PF00069	0.373
MOD_Plk_4	130	136	PF00069	0.653
MOD_Plk_4	375	381	PF00069	0.418
MOD_Plk_4	383	389	PF00069	0.422
MOD_Plk_4	438	444	PF00069	0.510
MOD_Plk_4	478	484	PF00069	0.341
MOD_Plk_4	546	552	PF00069	0.474
MOD_Plk_4	587	593	PF00069	0.552
MOD_Plk_4	704	710	PF00069	0.516
MOD_Plk_4	740	746	PF00069	0.485
MOD_Plk_4	792	798	PF00069	0.360
MOD_ProDKin_1	110	116	PF00069	0.699
MOD_ProDKin_1	161	167	PF00069	0.673
MOD_ProDKin_1	222	228	PF00069	0.571
MOD_ProDKin_1	31	37	PF00069	0.630
MOD_ProDKin_1	344	350	PF00069	0.523
MOD_ProDKin_1	360	366	PF00069	0.319
MOD_ProDKin_1	369	375	PF00069	0.610
MOD_ProDKin_1	578	584	PF00069	0.530
MOD_ProDKin_1	600	606	PF00069	0.675
MOD_ProDKin_1	630	636	PF00069	0.744
MOD_ProDKin_1	646	652	PF00069	0.641
MOD_ProDKin_1	653	659	PF00069	0.558
TRG_DiLeu_BaLyEn_6	776	781	PF01217	0.333
TRG_ENDOCYTIC_2	232	235	PF00928	0.577
TRG_ENDOCYTIC_2	412	415	PF00928	0.495
TRG_ER_diArg_1	221	223	PF00400	0.556
TRG_ER_diArg_1	251	254	PF00400	0.673
TRG_ER_diArg_1	263	265	PF00400	0.404
TRG_ER_diArg_1	31	33	PF00400	0.556
TRG_ER_diArg_1	642	644	PF00400	0.701
TRG_ER_diArg_1	671	673	PF00400	0.622
TRG_ER_diArg_1	739	741	PF00400	0.479
TRG_ER_diArg_1	761	763	PF00400	0.450
TRG_ER_diArg_1	800	802	PF00400	0.437
TRG_ER_diArg_1	809	811	PF00400	0.542
TRG_ER_diArg_1	91	93	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J3	Leptomonas seymouri	43%	100%
A0A422P2B7	Trypanosoma rangeli	32%	100%
A4HNN5	Leishmania braziliensis	72%	100%
A4ICW0	Leishmania infantum	99%	100%
D0A2I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ASE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q251	Leishmania major	89%	100%