Proteasome subunit beta

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome subunit beta type-5, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIY4_LEIDO

TriTrypDb:

LdBPK_361730.1 , LdCL_360022800 , LDHU3_36.2290

Length:

302

Annotations

Annotations by Jardim et al.

Proteasome, Proteasome subunit beta type

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:0019774	proteasome core complex, beta-subunit complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IIY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIY4

PDB structure(s): 6qm7_L , 6qm7_Z , 6qm8_L , 6qm8_Z , 6tcz_l , 6td5_l

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004298	threonine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0016787	hydrolase activity	2	12
GO:0070003	threonine-type peptidase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.481
CLV_NRD_NRD_1	242	244	PF00675	0.297
CLV_NRD_NRD_1	256	258	PF00675	0.246
CLV_NRD_NRD_1	44	46	PF00675	0.739
CLV_PCSK_KEX2_1	256	258	PF00082	0.281
CLV_PCSK_KEX2_1	44	46	PF00082	0.739
CLV_PCSK_SKI1_1	257	261	PF00082	0.305
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.758
DOC_MAPK_gen_1	97	105	PF00069	0.481
DOC_MAPK_HePTP_8	103	115	PF00069	0.567
DOC_MAPK_MEF2A_6	106	115	PF00069	0.481
DOC_MAPK_MEF2A_6	89	96	PF00069	0.538
DOC_USP7_MATH_1	114	118	PF00917	0.481
DOC_USP7_MATH_1	176	180	PF00917	0.472
DOC_USP7_MATH_1	255	259	PF00917	0.473
DOC_USP7_MATH_1	65	69	PF00917	0.659
DOC_USP7_UBL2_3	281	285	PF12436	0.529
DOC_USP7_UBL2_3	93	97	PF12436	0.544
DOC_WW_Pin1_4	51	56	PF00397	0.725
LIG_14-3-3_CanoR_1	118	125	PF00244	0.473
LIG_14-3-3_CanoR_1	172	176	PF00244	0.477
LIG_14-3-3_CanoR_1	53	61	PF00244	0.700
LIG_14-3-3_CanoR_1	77	82	PF00244	0.609
LIG_Actin_WH2_2	153	170	PF00022	0.544
LIG_APCC_Cbox_2	296	302	PF00515	0.621
LIG_BRCT_BRCA1_1	9	13	PF00533	0.625
LIG_FHA_1	98	104	PF00498	0.490
LIG_FHA_2	12	18	PF00498	0.614
LIG_FHA_2	261	267	PF00498	0.512
LIG_FHA_2	31	37	PF00498	0.702
LIG_LIR_Gen_1	25	34	PF02991	0.624
LIG_LIR_Gen_1	280	290	PF02991	0.512
LIG_LIR_Gen_1	4	13	PF02991	0.540
LIG_LIR_Nem_3	280	286	PF02991	0.472
LIG_LIR_Nem_3	292	298	PF02991	0.397
LIG_LIR_Nem_3	4	8	PF02991	0.539
LIG_PTB_Apo_2	181	188	PF02174	0.472
LIG_PTB_Phospho_1	181	187	PF10480	0.481
LIG_SH2_GRB2like	26	29	PF00017	0.736
LIG_SH2_SRC	233	236	PF00017	0.481
LIG_SH2_SRC	71	74	PF00017	0.623
LIG_SH2_STAP1	295	299	PF00017	0.504
LIG_SH2_STAT5	124	127	PF00017	0.481
LIG_SH2_STAT5	139	142	PF00017	0.481
LIG_SH2_STAT5	212	215	PF00017	0.481
LIG_SH2_STAT5	298	301	PF00017	0.571
LIG_SH2_STAT5	71	74	PF00017	0.623
LIG_SUMO_SIM_par_1	111	117	PF11976	0.481
LIG_SUMO_SIM_par_1	132	138	PF11976	0.481
LIG_SUMO_SIM_par_1	35	42	PF11976	0.733
LIG_TRAF2_1	33	36	PF00917	0.671
MOD_CK1_1	117	123	PF00069	0.476
MOD_CK1_1	171	177	PF00069	0.542
MOD_CK1_1	195	201	PF00069	0.481
MOD_CK1_1	226	232	PF00069	0.481
MOD_CK1_1	39	45	PF00069	0.698
MOD_CK1_1	54	60	PF00069	0.720
MOD_CK1_1	7	13	PF00069	0.600
MOD_CK2_1	30	36	PF00069	0.752
MOD_GlcNHglycan	228	231	PF01048	0.278
MOD_GlcNHglycan	268	271	PF01048	0.281
MOD_GSK3_1	114	121	PF00069	0.478
MOD_GSK3_1	4	11	PF00069	0.554
MOD_GSK3_1	47	54	PF00069	0.746
MOD_GSK3_1	77	84	PF00069	0.667
MOD_LATS_1	279	285	PF00433	0.489
MOD_N-GLC_1	11	16	PF02516	0.653
MOD_N-GLC_1	168	173	PF02516	0.342
MOD_N-GLC_1	183	188	PF02516	0.150
MOD_N-GLC_2	76	78	PF02516	0.701
MOD_NEK2_1	140	145	PF00069	0.481
MOD_NEK2_1	260	265	PF00069	0.481
MOD_NEK2_1	66	71	PF00069	0.561
MOD_NEK2_1	81	86	PF00069	0.545
MOD_NEK2_2	228	233	PF00069	0.481
MOD_NEK2_2	255	260	PF00069	0.481
MOD_NEK2_2	271	276	PF00069	0.481
MOD_OFUCOSY	78	85	PF10250	0.699
MOD_PIKK_1	124	130	PF00454	0.481
MOD_PK_1	244	250	PF00069	0.567
MOD_PKA_1	97	103	PF00069	0.481
MOD_PKA_2	117	123	PF00069	0.481
MOD_PKA_2	171	177	PF00069	0.475
MOD_PKA_2	255	261	PF00069	0.481
MOD_Plk_1	11	17	PF00069	0.568
MOD_Plk_1	183	189	PF00069	0.485
MOD_Plk_1	244	250	PF00069	0.479
MOD_Plk_1	30	36	PF00069	0.716
MOD_Plk_1	66	72	PF00069	0.635
MOD_Plk_2-3	30	36	PF00069	0.674
MOD_Plk_4	126	132	PF00069	0.492
MOD_Plk_4	195	201	PF00069	0.481
MOD_Plk_4	206	212	PF00069	0.481
MOD_Plk_4	228	234	PF00069	0.481
MOD_Plk_4	271	277	PF00069	0.481
MOD_Plk_4	4	10	PF00069	0.557
MOD_ProDKin_1	51	57	PF00069	0.724
MOD_SUMO_rev_2	209	218	PF00179	0.492
TRG_DiLeu_BaEn_4	35	41	PF01217	0.680
TRG_ENDOCYTIC_2	235	238	PF00928	0.481
TRG_ENDOCYTIC_2	26	29	PF00928	0.739
TRG_ER_diArg_1	43	45	PF00400	0.743
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F8	Leptomonas seymouri	89%	100%
A0A0N1HVL0	Leptomonas seymouri	27%	100%
A0A0S4IX63	Bodo saltans	67%	100%
A0A1X0P7U3	Trypanosomatidae	74%	97%
A0A3Q8IB07	Leishmania donovani	25%	100%
A0A3Q8IC41	Leishmania donovani	22%	100%
A0A3Q8IVH0	Leishmania donovani	28%	100%
A0A3R7MZI3	Trypanosoma rangeli	72%	97%
A0JWY6	Arthrobacter sp. (strain FB24)	28%	100%
A1R6Q7	Paenarthrobacter aurescens (strain TC1)	29%	100%
A4FBY1	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	28%	100%
A4HC34	Leishmania braziliensis	25%	100%
A4HLC5	Leishmania braziliensis	21%	100%
A4HN55	Leishmania braziliensis	27%	100%
A4HP29	Leishmania braziliensis	94%	100%
A4HZI9	Leishmania infantum	22%	100%
A4IBS2	Leishmania infantum	28%	100%
A4IDD6	Leishmania infantum	100%	100%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	22%	100%
A6USJ3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	30%	100%
A7KE01	Salmo salar	34%	100%
A7KII6	Salmo salar	34%	100%
B1W306	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	26%	100%
B6YSH9	Thermococcus onnurineus (strain NA1)	22%	100%
B8H8L6	Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6)	30%	100%
C1ASP7	Rhodococcus opacus (strain B4)	28%	100%
C5A2C2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	22%	100%
C6A2V9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	28%	100%
C6A459	Thermococcus sibiricus (strain DSM 12597 / MM 739)	22%	100%
C6WID8	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)	29%	100%
C7P6N4	Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)	33%	100%
C7PVV2	Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908)	28%	100%
C9REN7	Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)	36%	100%
C9Z4D0	Streptomyces scabiei (strain 87.22)	27%	100%
D0A312	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	97%
D1BHT9	Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)	29%	100%
D1BS26	Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07)	25%	100%
D2S6E2	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20)	26%	100%
D3S8M7	Methanocaldococcus sp. (strain FS406-22)	32%	100%
E9AFK8	Leishmania major	28%	100%
E9AST7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AVG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AVH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	100%
E9B6R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O23717	Arabidopsis thaliana	64%	100%
O24361	Spinacia oleracea	62%	100%
O24733	Thermococcus sp. (strain JCM 11816 / KS-1)	23%	100%
O35521	Mus terricolor	30%	100%
O35522	Mus musculus bactrianus	30%	100%
O35523	Mus platythrix	30%	100%
O35524	Mus spicilegus	30%	100%
O55234	Mus musculus	64%	100%
O59219	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	24%	100%
P28062	Homo sapiens	59%	100%
P28063	Mus musculus	60%	100%
P28064	Rattus norvegicus	61%	100%
P28065	Homo sapiens	31%	100%
P28074	Homo sapiens	63%	100%
P28075	Rattus norvegicus	63%	100%
P28076	Mus musculus	30%	100%
P28077	Rattus norvegicus	31%	100%
P30656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	100%
P34065	Gallus gallus	54%	100%
P99026	Mus musculus	29%	100%
Q0RLT7	Frankia alni (strain ACN14a)	31%	100%
Q0SIF9	Rhodococcus jostii (strain RHA1)	29%	100%
Q18GX3	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	37%	100%
Q2FQL8	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	35%	100%
Q32KL2	Bos taurus	63%	100%
Q3SZC2	Bos taurus	32%	100%
Q3T112	Bos taurus	60%	100%
Q4Q1Q9	Leishmania major	99%	100%
Q4QC00	Leishmania major	21%	100%
Q4QC13	Leishmania major	25%	100%
Q4QGU1	Leishmania major	32%	100%
Q53079	Rhodococcus erythropolis	28%	100%
Q54BC8	Dictyostelium discoideum	59%	100%
Q58634	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
Q5JIU9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	23%	100%
Q5R8S2	Pongo abelii	63%	100%
Q5W416	Canis lupus familiaris	58%	100%
Q7AKQ5	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	26%	100%
Q828I8	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	26%	100%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	33%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	25%	100%
Q8U0L6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	24%	100%
Q95083	Drosophila melanogaster	21%	100%
Q9GNZ8	Leishmania infantum	25%	100%
Q9LIP2	Arabidopsis thaliana	63%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	32%	100%
Q9V122	Pyrococcus abyssi (strain GE5 / Orsay)	23%	100%
Q9XUV0	Caenorhabditis elegans	48%	100%
Q9YC01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	25%	100%
V5B1X4	Trypanosoma cruzi	23%	100%
V5BU39	Trypanosoma cruzi	72%	97%