Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIY2_LEIDO

TriTrypDb:

LdBPK_160280.1 , LdCL_160007700 , LDHU3_16.0340

Length:

1042

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	625	629	PF00656	0.594
CLV_C14_Caspase3-7	715	719	PF00656	0.460
CLV_NRD_NRD_1	252	254	PF00675	0.522
CLV_NRD_NRD_1	268	270	PF00675	0.525
CLV_NRD_NRD_1	328	330	PF00675	0.677
CLV_NRD_NRD_1	907	909	PF00675	0.459
CLV_NRD_NRD_1	982	984	PF00675	0.634
CLV_PCSK_KEX2_1	251	253	PF00082	0.595
CLV_PCSK_KEX2_1	268	270	PF00082	0.576
CLV_PCSK_KEX2_1	328	330	PF00082	0.677
CLV_PCSK_KEX2_1	907	909	PF00082	0.459
CLV_PCSK_KEX2_1	982	984	PF00082	0.634
CLV_PCSK_SKI1_1	197	201	PF00082	0.546
CLV_PCSK_SKI1_1	296	300	PF00082	0.514
CLV_PCSK_SKI1_1	666	670	PF00082	0.451
CLV_PCSK_SKI1_1	686	690	PF00082	0.242
CLV_PCSK_SKI1_1	757	761	PF00082	0.549
CLV_PCSK_SKI1_1	926	930	PF00082	0.528
CLV_PCSK_SKI1_1	956	960	PF00082	0.587
CLV_PCSK_SKI1_1	997	1001	PF00082	0.575
CLV_Separin_Metazoa	207	211	PF03568	0.508
DEG_APCC_DBOX_1	335	343	PF00400	0.662
DEG_APCC_DBOX_1	665	673	PF00400	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DEG_SCF_FBW7_1	177	184	PF00400	0.780
DEG_SCF_FBW7_2	405	412	PF00400	0.696
DEG_SPOP_SBC_1	176	180	PF00917	0.779
DOC_CYCLIN_RxL_1	266	277	PF00134	0.562
DOC_CYCLIN_yClb1_LxF_4	924	929	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.580
DOC_CYCLIN_yCln2_LP_2	921	927	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	986	992	PF00134	0.531
DOC_MAPK_DCC_7	748	758	PF00069	0.574
DOC_MAPK_gen_1	12	21	PF00069	0.620
DOC_MAPK_gen_1	251	259	PF00069	0.569
DOC_MAPK_gen_1	542	550	PF00069	0.662
DOC_MAPK_gen_1	782	792	PF00069	0.498
DOC_MAPK_gen_1	800	809	PF00069	0.674
DOC_MAPK_gen_1	982	990	PF00069	0.584
DOC_MAPK_MEF2A_6	15	23	PF00069	0.581
DOC_MAPK_MEF2A_6	589	598	PF00069	0.487
DOC_MAPK_MEF2A_6	702	711	PF00069	0.473
DOC_MAPK_MEF2A_6	785	792	PF00069	0.467
DOC_MAPK_MEF2A_6	982	990	PF00069	0.584
DOC_MAPK_NFAT4_5	785	793	PF00069	0.531
DOC_PP1_RVXF_1	297	304	PF00149	0.481
DOC_PP1_RVXF_1	924	930	PF00149	0.462
DOC_PP2B_LxvP_1	594	597	PF13499	0.564
DOC_PP2B_LxvP_1	921	924	PF13499	0.500
DOC_PP2B_LxvP_1	986	989	PF13499	0.538
DOC_PP4_FxxP_1	305	308	PF00568	0.574
DOC_USP7_MATH_1	176	180	PF00917	0.796
DOC_USP7_MATH_1	188	192	PF00917	0.614
DOC_USP7_MATH_1	232	236	PF00917	0.732
DOC_USP7_MATH_1	321	325	PF00917	0.700
DOC_USP7_MATH_1	331	335	PF00917	0.722
DOC_USP7_MATH_1	421	425	PF00917	0.721
DOC_USP7_MATH_1	438	442	PF00917	0.680
DOC_USP7_MATH_1	50	54	PF00917	0.700
DOC_USP7_MATH_1	519	523	PF00917	0.719
DOC_USP7_MATH_1	534	538	PF00917	0.574
DOC_USP7_MATH_1	561	565	PF00917	0.549
DOC_USP7_MATH_1	734	738	PF00917	0.586
DOC_USP7_MATH_1	780	784	PF00917	0.455
DOC_USP7_MATH_1	857	861	PF00917	0.579
DOC_USP7_MATH_1	898	902	PF00917	0.472
DOC_USP7_MATH_1	950	954	PF00917	0.543
DOC_WW_Pin1_4	172	177	PF00397	0.811
DOC_WW_Pin1_4	228	233	PF00397	0.740
DOC_WW_Pin1_4	405	410	PF00397	0.697
DOC_WW_Pin1_4	564	569	PF00397	0.457
DOC_WW_Pin1_4	612	617	PF00397	0.455
DOC_WW_Pin1_4	732	737	PF00397	0.504
DOC_WW_Pin1_4	78	83	PF00397	0.722
DOC_WW_Pin1_4	807	812	PF00397	0.531
DOC_WW_Pin1_4	944	949	PF00397	0.737
LIG_14-3-3_CanoR_1	15	19	PF00244	0.559
LIG_14-3-3_CanoR_1	210	216	PF00244	0.519
LIG_14-3-3_CanoR_1	4	8	PF00244	0.731
LIG_14-3-3_CanoR_1	432	440	PF00244	0.626
LIG_14-3-3_CanoR_1	471	477	PF00244	0.377
LIG_14-3-3_CanoR_1	518	528	PF00244	0.744
LIG_14-3-3_CanoR_1	542	548	PF00244	0.598
LIG_14-3-3_CanoR_1	686	695	PF00244	0.572
LIG_14-3-3_CanoR_1	782	792	PF00244	0.483
LIG_14-3-3_CanoR_1	800	809	PF00244	0.674
LIG_Actin_WH2_2	735	750	PF00022	0.464
LIG_APCC_ABBA_1	809	814	PF00400	0.475
LIG_BRCT_BRCA1_1	224	228	PF00533	0.494
LIG_BRCT_BRCA1_1	496	500	PF00533	0.389
LIG_Clathr_ClatBox_1	864	868	PF01394	0.579
LIG_eIF4E_1	1036	1042	PF01652	0.504
LIG_EVH1_1	144	148	PF00568	0.627
LIG_FHA_1	1018	1024	PF00498	0.614
LIG_FHA_1	1036	1042	PF00498	0.412
LIG_FHA_1	203	209	PF00498	0.633
LIG_FHA_1	222	228	PF00498	0.465
LIG_FHA_1	55	61	PF00498	0.714
LIG_FHA_1	613	619	PF00498	0.490
LIG_FHA_1	629	635	PF00498	0.554
LIG_FHA_1	680	686	PF00498	0.569
LIG_FHA_1	704	710	PF00498	0.540
LIG_FHA_1	814	820	PF00498	0.434
LIG_FHA_2	281	287	PF00498	0.677
LIG_FHA_2	365	371	PF00498	0.564
LIG_FHA_2	39	45	PF00498	0.617
LIG_FHA_2	488	494	PF00498	0.619
LIG_FHA_2	623	629	PF00498	0.613
LIG_FHA_2	687	693	PF00498	0.444
LIG_GBD_Chelix_1	602	610	PF00786	0.535
LIG_LIR_Apic_2	142	147	PF02991	0.569
LIG_LIR_Apic_2	751	755	PF02991	0.473
LIG_LIR_Gen_1	17	23	PF02991	0.566
LIG_LIR_Gen_1	497	505	PF02991	0.388
LIG_LIR_Gen_1	692	699	PF02991	0.517
LIG_LIR_Gen_1	810	820	PF02991	0.448
LIG_LIR_Nem_3	1002	1007	PF02991	0.533
LIG_LIR_Nem_3	17	21	PF02991	0.585
LIG_LIR_Nem_3	290	295	PF02991	0.532
LIG_LIR_Nem_3	467	473	PF02991	0.457
LIG_LIR_Nem_3	497	503	PF02991	0.387
LIG_LIR_Nem_3	718	723	PF02991	0.455
LIG_LIR_Nem_3	768	773	PF02991	0.453
LIG_LIR_Nem_3	810	815	PF02991	0.463
LIG_NRBOX	472	478	PF00104	0.562
LIG_NRBOX	911	917	PF00104	0.456
LIG_PCNA_PIPBox_1	66	75	PF02747	0.753
LIG_Pex14_1	716	720	PF04695	0.472
LIG_PTB_Apo_2	769	776	PF02174	0.433
LIG_PTB_Phospho_1	769	775	PF10480	0.436
LIG_REV1ctd_RIR_1	790	798	PF16727	0.546
LIG_RPA_C_Fungi	883	895	PF08784	0.383
LIG_SH2_PTP2	987	990	PF00017	0.651
LIG_SH2_SRC	483	486	PF00017	0.574
LIG_SH2_SRC	725	728	PF00017	0.616
LIG_SH2_SRC	987	990	PF00017	0.607
LIG_SH2_STAP1	556	560	PF00017	0.525
LIG_SH2_STAT5	1036	1039	PF00017	0.588
LIG_SH2_STAT5	149	152	PF00017	0.496
LIG_SH2_STAT5	483	486	PF00017	0.574
LIG_SH2_STAT5	633	636	PF00017	0.581
LIG_SH2_STAT5	725	728	PF00017	0.616
LIG_SH2_STAT5	773	776	PF00017	0.378
LIG_SH2_STAT5	987	990	PF00017	0.651
LIG_SH3_2	304	309	PF14604	0.724
LIG_SH3_3	142	148	PF00018	0.639
LIG_SH3_3	298	304	PF00018	0.492
LIG_SH3_3	476	482	PF00018	0.580
LIG_SH3_3	527	533	PF00018	0.682
LIG_SH3_3	562	568	PF00018	0.458
LIG_SH3_3	593	599	PF00018	0.481
LIG_SH3_3	611	617	PF00018	0.542
LIG_SH3_3	82	88	PF00018	0.633
LIG_SH3_3	942	948	PF00018	0.754
LIG_SH3_CIN85_PxpxPR_1	304	309	PF14604	0.571
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.573
LIG_SUMO_SIM_par_1	526	531	PF11976	0.594
LIG_SUMO_SIM_par_1	546	552	PF11976	0.490
LIG_SUMO_SIM_par_1	804	810	PF11976	0.569
LIG_SUMO_SIM_par_1	863	868	PF11976	0.608
LIG_TRFH_1	478	482	PF08558	0.595
LIG_TRFH_1	695	699	PF08558	0.511
LIG_UBA3_1	499	507	PF00899	0.537
LIG_UBA3_1	583	589	PF00899	0.510
LIG_UBA3_1	707	712	PF00899	0.430
LIG_WRC_WIRS_1	189	194	PF05994	0.727
LIG_WRC_WIRS_1	890	895	PF05994	0.523
LIG_WW_1	337	340	PF00397	0.594
LIG_WW_3	306	310	PF00397	0.606
MOD_CDK_SPK_2	78	83	PF00069	0.703
MOD_CDK_SPxK_1	177	183	PF00069	0.780
MOD_CK1_1	191	197	PF00069	0.684
MOD_CK1_1	284	290	PF00069	0.718
MOD_CK1_1	397	403	PF00069	0.670
MOD_CK1_1	424	430	PF00069	0.793
MOD_CK1_1	433	439	PF00069	0.649
MOD_CK1_1	448	454	PF00069	0.551
MOD_CK1_1	5	11	PF00069	0.754
MOD_CK1_1	517	523	PF00069	0.732
MOD_CK1_1	564	570	PF00069	0.473
MOD_CK1_1	620	626	PF00069	0.627
MOD_CK1_1	76	82	PF00069	0.742
MOD_CK1_1	783	789	PF00069	0.482
MOD_CK1_1	850	856	PF00069	0.533
MOD_CK2_1	1023	1029	PF00069	0.508
MOD_CK2_1	417	423	PF00069	0.626
MOD_CK2_1	487	493	PF00069	0.614
MOD_CK2_1	686	692	PF00069	0.441
MOD_Cter_Amidation	326	329	PF01082	0.571
MOD_GlcNHglycan	113	116	PF01048	0.601
MOD_GlcNHglycan	283	286	PF01048	0.745
MOD_GlcNHglycan	315	318	PF01048	0.769
MOD_GlcNHglycan	323	326	PF01048	0.686
MOD_GlcNHglycan	329	332	PF01048	0.604
MOD_GlcNHglycan	333	336	PF01048	0.516
MOD_GlcNHglycan	396	399	PF01048	0.634
MOD_GlcNHglycan	419	422	PF01048	0.747
MOD_GlcNHglycan	423	426	PF01048	0.761
MOD_GlcNHglycan	440	443	PF01048	0.519
MOD_GlcNHglycan	48	51	PF01048	0.681
MOD_GlcNHglycan	496	499	PF01048	0.586
MOD_GlcNHglycan	52	55	PF01048	0.670
MOD_GlcNHglycan	521	524	PF01048	0.785
MOD_GlcNHglycan	619	622	PF01048	0.738
MOD_GlcNHglycan	654	658	PF01048	0.600
MOD_GlcNHglycan	66	69	PF01048	0.612
MOD_GlcNHglycan	660	663	PF01048	0.496
MOD_GlcNHglycan	669	672	PF01048	0.339
MOD_GlcNHglycan	682	685	PF01048	0.460
MOD_GlcNHglycan	782	785	PF01048	0.478
MOD_GlcNHglycan	803	806	PF01048	0.679
MOD_GlcNHglycan	848	852	PF01048	0.622
MOD_GlcNHglycan	859	862	PF01048	0.514
MOD_GSK3_1	127	134	PF00069	0.624
MOD_GSK3_1	172	179	PF00069	0.820
MOD_GSK3_1	228	235	PF00069	0.784
MOD_GSK3_1	273	280	PF00069	0.658
MOD_GSK3_1	284	291	PF00069	0.569
MOD_GSK3_1	327	334	PF00069	0.766
MOD_GSK3_1	38	45	PF00069	0.584
MOD_GSK3_1	417	424	PF00069	0.725
MOD_GSK3_1	432	439	PF00069	0.621
MOD_GSK3_1	448	455	PF00069	0.611
MOD_GSK3_1	46	53	PF00069	0.753
MOD_GSK3_1	514	521	PF00069	0.717
MOD_GSK3_1	56	63	PF00069	0.556
MOD_GSK3_1	564	571	PF00069	0.569
MOD_GSK3_1	620	627	PF00069	0.650
MOD_GSK3_1	628	635	PF00069	0.532
MOD_GSK3_1	64	71	PF00069	0.728
MOD_GSK3_1	667	674	PF00069	0.458
MOD_GSK3_1	675	682	PF00069	0.495
MOD_GSK3_1	72	79	PF00069	0.759
MOD_GSK3_1	801	808	PF00069	0.641
MOD_GSK3_1	846	853	PF00069	0.576
MOD_LATS_1	516	522	PF00433	0.728
MOD_N-GLC_1	163	168	PF02516	0.720
MOD_NEK2_1	2	7	PF00069	0.675
MOD_NEK2_1	42	47	PF00069	0.663
MOD_NEK2_1	503	508	PF00069	0.494
MOD_NEK2_1	610	615	PF00069	0.570
MOD_NEK2_1	73	78	PF00069	0.646
MOD_NEK2_1	792	797	PF00069	0.475
MOD_NEK2_2	223	228	PF00069	0.517
MOD_PIKK_1	191	197	PF00454	0.665
MOD_PIKK_1	448	454	PF00454	0.752
MOD_PIKK_1	62	68	PF00454	0.729
MOD_PIKK_1	870	876	PF00454	0.465
MOD_PK_1	56	62	PF00069	0.653
MOD_PKA_2	132	138	PF00069	0.522
MOD_PKA_2	14	20	PF00069	0.544
MOD_PKA_2	150	156	PF00069	0.383
MOD_PKA_2	3	9	PF00069	0.747
MOD_PKA_2	327	333	PF00069	0.808
MOD_PKA_2	433	439	PF00069	0.625
MOD_PKA_2	517	523	PF00069	0.774
MOD_PKA_2	658	664	PF00069	0.474
MOD_PKA_2	801	807	PF00069	0.682
MOD_PKA_2	976	982	PF00069	0.643
MOD_Plk_1	364	370	PF00069	0.565
MOD_Plk_1	42	48	PF00069	0.519
MOD_Plk_1	653	659	PF00069	0.472
MOD_Plk_1	700	706	PF00069	0.487
MOD_Plk_1	813	819	PF00069	0.438
MOD_Plk_4	1023	1029	PF00069	0.508
MOD_Plk_4	14	20	PF00069	0.606
MOD_Plk_4	223	229	PF00069	0.713
MOD_Plk_4	445	451	PF00069	0.646
MOD_Plk_4	472	478	PF00069	0.383
MOD_Plk_4	703	709	PF00069	0.471
MOD_Plk_4	734	740	PF00069	0.548
MOD_Plk_4	748	754	PF00069	0.577
MOD_Plk_4	889	895	PF00069	0.570
MOD_Plk_4	934	940	PF00069	0.599
MOD_ProDKin_1	172	178	PF00069	0.810
MOD_ProDKin_1	228	234	PF00069	0.740
MOD_ProDKin_1	405	411	PF00069	0.696
MOD_ProDKin_1	564	570	PF00069	0.461
MOD_ProDKin_1	612	618	PF00069	0.464
MOD_ProDKin_1	732	738	PF00069	0.498
MOD_ProDKin_1	78	84	PF00069	0.722
MOD_ProDKin_1	807	813	PF00069	0.520
MOD_ProDKin_1	944	950	PF00069	0.731
MOD_SUMO_for_1	239	242	PF00179	0.615
MOD_SUMO_rev_2	504	509	PF00179	0.517
TRG_DiLeu_BaEn_1	43	48	PF01217	0.537
TRG_DiLeu_BaEn_1	859	864	PF01217	0.467
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.492
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.571
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.462
TRG_ENDOCYTIC_2	695	698	PF00928	0.522
TRG_ENDOCYTIC_2	812	815	PF00928	0.528
TRG_ENDOCYTIC_2	987	990	PF00928	0.651
TRG_ER_diArg_1	250	253	PF00400	0.574
TRG_ER_diArg_1	431	434	PF00400	0.640
TRG_ER_diArg_1	906	908	PF00400	0.461
TRG_ER_diArg_1	982	985	PF00400	0.614
TRG_NES_CRM1_1	814	826	PF08389	0.533
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ5	Leptomonas seymouri	46%	100%
A4H8F6	Leishmania braziliensis	70%	93%
A4HWS6	Leishmania infantum	99%	100%
E9AQI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QEZ3	Leishmania major	90%	100%