Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IIY0_LEIDO

TriTrypDb:

LdBPK_343880.1 , LdCL_340048200 , LDHU3_34.6180

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIY0

Function

Biological processes
Term	Name	Level	Count
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.482
CLV_C14_Caspase3-7	259	263	PF00656	0.666
CLV_C14_Caspase3-7	393	397	PF00656	0.634
CLV_NRD_NRD_1	130	132	PF00675	0.651
CLV_NRD_NRD_1	36	38	PF00675	0.635
CLV_NRD_NRD_1	369	371	PF00675	0.603
CLV_NRD_NRD_1	433	435	PF00675	0.641
CLV_NRD_NRD_1	639	641	PF00675	0.766
CLV_NRD_NRD_1	79	81	PF00675	0.591
CLV_PCSK_FUR_1	27	31	PF00082	0.627
CLV_PCSK_KEX2_1	29	31	PF00082	0.606
CLV_PCSK_KEX2_1	36	38	PF00082	0.619
CLV_PCSK_KEX2_1	369	371	PF00082	0.628
CLV_PCSK_KEX2_1	432	434	PF00082	0.688
CLV_PCSK_KEX2_1	609	611	PF00082	0.572
CLV_PCSK_KEX2_1	639	641	PF00082	0.766
CLV_PCSK_KEX2_1	79	81	PF00082	0.462
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.631
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.619
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.600
CLV_PCSK_SKI1_1	132	136	PF00082	0.664
CLV_PCSK_SKI1_1	176	180	PF00082	0.474
CLV_PCSK_SKI1_1	370	374	PF00082	0.665
CLV_PCSK_SKI1_1	454	458	PF00082	0.617
CLV_PCSK_SKI1_1	485	489	PF00082	0.484
CLV_PCSK_SKI1_1	640	644	PF00082	0.768
CLV_PCSK_SKI1_1	672	676	PF00082	0.698
CLV_Separin_Metazoa	197	201	PF03568	0.387
DEG_APCC_DBOX_1	432	440	PF00400	0.736
DEG_APCC_DBOX_1	484	492	PF00400	0.484
DEG_Nend_UBRbox_2	1	3	PF02207	0.675
DEG_SPOP_SBC_1	144	148	PF00917	0.723
DEG_SPOP_SBC_1	273	277	PF00917	0.697
DOC_CKS1_1	83	88	PF01111	0.602
DOC_MAPK_gen_1	102	110	PF00069	0.636
DOC_MAPK_gen_1	432	438	PF00069	0.648
DOC_MAPK_gen_1	609	615	PF00069	0.607
DOC_MAPK_gen_1	624	632	PF00069	0.680
DOC_MAPK_MEF2A_6	286	293	PF00069	0.468
DOC_MAPK_MEF2A_6	353	360	PF00069	0.450
DOC_MAPK_MEF2A_6	624	632	PF00069	0.636
DOC_MAPK_NFAT4_5	286	294	PF00069	0.468
DOC_PP2B_LxvP_1	289	292	PF13499	0.533
DOC_PP2B_LxvP_1	535	538	PF13499	0.647
DOC_PP4_FxxP_1	593	596	PF00568	0.716
DOC_PP4_FxxP_1	670	673	PF00568	0.705
DOC_USP7_MATH_1	144	148	PF00917	0.684
DOC_USP7_MATH_1	225	229	PF00917	0.574
DOC_USP7_MATH_1	445	449	PF00917	0.652
DOC_USP7_MATH_1	49	53	PF00917	0.710
DOC_USP7_MATH_1	656	660	PF00917	0.621
DOC_USP7_MATH_1	8	12	PF00917	0.659
DOC_USP7_UBL2_3	660	664	PF12436	0.768
DOC_WW_Pin1_4	140	145	PF00397	0.714
DOC_WW_Pin1_4	162	167	PF00397	0.756
DOC_WW_Pin1_4	292	297	PF00397	0.565
DOC_WW_Pin1_4	406	411	PF00397	0.653
DOC_WW_Pin1_4	584	589	PF00397	0.612
DOC_WW_Pin1_4	82	87	PF00397	0.605
LIG_14-3-3_CanoR_1	582	587	PF00244	0.618
LIG_14-3-3_CanoR_1	600	606	PF00244	0.653
LIG_Actin_WH2_2	196	213	PF00022	0.467
LIG_Actin_WH2_2	474	491	PF00022	0.501
LIG_BRCT_BRCA1_1	447	451	PF00533	0.685
LIG_BRCT_BRCA1_1	589	593	PF00533	0.710
LIG_CaM_IQ_9	561	576	PF13499	0.580
LIG_EH1_1	481	489	PF00400	0.563
LIG_FHA_1	144	150	PF00498	0.724
LIG_FHA_1	285	291	PF00498	0.514
LIG_FHA_1	381	387	PF00498	0.587
LIG_FHA_1	407	413	PF00498	0.617
LIG_FHA_1	55	61	PF00498	0.547
LIG_FHA_1	63	69	PF00498	0.465
LIG_FHA_2	163	169	PF00498	0.707
LIG_FHA_2	331	337	PF00498	0.521
LIG_FHA_2	474	480	PF00498	0.645
LIG_FHA_2	98	104	PF00498	0.549
LIG_GBD_Chelix_1	343	351	PF00786	0.528
LIG_LIR_Apic_2	590	596	PF02991	0.697
LIG_LIR_Apic_2	81	86	PF02991	0.575
LIG_LIR_Gen_1	116	123	PF02991	0.561
LIG_LIR_Gen_1	228	236	PF02991	0.629
LIG_LIR_Gen_1	67	76	PF02991	0.528
LIG_LIR_Nem_3	116	122	PF02991	0.565
LIG_LIR_Nem_3	228	233	PF02991	0.559
LIG_LIR_Nem_3	67	72	PF02991	0.526
LIG_NRBOX	189	195	PF00104	0.487
LIG_NRBOX	71	77	PF00104	0.586
LIG_PDZ_Class_2	671	676	PF00595	0.709
LIG_Pex14_2	670	674	PF04695	0.700
LIG_Rb_LxCxE_1	238	259	PF01857	0.636
LIG_SH2_CRK	303	307	PF00017	0.469
LIG_SH2_STAP1	204	208	PF00017	0.554
LIG_SH2_STAT3	218	221	PF00017	0.526
LIG_SH2_STAT3	25	28	PF00017	0.615
LIG_SH2_STAT5	115	118	PF00017	0.625
LIG_SH2_STAT5	202	205	PF00017	0.395
LIG_SH2_STAT5	230	233	PF00017	0.612
LIG_SH2_STAT5	25	28	PF00017	0.642
LIG_SH2_STAT5	529	532	PF00017	0.606
LIG_SH2_STAT5	602	605	PF00017	0.687
LIG_SH3_3	164	170	PF00018	0.698
LIG_SH3_3	2	8	PF00018	0.680
LIG_SH3_3	435	441	PF00018	0.709
LIG_SH3_3	539	545	PF00018	0.666
LIG_SH3_3	625	631	PF00018	0.752
LIG_SH3_4	660	667	PF00018	0.632
LIG_SUMO_SIM_anti_2	180	189	PF11976	0.514
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.529
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.488
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.541
LIG_SUMO_SIM_par_1	378	383	PF11976	0.676
LIG_SUMO_SIM_par_1	52	59	PF11976	0.586
LIG_SUMO_SIM_par_1	531	539	PF11976	0.615
LIG_TRAF2_1	476	479	PF00917	0.564
MOD_CDK_SPxK_1	82	88	PF00069	0.604
MOD_CK1_1	143	149	PF00069	0.755
MOD_CK1_1	171	177	PF00069	0.532
MOD_CK1_1	3	9	PF00069	0.726
MOD_CK1_1	406	412	PF00069	0.705
MOD_CK1_1	601	607	PF00069	0.685
MOD_CK1_1	62	68	PF00069	0.514
MOD_CK2_1	106	112	PF00069	0.559
MOD_CK2_1	114	120	PF00069	0.564
MOD_CK2_1	171	177	PF00069	0.520
MOD_CK2_1	277	283	PF00069	0.675
MOD_CK2_1	444	450	PF00069	0.580
MOD_CK2_1	473	479	PF00069	0.576
MOD_CK2_1	97	103	PF00069	0.520
MOD_Cter_Amidation	129	132	PF01082	0.597
MOD_Cter_Amidation	430	433	PF01082	0.713
MOD_Cter_Amidation	637	640	PF01082	0.717
MOD_GlcNHglycan	116	119	PF01048	0.530
MOD_GlcNHglycan	132	135	PF01048	0.576
MOD_GlcNHglycan	258	261	PF01048	0.684
MOD_GlcNHglycan	262	266	PF01048	0.680
MOD_GlcNHglycan	279	282	PF01048	0.444
MOD_GlcNHglycan	361	364	PF01048	0.531
MOD_GlcNHglycan	370	373	PF01048	0.656
MOD_GlcNHglycan	596	599	PF01048	0.651
MOD_GSK3_1	140	147	PF00069	0.686
MOD_GSK3_1	156	163	PF00069	0.673
MOD_GSK3_1	177	184	PF00069	0.446
MOD_GSK3_1	252	259	PF00069	0.653
MOD_GSK3_1	273	280	PF00069	0.681
MOD_GSK3_1	318	325	PF00069	0.723
MOD_GSK3_1	335	342	PF00069	0.508
MOD_GSK3_1	568	575	PF00069	0.640
MOD_GSK3_1	594	601	PF00069	0.633
MOD_GSK3_1	642	649	PF00069	0.712
MOD_LATS_1	580	586	PF00433	0.592
MOD_LATS_1	95	101	PF00433	0.426
MOD_N-GLC_1	466	471	PF02516	0.651
MOD_N-GLC_1	561	566	PF02516	0.727
MOD_NEK2_1	123	128	PF00069	0.692
MOD_NEK2_1	179	184	PF00069	0.438
MOD_NEK2_1	186	191	PF00069	0.395
MOD_NEK2_1	203	208	PF00069	0.497
MOD_NEK2_1	21	26	PF00069	0.591
MOD_NEK2_1	226	231	PF00069	0.592
MOD_NEK2_1	254	259	PF00069	0.679
MOD_NEK2_1	339	344	PF00069	0.466
MOD_NEK2_1	359	364	PF00069	0.467
MOD_NEK2_1	368	373	PF00069	0.522
MOD_NEK2_1	380	385	PF00069	0.548
MOD_NEK2_1	403	408	PF00069	0.696
MOD_NEK2_1	459	464	PF00069	0.580
MOD_NEK2_2	64	69	PF00069	0.424
MOD_PIKK_1	254	260	PF00454	0.601
MOD_PIKK_1	561	567	PF00454	0.671
MOD_PK_1	156	162	PF00069	0.695
MOD_PKA_2	123	129	PF00069	0.663
MOD_PKA_2	130	136	PF00069	0.666
MOD_PKA_2	368	374	PF00069	0.613
MOD_PKA_2	568	574	PF00069	0.546
MOD_PKA_2	656	662	PF00069	0.750
MOD_Plk_1	335	341	PF00069	0.537
MOD_Plk_1	466	472	PF00069	0.609
MOD_Plk_1	538	544	PF00069	0.711
MOD_Plk_1	561	567	PF00069	0.719
MOD_Plk_2-3	106	112	PF00069	0.651
MOD_Plk_4	106	112	PF00069	0.595
MOD_Plk_4	226	232	PF00069	0.640
MOD_Plk_4	346	352	PF00069	0.549
MOD_Plk_4	64	70	PF00069	0.539
MOD_ProDKin_1	140	146	PF00069	0.715
MOD_ProDKin_1	162	168	PF00069	0.754
MOD_ProDKin_1	292	298	PF00069	0.574
MOD_ProDKin_1	406	412	PF00069	0.654
MOD_ProDKin_1	584	590	PF00069	0.614
MOD_ProDKin_1	82	88	PF00069	0.604
TRG_DiLeu_BaEn_1	181	186	PF01217	0.473
TRG_DiLeu_BaEn_1	71	76	PF01217	0.583
TRG_DiLeu_BaEn_2	105	111	PF01217	0.646
TRG_DiLeu_BaEn_2	610	616	PF01217	0.630
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.539
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.574
TRG_DiLeu_LyEn_5	71	76	PF01217	0.532
TRG_ENDOCYTIC_2	230	233	PF00928	0.633
TRG_ENDOCYTIC_2	303	306	PF00928	0.469
TRG_ER_diArg_1	368	370	PF00400	0.581
TRG_ER_diArg_1	432	434	PF00400	0.716
TRG_NES_CRM1_1	181	195	PF08389	0.468
TRG_NLS_MonoExtC_3	35	41	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E6	Leptomonas seymouri	49%	100%
A0A0S4KLZ0	Bodo saltans	27%	85%
A0A1X0PAG6	Trypanosomatidae	35%	100%
A0A422NVB5	Trypanosoma rangeli	32%	100%
A4HBC8	Leishmania braziliensis	74%	100%
A4IAH6	Leishmania infantum	100%	100%
C9ZLR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2D6	Leishmania major	90%	98%
V5BRF7	Trypanosoma cruzi	33%	100%