LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Methyltransferase domain/ubiE/COQ5 methyltransferase family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransferase domain/ubiE/COQ5 methyltransferase family, putative
Gene product:
methyltransferase domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IIX0_LEIDO
TriTrypDb:
LdBPK_351570.1 , LdCL_350020600 , LDHU3_35.2090
Length:
351

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3Q8IIX0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIX0

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 3
GO:0032259 methylation 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0008168 methyltransferase activity 4 4
GO:0016740 transferase activity 2 4
GO:0016741 transferase activity, transferring one-carbon groups 3 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 220 224 PF00656 0.359
CLV_C14_Caspase3-7 54 58 PF00656 0.634
CLV_NRD_NRD_1 47 49 PF00675 0.483
CLV_PCSK_FUR_1 112 116 PF00082 0.425
CLV_PCSK_KEX2_1 114 116 PF00082 0.417
CLV_PCSK_KEX2_1 215 217 PF00082 0.476
CLV_PCSK_PC1ET2_1 114 116 PF00082 0.417
CLV_PCSK_PC1ET2_1 215 217 PF00082 0.553
CLV_PCSK_SKI1_1 115 119 PF00082 0.421
CLV_PCSK_SKI1_1 254 258 PF00082 0.475
CLV_PCSK_SKI1_1 48 52 PF00082 0.397
CLV_PCSK_SKI1_1 91 95 PF00082 0.449
DOC_CYCLIN_yCln2_LP_2 242 248 PF00134 0.265
DOC_MAPK_gen_1 114 123 PF00069 0.598
DOC_MAPK_gen_1 254 264 PF00069 0.281
DOC_MAPK_MEF2A_6 257 265 PF00069 0.281
DOC_PP4_FxxP_1 35 38 PF00568 0.606
DOC_USP7_MATH_1 9 13 PF00917 0.791
DOC_USP7_UBL2_3 114 118 PF12436 0.614
DOC_USP7_UBL2_3 211 215 PF12436 0.367
DOC_USP7_UBL2_3 335 339 PF12436 0.390
DOC_USP7_UBL2_3 345 349 PF12436 0.497
DOC_WW_Pin1_4 267 272 PF00397 0.281
DOC_WW_Pin1_4 294 299 PF00397 0.305
LIG_14-3-3_CanoR_1 203 212 PF00244 0.281
LIG_14-3-3_CanoR_1 216 225 PF00244 0.283
LIG_14-3-3_CterR_2 347 351 PF00244 0.419
LIG_AP2alpha_1 278 282 PF02296 0.305
LIG_BIR_II_1 1 5 PF00653 0.674
LIG_BIR_III_2 57 61 PF00653 0.624
LIG_FHA_1 23 29 PF00498 0.773
LIG_FHA_1 319 325 PF00498 0.300
LIG_FHA_1 84 90 PF00498 0.621
LIG_LIR_Gen_1 227 237 PF02991 0.281
LIG_LIR_Nem_3 106 110 PF02991 0.613
LIG_LIR_Nem_3 139 143 PF02991 0.496
LIG_LIR_Nem_3 162 166 PF02991 0.285
LIG_LIR_Nem_3 207 212 PF02991 0.281
LIG_LIR_Nem_3 227 233 PF02991 0.281
LIG_LIR_Nem_3 270 275 PF02991 0.282
LIG_LIR_Nem_3 320 325 PF02991 0.299
LIG_LYPXL_SIV_4 271 279 PF13949 0.292
LIG_LYPXL_yS_3 272 275 PF13949 0.292
LIG_LYPXL_yS_3 327 330 PF13949 0.344
LIG_NRP_CendR_1 349 351 PF00754 0.630
LIG_PCNA_yPIPBox_3 294 303 PF02747 0.279
LIG_Pex14_1 277 281 PF04695 0.274
LIG_Pex14_1 97 101 PF04695 0.609
LIG_Pex14_2 140 144 PF04695 0.477
LIG_Pex14_2 278 282 PF04695 0.281
LIG_PTB_Apo_2 312 319 PF02174 0.336
LIG_PTB_Phospho_1 312 318 PF10480 0.339
LIG_REV1ctd_RIR_1 138 146 PF16727 0.493
LIG_SH2_CRK 163 167 PF00017 0.281
LIG_SH2_CRK 202 206 PF00017 0.281
LIG_SH2_STAT3 101 104 PF00017 0.607
LIG_SH2_STAT3 281 284 PF00017 0.321
LIG_SH2_STAT5 107 110 PF00017 0.603
LIG_SH2_STAT5 281 284 PF00017 0.300
LIG_SH2_STAT5 302 305 PF00017 0.281
LIG_SH2_STAT5 323 326 PF00017 0.294
LIG_SH3_3 142 148 PF00018 0.360
LIG_SH3_3 252 258 PF00018 0.292
LIG_SH3_3 268 274 PF00018 0.292
LIG_SH3_3 322 328 PF00018 0.298
LIG_SUMO_SIM_par_1 259 266 PF11976 0.281
LIG_TYR_ITIM 325 330 PF00017 0.328
LIG_TYR_ITSM 318 325 PF00017 0.307
LIG_WRC_WIRS_1 137 142 PF05994 0.358
MOD_CDC14_SPxK_1 297 300 PF00782 0.305
MOD_CDK_SPxK_1 294 300 PF00069 0.305
MOD_CK1_1 20 26 PF00069 0.762
MOD_CK1_1 66 72 PF00069 0.712
MOD_CK2_1 303 309 PF00069 0.292
MOD_GlcNHglycan 1 4 PF01048 0.517
MOD_GlcNHglycan 19 22 PF01048 0.542
MOD_GlcNHglycan 258 261 PF01048 0.492
MOD_GlcNHglycan 9 12 PF01048 0.534
MOD_GSK3_1 63 70 PF00069 0.683
MOD_NEK2_1 159 164 PF00069 0.292
MOD_NEK2_1 189 194 PF00069 0.287
MOD_NEK2_1 303 308 PF00069 0.292
MOD_NEK2_2 136 141 PF00069 0.414
MOD_PKA_2 7 13 PF00069 0.740
MOD_PKB_1 216 224 PF00069 0.367
MOD_Plk_4 136 142 PF00069 0.358
MOD_Plk_4 318 324 PF00069 0.309
MOD_ProDKin_1 267 273 PF00069 0.281
MOD_ProDKin_1 294 300 PF00069 0.305
MOD_SUMO_rev_2 305 313 PF00179 0.292
TRG_ENDOCYTIC_2 107 110 PF00928 0.614
TRG_ENDOCYTIC_2 163 166 PF00928 0.281
TRG_ENDOCYTIC_2 272 275 PF00928 0.271
TRG_ENDOCYTIC_2 322 325 PF00928 0.295
TRG_ENDOCYTIC_2 327 330 PF00928 0.339
TRG_NLS_MonoExtC_3 214 220 PF00514 0.367
TRG_Pf-PMV_PEXEL_1 115 119 PF00026 0.421
TRG_Pf-PMV_PEXEL_1 149 153 PF00026 0.486

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I341 Leptomonas seymouri 86% 87%
A0A0S4J626 Bodo saltans 70% 89%
A0A1X0P6L5 Trypanosomatidae 75% 89%
A0A422NQ76 Trypanosoma rangeli 75% 93%
A4HMH8 Leishmania braziliensis 90% 100%
A4IB48 Leishmania infantum 99% 100%
A4IB58 Leishmania infantum 100% 100%
C9ZZG6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 78% 91%
E9AEX9 Leishmania major 98% 100%
E9B635 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5DKE6 Trypanosoma cruzi 73% 92%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS