LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3Q8IIW4_LEIDO
TriTrypDb:
LdBPK_364150.1 * , LdCL_360048500 , LDHU3_36.5570
Length:
1009

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIW4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIW4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 314 318 PF00656 0.697
CLV_C14_Caspase3-7 972 976 PF00656 0.647
CLV_NRD_NRD_1 349 351 PF00675 0.728
CLV_NRD_NRD_1 502 504 PF00675 0.674
CLV_NRD_NRD_1 532 534 PF00675 0.718
CLV_NRD_NRD_1 62 64 PF00675 0.669
CLV_NRD_NRD_1 741 743 PF00675 0.572
CLV_NRD_NRD_1 925 927 PF00675 0.666
CLV_NRD_NRD_1 996 998 PF00675 0.691
CLV_PCSK_FUR_1 221 225 PF00082 0.594
CLV_PCSK_FUR_1 530 534 PF00082 0.718
CLV_PCSK_KEX2_1 223 225 PF00082 0.598
CLV_PCSK_KEX2_1 349 351 PF00082 0.728
CLV_PCSK_KEX2_1 353 355 PF00082 0.687
CLV_PCSK_KEX2_1 502 504 PF00082 0.723
CLV_PCSK_KEX2_1 532 534 PF00082 0.664
CLV_PCSK_KEX2_1 741 743 PF00082 0.572
CLV_PCSK_KEX2_1 884 886 PF00082 0.637
CLV_PCSK_KEX2_1 925 927 PF00082 0.668
CLV_PCSK_KEX2_1 996 998 PF00082 0.691
CLV_PCSK_PC1ET2_1 223 225 PF00082 0.598
CLV_PCSK_PC1ET2_1 353 355 PF00082 0.699
CLV_PCSK_PC1ET2_1 884 886 PF00082 0.637
CLV_PCSK_PC7_1 349 355 PF00082 0.730
CLV_PCSK_PC7_1 992 998 PF00082 0.683
CLV_PCSK_SKI1_1 569 573 PF00082 0.641
CLV_PCSK_SKI1_1 763 767 PF00082 0.664
CLV_PCSK_SKI1_1 789 793 PF00082 0.659
DEG_COP1_1 179 191 PF00400 0.589
DEG_COP1_1 373 385 PF00400 0.641
DEG_SCF_FBW7_1 445 452 PF00400 0.691
DEG_SPOP_SBC_1 141 145 PF00917 0.645
DEG_SPOP_SBC_1 518 522 PF00917 0.661
DEG_SPOP_SBC_1 673 677 PF00917 0.576
DOC_CKS1_1 21 26 PF01111 0.682
DOC_CYCLIN_RxL_1 786 795 PF00134 0.656
DOC_CYCLIN_yCln2_LP_2 129 135 PF00134 0.630
DOC_MAPK_HePTP_8 237 249 PF00069 0.592
DOC_MAPK_MEF2A_6 240 249 PF00069 0.599
DOC_PP2B_LxvP_1 129 132 PF13499 0.691
DOC_PP2B_LxvP_1 561 564 PF13499 0.674
DOC_PP4_FxxP_1 524 527 PF00568 0.731
DOC_PP4_FxxP_1 573 576 PF00568 0.660
DOC_USP7_MATH_1 123 127 PF00917 0.702
DOC_USP7_MATH_1 141 145 PF00917 0.509
DOC_USP7_MATH_1 176 180 PF00917 0.717
DOC_USP7_MATH_1 368 372 PF00917 0.668
DOC_USP7_MATH_1 39 43 PF00917 0.703
DOC_USP7_MATH_1 410 414 PF00917 0.731
DOC_USP7_MATH_1 440 444 PF00917 0.692
DOC_USP7_MATH_1 450 454 PF00917 0.749
DOC_USP7_MATH_1 476 480 PF00917 0.645
DOC_USP7_MATH_1 518 522 PF00917 0.689
DOC_USP7_MATH_1 557 561 PF00917 0.685
DOC_USP7_MATH_1 673 677 PF00917 0.642
DOC_USP7_MATH_1 715 719 PF00917 0.617
DOC_USP7_MATH_1 954 958 PF00917 0.712
DOC_USP7_MATH_1 96 100 PF00917 0.684
DOC_USP7_MATH_2 9 15 PF00917 0.604
DOC_WW_Pin1_4 133 138 PF00397 0.643
DOC_WW_Pin1_4 20 25 PF00397 0.733
DOC_WW_Pin1_4 273 278 PF00397 0.539
DOC_WW_Pin1_4 326 331 PF00397 0.739
DOC_WW_Pin1_4 336 341 PF00397 0.611
DOC_WW_Pin1_4 356 361 PF00397 0.517
DOC_WW_Pin1_4 416 421 PF00397 0.718
DOC_WW_Pin1_4 445 450 PF00397 0.734
DOC_WW_Pin1_4 478 483 PF00397 0.638
DOC_WW_Pin1_4 514 519 PF00397 0.681
DOC_WW_Pin1_4 523 528 PF00397 0.636
DOC_WW_Pin1_4 559 564 PF00397 0.822
DOC_WW_Pin1_4 582 587 PF00397 0.700
DOC_WW_Pin1_4 669 674 PF00397 0.598
DOC_WW_Pin1_4 850 855 PF00397 0.687
DOC_WW_Pin1_4 860 865 PF00397 0.675
DOC_WW_Pin1_4 916 921 PF00397 0.705
LIG_14-3-3_CanoR_1 146 153 PF00244 0.650
LIG_14-3-3_CanoR_1 198 202 PF00244 0.644
LIG_14-3-3_CanoR_1 224 233 PF00244 0.554
LIG_14-3-3_CanoR_1 362 370 PF00244 0.697
LIG_14-3-3_CanoR_1 451 459 PF00244 0.746
LIG_14-3-3_CanoR_1 502 508 PF00244 0.659
LIG_14-3-3_CanoR_1 530 536 PF00244 0.690
LIG_14-3-3_CanoR_1 569 574 PF00244 0.639
LIG_14-3-3_CanoR_1 63 69 PF00244 0.700
LIG_14-3-3_CanoR_1 647 657 PF00244 0.666
LIG_14-3-3_CanoR_1 691 695 PF00244 0.609
LIG_14-3-3_CanoR_1 701 705 PF00244 0.496
LIG_Actin_WH2_2 554 571 PF00022 0.669
LIG_AP2alpha_2 980 982 PF02296 0.552
LIG_BIR_III_4 975 979 PF00653 0.683
LIG_BRCT_BRCA1_1 520 524 PF00533 0.743
LIG_BRCT_BRCA1_1 634 638 PF00533 0.604
LIG_CtBP_PxDLS_1 428 432 PF00389 0.690
LIG_FHA_1 232 238 PF00498 0.523
LIG_FHA_1 289 295 PF00498 0.574
LIG_FHA_1 32 38 PF00498 0.709
LIG_FHA_1 365 371 PF00498 0.736
LIG_FHA_1 372 378 PF00498 0.676
LIG_FHA_1 459 465 PF00498 0.810
LIG_FHA_1 572 578 PF00498 0.623
LIG_FHA_1 63 69 PF00498 0.588
LIG_FHA_1 649 655 PF00498 0.576
LIG_FHA_1 675 681 PF00498 0.652
LIG_FHA_1 898 904 PF00498 0.667
LIG_FHA_1 969 975 PF00498 0.595
LIG_FHA_2 294 300 PF00498 0.538
LIG_FHA_2 704 710 PF00498 0.625
LIG_FHA_2 762 768 PF00498 0.710
LIG_FHA_2 805 811 PF00498 0.635
LIG_FHA_2 970 976 PF00498 0.673
LIG_FHA_2 981 987 PF00498 0.573
LIG_HCF-1_HBM_1 840 843 PF13415 0.693
LIG_Integrin_RGD_1 722 724 PF01839 0.601
LIG_LIR_Apic_2 521 527 PF02991 0.736
LIG_LIR_Apic_2 570 576 PF02991 0.676
LIG_LIR_Gen_1 635 644 PF02991 0.632
LIG_LIR_Gen_1 702 712 PF02991 0.588
LIG_LIR_Gen_1 980 989 PF02991 0.559
LIG_LIR_Nem_3 877 883 PF02991 0.722
LIG_MYND_1 336 340 PF01753 0.646
LIG_SH2_STAT5 286 289 PF00017 0.500
LIG_SH2_STAT5 363 366 PF00017 0.547
LIG_SH2_STAT5 824 827 PF00017 0.694
LIG_SH2_STAT5 849 852 PF00017 0.717
LIG_SH2_STAT5 987 990 PF00017 0.658
LIG_SH3_1 781 787 PF00018 0.649
LIG_SH3_2 420 425 PF14604 0.662
LIG_SH3_2 784 789 PF14604 0.684
LIG_SH3_3 131 137 PF00018 0.627
LIG_SH3_3 202 208 PF00018 0.660
LIG_SH3_3 324 330 PF00018 0.693
LIG_SH3_3 400 406 PF00018 0.616
LIG_SH3_3 417 423 PF00018 0.610
LIG_SH3_3 481 487 PF00018 0.744
LIG_SH3_3 651 657 PF00018 0.644
LIG_SH3_3 74 80 PF00018 0.681
LIG_SH3_3 781 787 PF00018 0.698
LIG_SH3_3 89 95 PF00018 0.585
LIG_SH3_3 962 968 PF00018 0.716
LIG_TRAF2_1 312 315 PF00917 0.743
LIG_TRAF2_1 453 456 PF00917 0.695
LIG_TRAF2_1 592 595 PF00917 0.703
LIG_TRAF2_1 735 738 PF00917 0.576
LIG_TRAF2_1 809 812 PF00917 0.604
LIG_WW_3 448 452 PF00397 0.665
LIG_WW_3 786 790 PF00397 0.676
MOD_CDC14_SPxK_1 359 362 PF00782 0.681
MOD_CDK_SPxK_1 356 362 PF00069 0.676
MOD_CDK_SPxK_1 445 451 PF00069 0.690
MOD_CDK_SPxK_1 860 866 PF00069 0.713
MOD_CDK_SPxxK_3 478 485 PF00069 0.639
MOD_CDK_SPxxK_3 523 530 PF00069 0.682
MOD_CDK_SPxxK_3 916 923 PF00069 0.639
MOD_CK1_1 115 121 PF00069 0.671
MOD_CK1_1 14 20 PF00069 0.730
MOD_CK1_1 145 151 PF00069 0.686
MOD_CK1_1 152 158 PF00069 0.621
MOD_CK1_1 180 186 PF00069 0.634
MOD_CK1_1 263 269 PF00069 0.672
MOD_CK1_1 298 304 PF00069 0.679
MOD_CK1_1 326 332 PF00069 0.694
MOD_CK1_1 366 372 PF00069 0.671
MOD_CK1_1 378 384 PF00069 0.586
MOD_CK1_1 414 420 PF00069 0.826
MOD_CK1_1 465 471 PF00069 0.749
MOD_CK1_1 498 504 PF00069 0.730
MOD_CK1_1 517 523 PF00069 0.540
MOD_CK1_1 548 554 PF00069 0.722
MOD_CK1_1 600 606 PF00069 0.647
MOD_CK1_1 620 626 PF00069 0.506
MOD_CK1_1 669 675 PF00069 0.836
MOD_CK1_1 67 73 PF00069 0.710
MOD_CK1_1 703 709 PF00069 0.569
MOD_CK1_1 853 859 PF00069 0.656
MOD_CK1_1 99 105 PF00069 0.715
MOD_CK2_1 105 111 PF00069 0.637
MOD_CK2_1 223 229 PF00069 0.560
MOD_CK2_1 315 321 PF00069 0.685
MOD_CK2_1 336 342 PF00069 0.640
MOD_CK2_1 381 387 PF00069 0.724
MOD_CK2_1 450 456 PF00069 0.718
MOD_CK2_1 703 709 PF00069 0.593
MOD_CK2_1 733 739 PF00069 0.622
MOD_CK2_1 804 810 PF00069 0.628
MOD_CK2_1 926 932 PF00069 0.682
MOD_DYRK1A_RPxSP_1 356 360 PF00069 0.671
MOD_GlcNHglycan 114 117 PF01048 0.660
MOD_GlcNHglycan 120 123 PF01048 0.585
MOD_GlcNHglycan 125 128 PF01048 0.616
MOD_GlcNHglycan 148 151 PF01048 0.625
MOD_GlcNHglycan 16 19 PF01048 0.735
MOD_GlcNHglycan 250 253 PF01048 0.503
MOD_GlcNHglycan 302 305 PF01048 0.692
MOD_GlcNHglycan 464 467 PF01048 0.751
MOD_GlcNHglycan 547 550 PF01048 0.697
MOD_GlcNHglycan 582 585 PF01048 0.777
MOD_GlcNHglycan 615 618 PF01048 0.664
MOD_GlcNHglycan 682 685 PF01048 0.582
MOD_GlcNHglycan 717 720 PF01048 0.638
MOD_GlcNHglycan 794 797 PF01048 0.642
MOD_GlcNHglycan 81 84 PF01048 0.631
MOD_GlcNHglycan 832 835 PF01048 0.675
MOD_GlcNHglycan 914 917 PF01048 0.683
MOD_GlcNHglycan 927 931 PF01048 0.580
MOD_GlcNHglycan 975 979 PF01048 0.662
MOD_GSK3_1 141 148 PF00069 0.689
MOD_GSK3_1 165 172 PF00069 0.692
MOD_GSK3_1 176 183 PF00069 0.619
MOD_GSK3_1 293 300 PF00069 0.594
MOD_GSK3_1 364 371 PF00069 0.701
MOD_GSK3_1 397 404 PF00069 0.714
MOD_GSK3_1 410 417 PF00069 0.637
MOD_GSK3_1 440 447 PF00069 0.780
MOD_GSK3_1 458 465 PF00069 0.598
MOD_GSK3_1 466 473 PF00069 0.652
MOD_GSK3_1 491 498 PF00069 0.701
MOD_GSK3_1 514 521 PF00069 0.712
MOD_GSK3_1 567 574 PF00069 0.689
MOD_GSK3_1 596 603 PF00069 0.634
MOD_GSK3_1 613 620 PF00069 0.686
MOD_GSK3_1 628 635 PF00069 0.429
MOD_GSK3_1 63 70 PF00069 0.713
MOD_GSK3_1 648 655 PF00069 0.499
MOD_GSK3_1 665 672 PF00069 0.600
MOD_GSK3_1 699 706 PF00069 0.701
MOD_GSK3_1 757 764 PF00069 0.773
MOD_GSK3_1 841 848 PF00069 0.698
MOD_GSK3_1 850 857 PF00069 0.565
MOD_GSK3_1 912 919 PF00069 0.659
MOD_GSK3_1 954 961 PF00069 0.713
MOD_GSK3_1 96 103 PF00069 0.677
MOD_N-GLC_1 263 268 PF02516 0.609
MOD_N-GLC_1 273 278 PF02516 0.575
MOD_N-GLC_1 411 416 PF02516 0.747
MOD_N-GLC_1 99 104 PF02516 0.604
MOD_N-GLC_2 4 6 PF02516 0.674
MOD_NEK2_1 142 147 PF00069 0.698
MOD_NEK2_1 177 182 PF00069 0.671
MOD_NEK2_1 297 302 PF00069 0.572
MOD_NEK2_1 444 449 PF00069 0.858
MOD_NEK2_1 579 584 PF00069 0.748
MOD_NEK2_1 596 601 PF00069 0.599
MOD_NEK2_1 628 633 PF00069 0.613
MOD_NEK2_1 680 685 PF00069 0.660
MOD_NEK2_1 708 713 PF00069 0.579
MOD_NEK2_1 958 963 PF00069 0.707
MOD_NEK2_2 954 959 PF00069 0.581
MOD_PIKK_1 105 111 PF00454 0.637
MOD_PIKK_1 17 23 PF00454 0.687
MOD_PIKK_1 401 407 PF00454 0.739
MOD_PIKK_1 458 464 PF00454 0.746
MOD_PIKK_1 621 627 PF00454 0.497
MOD_PIKK_1 652 658 PF00454 0.695
MOD_PIKK_1 958 964 PF00454 0.670
MOD_PK_1 223 229 PF00069 0.560
MOD_PK_1 64 70 PF00069 0.585
MOD_PKA_1 223 229 PF00069 0.560
MOD_PKA_1 401 407 PF00069 0.739
MOD_PKA_1 63 69 PF00069 0.673
MOD_PKA_2 145 151 PF00069 0.648
MOD_PKA_2 197 203 PF00069 0.652
MOD_PKA_2 223 229 PF00069 0.560
MOD_PKA_2 245 251 PF00069 0.562
MOD_PKA_2 361 367 PF00069 0.715
MOD_PKA_2 371 377 PF00069 0.623
MOD_PKA_2 450 456 PF00069 0.790
MOD_PKA_2 531 537 PF00069 0.686
MOD_PKA_2 62 68 PF00069 0.668
MOD_PKA_2 690 696 PF00069 0.610
MOD_PKA_2 700 706 PF00069 0.498
MOD_PKA_2 804 810 PF00069 0.622
MOD_PKA_2 845 851 PF00069 0.709
MOD_PKA_2 991 997 PF00069 0.679
MOD_PKB_1 352 360 PF00069 0.680
MOD_PKB_1 697 705 PF00069 0.578
MOD_Plk_1 414 420 PF00069 0.770
MOD_Plk_1 440 446 PF00069 0.738
MOD_Plk_1 621 627 PF00069 0.636
MOD_Plk_1 699 705 PF00069 0.657
MOD_Plk_1 708 714 PF00069 0.506
MOD_Plk_1 839 845 PF00069 0.692
MOD_Plk_1 897 903 PF00069 0.599
MOD_Plk_1 99 105 PF00069 0.666
MOD_Plk_2-3 980 986 PF00069 0.542
MOD_Plk_4 440 446 PF00069 0.732
MOD_Plk_4 466 472 PF00069 0.754
MOD_Plk_4 519 525 PF00069 0.740
MOD_Plk_4 608 614 PF00069 0.772
MOD_Plk_4 690 696 PF00069 0.610
MOD_Plk_4 700 706 PF00069 0.606
MOD_Plk_4 845 851 PF00069 0.709
MOD_Plk_4 969 975 PF00069 0.595
MOD_ProDKin_1 133 139 PF00069 0.645
MOD_ProDKin_1 20 26 PF00069 0.730
MOD_ProDKin_1 273 279 PF00069 0.535
MOD_ProDKin_1 326 332 PF00069 0.738
MOD_ProDKin_1 336 342 PF00069 0.608
MOD_ProDKin_1 356 362 PF00069 0.519
MOD_ProDKin_1 416 422 PF00069 0.711
MOD_ProDKin_1 445 451 PF00069 0.738
MOD_ProDKin_1 478 484 PF00069 0.636
MOD_ProDKin_1 514 520 PF00069 0.684
MOD_ProDKin_1 523 529 PF00069 0.635
MOD_ProDKin_1 559 565 PF00069 0.821
MOD_ProDKin_1 582 588 PF00069 0.700
MOD_ProDKin_1 669 675 PF00069 0.597
MOD_ProDKin_1 850 856 PF00069 0.684
MOD_ProDKin_1 860 866 PF00069 0.678
MOD_ProDKin_1 916 922 PF00069 0.707
MOD_SUMO_for_1 436 439 PF00179 0.628
MOD_SUMO_rev_2 430 438 PF00179 0.647
MOD_SUMO_rev_2 944 954 PF00179 0.708
TRG_DiLeu_BaLyEn_6 202 207 PF01217 0.608
TRG_DiLeu_BaLyEn_6 333 338 PF01217 0.668
TRG_DiLeu_BaLyEn_6 863 868 PF01217 0.676
TRG_ENDOCYTIC_2 743 746 PF00928 0.637
TRG_ENDOCYTIC_2 883 886 PF00928 0.747
TRG_ER_diArg_1 349 352 PF00400 0.630
TRG_ER_diArg_1 529 532 PF00400 0.719
TRG_ER_diArg_1 55 58 PF00400 0.720
TRG_ER_diArg_1 644 647 PF00400 0.603
TRG_ER_diArg_1 741 743 PF00400 0.572
TRG_ER_diArg_1 924 926 PF00400 0.670
TRG_ER_diArg_1 989 992 PF00400 0.651
TRG_ER_diArg_1 995 997 PF00400 0.633
TRG_NLS_MonoExtC_3 351 356 PF00514 0.636
TRG_NLS_MonoExtN_4 349 356 PF00514 0.694
TRG_Pf-PMV_PEXEL_1 866 871 PF00026 0.717

Homologs

Protein Taxonomy Sequence identity Coverage
A4HPR4 Leishmania braziliensis 67% 100%
A4ID00 Leishmania infantum 99% 100%
E9ATH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q119 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS