Diacylglycerol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol kinase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IIW3_LEIDO

TriTrypDb:

LdBPK_355060.1 , LdCL_350059200 , LDHU3_35.7110

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IIW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIW3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0007165	signal transduction	2	9
GO:0007186	G protein-coupled receptor signaling pathway	3	9
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0044237	cellular metabolic process	2	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0065007	biological regulation	1	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004143	diacylglycerol kinase activity	5	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	240	242	PF00675	0.300
CLV_NRD_NRD_1	28	30	PF00675	0.335
CLV_NRD_NRD_1	67	69	PF00675	0.374
CLV_PCSK_KEX2_1	137	139	PF00082	0.314
CLV_PCSK_KEX2_1	240	242	PF00082	0.300
CLV_PCSK_KEX2_1	28	30	PF00082	0.381
CLV_PCSK_KEX2_1	92	94	PF00082	0.374
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.318
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.374
CLV_PCSK_PC7_1	24	30	PF00082	0.330
CLV_PCSK_SKI1_1	15	19	PF00082	0.364
DEG_MDM2_SWIB_1	289	297	PF02201	0.536
DEG_ODPH_VHL_1	107	120	PF01847	0.520
DEG_SPOP_SBC_1	161	165	PF00917	0.600
DOC_CYCLIN_RxL_1	337	351	PF00134	0.473
DOC_MAPK_gen_1	227	235	PF00069	0.489
DOC_MAPK_gen_1	58	67	PF00069	0.536
DOC_MAPK_MEF2A_6	228	237	PF00069	0.489
DOC_MAPK_MEF2A_6	358	367	PF00069	0.456
DOC_MAPK_MEF2A_6	58	67	PF00069	0.555
DOC_MAPK_NFAT4_5	60	68	PF00069	0.530
DOC_PP1_RVXF_1	297	303	PF00149	0.536
DOC_PP1_RVXF_1	341	348	PF00149	0.536
DOC_PP2B_LxvP_1	353	356	PF13499	0.572
DOC_USP7_MATH_1	275	279	PF00917	0.485
DOC_USP7_UBL2_3	69	73	PF12436	0.427
DOC_WW_Pin1_4	381	386	PF00397	0.492
DOC_WW_Pin1_4	4	9	PF00397	0.745
DOC_WW_Pin1_4	98	103	PF00397	0.500
LIG_14-3-3_CanoR_1	156	160	PF00244	0.551
LIG_14-3-3_CanoR_1	28	35	PF00244	0.563
LIG_14-3-3_CanoR_1	58	67	PF00244	0.456
LIG_14-3-3_CterR_2	383	387	PF00244	0.399
LIG_APCC_ABBA_1	221	226	PF00400	0.527
LIG_BRCT_BRCA1_1	182	186	PF00533	0.460
LIG_BRCT_BRCA1_1	321	325	PF00533	0.494
LIG_Clathr_ClatBox_1	234	238	PF01394	0.574
LIG_deltaCOP1_diTrp_1	45	51	PF00928	0.574
LIG_FHA_1	146	152	PF00498	0.588
LIG_FHA_1	205	211	PF00498	0.536
LIG_FHA_1	311	317	PF00498	0.574
LIG_FHA_1	339	345	PF00498	0.545
LIG_FHA_2	112	118	PF00498	0.478
LIG_FHA_2	150	156	PF00498	0.573
LIG_LIR_Apic_2	272	277	PF02991	0.536
LIG_LIR_Gen_1	136	146	PF02991	0.592
LIG_LIR_Gen_1	16	23	PF02991	0.527
LIG_LIR_Gen_1	361	372	PF02991	0.418
LIG_LIR_Gen_1	45	56	PF02991	0.536
LIG_LIR_Nem_3	136	142	PF02991	0.556
LIG_LIR_Nem_3	16	21	PF02991	0.491
LIG_LIR_Nem_3	175	181	PF02991	0.530
LIG_LIR_Nem_3	340	345	PF02991	0.531
LIG_LIR_Nem_3	361	367	PF02991	0.418
LIG_LIR_Nem_3	45	51	PF02991	0.502
LIG_PCNA_TLS_4	60	67	PF02747	0.574
LIG_Pex14_1	214	218	PF04695	0.460
LIG_Pex14_2	120	124	PF04695	0.534
LIG_Pex14_2	178	182	PF04695	0.491
LIG_Pex14_2	289	293	PF04695	0.536
LIG_PTB_Apo_2	176	183	PF02174	0.536
LIG_SH2_CRK	274	278	PF00017	0.536
LIG_SH2_CRK	382	386	PF00017	0.465
LIG_SH2_NCK_1	146	150	PF00017	0.593
LIG_SH2_NCK_1	274	278	PF00017	0.527
LIG_SH2_PTP2	74	77	PF00017	0.574
LIG_SH2_SRC	74	77	PF00017	0.574
LIG_SH2_STAP1	215	219	PF00017	0.536
LIG_SH2_STAT5	181	184	PF00017	0.475
LIG_SH2_STAT5	33	36	PF00017	0.534
LIG_SH2_STAT5	74	77	PF00017	0.536
LIG_SH3_3	103	109	PF00018	0.548
LIG_SH3_3	239	245	PF00018	0.480
LIG_Sin3_3	364	371	PF02671	0.365
LIG_SUMO_SIM_par_1	231	238	PF11976	0.574
LIG_TRAF2_1	357	360	PF00917	0.641
LIG_WW_3	355	359	PF00397	0.627
MOD_CDC14_SPxK_1	101	104	PF00782	0.500
MOD_CDK_SPK_2	4	9	PF00069	0.736
MOD_CDK_SPxK_1	98	104	PF00069	0.500
MOD_CDK_SPxxK_3	4	11	PF00069	0.657
MOD_CK1_1	247	253	PF00069	0.536
MOD_CK1_1	7	13	PF00069	0.609
MOD_CK2_1	345	351	PF00069	0.570
MOD_CK2_1	58	64	PF00069	0.574
MOD_Cter_Amidation	238	241	PF01082	0.300
MOD_Cter_Amidation	26	29	PF01082	0.330
MOD_Cter_Amidation	304	307	PF01082	0.336
MOD_GlcNHglycan	125	128	PF01048	0.363
MOD_GlcNHglycan	169	172	PF01048	0.473
MOD_GlcNHglycan	24	27	PF01048	0.252
MOD_GlcNHglycan	246	249	PF01048	0.303
MOD_GSK3_1	145	152	PF00069	0.555
MOD_GSK3_1	155	162	PF00069	0.520
MOD_GSK3_1	315	322	PF00069	0.503
MOD_GSK3_1	333	340	PF00069	0.481
MOD_GSK3_1	347	354	PF00069	0.411
MOD_NEK2_1	118	123	PF00069	0.499
MOD_NEK2_1	159	164	PF00069	0.578
MOD_NEK2_1	172	177	PF00069	0.594
MOD_NEK2_1	204	209	PF00069	0.502
MOD_NEK2_1	345	350	PF00069	0.491
MOD_NEK2_1	38	43	PF00069	0.574
MOD_NEK2_2	13	18	PF00069	0.613
MOD_NEK2_2	338	343	PF00069	0.620
MOD_PIKK_1	58	64	PF00454	0.501
MOD_PKA_1	28	34	PF00069	0.566
MOD_PKA_2	155	161	PF00069	0.531
MOD_PKA_2	27	33	PF00069	0.563
MOD_Plk_1	116	122	PF00069	0.527
MOD_Plk_4	229	235	PF00069	0.574
MOD_Plk_4	275	281	PF00069	0.581
MOD_ProDKin_1	381	387	PF00069	0.497
MOD_ProDKin_1	4	10	PF00069	0.742
MOD_ProDKin_1	98	104	PF00069	0.500
TRG_DiLeu_BaEn_2	359	365	PF01217	0.500
TRG_ENDOCYTIC_2	181	184	PF00928	0.483
TRG_ENDOCYTIC_2	215	218	PF00928	0.455
TRG_ENDOCYTIC_2	74	77	PF00928	0.574
TRG_ER_diArg_1	197	200	PF00400	0.574
TRG_ER_diArg_1	240	242	PF00400	0.500
TRG_ER_diArg_1	8	11	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR4	Leptomonas seymouri	69%	100%
A0A0S4KIS7	Bodo saltans	23%	87%
A0A1X0NZZ0	Trypanosomatidae	35%	100%
A4HNJ8	Leishmania braziliensis	81%	100%
A4IC67	Leishmania infantum	100%	100%
C9ZVX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	67%
E9AG10	Leishmania major	95%	100%
E9B763	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P52429	Homo sapiens	31%	68%
Q1PDI2	Arabidopsis thaliana	24%	79%
Q7XQT2	Oryza sativa subsp. japonica	23%	78%
Q9C5E5	Arabidopsis thaliana	25%	76%
Q9R1C6	Mus musculus	32%	69%
V5AWH3	Trypanosoma cruzi	36%	100%