EOG090X093U

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

EOG090X093U

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIW2_LEIDO

TriTrypDb:

LdBPK_361430.1 , LdCL_360019800 , LDHU3_36.1820

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.602
CLV_PCSK_KEX2_1	170	172	PF00082	0.364
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.364
CLV_PCSK_SKI1_1	231	235	PF00082	0.321
CLV_PCSK_SKI1_1	275	279	PF00082	0.315
CLV_PCSK_SKI1_1	391	395	PF00082	0.413
CLV_PCSK_SKI1_1	411	415	PF00082	0.172
CLV_PCSK_SKI1_1	449	453	PF00082	0.466
CLV_Separin_Metazoa	174	178	PF03568	0.330
DEG_APCC_DBOX_1	537	545	PF00400	0.363
DOC_ANK_TNKS_1	212	219	PF00023	0.504
DOC_CYCLIN_RxL_1	219	228	PF00134	0.442
DOC_MAPK_gen_1	177	184	PF00069	0.428
DOC_MAPK_gen_1	447	456	PF00069	0.394
DOC_MAPK_gen_1	64	72	PF00069	0.385
DOC_MAPK_MEF2A_6	449	458	PF00069	0.525
DOC_MAPK_MEF2A_6	532	541	PF00069	0.364
DOC_MAPK_MEF2A_6	64	72	PF00069	0.385
DOC_PP1_RVXF_1	277	284	PF00149	0.264
DOC_PP2B_LxvP_1	33	36	PF13499	0.355
DOC_USP7_MATH_1	47	51	PF00917	0.508
DOC_USP7_MATH_1	482	486	PF00917	0.483
DOC_WW_Pin1_4	100	105	PF00397	0.397
DOC_WW_Pin1_4	475	480	PF00397	0.550
LIG_14-3-3_CanoR_1	179	185	PF00244	0.329
LIG_14-3-3_CanoR_1	222	227	PF00244	0.515
LIG_14-3-3_CanoR_1	51	59	PF00244	0.406
LIG_14-3-3_CanoR_1	538	542	PF00244	0.373
LIG_BRCT_BRCA1_1	423	427	PF00533	0.225
LIG_deltaCOP1_diTrp_1	250	256	PF00928	0.330
LIG_EH1_1	487	495	PF00400	0.456
LIG_eIF4E_1	488	494	PF01652	0.420
LIG_FHA_1	253	259	PF00498	0.363
LIG_FHA_1	261	267	PF00498	0.385
LIG_FHA_1	276	282	PF00498	0.393
LIG_FHA_1	439	445	PF00498	0.366
LIG_FHA_1	468	474	PF00498	0.486
LIG_FHA_1	51	57	PF00498	0.426
LIG_FHA_2	246	252	PF00498	0.477
LIG_FHA_2	348	354	PF00498	0.392
LIG_FHA_2	361	367	PF00498	0.382
LIG_FHA_2	56	62	PF00498	0.515
LIG_IRF3_LxIS_1	534	540	PF10401	0.447
LIG_LIR_Gen_1	156	167	PF02991	0.530
LIG_LIR_Gen_1	246	257	PF02991	0.355
LIG_LIR_Gen_1	415	423	PF02991	0.338
LIG_LIR_Gen_1	86	97	PF02991	0.335
LIG_LIR_Nem_3	111	117	PF02991	0.361
LIG_LIR_Nem_3	156	162	PF02991	0.560
LIG_LIR_Nem_3	246	252	PF02991	0.363
LIG_LIR_Nem_3	366	370	PF02991	0.349
LIG_LIR_Nem_3	415	420	PF02991	0.325
LIG_LIR_Nem_3	499	503	PF02991	0.563
LIG_LIR_Nem_3	86	92	PF02991	0.323
LIG_LYPXL_S_1	396	400	PF13949	0.444
LIG_NRBOX	488	494	PF00104	0.361
LIG_NRBOX	502	508	PF00104	0.388
LIG_Pex14_1	253	257	PF04695	0.324
LIG_Pex14_2	249	253	PF04695	0.323
LIG_Pex14_2	412	416	PF04695	0.288
LIG_Rb_LxCxE_1	88	103	PF01857	0.416
LIG_SH2_CRK	89	93	PF00017	0.302
LIG_SH2_NCK_1	481	485	PF00017	0.409
LIG_SH2_STAT3	166	169	PF00017	0.548
LIG_SH2_STAT5	166	169	PF00017	0.521
LIG_SH2_STAT5	257	260	PF00017	0.348
LIG_SH2_STAT5	488	491	PF00017	0.421
LIG_SH2_STAT5	78	81	PF00017	0.355
LIG_SH2_STAT5	89	92	PF00017	0.265
LIG_SH3_3	123	129	PF00018	0.333
LIG_SH3_3	159	165	PF00018	0.546
LIG_SH3_3	234	240	PF00018	0.477
LIG_SH3_5	85	89	PF00018	0.350
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.347
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.450
LIG_SUMO_SIM_anti_2	350	357	PF11976	0.403
LIG_SUMO_SIM_anti_2	470	475	PF11976	0.519
LIG_SUMO_SIM_par_1	121	127	PF11976	0.491
LIG_SUMO_SIM_par_1	222	228	PF11976	0.284
LIG_SUMO_SIM_par_1	350	357	PF11976	0.362
LIG_SxIP_EBH_1	39	51	PF03271	0.360
LIG_TRAF2_1	116	119	PF00917	0.582
LIG_TRAF2_1	93	96	PF00917	0.428
LIG_TYR_ITIM	498	503	PF00017	0.456
LIG_UBA3_1	223	231	PF00899	0.453
LIG_UBA3_1	265	273	PF00899	0.434
LIG_UBA3_1	492	501	PF00899	0.368
LIG_WRC_WIRS_1	56	61	PF05994	0.495
MOD_CK1_1	149	155	PF00069	0.688
MOD_CK1_1	225	231	PF00069	0.374
MOD_CK1_1	297	303	PF00069	0.493
MOD_CK1_1	3	9	PF00069	0.550
MOD_CK1_1	50	56	PF00069	0.430
MOD_CK2_1	329	335	PF00069	0.338
MOD_CK2_1	360	366	PF00069	0.392
MOD_CK2_1	55	61	PF00069	0.445
MOD_CK2_1	90	96	PF00069	0.476
MOD_CMANNOS	253	256	PF00535	0.328
MOD_GlcNHglycan	151	154	PF01048	0.662
MOD_GlcNHglycan	29	32	PF01048	0.465
MOD_GlcNHglycan	41	44	PF01048	0.432
MOD_GlcNHglycan	508	511	PF01048	0.417
MOD_GlcNHglycan	65	68	PF01048	0.573
MOD_GSK3_1	1	8	PF00069	0.640
MOD_GSK3_1	143	150	PF00069	0.694
MOD_GSK3_1	180	187	PF00069	0.405
MOD_GSK3_1	252	259	PF00069	0.430
MOD_GSK3_1	309	316	PF00069	0.499
MOD_GSK3_1	41	48	PF00069	0.564
MOD_GSK3_1	412	419	PF00069	0.319
MOD_GSK3_1	502	509	PF00069	0.461
MOD_N-GLC_1	100	105	PF02516	0.397
MOD_N-GLC_1	180	185	PF02516	0.423
MOD_N-GLC_1	24	29	PF02516	0.498
MOD_N-GLC_1	309	314	PF02516	0.473
MOD_N-GLC_1	329	334	PF02516	0.208
MOD_N-GLC_1	360	365	PF02516	0.393
MOD_N-GLC_1	382	387	PF02516	0.413
MOD_N-GLC_1	475	480	PF02516	0.344
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	147	152	PF00069	0.598
MOD_NEK2_1	184	189	PF00069	0.498
MOD_NEK2_1	294	299	PF00069	0.386
MOD_NEK2_1	38	43	PF00069	0.319
MOD_NEK2_1	403	408	PF00069	0.349
MOD_NEK2_1	412	417	PF00069	0.300
MOD_NEK2_1	506	511	PF00069	0.381
MOD_NEK2_1	537	542	PF00069	0.340
MOD_NEK2_1	544	549	PF00069	0.373
MOD_NEK2_1	60	65	PF00069	0.440
MOD_PIKK_1	207	213	PF00454	0.374
MOD_PIKK_1	45	51	PF00454	0.376
MOD_PKA_2	21	27	PF00069	0.417
MOD_PKA_2	403	409	PF00069	0.464
MOD_PKA_2	421	427	PF00069	0.472
MOD_PKA_2	50	56	PF00069	0.368
MOD_PKA_2	537	543	PF00069	0.386
MOD_Plk_1	180	186	PF00069	0.580
MOD_Plk_1	24	30	PF00069	0.498
MOD_Plk_1	245	251	PF00069	0.409
MOD_Plk_1	260	266	PF00069	0.263
MOD_Plk_1	309	315	PF00069	0.476
MOD_Plk_1	329	335	PF00069	0.208
MOD_Plk_1	360	366	PF00069	0.378
MOD_Plk_2-3	245	251	PF00069	0.506
MOD_Plk_4	180	186	PF00069	0.580
MOD_Plk_4	222	228	PF00069	0.335
MOD_Plk_4	252	258	PF00069	0.338
MOD_Plk_4	309	315	PF00069	0.436
MOD_Plk_4	338	344	PF00069	0.440
MOD_Plk_4	347	353	PF00069	0.355
MOD_Plk_4	360	366	PF00069	0.345
MOD_Plk_4	403	409	PF00069	0.344
MOD_Plk_4	412	418	PF00069	0.282
MOD_Plk_4	502	508	PF00069	0.374
MOD_Plk_4	55	61	PF00069	0.495
MOD_ProDKin_1	100	106	PF00069	0.400
MOD_ProDKin_1	475	481	PF00069	0.553
MOD_SUMO_for_1	343	346	PF00179	0.554
MOD_SUMO_rev_2	312	321	PF00179	0.343
TRG_DiLeu_BaEn_1	201	206	PF01217	0.470
TRG_ENDOCYTIC_2	397	400	PF00928	0.448
TRG_ENDOCYTIC_2	500	503	PF00928	0.369
TRG_ENDOCYTIC_2	89	92	PF00928	0.300
TRG_ER_diArg_1	176	179	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E7	Leptomonas seymouri	68%	98%
A0A0S4JC36	Bodo saltans	41%	100%
A0A1X0P7Z1	Trypanosomatidae	45%	100%
A0A422MZU5	Trypanosoma rangeli	46%	100%
A4HNZ3	Leishmania braziliensis	79%	100%
A4HNZ7	Leishmania braziliensis	78%	100%
A4ICJ8	Leishmania infantum	99%	100%
D0A2X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ASQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q1T8	Leishmania major	95%	100%
V5BU60	Trypanosoma cruzi	47%	100%