Pre-RNA_processing_PIH1/Nop17_putative/Pfam:PF081 90

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIW1_LEIDO

TriTrypDb:

LdBPK_291970.1 , LdCL_290025600 , LDHU3_29.2820

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIW1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0022607	cellular component assembly	4	13
GO:0043933	protein-containing complex organization	4	13
GO:0065003	protein-containing complex assembly	5	13
GO:0070286	axonemal dynein complex assembly	6	13
GO:0071840	cellular component organization or biogenesis	2	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0051087	protein-folding chaperone binding	3	13
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.648
CLV_C14_Caspase3-7	249	253	PF00656	0.562
CLV_NRD_NRD_1	125	127	PF00675	0.657
CLV_NRD_NRD_1	244	246	PF00675	0.354
CLV_NRD_NRD_1	95	97	PF00675	0.601
CLV_PCSK_FUR_1	123	127	PF00082	0.598
CLV_PCSK_KEX2_1	125	127	PF00082	0.693
CLV_PCSK_KEX2_1	244	246	PF00082	0.328
CLV_PCSK_SKI1_1	153	157	PF00082	0.734
CLV_PCSK_SKI1_1	259	263	PF00082	0.342
CLV_Separin_Metazoa	209	213	PF03568	0.577
DEG_APCC_DBOX_1	206	214	PF00400	0.562
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.691
DOC_MAPK_gen_1	259	266	PF00069	0.540
DOC_MAPK_MEF2A_6	259	266	PF00069	0.522
DOC_PP2B_LxvP_1	238	241	PF13499	0.564
DOC_PP2B_LxvP_1	83	86	PF13499	0.581
DOC_PP4_FxxP_1	168	171	PF00568	0.538
DOC_PP4_FxxP_1	21	24	PF00568	0.575
DOC_USP7_MATH_1	104	108	PF00917	0.732
DOC_USP7_MATH_1	160	164	PF00917	0.620
DOC_USP7_MATH_1	268	272	PF00917	0.570
DOC_USP7_MATH_1	86	90	PF00917	0.621
DOC_WW_Pin1_4	158	163	PF00397	0.591
LIG_14-3-3_CanoR_1	153	158	PF00244	0.725
LIG_14-3-3_CanoR_1	212	217	PF00244	0.551
LIG_14-3-3_CanoR_1	229	233	PF00244	0.393
LIG_14-3-3_CanoR_1	245	255	PF00244	0.466
LIG_14-3-3_CanoR_1	270	278	PF00244	0.655
LIG_Actin_WH2_2	216	231	PF00022	0.510
LIG_FHA_1	203	209	PF00498	0.542
LIG_FHA_1	218	224	PF00498	0.552
LIG_FHA_1	261	267	PF00498	0.515
LIG_FHA_2	111	117	PF00498	0.539
LIG_FHA_2	247	253	PF00498	0.539
LIG_FHA_2	75	81	PF00498	0.636
LIG_LIR_Nem_3	184	190	PF02991	0.518
LIG_PCNA_PIPBox_1	114	123	PF02747	0.650
LIG_PCNA_yPIPBox_3	114	126	PF02747	0.657
LIG_PDZ_Class_2	275	280	PF00595	0.702
LIG_SH2_STAP1	226	230	PF00017	0.504
LIG_SH2_STAT5	187	190	PF00017	0.461
LIG_SH2_STAT5	237	240	PF00017	0.466
LIG_SH3_3	100	106	PF00018	0.600
LIG_SH3_3	205	211	PF00018	0.499
LIG_TRAF2_1	167	170	PF00917	0.587
LIG_TRAF2_1	32	35	PF00917	0.610
MOD_CK1_1	144	150	PF00069	0.650
MOD_CK1_1	198	204	PF00069	0.520
MOD_CK1_1	217	223	PF00069	0.520
MOD_CK1_1	271	277	PF00069	0.675
MOD_CK1_1	62	68	PF00069	0.703
MOD_CK2_1	104	110	PF00069	0.628
MOD_CK2_1	212	218	PF00069	0.577
MOD_CK2_1	29	35	PF00069	0.563
MOD_CK2_1	3	9	PF00069	0.583
MOD_GlcNHglycan	106	109	PF01048	0.709
MOD_GlcNHglycan	146	149	PF01048	0.664
MOD_GlcNHglycan	181	184	PF01048	0.558
MOD_GlcNHglycan	197	200	PF01048	0.287
MOD_GlcNHglycan	48	51	PF01048	0.695
MOD_GlcNHglycan	53	56	PF01048	0.705
MOD_GSK3_1	10	17	PF00069	0.611
MOD_GSK3_1	149	156	PF00069	0.735
MOD_GSK3_1	190	197	PF00069	0.496
MOD_GSK3_1	198	205	PF00069	0.489
MOD_N-GLC_1	3	8	PF02516	0.614
MOD_NEK2_1	14	19	PF00069	0.714
MOD_NEK2_1	228	233	PF00069	0.491
MOD_PIKK_1	110	116	PF00454	0.644
MOD_PIKK_1	62	68	PF00454	0.554
MOD_PK_1	212	218	PF00069	0.577
MOD_PKA_2	104	110	PF00069	0.711
MOD_PKA_2	211	217	PF00069	0.539
MOD_PKA_2	228	234	PF00069	0.451
MOD_PKA_2	269	275	PF00069	0.629
MOD_Plk_1	217	223	PF00069	0.584
MOD_Plk_2-3	269	275	PF00069	0.639
MOD_Plk_4	10	16	PF00069	0.570
MOD_Plk_4	153	159	PF00069	0.719
MOD_Plk_4	171	177	PF00069	0.251
MOD_Plk_4	74	80	PF00069	0.554
MOD_ProDKin_1	158	164	PF00069	0.590
MOD_SUMO_rev_2	269	279	PF00179	0.584
TRG_ENDOCYTIC_2	187	190	PF00928	0.489
TRG_ER_diArg_1	122	125	PF00400	0.608
TRG_ER_diArg_1	243	245	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH00	Leptomonas seymouri	66%	100%
A0A0S4IJ87	Bodo saltans	37%	100%
A0A0S4JAL6	Bodo saltans	38%	100%
A0A1X0NZY8	Trypanosomatidae	31%	100%
A0A422NNL4	Trypanosoma rangeli	38%	100%
A4HIY9	Leishmania braziliensis	85%	98%
A4I4P3	Leishmania infantum	100%	100%
C9ZLD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AE46	Leishmania major	94%	99%
E9ALN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BBV3	Trypanosoma cruzi	37%	100%