Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIW0_LEIDO

TriTrypDb:

LdBPK_343500.1 , LdCL_340044400 , LDHU3_34.5740

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.500
CLV_NRD_NRD_1	127	129	PF00675	0.453
CLV_NRD_NRD_1	131	133	PF00675	0.435
CLV_NRD_NRD_1	77	79	PF00675	0.494
CLV_NRD_NRD_1	81	83	PF00675	0.503
CLV_PCSK_KEX2_1	119	121	PF00082	0.634
CLV_PCSK_KEX2_1	77	79	PF00082	0.500
CLV_PCSK_KEX2_1	81	83	PF00082	0.515
CLV_PCSK_PC7_1	77	83	PF00082	0.504
CLV_PCSK_SKI1_1	107	111	PF00082	0.663
CLV_PCSK_SKI1_1	148	152	PF00082	0.606
CLV_PCSK_SKI1_1	154	158	PF00082	0.556
CLV_PCSK_SKI1_1	38	42	PF00082	0.599
DEG_SCF_FBW7_2	16	23	PF00400	0.462
DOC_CKS1_1	17	22	PF01111	0.457
DOC_MAPK_gen_1	81	90	PF00069	0.650
DOC_MAPK_RevD_3	116	130	PF00069	0.526
DOC_USP7_MATH_1	97	101	PF00917	0.554
DOC_USP7_UBL2_3	129	133	PF12436	0.615
DOC_WW_Pin1_4	16	21	PF00397	0.610
LIG_14-3-3_CanoR_1	29	36	PF00244	0.652
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_FHA_1	106	112	PF00498	0.517
LIG_FHA_1	30	36	PF00498	0.628
LIG_FHA_2	171	177	PF00498	0.489
LIG_FHA_2	39	45	PF00498	0.520
LIG_LIR_Nem_3	46	52	PF02991	0.650
LIG_PDZ_Class_2	178	183	PF00595	0.579
LIG_Rb_pABgroove_1	116	124	PF01858	0.602
LIG_SH2_STAP1	122	126	PF00017	0.453
LIG_SH2_STAP1	31	35	PF00017	0.643
LIG_SH2_STAT5	17	20	PF00017	0.631
LIG_SH2_STAT5	31	34	PF00017	0.679
LIG_TRAF2_1	156	159	PF00917	0.602
LIG_TRAF2_1	20	23	PF00917	0.549
MOD_CK1_1	105	111	PF00069	0.647
MOD_CK2_1	170	176	PF00069	0.511
MOD_CK2_1	38	44	PF00069	0.497
MOD_GlcNHglycan	148	151	PF01048	0.697
MOD_GSK3_1	107	114	PF00069	0.647
MOD_GSK3_1	146	153	PF00069	0.573
MOD_GSK3_1	52	59	PF00069	0.591
MOD_N-GLC_1	97	102	PF02516	0.731
MOD_NEK2_1	157	162	PF00069	0.565
MOD_NEK2_1	63	68	PF00069	0.653
MOD_PIKK_1	29	35	PF00454	0.651
MOD_PIKK_1	52	58	PF00454	0.558
MOD_PKA_2	162	168	PF00069	0.621
MOD_Plk_1	114	120	PF00069	0.494
MOD_Plk_1	122	128	PF00069	0.492
MOD_Plk_1	170	176	PF00069	0.570
MOD_Plk_1	38	44	PF00069	0.507
MOD_Plk_4	31	37	PF00069	0.644
MOD_ProDKin_1	16	22	PF00069	0.608
MOD_SUMO_rev_2	145	150	PF00179	0.652
TRG_ENDOCYTIC_2	49	52	PF00928	0.614
TRG_ER_diArg_1	118	120	PF00400	0.596
TRG_NES_CRM1_1	61	76	PF08389	0.524
TRG_NLS_Bipartite_1	119	133	PF00514	0.687
TRG_NLS_MonoExtC_3	127	132	PF00514	0.514
TRG_NLS_MonoExtN_4	128	133	PF00514	0.466
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P774	Leptomonas seymouri	61%	100%
A0A0S4J6R9	Bodo saltans	28%	98%
A0A0S4KRE5	Bodo saltans	29%	100%
A0A1X0PA28	Trypanosomatidae	37%	100%
A0A3R7M5H7	Trypanosoma rangeli	38%	92%
A4HB90	Leishmania braziliensis	76%	100%
A4IAD8	Leishmania infantum	99%	100%
C9ZLV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B5G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q2H3	Leishmania major	89%	100%