Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIU7_LEIDO

TriTrypDb:

LdBPK_312930.1 , LdCL_310037600 , LDHU3_31.5100

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.761
CLV_C14_Caspase3-7	55	59	PF00656	0.738
CLV_C14_Caspase3-7	64	68	PF00656	0.746
CLV_NRD_NRD_1	11	13	PF00675	0.715
CLV_NRD_NRD_1	132	134	PF00675	0.785
CLV_NRD_NRD_1	139	141	PF00675	0.673
CLV_NRD_NRD_1	242	244	PF00675	0.697
CLV_NRD_NRD_1	250	252	PF00675	0.594
CLV_NRD_NRD_1	331	333	PF00675	0.664
CLV_NRD_NRD_1	423	425	PF00675	0.861
CLV_NRD_NRD_1	482	484	PF00675	0.809
CLV_NRD_NRD_1	486	488	PF00675	0.733
CLV_NRD_NRD_1	520	522	PF00675	0.860
CLV_NRD_NRD_1	555	557	PF00675	0.708
CLV_NRD_NRD_1	612	614	PF00675	0.826
CLV_NRD_NRD_1	83	85	PF00675	0.762
CLV_PCSK_KEX2_1	132	134	PF00082	0.785
CLV_PCSK_KEX2_1	139	141	PF00082	0.673
CLV_PCSK_KEX2_1	242	244	PF00082	0.697
CLV_PCSK_KEX2_1	250	252	PF00082	0.594
CLV_PCSK_KEX2_1	333	335	PF00082	0.669
CLV_PCSK_KEX2_1	484	486	PF00082	0.789
CLV_PCSK_KEX2_1	498	500	PF00082	0.627
CLV_PCSK_KEX2_1	519	521	PF00082	0.783
CLV_PCSK_KEX2_1	587	589	PF00082	0.809
CLV_PCSK_KEX2_1	607	609	PF00082	0.538
CLV_PCSK_KEX2_1	83	85	PF00082	0.762
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.669
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.754
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.576
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.783
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.809
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.538
CLV_PCSK_PC7_1	516	522	PF00082	0.777
CLV_PCSK_SKI1_1	133	137	PF00082	0.800
CLV_PCSK_SKI1_1	227	231	PF00082	0.554
CLV_PCSK_SKI1_1	263	267	PF00082	0.688
CLV_PCSK_SKI1_1	351	355	PF00082	0.701
CLV_PCSK_SKI1_1	584	588	PF00082	0.799
CLV_PCSK_SKI1_1	602	606	PF00082	0.564
DEG_APCC_DBOX_1	226	234	PF00400	0.659
DEG_APCC_DBOX_1	346	354	PF00400	0.679
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DEG_SPOP_SBC_1	163	167	PF00917	0.821
DOC_CYCLIN_RxL_1	221	234	PF00134	0.672
DOC_CYCLIN_RxL_1	257	270	PF00134	0.692
DOC_MAPK_RevD_3	235	251	PF00069	0.680
DOC_USP7_MATH_1	146	150	PF00917	0.742
DOC_USP7_MATH_1	163	167	PF00917	0.762
DOC_USP7_MATH_1	220	224	PF00917	0.706
DOC_USP7_MATH_1	30	34	PF00917	0.786
DOC_USP7_MATH_1	40	44	PF00917	0.694
DOC_USP7_MATH_1	536	540	PF00917	0.705
DOC_USP7_MATH_1	59	63	PF00917	0.703
DOC_USP7_MATH_1	593	597	PF00917	0.814
DOC_USP7_MATH_1	609	613	PF00917	0.623
DOC_USP7_MATH_1	95	99	PF00917	0.731
DOC_USP7_MATH_2	145	151	PF00917	0.685
DOC_USP7_UBL2_3	484	488	PF12436	0.739
DOC_USP7_UBL2_3	553	557	PF12436	0.685
DOC_USP7_UBL2_3	601	605	PF12436	0.862
DOC_WW_Pin1_4	126	131	PF00397	0.844
DOC_WW_Pin1_4	140	145	PF00397	0.607
DOC_WW_Pin1_4	164	169	PF00397	0.760
DOC_WW_Pin1_4	405	410	PF00397	0.827
DOC_WW_Pin1_4	589	594	PF00397	0.817
DOC_WW_Pin1_4	607	612	PF00397	0.559
LIG_14-3-3_CanoR_1	132	138	PF00244	0.771
LIG_14-3-3_CanoR_1	21	30	PF00244	0.827
LIG_14-3-3_CanoR_1	242	248	PF00244	0.691
LIG_14-3-3_CanoR_1	250	255	PF00244	0.585
LIG_14-3-3_CanoR_1	257	265	PF00244	0.450
LIG_14-3-3_CanoR_1	422	432	PF00244	0.854
LIG_14-3-3_CanoR_1	556	561	PF00244	0.823
LIG_14-3-3_CanoR_1	588	593	PF00244	0.738
LIG_14-3-3_CanoR_1	94	100	PF00244	0.841
LIG_BIR_III_2	533	537	PF00653	0.741
LIG_FHA_1	257	263	PF00498	0.539
LIG_FHA_1	304	310	PF00498	0.640
LIG_FHA_1	49	55	PF00498	0.740
LIG_FHA_2	203	209	PF00498	0.695
LIG_FHA_2	285	291	PF00498	0.633
LIG_FHA_2	365	371	PF00498	0.656
LIG_FHA_2	452	458	PF00498	0.844
LIG_FHA_2	462	468	PF00498	0.697
LIG_LIR_Gen_1	264	272	PF02991	0.683
LIG_LIR_Gen_1	359	368	PF02991	0.675
LIG_LIR_Nem_3	223	229	PF02991	0.674
LIG_LIR_Nem_3	270	276	PF02991	0.715
LIG_LIR_Nem_3	359	364	PF02991	0.687
LIG_NRBOX	349	355	PF00104	0.696
LIG_NRP_CendR_1	621	624	PF00754	0.784
LIG_RPA_C_Fungi	246	258	PF08784	0.630
LIG_SH2_CRK	226	230	PF00017	0.668
LIG_SH2_NCK_1	336	340	PF00017	0.642
LIG_SH2_SRC	336	339	PF00017	0.651
LIG_SH2_STAP1	336	340	PF00017	0.642
LIG_SH2_STAT5	292	295	PF00017	0.639
LIG_SH2_STAT5	317	320	PF00017	0.649
LIG_SH2_STAT5	352	355	PF00017	0.707
LIG_SH3_3	189	195	PF00018	0.745
LIG_SH3_3	279	285	PF00018	0.718
LIG_SH3_3	379	385	PF00018	0.780
LIG_SH3_3	67	73	PF00018	0.636
LIG_SH3_3	85	91	PF00018	0.698
LIG_TRAF2_1	437	440	PF00917	0.836
MOD_CDC14_SPxK_1	129	132	PF00782	0.751
MOD_CDC14_SPxK_1	610	613	PF00782	0.740
MOD_CDK_SPK_2	164	169	PF00069	0.855
MOD_CDK_SPK_2	405	410	PF00069	0.765
MOD_CDK_SPxK_1	126	132	PF00069	0.856
MOD_CDK_SPxK_1	607	613	PF00069	0.745
MOD_CDK_SPxxK_3	126	133	PF00069	0.856
MOD_CDK_SPxxK_3	607	614	PF00069	0.815
MOD_CK1_1	100	106	PF00069	0.798
MOD_CK1_1	149	155	PF00069	0.688
MOD_CK1_1	212	218	PF00069	0.757
MOD_CK1_1	246	252	PF00069	0.707
MOD_CK1_1	253	259	PF00069	0.592
MOD_CK1_1	423	429	PF00069	0.823
MOD_CK1_1	43	49	PF00069	0.802
MOD_CK1_1	524	530	PF00069	0.784
MOD_CK1_1	592	598	PF00069	0.633
MOD_CK2_1	119	125	PF00069	0.645
MOD_CK2_1	164	170	PF00069	0.854
MOD_CK2_1	202	208	PF00069	0.837
MOD_CK2_1	356	362	PF00069	0.696
MOD_CK2_1	364	370	PF00069	0.527
MOD_CK2_1	451	457	PF00069	0.780
MOD_Cter_Amidation	330	333	PF01082	0.668
MOD_Cter_Amidation	481	484	PF01082	0.766
MOD_Cter_Amidation	485	488	PF01082	0.706
MOD_DYRK1A_RPxSP_1	126	130	PF00069	0.779
MOD_GlcNHglycan	102	105	PF01048	0.833
MOD_GlcNHglycan	106	109	PF01048	0.777
MOD_GlcNHglycan	111	114	PF01048	0.713
MOD_GlcNHglycan	124	129	PF01048	0.558
MOD_GlcNHglycan	202	205	PF01048	0.799
MOD_GlcNHglycan	211	214	PF01048	0.641
MOD_GlcNHglycan	34	37	PF01048	0.805
MOD_GlcNHglycan	440	444	PF01048	0.793
MOD_GlcNHglycan	494	497	PF01048	0.741
MOD_GlcNHglycan	503	506	PF01048	0.691
MOD_GlcNHglycan	513	516	PF01048	0.608
MOD_GlcNHglycan	526	529	PF01048	0.671
MOD_GlcNHglycan	538	541	PF01048	0.670
MOD_GlcNHglycan	543	546	PF01048	0.584
MOD_GlcNHglycan	595	598	PF01048	0.841
MOD_GlcNHglycan	78	81	PF01048	0.748
MOD_GSK3_1	202	209	PF00069	0.695
MOD_GSK3_1	215	222	PF00069	0.519
MOD_GSK3_1	246	253	PF00069	0.692
MOD_GSK3_1	271	278	PF00069	0.733
MOD_GSK3_1	28	35	PF00069	0.837
MOD_GSK3_1	352	359	PF00069	0.704
MOD_GSK3_1	40	47	PF00069	0.632
MOD_GSK3_1	461	468	PF00069	0.738
MOD_GSK3_1	588	595	PF00069	0.779
MOD_GSK3_1	95	102	PF00069	0.843
MOD_N-GLC_1	303	308	PF02516	0.547
MOD_NEK2_1	22	27	PF00069	0.611
MOD_NEK2_1	364	369	PF00069	0.655
MOD_NEK2_2	23	28	PF00069	0.750
MOD_PIKK_1	119	125	PF00454	0.652
MOD_PIKK_1	256	262	PF00454	0.701
MOD_PIKK_1	487	493	PF00454	0.750
MOD_PIKK_1	521	527	PF00454	0.779
MOD_PK_1	243	249	PF00069	0.692
MOD_PK_1	250	256	PF00069	0.601
MOD_PK_1	28	34	PF00069	0.758
MOD_PK_1	477	483	PF00069	0.771
MOD_PKA_1	250	256	PF00069	0.686
MOD_PKA_1	487	493	PF00069	0.711
MOD_PKA_1	556	562	PF00069	0.687
MOD_PKA_2	119	125	PF00069	0.652
MOD_PKA_2	2	8	PF00069	0.726
MOD_PKA_2	23	29	PF00069	0.749
MOD_PKA_2	250	256	PF00069	0.686
MOD_PKA_2	423	429	PF00069	0.858
MOD_PKA_2	564	570	PF00069	0.813
MOD_PKB_1	485	493	PF00069	0.710
MOD_Plk_1	146	152	PF00069	0.649
MOD_Plk_1	369	375	PF00069	0.666
MOD_Plk_4	44	50	PF00069	0.825
MOD_ProDKin_1	126	132	PF00069	0.844
MOD_ProDKin_1	140	146	PF00069	0.607
MOD_ProDKin_1	164	170	PF00069	0.759
MOD_ProDKin_1	405	411	PF00069	0.829
MOD_ProDKin_1	589	595	PF00069	0.821
MOD_ProDKin_1	607	613	PF00069	0.560
MOD_SUMO_rev_2	348	353	PF00179	0.688
MOD_SUMO_rev_2	552	559	PF00179	0.753
TRG_DiLeu_BaEn_1	349	354	PF01217	0.692
TRG_ENDOCYTIC_2	226	229	PF00928	0.671
TRG_ENDOCYTIC_2	325	328	PF00928	0.635
TRG_ER_diArg_1	132	134	PF00400	0.725
TRG_ER_diArg_1	332	335	PF00400	0.674
TRG_ER_diArg_1	82	84	PF00400	0.765
TRG_ER_diArg_1	91	94	PF00400	0.645
TRG_ER_diLys_1	621	624	PF00400	0.858
TRG_NLS_MonoExtC_3	331	337	PF00514	0.663
TRG_NLS_MonoExtC_3	482	487	PF00514	0.731
TRG_NLS_MonoExtC_3	583	588	PF00514	0.797
TRG_NLS_MonoExtN_4	329	336	PF00514	0.666
TRG_NLS_MonoExtN_4	483	488	PF00514	0.722
TRG_NLS_MonoExtN_4	516	523	PF00514	0.776
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.778
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJS1	Leishmania braziliensis	69%	100%
A4I787	Leishmania infantum	100%	100%
E9B282	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q5X6	Leishmania major	91%	100%