Zinc finger protein family member, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIU2_LEIDO

TriTrypDb:

LdBPK_355000.1 , LdCL_350055000 , LDHU3_35.6550

Length:

1032

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIU2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.503
CLV_C14_Caspase3-7	2	6	PF00656	0.693
CLV_MEL_PAP_1	772	778	PF00089	0.641
CLV_NRD_NRD_1	518	520	PF00675	0.742
CLV_NRD_NRD_1	66	68	PF00675	0.609
CLV_NRD_NRD_1	843	845	PF00675	0.846
CLV_NRD_NRD_1	865	867	PF00675	0.843
CLV_NRD_NRD_1	987	989	PF00675	0.838
CLV_NRD_NRD_1	992	994	PF00675	0.760
CLV_PCSK_KEX2_1	518	520	PF00082	0.742
CLV_PCSK_KEX2_1	865	867	PF00082	0.843
CLV_PCSK_KEX2_1	935	937	PF00082	0.833
CLV_PCSK_KEX2_1	987	989	PF00082	0.850
CLV_PCSK_KEX2_1	992	994	PF00082	0.760
CLV_PCSK_KEX2_1	996	998	PF00082	0.662
CLV_PCSK_PC1ET2_1	935	937	PF00082	0.833
CLV_PCSK_PC1ET2_1	996	998	PF00082	0.809
CLV_PCSK_PC7_1	988	994	PF00082	0.846
CLV_PCSK_SKI1_1	161	165	PF00082	0.455
CLV_PCSK_SKI1_1	293	297	PF00082	0.776
CLV_PCSK_SKI1_1	470	474	PF00082	0.798
CLV_PCSK_SKI1_1	635	639	PF00082	0.763
CLV_PCSK_SKI1_1	737	741	PF00082	0.757
CLV_PCSK_SKI1_1	768	772	PF00082	0.644
CLV_PCSK_SKI1_1	794	798	PF00082	0.650
CLV_PCSK_SKI1_1	819	823	PF00082	0.606
CLV_PCSK_SKI1_1	845	849	PF00082	0.748
DEG_SCF_FBW7_1	957	964	PF00400	0.833
DEG_SPOP_SBC_1	411	415	PF00917	0.760
DEG_SPOP_SBC_1	674	678	PF00917	0.807
DEG_SPOP_SBC_1	821	825	PF00917	0.745
DOC_CKS1_1	400	405	PF01111	0.808
DOC_CKS1_1	474	479	PF01111	0.786
DOC_CYCLIN_yCln2_LP_2	386	389	PF00134	0.748
DOC_MAPK_DCC_7	506	516	PF00069	0.746
DOC_MAPK_gen_1	803	813	PF00069	0.605
DOC_MAPK_MEF2A_6	422	429	PF00069	0.809
DOC_MAPK_MEF2A_6	804	813	PF00069	0.606
DOC_MAPK_NFAT4_5	806	814	PF00069	0.688
DOC_PP1_RVXF_1	109	116	PF00149	0.598
DOC_PP1_RVXF_1	795	802	PF00149	0.723
DOC_PP2B_LxvP_1	386	389	PF13499	0.836
DOC_PP2B_LxvP_1	472	475	PF13499	0.843
DOC_PP4_FxxP_1	926	929	PF00568	0.799
DOC_USP7_MATH_1	246	250	PF00917	0.734
DOC_USP7_MATH_1	254	258	PF00917	0.753
DOC_USP7_MATH_1	368	372	PF00917	0.795
DOC_USP7_MATH_1	393	397	PF00917	0.761
DOC_USP7_MATH_1	398	402	PF00917	0.766
DOC_USP7_MATH_1	406	410	PF00917	0.724
DOC_USP7_MATH_1	442	446	PF00917	0.830
DOC_USP7_MATH_1	453	457	PF00917	0.555
DOC_USP7_MATH_1	544	548	PF00917	0.744
DOC_USP7_MATH_1	549	553	PF00917	0.735
DOC_USP7_MATH_1	640	644	PF00917	0.691
DOC_USP7_MATH_1	658	662	PF00917	0.702
DOC_USP7_MATH_1	670	674	PF00917	0.626
DOC_USP7_MATH_1	675	679	PF00917	0.548
DOC_USP7_MATH_1	774	778	PF00917	0.627
DOC_USP7_MATH_1	827	831	PF00917	0.707
DOC_USP7_MATH_1	858	862	PF00917	0.828
DOC_USP7_MATH_1	877	881	PF00917	0.637
DOC_USP7_MATH_1	922	926	PF00917	0.769
DOC_USP7_MATH_1	965	969	PF00917	0.849
DOC_USP7_MATH_1	978	982	PF00917	0.673
DOC_USP7_UBL2_3	931	935	PF12436	0.847
DOC_WW_Pin1_4	231	236	PF00397	0.830
DOC_WW_Pin1_4	29	34	PF00397	0.784
DOC_WW_Pin1_4	389	394	PF00397	0.844
DOC_WW_Pin1_4	399	404	PF00397	0.809
DOC_WW_Pin1_4	412	417	PF00397	0.631
DOC_WW_Pin1_4	458	463	PF00397	0.678
DOC_WW_Pin1_4	46	51	PF00397	0.525
DOC_WW_Pin1_4	470	475	PF00397	0.821
DOC_WW_Pin1_4	609	614	PF00397	0.695
DOC_WW_Pin1_4	625	630	PF00397	0.829
DOC_WW_Pin1_4	643	648	PF00397	0.844
DOC_WW_Pin1_4	659	664	PF00397	0.604
DOC_WW_Pin1_4	665	670	PF00397	0.811
DOC_WW_Pin1_4	873	878	PF00397	0.762
DOC_WW_Pin1_4	881	886	PF00397	0.712
DOC_WW_Pin1_4	917	922	PF00397	0.840
DOC_WW_Pin1_4	925	930	PF00397	0.651
DOC_WW_Pin1_4	941	946	PF00397	0.563
DOC_WW_Pin1_4	951	956	PF00397	0.765
DOC_WW_Pin1_4	957	962	PF00397	0.708
DOC_WW_Pin1_4	967	972	PF00397	0.636
LIG_14-3-3_CanoR_1	1002	1010	PF00244	0.614
LIG_14-3-3_CanoR_1	18	25	PF00244	0.723
LIG_14-3-3_CanoR_1	227	232	PF00244	0.846
LIG_14-3-3_CanoR_1	269	275	PF00244	0.792
LIG_14-3-3_CanoR_1	293	301	PF00244	0.846
LIG_14-3-3_CanoR_1	347	353	PF00244	0.774
LIG_14-3-3_CanoR_1	399	403	PF00244	0.646
LIG_14-3-3_CanoR_1	569	574	PF00244	0.711
LIG_14-3-3_CanoR_1	585	591	PF00244	0.852
LIG_14-3-3_CanoR_1	737	744	PF00244	0.737
LIG_14-3-3_CanoR_1	775	783	PF00244	0.606
LIG_14-3-3_CanoR_1	819	828	PF00244	0.680
LIG_14-3-3_CanoR_1	844	851	PF00244	0.806
LIG_14-3-3_CanoR_1	904	912	PF00244	0.528
LIG_Actin_WH2_2	781	799	PF00022	0.725
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BRCT_BRCA1_1	130	134	PF00533	0.625
LIG_EH1_1	139	147	PF00400	0.497
LIG_EH1_1	696	704	PF00400	0.740
LIG_FHA_1	125	131	PF00498	0.497
LIG_FHA_1	136	142	PF00498	0.518
LIG_FHA_1	269	275	PF00498	0.748
LIG_FHA_1	296	302	PF00498	0.776
LIG_FHA_1	459	465	PF00498	0.731
LIG_FHA_1	505	511	PF00498	0.760
LIG_FHA_1	615	621	PF00498	0.746
LIG_FHA_1	720	726	PF00498	0.664
LIG_FHA_1	771	777	PF00498	0.738
LIG_FHA_1	780	786	PF00498	0.578
LIG_FHA_1	846	852	PF00498	0.788
LIG_FHA_1	951	957	PF00498	0.751
LIG_FHA_2	147	153	PF00498	0.600
LIG_FHA_2	738	744	PF00498	0.735
LIG_FHA_2	971	977	PF00498	0.852
LIG_Integrin_isoDGR_2	757	759	PF01839	0.831
LIG_LIR_Apic_2	923	929	PF02991	0.803
LIG_LIR_Gen_1	152	163	PF02991	0.480
LIG_LIR_Gen_1	93	103	PF02991	0.532
LIG_LIR_Nem_3	152	158	PF02991	0.471
LIG_LIR_Nem_3	93	98	PF02991	0.441
LIG_LIR_Nem_3	99	105	PF02991	0.470
LIG_PCNA_yPIPBox_3	83	95	PF02747	0.606
LIG_PTB_Apo_2	199	206	PF02174	0.690
LIG_PTB_Phospho_1	199	205	PF10480	0.689
LIG_SH2_CRK	95	99	PF00017	0.515
LIG_SH2_PTP2	102	105	PF00017	0.590
LIG_SH2_STAP1	170	174	PF00017	0.496
LIG_SH2_STAT3	184	187	PF00017	0.794
LIG_SH2_STAT5	102	105	PF00017	0.521
LIG_SH2_STAT5	140	143	PF00017	0.596
LIG_SH2_STAT5	148	151	PF00017	0.458
LIG_SH2_STAT5	783	786	PF00017	0.664
LIG_SH2_STAT5	798	801	PF00017	0.514
LIG_SH3_1	422	428	PF00018	0.811
LIG_SH3_2	243	248	PF14604	0.711
LIG_SH3_2	501	506	PF14604	0.666
LIG_SH3_3	240	246	PF00018	0.707
LIG_SH3_3	397	403	PF00018	0.824
LIG_SH3_3	422	428	PF00018	0.862
LIG_SH3_3	471	477	PF00018	0.809
LIG_SH3_3	498	504	PF00018	0.664
LIG_SH3_3	578	584	PF00018	0.837
LIG_SH3_3	607	613	PF00018	0.782
LIG_SH3_3	617	623	PF00018	0.702
LIG_SH3_3	69	75	PF00018	0.444
LIG_SH3_3	726	732	PF00018	0.756
LIG_SH3_3	861	867	PF00018	0.823
LIG_SH3_3	871	877	PF00018	0.809
LIG_SH3_3	888	894	PF00018	0.612
LIG_SH3_3	915	921	PF00018	0.755
LIG_SH3_3	949	955	PF00018	0.841
LIG_SUMO_SIM_par_1	809	814	PF11976	0.734
LIG_TRAF2_1	853	856	PF00917	0.751
LIG_TRAF2_1	981	984	PF00917	0.761
LIG_UBA3_1	154	161	PF00899	0.567
LIG_WW_3	290	294	PF00397	0.697
LIG_WW_3	387	391	PF00397	0.754
MOD_CDC14_SPxK_1	928	931	PF00782	0.844
MOD_CDK_SPxK_1	925	931	PF00069	0.849
MOD_CDK_SPxxK_3	881	888	PF00069	0.714
MOD_CDK_SPxxK_3	967	974	PF00069	0.753
MOD_CK1_1	157	163	PF00069	0.483
MOD_CK1_1	173	179	PF00069	0.546
MOD_CK1_1	21	27	PF00069	0.831
MOD_CK1_1	29	35	PF00069	0.688
MOD_CK1_1	332	338	PF00069	0.619
MOD_CK1_1	354	360	PF00069	0.705
MOD_CK1_1	392	398	PF00069	0.848
MOD_CK1_1	409	415	PF00069	0.738
MOD_CK1_1	458	464	PF00069	0.721
MOD_CK1_1	643	649	PF00069	0.728
MOD_CK1_1	659	665	PF00069	0.696
MOD_CK1_1	673	679	PF00069	0.762
MOD_CK1_1	779	785	PF00069	0.654
MOD_CK1_1	830	836	PF00069	0.756
MOD_CK1_1	838	844	PF00069	0.720
MOD_CK1_1	876	882	PF00069	0.752
MOD_CK1_1	884	890	PF00069	0.720
MOD_CK1_1	925	931	PF00069	0.754
MOD_CK1_1	944	950	PF00069	0.753
MOD_CK1_1	964	970	PF00069	0.836
MOD_CK2_1	273	279	PF00069	0.733
MOD_CK2_1	322	328	PF00069	0.753
MOD_CK2_1	368	374	PF00069	0.788
MOD_CK2_1	924	930	PF00069	0.847
MOD_CK2_1	970	976	PF00069	0.852
MOD_CK2_1	978	984	PF00069	0.680
MOD_Cter_Amidation	990	993	PF01082	0.848
MOD_Cter_Amidation	994	997	PF01082	0.744
MOD_DYRK1A_RPxSP_1	399	403	PF00069	0.805
MOD_GlcNHglycan	1	4	PF01048	0.810
MOD_GlcNHglycan	175	178	PF01048	0.656
MOD_GlcNHglycan	187	190	PF01048	0.720
MOD_GlcNHglycan	249	252	PF01048	0.850
MOD_GlcNHglycan	316	319	PF01048	0.751
MOD_GlcNHglycan	339	342	PF01048	0.840
MOD_GlcNHglycan	378	381	PF01048	0.696
MOD_GlcNHglycan	444	447	PF01048	0.725
MOD_GlcNHglycan	457	460	PF01048	0.661
MOD_GlcNHglycan	478	481	PF01048	0.795
MOD_GlcNHglycan	546	549	PF01048	0.762
MOD_GlcNHglycan	552	555	PF01048	0.777
MOD_GlcNHglycan	558	561	PF01048	0.818
MOD_GlcNHglycan	571	574	PF01048	0.769
MOD_GlcNHglycan	577	580	PF01048	0.655
MOD_GlcNHglycan	623	626	PF01048	0.761
MOD_GlcNHglycan	631	634	PF01048	0.773
MOD_GlcNHglycan	658	661	PF01048	0.726
MOD_GlcNHglycan	677	680	PF01048	0.705
MOD_GlcNHglycan	709	712	PF01048	0.829
MOD_GlcNHglycan	778	781	PF01048	0.638
MOD_GlcNHglycan	824	827	PF01048	0.686
MOD_GlcNHglycan	83	86	PF01048	0.508
MOD_GlcNHglycan	848	851	PF01048	0.663
MOD_GlcNHglycan	860	863	PF01048	0.741
MOD_GlcNHglycan	915	918	PF01048	0.772
MOD_GlcNHglycan	948	951	PF01048	0.692
MOD_GlcNHglycan	989	992	PF01048	0.775
MOD_GSK3_1	124	131	PF00069	0.598
MOD_GSK3_1	146	153	PF00069	0.515
MOD_GSK3_1	166	173	PF00069	0.269
MOD_GSK3_1	19	26	PF00069	0.782
MOD_GSK3_1	227	234	PF00069	0.801
MOD_GSK3_1	269	276	PF00069	0.693
MOD_GSK3_1	329	336	PF00069	0.732
MOD_GSK3_1	389	396	PF00069	0.726
MOD_GSK3_1	406	413	PF00069	0.768
MOD_GSK3_1	442	449	PF00069	0.786
MOD_GSK3_1	451	458	PF00069	0.576
MOD_GSK3_1	550	557	PF00069	0.778
MOD_GSK3_1	621	628	PF00069	0.806
MOD_GSK3_1	665	672	PF00069	0.809
MOD_GSK3_1	770	777	PF00069	0.608
MOD_GSK3_1	779	786	PF00069	0.626
MOD_GSK3_1	835	842	PF00069	0.685
MOD_GSK3_1	869	876	PF00069	0.764
MOD_GSK3_1	877	884	PF00069	0.759
MOD_GSK3_1	913	920	PF00069	0.771
MOD_GSK3_1	937	944	PF00069	0.810
MOD_GSK3_1	946	953	PF00069	0.780
MOD_GSK3_1	957	964	PF00069	0.794
MOD_GSK3_1	965	972	PF00069	0.728
MOD_N-GLC_1	219	224	PF02516	0.804
MOD_N-GLC_1	544	549	PF02516	0.738
MOD_N-GLC_1	550	555	PF02516	0.738
MOD_N-GLC_1	569	574	PF02516	0.668
MOD_N-GLC_1	87	92	PF02516	0.631
MOD_N-GLC_1	96	101	PF02516	0.496
MOD_N-GLC_1	965	970	PF02516	0.847
MOD_NEK2_1	1005	1010	PF00069	0.636
MOD_NEK2_1	141	146	PF00069	0.475
MOD_NEK2_1	154	159	PF00069	0.456
MOD_NEK2_1	20	25	PF00069	0.747
MOD_NEK2_1	226	231	PF00069	0.758
MOD_NEK2_1	353	358	PF00069	0.650
MOD_NEK2_1	555	560	PF00069	0.596
MOD_NEK2_1	575	580	PF00069	0.766
MOD_NEK2_1	770	775	PF00069	0.629
MOD_NEK2_1	822	827	PF00069	0.752
MOD_NEK2_1	87	92	PF00069	0.561
MOD_NEK2_2	150	155	PF00069	0.581
MOD_PIKK_1	124	130	PF00454	0.494
MOD_PIKK_1	273	279	PF00454	0.704
MOD_PIKK_1	393	399	PF00454	0.762
MOD_PIKK_1	406	412	PF00454	0.716
MOD_PIKK_1	491	497	PF00454	0.761
MOD_PIKK_1	827	833	PF00454	0.737
MOD_PIKK_1	905	911	PF00454	0.741
MOD_PK_1	227	233	PF00069	0.846
MOD_PKA_1	987	993	PF00069	0.805
MOD_PKA_2	194	200	PF00069	0.728
MOD_PKA_2	226	232	PF00069	0.757
MOD_PKA_2	247	253	PF00069	0.745
MOD_PKA_2	262	268	PF00069	0.744
MOD_PKA_2	332	338	PF00069	0.654
MOD_PKA_2	346	352	PF00069	0.707
MOD_PKA_2	398	404	PF00069	0.608
MOD_PKA_2	517	523	PF00069	0.842
MOD_PKA_2	774	780	PF00069	0.604
MOD_PKA_2	843	849	PF00069	0.789
MOD_PKA_2	987	993	PF00069	0.805
MOD_Plk_1	116	122	PF00069	0.538
MOD_Plk_1	303	309	PF00069	0.679
MOD_Plk_1	327	333	PF00069	0.841
MOD_Plk_1	835	841	PF00069	0.713
MOD_Plk_1	87	93	PF00069	0.622
MOD_Plk_1	922	928	PF00069	0.778
MOD_Plk_1	965	971	PF00069	0.849
MOD_Plk_2-3	262	268	PF00069	0.744
MOD_Plk_4	141	147	PF00069	0.433
MOD_Plk_4	150	156	PF00069	0.438
MOD_Plk_4	159	165	PF00069	0.487
MOD_Plk_4	170	176	PF00069	0.276
MOD_Plk_4	200	206	PF00069	0.823
MOD_Plk_4	779	785	PF00069	0.692
MOD_Plk_4	87	93	PF00069	0.599
MOD_ProDKin_1	231	237	PF00069	0.831
MOD_ProDKin_1	29	35	PF00069	0.782
MOD_ProDKin_1	389	395	PF00069	0.846
MOD_ProDKin_1	399	405	PF00069	0.810
MOD_ProDKin_1	412	418	PF00069	0.628
MOD_ProDKin_1	458	464	PF00069	0.679
MOD_ProDKin_1	46	52	PF00069	0.523
MOD_ProDKin_1	470	476	PF00069	0.822
MOD_ProDKin_1	609	615	PF00069	0.695
MOD_ProDKin_1	625	631	PF00069	0.830
MOD_ProDKin_1	643	649	PF00069	0.840
MOD_ProDKin_1	659	665	PF00069	0.601
MOD_ProDKin_1	873	879	PF00069	0.762
MOD_ProDKin_1	881	887	PF00069	0.713
MOD_ProDKin_1	917	923	PF00069	0.843
MOD_ProDKin_1	925	931	PF00069	0.652
MOD_ProDKin_1	941	947	PF00069	0.563
MOD_ProDKin_1	951	957	PF00069	0.763
MOD_ProDKin_1	961	967	PF00069	0.694
MOD_SUMO_rev_2	800	805	PF00179	0.605
TRG_DiLeu_BaEn_3	765	771	PF01217	0.743
TRG_DiLeu_BaEn_4	791	797	PF01217	0.720
TRG_ENDOCYTIC_2	102	105	PF00928	0.562
TRG_ENDOCYTIC_2	798	801	PF00928	0.619
TRG_ENDOCYTIC_2	95	98	PF00928	0.516
TRG_ER_diArg_1	815	818	PF00400	0.651
TRG_ER_diArg_1	864	866	PF00400	0.841

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMU9	Leptomonas seymouri	41%	87%
A4HNF8	Leishmania braziliensis	76%	97%
E9AFW9	Leishmania major	94%	100%
E9AHX0	Leishmania infantum	98%	99%
E9B722	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%