Cytochrome p450-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome p450-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IIT3_LEIDO

TriTrypDb:

LdBPK_343110.1 , LdCL_340040000 , LDHU3_34.5270

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004497	monooxygenase activity	3	8
GO:0005488	binding	1	8
GO:0005506	iron ion binding	6	8
GO:0016491	oxidoreductase activity	2	8
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	8
GO:0020037	heme binding	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046906	tetrapyrrole binding	3	8
GO:0046914	transition metal ion binding	5	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	498	502	PF00656	0.540
CLV_MEL_PAP_1	129	135	PF00089	0.363
CLV_NRD_NRD_1	148	150	PF00675	0.303
CLV_NRD_NRD_1	430	432	PF00675	0.421
CLV_NRD_NRD_1	67	69	PF00675	0.328
CLV_PCSK_KEX2_1	148	150	PF00082	0.303
CLV_PCSK_KEX2_1	432	434	PF00082	0.363
CLV_PCSK_KEX2_1	446	448	PF00082	0.363
CLV_PCSK_KEX2_1	57	59	PF00082	0.430
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.363
CLV_PCSK_PC1ET2_1	446	448	PF00082	0.363
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.490
CLV_PCSK_SKI1_1	148	152	PF00082	0.321
CLV_PCSK_SKI1_1	201	205	PF00082	0.363
CLV_PCSK_SKI1_1	361	365	PF00082	0.363
CLV_PCSK_SKI1_1	392	396	PF00082	0.337
CLV_PCSK_SKI1_1	468	472	PF00082	0.370
CLV_PCSK_SKI1_1	527	531	PF00082	0.616
CLV_PCSK_SKI1_1	57	61	PF00082	0.430
CLV_PCSK_SKI1_1	91	95	PF00082	0.321
CLV_Separin_Metazoa	362	366	PF03568	0.421
DEG_APCC_DBOX_1	131	139	PF00400	0.347
DEG_APCC_DBOX_1	147	155	PF00400	0.222
DEG_APCC_DBOX_1	200	208	PF00400	0.303
DEG_APCC_DBOX_1	250	258	PF00400	0.363
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.357
DOC_MAPK_gen_1	148	154	PF00069	0.363
DOC_MAPK_gen_1	213	222	PF00069	0.363
DOC_MAPK_gen_1	431	442	PF00069	0.363
DOC_MAPK_MEF2A_6	392	400	PF00069	0.421
DOC_MAPK_MEF2A_6	482	489	PF00069	0.519
DOC_MAPK_MEF2A_6	86	94	PF00069	0.314
DOC_PP1_RVXF_1	89	95	PF00149	0.347
DOC_PP4_FxxP_1	93	96	PF00568	0.292
DOC_WW_Pin1_4	3	8	PF00397	0.514
DOC_WW_Pin1_4	99	104	PF00397	0.340
LIG_14-3-3_CanoR_1	251	255	PF00244	0.341
LIG_14-3-3_CanoR_1	496	504	PF00244	0.509
LIG_Actin_WH2_2	228	245	PF00022	0.421
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_CtBP_PxDLS_1	217	223	PF00389	0.246
LIG_EH1_1	122	130	PF00400	0.421
LIG_FHA_1	23	29	PF00498	0.506
LIG_FHA_1	393	399	PF00498	0.380
LIG_FHA_1	461	467	PF00498	0.341
LIG_FHA_1	484	490	PF00498	0.406
LIG_FHA_2	119	125	PF00498	0.421
LIG_FHA_2	251	257	PF00498	0.325
LIG_FHA_2	320	326	PF00498	0.357
LIG_FHA_2	344	350	PF00498	0.320
LIG_FHA_2	496	502	PF00498	0.493
LIG_LIR_Gen_1	120	130	PF02991	0.307
LIG_LIR_Gen_1	273	282	PF02991	0.387
LIG_LIR_Gen_1	283	294	PF02991	0.376
LIG_LIR_Gen_1	328	339	PF02991	0.434
LIG_LIR_Gen_1	453	464	PF02991	0.363
LIG_LIR_Gen_1	507	516	PF02991	0.510
LIG_LIR_LC3C_4	458	462	PF02991	0.357
LIG_LIR_Nem_3	120	126	PF02991	0.307
LIG_LIR_Nem_3	16	22	PF02991	0.487
LIG_LIR_Nem_3	283	289	PF02991	0.380
LIG_LIR_Nem_3	314	320	PF02991	0.367
LIG_LIR_Nem_3	328	334	PF02991	0.404
LIG_LIR_Nem_3	453	459	PF02991	0.303
LIG_LIR_Nem_3	507	512	PF02991	0.498
LIG_LIR_Nem_3	82	88	PF02991	0.337
LIG_NRBOX	315	321	PF00104	0.303
LIG_Pex14_1	79	83	PF04695	0.303
LIG_Rb_pABgroove_1	174	182	PF01858	0.333
LIG_REV1ctd_RIR_1	91	95	PF16727	0.303
LIG_SH2_CRK	123	127	PF00017	0.370
LIG_SH2_CRK	32	36	PF00017	0.589
LIG_SH2_NCK_1	32	36	PF00017	0.537
LIG_SH2_NCK_1	509	513	PF00017	0.502
LIG_SH2_SRC	123	126	PF00017	0.421
LIG_SH2_SRC	382	385	PF00017	0.325
LIG_SH2_STAP1	509	513	PF00017	0.502
LIG_SH2_STAT5	237	240	PF00017	0.303
LIG_SH2_STAT5	241	244	PF00017	0.303
LIG_SH2_STAT5	286	289	PF00017	0.352
LIG_SH2_STAT5	355	358	PF00017	0.303
LIG_SH2_STAT5	382	385	PF00017	0.352
LIG_SH2_STAT5	439	442	PF00017	0.421
LIG_SH2_STAT5	456	459	PF00017	0.421
LIG_SH2_STAT5	65	68	PF00017	0.405
LIG_SH3_1	365	371	PF00018	0.303
LIG_SH3_3	33	39	PF00018	0.460
LIG_SH3_3	365	371	PF00018	0.303
LIG_SH3_3	378	384	PF00018	0.303
LIG_SH3_3	385	391	PF00018	0.378
LIG_SH3_3	413	419	PF00018	0.367
LIG_SUMO_SIM_anti_2	458	463	PF11976	0.363
LIG_SUMO_SIM_par_1	101	107	PF11976	0.392
LIG_SUMO_SIM_par_1	394	399	PF11976	0.367
LIG_SUMO_SIM_par_1	458	463	PF11976	0.478
LIG_SUMO_SIM_par_1	485	490	PF11976	0.416
LIG_SUMO_SIM_par_1	514	522	PF11976	0.628
LIG_TRAF2_1	346	349	PF00917	0.303
LIG_TYR_ITIM	454	459	PF00017	0.325
LIG_TYR_ITSM	119	126	PF00017	0.421
LIG_WRC_WIRS_1	298	303	PF05994	0.340
LIG_WRPW_2	85	88	PF00400	0.363
MOD_CK1_1	340	346	PF00069	0.328
MOD_CK2_1	212	218	PF00069	0.363
MOD_CK2_1	250	256	PF00069	0.362
MOD_CK2_1	319	325	PF00069	0.357
MOD_CK2_1	343	349	PF00069	0.320
MOD_CK2_1	535	541	PF00069	0.509
MOD_Cter_Amidation	444	447	PF01082	0.363
MOD_GlcNHglycan	204	207	PF01048	0.379
MOD_GlcNHglycan	244	247	PF01048	0.417
MOD_GlcNHglycan	32	35	PF01048	0.587
MOD_GlcNHglycan	385	388	PF01048	0.325
MOD_GlcNHglycan	400	403	PF01048	0.182
MOD_GlcNHglycan	524	527	PF01048	0.631
MOD_GSK3_1	212	219	PF00069	0.309
MOD_GSK3_1	305	312	PF00069	0.303
MOD_GSK3_1	392	399	PF00069	0.363
MOD_GSK3_1	483	490	PF00069	0.375
MOD_GSK3_1	491	498	PF00069	0.387
MOD_N-GLC_1	193	198	PF02516	0.303
MOD_N-GLC_1	483	488	PF02516	0.434
MOD_N-GLC_1	527	532	PF02516	0.620
MOD_NEK2_1	202	207	PF00069	0.363
MOD_NEK2_1	212	217	PF00069	0.363
MOD_NEK2_1	230	235	PF00069	0.367
MOD_NEK2_1	242	247	PF00069	0.395
MOD_NEK2_1	319	324	PF00069	0.373
MOD_NEK2_1	460	465	PF00069	0.347
MOD_NEK2_1	495	500	PF00069	0.422
MOD_NEK2_1	51	56	PF00069	0.501
MOD_NEK2_2	250	255	PF00069	0.325
MOD_NEK2_2	535	540	PF00069	0.507
MOD_OFUCOSY	437	444	PF10250	0.363
MOD_PIKK_1	154	160	PF00454	0.355
MOD_PKA_2	212	218	PF00069	0.337
MOD_PKA_2	250	256	PF00069	0.352
MOD_PKA_2	404	410	PF00069	0.363
MOD_PKA_2	495	501	PF00069	0.567
MOD_Plk_1	483	489	PF00069	0.432
MOD_Plk_4	297	303	PF00069	0.340
MOD_Plk_4	392	398	PF00069	0.421
MOD_ProDKin_1	3	9	PF00069	0.514
MOD_ProDKin_1	99	105	PF00069	0.340
MOD_SUMO_for_1	470	473	PF00179	0.363
MOD_SUMO_rev_2	82	88	PF00179	0.381
TRG_DiLeu_BaEn_1	352	357	PF01217	0.363
TRG_DiLeu_BaEn_4	425	431	PF01217	0.363
TRG_ENDOCYTIC_2	123	126	PF00928	0.311
TRG_ENDOCYTIC_2	286	289	PF00928	0.380
TRG_ENDOCYTIC_2	331	334	PF00928	0.321
TRG_ENDOCYTIC_2	439	442	PF00928	0.363
TRG_ENDOCYTIC_2	456	459	PF00928	0.363
TRG_ENDOCYTIC_2	509	512	PF00928	0.503
TRG_ENDOCYTIC_2	61	64	PF00928	0.452
TRG_ENDOCYTIC_2	85	88	PF00928	0.363
TRG_ER_diArg_1	148	150	PF00400	0.303
TRG_ER_diArg_1	220	223	PF00400	0.363
TRG_ER_diArg_1	430	433	PF00400	0.363
TRG_NES_CRM1_1	279	293	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1DMJ7	Ustilago maydis (strain 521 / FGSC 9021)	22%	85%
A0A0D1DT62	Ustilago maydis (strain 521 / FGSC 9021)	23%	100%
A0A0E3D8M1	Penicillium crustosum	23%	100%
A0A0N1PC71	Leptomonas seymouri	75%	99%
A0A0S4ILM5	Bodo saltans	26%	100%
A0A0S4IUA7	Bodo saltans	23%	100%
A0A0S4KIN8	Bodo saltans	23%	100%
A0A140IL90	Narcissus aff. pseudonarcissus MK-2014	24%	100%
A0A140IL92	Narcissus aff. pseudonarcissus MK-2014	24%	100%
A0A140JWT9	Penicillium simplicissimum	24%	100%
A0A1B2CTB6	Penicillium thymicola	24%	100%
A0A1L9WVI3	Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094)	23%	100%
A0A1V0QSE9	Hericium erinaceus	25%	99%
A0A1X0NLV1	Trypanosomatidae	24%	94%
A0A1X0P9X8	Trypanosomatidae	47%	100%
A0A2P1DPA5	Penicillium terrestre	26%	100%
A0A2R4SBW0	Ganoderma lucidum	25%	100%
A0A386KZI3	Pseudo-nitzschia multiseries	26%	98%
A0A3G9HB50	Alternaria alternata	23%	91%
A0A411KZY9	Aspergillus burnettii	25%	100%
A0A422N4L6	Trypanosoma rangeli	22%	94%
A0A481NR20	Barbarea vulgaris	23%	100%
A0A517FNC4	Paris polyphylla	21%	100%
A0A517FNC7	Paris polyphylla	27%	100%
A1DN29	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	100%
A4HB52	Leishmania braziliensis	85%	100%
A4IAA0	Leishmania infantum	99%	100%
A7VMU4	Alternaria alternata	24%	100%
B2RML6	Botryotinia fuckeliana	24%	100%
B9G934	Oryza sativa subsp. japonica	27%	100%
B9GBJ9	Oryza sativa subsp. japonica	25%	100%
B9X287	Oryza sativa subsp. japonica	25%	100%
C9K1X6	Streptomyces melanosporofaciens	25%	100%
C9ZKU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	93%
E3W9C4	Zingiber zerumbet	23%	100%
E9B5C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9RHV4	Ustilago maydis	22%	100%
F1SY77	Postia placenta (strain ATCC 44394 / Madison 698-R)	21%	100%
F1SYB6	Postia placenta (strain ATCC 44394 / Madison 698-R)	24%	100%
F1SYE5	Postia placenta (strain ATCC 44394 / Madison 698-R)	27%	100%
F1SYG6	Postia placenta (strain ATCC 44394 / Madison 698-R)	26%	100%
F1SYH0	Postia placenta (strain ATCC 44394 / Madison 698-R)	27%	100%
F1SYH7	Postia placenta (strain ATCC 44394 / Madison 698-R)	24%	100%
F4IK45	Arabidopsis thaliana	24%	95%
G1XU01	Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491)	26%	100%
G3Y420	Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a / NRRL 328 / USDA 3528.7)	26%	100%
H1A988	Glycyrrhiza uralensis	23%	100%
H2DH21	Panax ginseng	23%	100%
I1S163	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	24%	98%
M1WEN7	Claviceps purpurea (strain 20.1)	24%	100%
O00061	Uromyces fabae	24%	100%
O23365	Arabidopsis thaliana	24%	94%
O44221	Drosophila mettleri	25%	100%
O48786	Arabidopsis thaliana	25%	100%
O48921	Glycine max	24%	95%
O81117	Vicia sativa	24%	100%
O88833	Mus musculus	25%	100%
P08516	Rattus norvegicus	24%	100%
P0DUL3	Aspergillus hancockii	24%	100%
P10611	Oryctolagus cuniculus	24%	100%
P13584	Homo sapiens	24%	100%
P14581	Oryctolagus cuniculus	26%	100%
P15128	Oryctolagus cuniculus	25%	100%
P20817	Rattus norvegicus	26%	100%
P24464	Rattus norvegicus	25%	100%
P29980	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	24%	100%
P29981	Blaberus discoidalis	26%	100%
P33274	Rattus norvegicus	25%	100%
P51871	Rattus norvegicus	26%	100%
P59954	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	100%
P78329	Homo sapiens	25%	100%
P82712	Drosophila melanogaster	26%	100%
P98187	Homo sapiens	27%	100%
P9WPN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WPN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q05047	Catharanthus roseus	24%	100%
Q08477	Homo sapiens	25%	100%
Q12585	Candida maltosa	24%	100%
Q12609	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q27589	Drosophila melanogaster	26%	100%
Q27606	Drosophila melanogaster	24%	100%
Q29496	Ovis aries	25%	100%
Q2MJ19	Medicago truncatula	22%	100%
Q2MJ21	Medicago truncatula	24%	100%
Q2PBY6	Claviceps purpurea	24%	100%
Q3MID2	Rattus norvegicus	25%	100%
Q43078	Pisum sativum	23%	99%
Q4Q2L1	Leishmania major	98%	100%
Q50EK0	Picea sitchensis	23%	100%
Q50EK1	Picea sitchensis	22%	100%
Q50EK3	Pinus taeda	24%	100%
Q50LG1	Alternaria alternata	25%	100%
Q50LH3	Eschscholzia californica	24%	100%
Q50LH4	Eschscholzia californica	25%	100%
Q54ZM4	Dictyostelium discoideum	22%	100%
Q5AR55	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q5TCH4	Homo sapiens	26%	100%
Q64462	Mus musculus	24%	100%
Q69XM6	Oryza sativa subsp. japonica	24%	100%
Q6A152	Mus musculus	25%	100%
Q6NKZ8	Arabidopsis thaliana	24%	100%
Q6NT55	Homo sapiens	25%	100%
Q6TBX7	Arabidopsis thaliana	23%	100%
Q6Z6D6	Oryza sativa subsp. japonica	23%	98%
Q7KR10	Drosophila melanogaster	25%	100%
Q86W10	Homo sapiens	25%	100%
Q8LIF2	Oryza sativa subsp. japonica	25%	100%
Q91WL5	Mus musculus	26%	100%
Q93Z79	Arabidopsis thaliana	23%	100%
Q964R0	Blattella germanica	24%	100%
Q964T1	Blattella germanica	28%	100%
Q98T91	Oryzias latipes	22%	100%
Q99N16	Mus musculus	24%	100%
Q9C788	Arabidopsis thaliana	21%	100%
Q9DBW0	Mus musculus	27%	100%
Q9EP75	Mus musculus	25%	100%
Q9FVS9	Arabidopsis thaliana	23%	100%
Q9GQM9	Blattella germanica	24%	100%
Q9HCS2	Homo sapiens	26%	100%
Q9K498	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	24%	100%
Q9LUC5	Arabidopsis thaliana	23%	100%
Q9LUC6	Arabidopsis thaliana	22%	100%
Q9LUC8	Arabidopsis thaliana	22%	100%
Q9LUC9	Arabidopsis thaliana	24%	100%
Q9PVE8	Fundulus heteroclitus	23%	100%
Q9SMP5	Arabidopsis thaliana	22%	100%
Q9V4T3	Drosophila melanogaster	24%	100%
Q9V4T5	Drosophila melanogaster	24%	100%
Q9V4U7	Drosophila melanogaster	21%	100%
Q9V557	Drosophila melanogaster	24%	100%
Q9V558	Drosophila melanogaster	26%	100%
Q9V559	Drosophila melanogaster	27%	100%
Q9V771	Drosophila melanogaster	24%	100%
Q9V7G5	Drosophila melanogaster	26%	100%
Q9VGB3	Drosophila melanogaster	24%	100%
Q9VL92	Drosophila melanogaster	26%	100%
Q9VS79	Drosophila melanogaster	25%	100%
Q9VXY0	Drosophila melanogaster	26%	100%
Q9VYQ7	Drosophila melanogaster	27%	100%
Q9WVK8	Mus musculus	24%	100%
Q9Y6A2	Homo sapiens	25%	100%
Q9Y757	Debaryomyces hansenii	26%	100%
Q9Y758	Debaryomyces hansenii	25%	100%
Q9ZUX1	Arabidopsis thaliana	24%	100%
U5NDT8	Catharanthus roseus	24%	100%
V5AWA4	Trypanosoma cruzi	24%	95%
W0FKI0	Persicaria hydropiper	23%	100%
W7LC91	Gibberella moniliformis (strain M3125 / FGSC 7600)	23%	92%
W8JWW3	Catharanthus roseus	22%	100%