DNA repair protein Rad9, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein Rad9, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIS7_LEIDO

TriTrypDb:

LdBPK_151040.1 , LdCL_150015900 , LDHU3_15.1330

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0030896	checkpoint clamp complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0140513	nuclear protein-containing complex	2	8
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIS7

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	8
GO:0000077	DNA damage checkpoint signaling	5	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0007165	signal transduction	2	8
GO:0009987	cellular process	1	8
GO:0010564	regulation of cell cycle process	5	8
GO:0010948	negative regulation of cell cycle process	6	8
GO:0031570	DNA integrity checkpoint signaling	5	8
GO:0033554	cellular response to stress	3	8
GO:0035556	intracellular signal transduction	3	8
GO:0042770	signal transduction in response to DNA damage	4	8
GO:0045786	negative regulation of cell cycle	5	8
GO:0048519	negative regulation of biological process	3	8
GO:0048523	negative regulation of cellular process	4	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0051726	regulation of cell cycle	4	8
GO:0065007	biological regulation	1	8
GO:1901987	regulation of cell cycle phase transition	6	8
GO:1901988	negative regulation of cell cycle phase transition	7	8
GO:0000076	DNA replication checkpoint signaling	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009314	response to radiation	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0010212	response to ionizing radiation	4	1
GO:0022402	cell cycle process	2	1
GO:0031573	mitotic intra-S DNA damage checkpoint signaling	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071478	cellular response to radiation	4	1
GO:0071479	cellular response to ionizing radiation	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.653
CLV_C14_Caspase3-7	581	585	PF00656	0.630
CLV_C14_Caspase3-7	695	699	PF00656	0.589
CLV_NRD_NRD_1	346	348	PF00675	0.747
CLV_NRD_NRD_1	417	419	PF00675	0.565
CLV_NRD_NRD_1	591	593	PF00675	0.591
CLV_NRD_NRD_1	622	624	PF00675	0.700
CLV_NRD_NRD_1	70	72	PF00675	0.645
CLV_PCSK_KEX2_1	346	348	PF00082	0.747
CLV_PCSK_KEX2_1	416	418	PF00082	0.560
CLV_PCSK_KEX2_1	591	593	PF00082	0.809
CLV_PCSK_KEX2_1	70	72	PF00082	0.634
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.560
CLV_PCSK_SKI1_1	13	17	PF00082	0.441
CLV_PCSK_SKI1_1	130	134	PF00082	0.458
CLV_PCSK_SKI1_1	179	183	PF00082	0.453
CLV_PCSK_SKI1_1	377	381	PF00082	0.434
CLV_PCSK_SKI1_1	417	421	PF00082	0.504
CLV_PCSK_SKI1_1	440	444	PF00082	0.764
CLV_PCSK_SKI1_1	508	512	PF00082	0.723
CLV_PCSK_SKI1_1	62	66	PF00082	0.566
CLV_PCSK_SKI1_1	702	706	PF00082	0.525
DEG_APCC_DBOX_1	12	20	PF00400	0.430
DEG_Kelch_Keap1_1	530	535	PF01344	0.727
DEG_SCF_FBW7_1	498	504	PF00400	0.687
DEG_SCF_FBW7_1	657	664	PF00400	0.649
DOC_CKS1_1	325	330	PF01111	0.694
DOC_CKS1_1	498	503	PF01111	0.686
DOC_CKS1_1	587	592	PF01111	0.716
DOC_MAPK_MEF2A_6	47	55	PF00069	0.459
DOC_MAPK_RevD_3	404	418	PF00069	0.510
DOC_PP1_RVXF_1	622	629	PF00149	0.695
DOC_PP2B_LxvP_1	231	234	PF13499	0.564
DOC_PP2B_LxvP_1	351	354	PF13499	0.677
DOC_PP2B_LxvP_1	65	68	PF13499	0.600
DOC_PP2B_PxIxI_1	9	15	PF00149	0.539
DOC_SPAK_OSR1_1	205	209	PF12202	0.505
DOC_USP7_MATH_1	132	136	PF00917	0.678
DOC_USP7_MATH_1	145	149	PF00917	0.585
DOC_USP7_MATH_1	214	218	PF00917	0.552
DOC_USP7_MATH_1	259	263	PF00917	0.660
DOC_USP7_MATH_1	270	274	PF00917	0.591
DOC_USP7_MATH_1	279	283	PF00917	0.463
DOC_USP7_MATH_1	288	292	PF00917	0.424
DOC_USP7_MATH_1	303	307	PF00917	0.637
DOC_USP7_MATH_1	455	459	PF00917	0.442
DOC_USP7_MATH_1	465	469	PF00917	0.527
DOC_USP7_MATH_1	475	479	PF00917	0.746
DOC_USP7_MATH_1	486	490	PF00917	0.594
DOC_USP7_MATH_1	493	497	PF00917	0.499
DOC_USP7_MATH_1	501	505	PF00917	0.713
DOC_USP7_MATH_1	540	544	PF00917	0.738
DOC_USP7_MATH_1	594	598	PF00917	0.791
DOC_USP7_MATH_1	622	626	PF00917	0.688
DOC_USP7_MATH_1	649	653	PF00917	0.775
DOC_USP7_MATH_1	665	669	PF00917	0.715
DOC_USP7_MATH_1	710	714	PF00917	0.524
DOC_WW_Pin1_4	301	306	PF00397	0.673
DOC_WW_Pin1_4	324	329	PF00397	0.722
DOC_WW_Pin1_4	341	346	PF00397	0.708
DOC_WW_Pin1_4	407	412	PF00397	0.497
DOC_WW_Pin1_4	41	46	PF00397	0.485
DOC_WW_Pin1_4	497	502	PF00397	0.709
DOC_WW_Pin1_4	520	525	PF00397	0.779
DOC_WW_Pin1_4	586	591	PF00397	0.658
DOC_WW_Pin1_4	592	597	PF00397	0.637
DOC_WW_Pin1_4	605	610	PF00397	0.675
DOC_WW_Pin1_4	657	662	PF00397	0.694
LIG_14-3-3_CanoR_1	13	19	PF00244	0.397
LIG_14-3-3_CanoR_1	172	178	PF00244	0.463
LIG_14-3-3_CanoR_1	346	351	PF00244	0.613
LIG_14-3-3_CanoR_1	502	510	PF00244	0.796
LIG_14-3-3_CanoR_1	591	599	PF00244	0.773
LIG_14-3-3_CanoR_1	623	627	PF00244	0.739
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_BIR_III_4	309	313	PF00653	0.709
LIG_BIR_III_4	615	619	PF00653	0.676
LIG_BRCT_BRCA1_1	1	5	PF00533	0.457
LIG_BRCT_BRCA1_1	123	127	PF00533	0.482
LIG_BRCT_BRCA1_1	624	628	PF00533	0.662
LIG_FHA_1	105	111	PF00498	0.457
LIG_FHA_1	182	188	PF00498	0.466
LIG_FHA_1	290	296	PF00498	0.516
LIG_FHA_1	371	377	PF00498	0.486
LIG_FHA_2	164	170	PF00498	0.522
LIG_FHA_2	230	236	PF00498	0.524
LIG_FHA_2	285	291	PF00498	0.574
LIG_FHA_2	306	312	PF00498	0.690
LIG_FHA_2	395	401	PF00498	0.505
LIG_FHA_2	408	414	PF00498	0.360
LIG_FHA_2	602	608	PF00498	0.668
LIG_GBD_Chelix_1	385	393	PF00786	0.460
LIG_LIR_Apic_2	584	590	PF02991	0.761
LIG_LIR_Gen_1	195	206	PF02991	0.567
LIG_LIR_Gen_1	290	299	PF02991	0.488
LIG_LIR_Gen_1	454	464	PF02991	0.500
LIG_LIR_Gen_1	57	68	PF02991	0.425
LIG_LIR_Gen_1	673	681	PF02991	0.514
LIG_LIR_Nem_3	195	201	PF02991	0.584
LIG_LIR_Nem_3	290	296	PF02991	0.481
LIG_LIR_Nem_3	363	369	PF02991	0.677
LIG_LIR_Nem_3	454	459	PF02991	0.453
LIG_LIR_Nem_3	57	63	PF02991	0.405
LIG_LIR_Nem_3	673	677	PF02991	0.514
LIG_Pex14_1	173	177	PF04695	0.451
LIG_Pex14_2	289	293	PF04695	0.498
LIG_REV1ctd_RIR_1	296	304	PF16727	0.446
LIG_SH2_CRK	215	219	PF00017	0.436
LIG_SH2_CRK	587	591	PF00017	0.744
LIG_SH2_NCK_1	681	685	PF00017	0.606
LIG_SH2_STAP1	153	157	PF00017	0.525
LIG_SH2_STAT5	102	105	PF00017	0.452
LIG_SH2_STAT5	30	33	PF00017	0.426
LIG_SH2_STAT5	462	465	PF00017	0.432
LIG_SH2_STAT5	681	684	PF00017	0.597
LIG_SH3_3	322	328	PF00018	0.731
LIG_SH3_3	330	336	PF00018	0.622
LIG_SH3_3	4	10	PF00018	0.533
LIG_SH3_3	446	452	PF00018	0.586
LIG_SH3_3	495	501	PF00018	0.679
LIG_SH3_3	635	641	PF00018	0.736
LIG_SUMO_SIM_anti_2	597	604	PF11976	0.748
LIG_SUMO_SIM_par_1	14	20	PF11976	0.463
LIG_SUMO_SIM_par_1	399	408	PF11976	0.487
LIG_SUMO_SIM_par_1	597	604	PF11976	0.675
LIG_SUMO_SIM_par_1	63	69	PF11976	0.534
LIG_TRAF2_1	397	400	PF00917	0.455
LIG_TRAF2_1	410	413	PF00917	0.409
LIG_TRAF2_1	691	694	PF00917	0.703
LIG_WRC_WIRS_1	456	461	PF05994	0.432
MOD_CDC14_SPxK_1	344	347	PF00782	0.737
MOD_CDC14_SPxK_1	44	47	PF00782	0.591
MOD_CDK_SPK_2	341	346	PF00069	0.739
MOD_CDK_SPK_2	497	502	PF00069	0.709
MOD_CDK_SPK_2	586	591	PF00069	0.718
MOD_CDK_SPxK_1	341	347	PF00069	0.757
MOD_CDK_SPxK_1	41	47	PF00069	0.485
MOD_CDK_SPxK_1	586	592	PF00069	0.601
MOD_CK1_1	134	140	PF00069	0.707
MOD_CK1_1	17	23	PF00069	0.491
MOD_CK1_1	221	227	PF00069	0.511
MOD_CK1_1	247	253	PF00069	0.754
MOD_CK1_1	291	297	PF00069	0.488
MOD_CK1_1	319	325	PF00069	0.665
MOD_CK1_1	349	355	PF00069	0.716
MOD_CK1_1	358	364	PF00069	0.621
MOD_CK1_1	41	47	PF00069	0.438
MOD_CK1_1	447	453	PF00069	0.616
MOD_CK1_1	468	474	PF00069	0.623
MOD_CK1_1	489	495	PF00069	0.679
MOD_CK1_1	543	549	PF00069	0.716
MOD_CK1_1	558	564	PF00069	0.643
MOD_CK1_1	576	582	PF00069	0.728
MOD_CK1_1	69	75	PF00069	0.704
MOD_CK2_1	229	235	PF00069	0.502
MOD_CK2_1	259	265	PF00069	0.771
MOD_CK2_1	284	290	PF00069	0.572
MOD_CK2_1	394	400	PF00069	0.441
MOD_CK2_1	407	413	PF00069	0.388
MOD_CK2_1	550	556	PF00069	0.777
MOD_CK2_1	592	598	PF00069	0.685
MOD_CK2_1	680	686	PF00069	0.684
MOD_DYRK1A_RPxSP_1	301	305	PF00069	0.521
MOD_GlcNHglycan	136	139	PF01048	0.707
MOD_GlcNHglycan	224	227	PF01048	0.505
MOD_GlcNHglycan	235	238	PF01048	0.454
MOD_GlcNHglycan	246	249	PF01048	0.679
MOD_GlcNHglycan	254	257	PF01048	0.685
MOD_GlcNHglycan	261	264	PF01048	0.674
MOD_GlcNHglycan	265	268	PF01048	0.706
MOD_GlcNHglycan	272	275	PF01048	0.674
MOD_GlcNHglycan	305	308	PF01048	0.668
MOD_GlcNHglycan	318	321	PF01048	0.646
MOD_GlcNHglycan	351	354	PF01048	0.712
MOD_GlcNHglycan	358	361	PF01048	0.604
MOD_GlcNHglycan	39	43	PF01048	0.448
MOD_GlcNHglycan	421	424	PF01048	0.527
MOD_GlcNHglycan	446	449	PF01048	0.695
MOD_GlcNHglycan	453	456	PF01048	0.454
MOD_GlcNHglycan	467	470	PF01048	0.513
MOD_GlcNHglycan	475	478	PF01048	0.707
MOD_GlcNHglycan	495	498	PF01048	0.479
MOD_GlcNHglycan	542	545	PF01048	0.806
MOD_GlcNHglycan	548	551	PF01048	0.742
MOD_GlcNHglycan	562	565	PF01048	0.472
MOD_GlcNHglycan	584	587	PF01048	0.723
MOD_GlcNHglycan	612	615	PF01048	0.755
MOD_GlcNHglycan	651	654	PF01048	0.743
MOD_GlcNHglycan	682	685	PF01048	0.620
MOD_GlcNHglycan	7	10	PF01048	0.465
MOD_GlcNHglycan	71	74	PF01048	0.653
MOD_GlcNHglycan	75	80	PF01048	0.698
MOD_GlcNHglycan	92	97	PF01048	0.541
MOD_GSK3_1	106	113	PF00069	0.454
MOD_GSK3_1	117	124	PF00069	0.551
MOD_GSK3_1	128	135	PF00069	0.550
MOD_GSK3_1	173	180	PF00069	0.430
MOD_GSK3_1	214	221	PF00069	0.456
MOD_GSK3_1	229	236	PF00069	0.523
MOD_GSK3_1	240	247	PF00069	0.558
MOD_GSK3_1	248	255	PF00069	0.760
MOD_GSK3_1	259	266	PF00069	0.704
MOD_GSK3_1	280	287	PF00069	0.585
MOD_GSK3_1	301	308	PF00069	0.652
MOD_GSK3_1	356	363	PF00069	0.718
MOD_GSK3_1	394	401	PF00069	0.369
MOD_GSK3_1	427	434	PF00069	0.655
MOD_GSK3_1	447	454	PF00069	0.676
MOD_GSK3_1	485	492	PF00069	0.648
MOD_GSK3_1	493	500	PF00069	0.645
MOD_GSK3_1	539	546	PF00069	0.700
MOD_GSK3_1	555	562	PF00069	0.633
MOD_GSK3_1	578	585	PF00069	0.752
MOD_GSK3_1	586	593	PF00069	0.613
MOD_GSK3_1	601	608	PF00069	0.706
MOD_GSK3_1	639	646	PF00069	0.661
MOD_GSK3_1	651	658	PF00069	0.670
MOD_GSK3_1	661	668	PF00069	0.701
MOD_GSK3_1	704	711	PF00069	0.521
MOD_GSK3_1	75	82	PF00069	0.718
MOD_N-GLC_1	151	156	PF02516	0.610
MOD_N-GLC_1	544	549	PF02516	0.728
MOD_N-GLC_1	579	584	PF02516	0.797
MOD_N-GLC_2	227	229	PF02516	0.566
MOD_NEK2_1	106	111	PF00069	0.419
MOD_NEK2_1	181	186	PF00069	0.576
MOD_NEK2_1	218	223	PF00069	0.477
MOD_NEK2_1	289	294	PF00069	0.589
MOD_NEK2_1	3	8	PF00069	0.385
MOD_NEK2_1	442	447	PF00069	0.753
MOD_NEK2_1	559	564	PF00069	0.685
MOD_NEK2_1	601	606	PF00069	0.752
MOD_NEK2_1	677	682	PF00069	0.564
MOD_NEK2_1	704	709	PF00069	0.442
MOD_NEK2_1	80	85	PF00069	0.563
MOD_NEK2_2	272	277	PF00069	0.615
MOD_NEK2_2	665	670	PF00069	0.701
MOD_PK_1	346	352	PF00069	0.733
MOD_PKA_1	346	352	PF00069	0.733
MOD_PKA_1	417	423	PF00069	0.489
MOD_PKA_2	244	250	PF00069	0.520
MOD_PKA_2	263	269	PF00069	0.774
MOD_PKA_2	346	352	PF00069	0.733
MOD_PKA_2	417	423	PF00069	0.595
MOD_PKA_2	473	479	PF00069	0.733
MOD_PKA_2	501	507	PF00069	0.716
MOD_PKA_2	573	579	PF00069	0.810
MOD_PKA_2	590	596	PF00069	0.813
MOD_PKA_2	622	628	PF00069	0.694
MOD_PKA_2	69	75	PF00069	0.650
MOD_Plk_1	199	205	PF00069	0.581
MOD_Plk_1	289	295	PF00069	0.562
MOD_Plk_1	38	44	PF00069	0.444
MOD_Plk_1	398	404	PF00069	0.370
MOD_Plk_1	486	492	PF00069	0.691
MOD_Plk_1	555	561	PF00069	0.763
MOD_Plk_1	579	585	PF00069	0.805
MOD_Plk_4	106	112	PF00069	0.417
MOD_Plk_4	14	20	PF00069	0.411
MOD_Plk_4	181	187	PF00069	0.462
MOD_Plk_4	193	199	PF00069	0.506
MOD_Plk_4	214	220	PF00069	0.452
MOD_Plk_4	281	287	PF00069	0.483
MOD_Plk_4	346	352	PF00069	0.733
MOD_Plk_4	455	461	PF00069	0.427
MOD_Plk_4	555	561	PF00069	0.712
MOD_Plk_4	665	671	PF00069	0.703
MOD_ProDKin_1	301	307	PF00069	0.677
MOD_ProDKin_1	324	330	PF00069	0.717
MOD_ProDKin_1	341	347	PF00069	0.708
MOD_ProDKin_1	407	413	PF00069	0.502
MOD_ProDKin_1	41	47	PF00069	0.493
MOD_ProDKin_1	497	503	PF00069	0.708
MOD_ProDKin_1	520	526	PF00069	0.776
MOD_ProDKin_1	586	592	PF00069	0.657
MOD_ProDKin_1	605	611	PF00069	0.750
MOD_ProDKin_1	657	663	PF00069	0.693
TRG_DiLeu_BaEn_2	699	705	PF01217	0.515
TRG_DiLeu_BaEn_3	399	405	PF01217	0.494
TRG_ENDOCYTIC_2	102	105	PF00928	0.452
TRG_ENDOCYTIC_2	198	201	PF00928	0.592
TRG_ENDOCYTIC_2	215	218	PF00928	0.436
TRG_ER_diArg_1	345	347	PF00400	0.736
TRG_ER_diArg_1	417	419	PF00400	0.565
TRG_ER_diArg_1	590	592	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	508	513	PF00026	0.723
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I126	Leptomonas seymouri	46%	91%
A0A1X0NTX6	Trypanosomatidae	23%	97%
A4H871	Leishmania braziliensis	73%	96%
A4HWJ6	Leishmania infantum	99%	100%
E9AQ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4QF86	Leishmania major	90%	100%