Ferredoxin_2fe-2s-like_protein/GeneDB:LmjF.31.249 0

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adrenodoxin-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IIS3_LEIDO

TriTrypDb:

LdBPK_312580.1 , LdCL_310033700 , LDHU3_31.4610

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 20
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IIS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIS3

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	23
GO:0008152	metabolic process	1	23
GO:0009987	cellular process	1	23
GO:0022900	electron transport chain	4	23
GO:0044237	cellular metabolic process	2	23
GO:0140647	P450-containing electron transport chain	5	23

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	23
GO:0051536	iron-sulfur cluster binding	3	23
GO:0051537	2 iron, 2 sulfur cluster binding	4	23
GO:0051540	metal cluster binding	2	23
GO:0003824	catalytic activity	1	3
GO:0009055	electron transfer activity	3	3
GO:0016491	oxidoreductase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	138	142	PF00082	0.433
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DOC_PP4_FxxP_1	51	54	PF00568	0.259
DOC_USP7_MATH_1	79	83	PF00917	0.232
DOC_USP7_UBL2_3	94	98	PF12436	0.377
DOC_WW_Pin1_4	123	128	PF00397	0.490
DOC_WW_Pin1_4	2	7	PF00397	0.595
DOC_WW_Pin1_4	44	49	PF00397	0.356
LIG_FHA_1	114	120	PF00498	0.295
LIG_FHA_1	139	145	PF00498	0.585
LIG_FHA_1	15	21	PF00498	0.527
LIG_FHA_1	24	30	PF00498	0.496
LIG_FHA_1	7	13	PF00498	0.560
LIG_FHA_1	81	87	PF00498	0.332
LIG_FHA_2	45	51	PF00498	0.318
LIG_LIR_Apic_2	50	54	PF02991	0.262
LIG_LIR_Nem_3	3	7	PF02991	0.543
LIG_LIR_Nem_3	90	96	PF02991	0.258
LIG_PDZ_Class_2	140	145	PF00595	0.417
LIG_SH2_CRK	31	35	PF00017	0.478
LIG_SH2_CRK	4	8	PF00017	0.473
LIG_SH2_NCK_1	31	35	PF00017	0.571
LIG_SH2_STAT5	87	90	PF00017	0.242
LIG_SH3_3	131	137	PF00018	0.425
MOD_CK2_1	97	103	PF00069	0.293
MOD_DYRK1A_RPxSP_1	2	6	PF00069	0.397
MOD_GSK3_1	2	9	PF00069	0.558
MOD_GSK3_1	40	47	PF00069	0.403
MOD_N-GLC_1	138	143	PF02516	0.406
MOD_NEK2_1	113	118	PF00069	0.389
MOD_NEK2_1	24	29	PF00069	0.510
MOD_NEK2_1	7	12	PF00069	0.541
MOD_OFUCOSY	78	84	PF10250	0.289
MOD_PKA_2	113	119	PF00069	0.233
MOD_PKA_2	14	20	PF00069	0.598
MOD_Plk_1	114	120	PF00069	0.327
MOD_Plk_4	55	61	PF00069	0.292
MOD_ProDKin_1	123	129	PF00069	0.489
MOD_ProDKin_1	2	8	PF00069	0.594
MOD_ProDKin_1	44	50	PF00069	0.347
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.453
TRG_ENDOCYTIC_2	4	7	PF00928	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	56%	100%
A0A0N0P799	Leptomonas seymouri	47%	88%
A0A0N1HYR7	Leptomonas seymouri	48%	99%
A0A0N1I5P4	Leptomonas seymouri	69%	100%
A0A0N1ILD8	Leptomonas seymouri	46%	85%
A0A0N1PE81	Leptomonas seymouri	51%	100%
A0A0S4J024	Bodo saltans	55%	94%
A0A3R7MK78	Trypanosoma rangeli	50%	89%
A0A3R7NM96	Trypanosoma rangeli	42%	76%
A0A3S7X4S6	Leishmania donovani	44%	91%
A0A3S7X4U4	Leishmania donovani	46%	80%
A0A3S7X4W8	Leishmania donovani	50%	100%
A4HJN2	Leishmania braziliensis	43%	100%
A4HJN3	Leishmania braziliensis	77%	100%
A4HJN4	Leishmania braziliensis	57%	100%
A4HJN8	Leishmania braziliensis	56%	100%
A4HJN9	Leishmania braziliensis	47%	81%
A4I755	Leishmania infantum	44%	100%
A4I756	Leishmania infantum	100%	100%
A4I757	Leishmania infantum	50%	100%
A4I758	Leishmania infantum	43%	100%
D5IGG4	Sphingomonas sp.	38%	100%
E9B248	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B249	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B250	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B251	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	80%
P00257	Bos taurus	36%	78%
P00258	Sus scrofa	37%	78%
P00259	Pseudomonas putida	39%	100%
P10109	Homo sapiens	38%	79%
P13216	Gallus gallus	36%	100%
P24483	Rattus norvegicus	37%	77%
P29330	Ovis aries	39%	100%
P37098	Caulobacter vibrioides (strain ATCC 19089 / CB15)	34%	100%
P37193	Drosophila melanogaster	37%	84%
P46656	Mus musculus	36%	77%
P80306	Rhodobacter capsulatus	39%	100%
Q05B51	Bos taurus	41%	78%
Q08C57	Danio rerio	39%	74%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	84%
Q1RJ69	Rickettsia bellii (strain RML369-C)	42%	100%
Q4Q610	Leishmania major	47%	80%
Q4Q611	Leishmania major	54%	100%
Q4Q612	Leishmania major	92%	100%
Q4Q613	Leishmania major	44%	100%
Q4UKL2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	45%	100%
Q5FWQ0	Xenopus laevis	41%	75%
Q5S3I4	Stenotrophomonas maltophilia	36%	100%
Q6P4F2	Homo sapiens	41%	78%
Q8S904	Arabidopsis thaliana	33%	74%
Q8SZA8	Drosophila melanogaster	42%	95%
Q92J08	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	44%	100%
Q9AKC4	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	44%	100%
Q9AKH1	Rickettsia rickettsii	45%	100%
Q9AKM6	Rickettsia montanensis	45%	100%
Q9M0V0	Arabidopsis thaliana	32%	74%
Q9ZDW6	Rickettsia prowazekii (strain Madrid E)	45%	100%
X5CWH9	Rhizorhabdus wittichii (strain DC-6 / KACC 16600)	39%	100%