Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIR9_LEIDO

TriTrypDb:

LdBPK_342940.1 , LdCL_340038200 , LDHU3_34.5060

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.481
CLV_C14_Caspase3-7	252	256	PF00656	0.548
CLV_C14_Caspase3-7	64	68	PF00656	0.596
CLV_NRD_NRD_1	100	102	PF00675	0.519
CLV_NRD_NRD_1	279	281	PF00675	0.404
CLV_NRD_NRD_1	35	37	PF00675	0.530
CLV_NRD_NRD_1	388	390	PF00675	0.425
CLV_NRD_NRD_1	444	446	PF00675	0.480
CLV_NRD_NRD_1	575	577	PF00675	0.627
CLV_NRD_NRD_1	92	94	PF00675	0.519
CLV_PCSK_KEX2_1	279	281	PF00082	0.331
CLV_PCSK_KEX2_1	388	390	PF00082	0.404
CLV_PCSK_KEX2_1	84	86	PF00082	0.580
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.580
CLV_PCSK_SKI1_1	164	168	PF00082	0.500
CLV_PCSK_SKI1_1	24	28	PF00082	0.570
CLV_PCSK_SKI1_1	280	284	PF00082	0.402
CLV_PCSK_SKI1_1	321	325	PF00082	0.298
CLV_PCSK_SKI1_1	391	395	PF00082	0.403
CLV_PCSK_SKI1_1	405	409	PF00082	0.432
CLV_PCSK_SKI1_1	523	527	PF00082	0.441
CLV_PCSK_SKI1_1	559	563	PF00082	0.425
CLV_PCSK_SKI1_1	84	88	PF00082	0.672
DEG_APCC_DBOX_1	163	171	PF00400	0.477
DEG_APCC_DBOX_1	388	396	PF00400	0.477
DEG_MDM2_SWIB_1	423	431	PF02201	0.398
DEG_SPOP_SBC_1	140	144	PF00917	0.605
DOC_CYCLIN_RxL_1	388	396	PF00134	0.439
DOC_CYCLIN_RxL_1	401	412	PF00134	0.356
DOC_MAPK_gen_1	388	395	PF00069	0.417
DOC_MAPK_gen_1	401	410	PF00069	0.398
DOC_MAPK_gen_1	44	53	PF00069	0.615
DOC_MAPK_gen_1	84	92	PF00069	0.613
DOC_PP1_RVXF_1	403	410	PF00149	0.384
DOC_PP2B_LxvP_1	381	384	PF13499	0.509
DOC_PP4_FxxP_1	69	72	PF00568	0.511
DOC_USP7_MATH_1	14	18	PF00917	0.577
DOC_USP7_MATH_1	176	180	PF00917	0.684
DOC_USP7_MATH_1	236	240	PF00917	0.628
DOC_USP7_MATH_1	250	254	PF00917	0.738
DOC_USP7_MATH_1	260	264	PF00917	0.739
DOC_USP7_MATH_1	384	388	PF00917	0.552
DOC_USP7_MATH_1	61	65	PF00917	0.498
DOC_USP7_UBL2_3	80	84	PF12436	0.587
DOC_WW_Pin1_4	200	205	PF00397	0.501
DOC_WW_Pin1_4	246	251	PF00397	0.774
DOC_WW_Pin1_4	415	420	PF00397	0.433
DOC_WW_Pin1_4	473	478	PF00397	0.622
LIG_14-3-3_CanoR_1	175	181	PF00244	0.613
LIG_14-3-3_CanoR_1	200	204	PF00244	0.432
LIG_14-3-3_CanoR_1	308	314	PF00244	0.466
LIG_Actin_WH2_2	187	202	PF00022	0.417
LIG_Actin_WH2_2	50	68	PF00022	0.630
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	381	385	PF00533	0.498
LIG_BRCT_BRCA1_1	432	436	PF00533	0.416
LIG_BRCT_BRCA1_1	450	454	PF00533	0.417
LIG_BRCT_BRCA1_1	580	584	PF00533	0.629
LIG_CaM_NSCaTE_8	427	434	PF13499	0.356
LIG_Clathr_ClatBox_1	342	346	PF01394	0.490
LIG_Clathr_ClatBox_1	392	396	PF01394	0.500
LIG_deltaCOP1_diTrp_1	414	423	PF00928	0.427
LIG_deltaCOP1_diTrp_1	534	539	PF00928	0.389
LIG_eIF4E_1	277	283	PF01652	0.460
LIG_FHA_1	175	181	PF00498	0.564
LIG_FHA_1	225	231	PF00498	0.591
LIG_FHA_1	262	268	PF00498	0.583
LIG_FHA_1	308	314	PF00498	0.523
LIG_FHA_1	416	422	PF00498	0.475
LIG_FHA_1	492	498	PF00498	0.394
LIG_FHA_2	111	117	PF00498	0.603
LIG_FHA_2	238	244	PF00498	0.647
LIG_FHA_2	345	351	PF00498	0.469
LIG_FHA_2	366	372	PF00498	0.398
LIG_FHA_2	547	553	PF00498	0.614
LIG_LIR_Apic_2	67	72	PF02991	0.521
LIG_LIR_Gen_1	2	11	PF02991	0.678
LIG_LIR_Gen_1	206	215	PF02991	0.374
LIG_LIR_Gen_1	316	326	PF02991	0.477
LIG_LIR_Gen_1	336	345	PF02991	0.217
LIG_LIR_Gen_1	433	443	PF02991	0.387
LIG_LIR_Gen_1	457	468	PF02991	0.458
LIG_LIR_Gen_1	489	497	PF02991	0.407
LIG_LIR_Gen_1	498	506	PF02991	0.331
LIG_LIR_Gen_1	530	541	PF02991	0.494
LIG_LIR_Nem_3	206	210	PF02991	0.383
LIG_LIR_Nem_3	316	322	PF02991	0.486
LIG_LIR_Nem_3	336	341	PF02991	0.220
LIG_LIR_Nem_3	350	355	PF02991	0.348
LIG_LIR_Nem_3	433	439	PF02991	0.408
LIG_LIR_Nem_3	457	463	PF02991	0.405
LIG_LIR_Nem_3	489	493	PF02991	0.396
LIG_LIR_Nem_3	498	502	PF02991	0.334
LIG_LIR_Nem_3	530	536	PF02991	0.520
LIG_MYND_1	77	81	PF01753	0.634
LIG_NRBOX	365	371	PF00104	0.459
LIG_Pex14_1	298	302	PF04695	0.358
LIG_Pex14_2	423	427	PF04695	0.450
LIG_Pex14_2	533	537	PF04695	0.448
LIG_SH2_CRK	287	291	PF00017	0.481
LIG_SH2_NCK_1	302	306	PF00017	0.466
LIG_SH2_NCK_1	460	464	PF00017	0.456
LIG_SH2_NCK_1	490	494	PF00017	0.488
LIG_SH2_SRC	70	73	PF00017	0.514
LIG_SH2_STAP1	22	26	PF00017	0.597
LIG_SH2_STAP1	302	306	PF00017	0.370
LIG_SH2_STAP1	460	464	PF00017	0.508
LIG_SH2_STAT5	277	280	PF00017	0.369
LIG_SH2_STAT5	302	305	PF00017	0.356
LIG_SH2_STAT5	306	309	PF00017	0.376
LIG_SH2_STAT5	524	527	PF00017	0.511
LIG_SH2_STAT5	70	73	PF00017	0.625
LIG_SH3_3	104	110	PF00018	0.587
LIG_SH3_3	227	233	PF00018	0.449
LIG_SH3_3	244	250	PF00018	0.662
LIG_SH3_3	380	386	PF00018	0.319
LIG_SH3_3	474	480	PF00018	0.604
LIG_SH3_3	72	78	PF00018	0.609
LIG_SH3_4	80	87	PF00018	0.613
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.419
LIG_SUMO_SIM_anti_2	390	396	PF11976	0.470
LIG_SUMO_SIM_par_1	339	347	PF11976	0.496
LIG_SUMO_SIM_par_1	390	396	PF11976	0.449
LIG_TRAF2_1	193	196	PF00917	0.582
LIG_TRAF2_1	548	551	PF00917	0.625
LIG_TYR_ITIM	488	493	PF00017	0.477
LIG_UBA3_1	341	348	PF00899	0.458
LIG_UBA3_1	86	94	PF00899	0.607
LIG_WW_1	19	22	PF00397	0.570
MOD_CK1_1	144	150	PF00069	0.656
MOD_CK1_1	174	180	PF00069	0.688
MOD_CK1_1	203	209	PF00069	0.463
MOD_CK1_1	258	264	PF00069	0.700
MOD_CK1_1	344	350	PF00069	0.536
MOD_CK1_1	376	382	PF00069	0.340
MOD_CK1_1	387	393	PF00069	0.400
MOD_CK1_1	580	586	PF00069	0.585
MOD_CK1_1	60	66	PF00069	0.507
MOD_CK2_1	110	116	PF00069	0.756
MOD_CK2_1	344	350	PF00069	0.480
MOD_CK2_1	455	461	PF00069	0.466
MOD_CK2_1	546	552	PF00069	0.548
MOD_GlcNHglycan	1	4	PF01048	0.708
MOD_GlcNHglycan	116	120	PF01048	0.668
MOD_GlcNHglycan	252	255	PF01048	0.799
MOD_GlcNHglycan	258	261	PF01048	0.725
MOD_GlcNHglycan	551	556	PF01048	0.511
MOD_GlcNHglycan	59	62	PF01048	0.653
MOD_GSK3_1	139	146	PF00069	0.672
MOD_GSK3_1	170	177	PF00069	0.593
MOD_GSK3_1	199	206	PF00069	0.486
MOD_GSK3_1	246	253	PF00069	0.666
MOD_GSK3_1	256	263	PF00069	0.700
MOD_GSK3_1	337	344	PF00069	0.509
MOD_GSK3_1	491	498	PF00069	0.441
MOD_GSK3_1	542	549	PF00069	0.520
MOD_GSK3_1	566	573	PF00069	0.671
MOD_GSK3_1	57	64	PF00069	0.674
MOD_GSK3_1	579	586	PF00069	0.626
MOD_N-GLC_1	12	17	PF02516	0.655
MOD_N-GLC_1	157	162	PF02516	0.519
MOD_N-GLC_1	336	341	PF02516	0.406
MOD_NEK2_1	103	108	PF00069	0.583
MOD_NEK2_1	141	146	PF00069	0.662
MOD_NEK2_1	170	175	PF00069	0.585
MOD_NEK2_1	199	204	PF00069	0.581
MOD_NEK2_1	210	215	PF00069	0.410
MOD_NEK2_1	300	305	PF00069	0.398
MOD_NEK2_1	307	312	PF00069	0.471
MOD_NEK2_1	431	436	PF00069	0.456
MOD_NEK2_1	448	453	PF00069	0.304
MOD_NEK2_1	454	459	PF00069	0.413
MOD_NEK2_1	526	531	PF00069	0.543
MOD_NEK2_1	553	558	PF00069	0.606
MOD_NEK2_1	57	62	PF00069	0.561
MOD_NEK2_2	176	181	PF00069	0.573
MOD_NEK2_2	61	66	PF00069	0.534
MOD_PIKK_1	546	552	PF00454	0.628
MOD_PKA_2	170	176	PF00069	0.611
MOD_PKA_2	199	205	PF00069	0.429
MOD_PKA_2	307	313	PF00069	0.456
MOD_PKA_2	387	393	PF00069	0.501
MOD_PKA_2	441	447	PF00069	0.442
MOD_PKA_2	466	472	PF00069	0.571
MOD_PKA_2	570	576	PF00069	0.722
MOD_Plk_1	103	109	PF00069	0.587
MOD_Plk_1	3	9	PF00069	0.574
MOD_Plk_1	336	342	PF00069	0.422
MOD_Plk_1	373	379	PF00069	0.428
MOD_Plk_1	413	419	PF00069	0.413
MOD_Plk_1	455	461	PF00069	0.406
MOD_Plk_2-3	237	243	PF00069	0.635
MOD_Plk_4	103	109	PF00069	0.510
MOD_Plk_4	337	343	PF00069	0.445
MOD_Plk_4	365	371	PF00069	0.401
MOD_Plk_4	376	382	PF00069	0.410
MOD_Plk_4	455	461	PF00069	0.550
MOD_Plk_4	508	514	PF00069	0.486
MOD_Plk_4	580	586	PF00069	0.681
MOD_ProDKin_1	200	206	PF00069	0.498
MOD_ProDKin_1	246	252	PF00069	0.777
MOD_ProDKin_1	415	421	PF00069	0.425
MOD_ProDKin_1	473	479	PF00069	0.615
MOD_SUMO_for_1	79	82	PF00179	0.628
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.379
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.392
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.512
TRG_ENDOCYTIC_2	287	290	PF00928	0.483
TRG_ENDOCYTIC_2	352	355	PF00928	0.348
TRG_ENDOCYTIC_2	460	463	PF00928	0.447
TRG_ENDOCYTIC_2	490	493	PF00928	0.480
TRG_ENDOCYTIC_2	5	8	PF00928	0.623
TRG_ER_diArg_1	388	391	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P314	Leptomonas seymouri	55%	93%
A0A1X0P9X4	Trypanosomatidae	31%	100%
A4HB35	Leishmania braziliensis	71%	100%
A4IAN4	Leishmania infantum	100%	100%
C9ZM12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B5A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2M8	Leishmania major	93%	100%
V5BV34	Trypanosoma cruzi	30%	100%