GPI_transamidase_component_Tta2_putative/GeneDB:L mjF.36.0650

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component Tta2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIQ8_LEIDO

TriTrypDb:

LdBPK_360710.1 , LdCL_360012000 , LDHU3_36.0870

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0008303	caspase complex	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0042765	GPI-anchor transamidase complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

A0A3Q8IIQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIQ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003923	GPI-anchor transamidase activity	6	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.701
CLV_NRD_NRD_1	214	216	PF00675	0.419
CLV_PCSK_KEX2_1	214	216	PF00082	0.417
CLV_PCSK_SKI1_1	21	25	PF00082	0.334
CLV_PCSK_SKI1_1	214	218	PF00082	0.510
CLV_PCSK_SKI1_1	253	257	PF00082	0.521
CLV_PCSK_SKI1_1	351	355	PF00082	0.371
CLV_PCSK_SKI1_1	37	41	PF00082	0.342
CLV_PCSK_SKI1_1	391	395	PF00082	0.473
CLV_PCSK_SKI1_1	399	403	PF00082	0.448
CLV_PCSK_SKI1_1	91	95	PF00082	0.740
DEG_APCC_DBOX_1	350	358	PF00400	0.602
DEG_APCC_DBOX_1	36	44	PF00400	0.266
DEG_MDM2_SWIB_1	457	465	PF02201	0.447
DEG_ODPH_VHL_1	244	256	PF01847	0.492
DEG_ODPH_VHL_1	317	329	PF01847	0.661
DEG_SPOP_SBC_1	337	341	PF00917	0.680
DOC_CDC14_PxL_1	315	323	PF14671	0.654
DOC_CKS1_1	92	97	PF01111	0.502
DOC_CYCLIN_RxL_1	296	305	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.703
DOC_CYCLIN_yCln2_LP_2	411	417	PF00134	0.373
DOC_MAPK_DCC_7	408	417	PF00069	0.562
DOC_MAPK_DCC_7	91	100	PF00069	0.565
DOC_MAPK_gen_1	408	417	PF00069	0.538
DOC_MAPK_MEF2A_6	21	30	PF00069	0.501
DOC_MAPK_MEF2A_6	408	417	PF00069	0.517
DOC_MAPK_MEF2A_6	91	100	PF00069	0.565
DOC_MAPK_RevD_3	200	215	PF00069	0.442
DOC_PP1_RVXF_1	251	257	PF00149	0.330
DOC_PP2B_LxvP_1	243	246	PF13499	0.558
DOC_PP2B_LxvP_1	286	289	PF13499	0.675
DOC_PP2B_LxvP_1	301	304	PF13499	0.577
DOC_PP2B_LxvP_1	321	324	PF13499	0.463
DOC_PP2B_LxvP_1	369	372	PF13499	0.663
DOC_PP2B_LxvP_1	411	414	PF13499	0.373
DOC_USP7_MATH_1	165	169	PF00917	0.599
DOC_USP7_MATH_1	337	341	PF00917	0.686
DOC_USP7_MATH_1	387	391	PF00917	0.674
DOC_USP7_MATH_1	57	61	PF00917	0.510
DOC_USP7_MATH_1	80	84	PF00917	0.509
DOC_WW_Pin1_4	401	406	PF00397	0.693
DOC_WW_Pin1_4	483	488	PF00397	0.760
DOC_WW_Pin1_4	50	55	PF00397	0.522
DOC_WW_Pin1_4	91	96	PF00397	0.501
LIG_14-3-3_CanoR_1	169	178	PF00244	0.562
LIG_14-3-3_CanoR_1	214	222	PF00244	0.655
LIG_14-3-3_CanoR_1	282	287	PF00244	0.634
LIG_14-3-3_CanoR_1	335	344	PF00244	0.720
LIG_14-3-3_CanoR_1	366	372	PF00244	0.684
LIG_14-3-3_CanoR_1	399	404	PF00244	0.659
LIG_14-3-3_CanoR_1	44	48	PF00244	0.496
LIG_AP_GAE_1	120	126	PF02883	0.481
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BIR_III_3	1	5	PF00653	0.652
LIG_BRCT_BRCA1_1	279	283	PF00533	0.729
LIG_BRCT_BRCA1_1	361	365	PF00533	0.632
LIG_EH_1	24	28	PF12763	0.305
LIG_EH1_1	255	263	PF00400	0.266
LIG_eIF4E_1	406	412	PF01652	0.562
LIG_EVH1_2	96	100	PF00568	0.543
LIG_FHA_1	150	156	PF00498	0.391
LIG_FHA_1	161	167	PF00498	0.556
LIG_FHA_1	204	210	PF00498	0.355
LIG_FHA_1	221	227	PF00498	0.496
LIG_FHA_1	390	396	PF00498	0.687
LIG_FHA_1	461	467	PF00498	0.504
LIG_FHA_2	109	115	PF00498	0.438
LIG_FHA_2	15	21	PF00498	0.738
LIG_FHA_2	190	196	PF00498	0.624
LIG_FHA_2	392	398	PF00498	0.698
LIG_HP1_1	240	244	PF01393	0.441
LIG_LIR_Apic_2	285	290	PF02991	0.632
LIG_LIR_Gen_1	120	131	PF02991	0.520
LIG_LIR_Gen_1	198	207	PF02991	0.468
LIG_LIR_Gen_1	234	244	PF02991	0.381
LIG_LIR_Gen_1	280	290	PF02991	0.731
LIG_LIR_Gen_1	370	381	PF02991	0.668
LIG_LIR_Gen_1	404	414	PF02991	0.490
LIG_LIR_Nem_3	110	115	PF02991	0.503
LIG_LIR_Nem_3	120	126	PF02991	0.483
LIG_LIR_Nem_3	198	203	PF02991	0.466
LIG_LIR_Nem_3	234	239	PF02991	0.377
LIG_LIR_Nem_3	280	286	PF02991	0.710
LIG_LIR_Nem_3	370	376	PF02991	0.657
LIG_LIR_Nem_3	402	406	PF02991	0.623
LIG_LIR_Nem_3	455	460	PF02991	0.381
LIG_Pex14_1	137	141	PF04695	0.508
LIG_Pex14_2	30	34	PF04695	0.447
LIG_Pex14_2	428	432	PF04695	0.539
LIG_Pex14_2	457	461	PF04695	0.335
LIG_RPA_C_Fungi	164	176	PF08784	0.601
LIG_SH2_CRK	269	273	PF00017	0.480
LIG_SH2_CRK	373	377	PF00017	0.586
LIG_SH2_CRK	382	386	PF00017	0.593
LIG_SH2_CRK	406	410	PF00017	0.579
LIG_SH2_NCK_1	287	291	PF00017	0.549
LIG_SH2_SRC	273	276	PF00017	0.619
LIG_SH2_SRC	287	290	PF00017	0.610
LIG_SH2_STAP1	179	183	PF00017	0.389
LIG_SH2_STAP1	269	273	PF00017	0.406
LIG_SH2_STAP1	275	279	PF00017	0.564
LIG_SH2_STAP1	462	466	PF00017	0.586
LIG_SH2_STAT3	129	132	PF00017	0.683
LIG_SH2_STAT3	297	300	PF00017	0.648
LIG_SH2_STAT3	333	336	PF00017	0.677
LIG_SH2_STAT5	130	133	PF00017	0.550
LIG_SH2_STAT5	138	141	PF00017	0.507
LIG_SH2_STAT5	222	225	PF00017	0.308
LIG_SH2_STAT5	273	276	PF00017	0.521
LIG_SH2_STAT5	297	300	PF00017	0.537
LIG_SH2_STAT5	333	336	PF00017	0.644
LIG_SH2_STAT5	373	376	PF00017	0.591
LIG_SH2_STAT5	462	465	PF00017	0.500
LIG_SH2_STAT5	50	53	PF00017	0.713
LIG_SH2_STAT5	81	84	PF00017	0.701
LIG_SH3_3	10	16	PF00018	0.686
LIG_SH3_3	180	186	PF00018	0.335
LIG_SH3_3	324	330	PF00018	0.559
LIG_SH3_3	51	57	PF00018	0.649
LIG_SH3_3	90	96	PF00018	0.670
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.434
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.557
LIG_SUMO_SIM_par_1	185	196	PF11976	0.480
LIG_SUMO_SIM_par_1	201	206	PF11976	0.366
LIG_SUMO_SIM_par_1	390	397	PF11976	0.595
LIG_TRFH_1	182	186	PF08558	0.355
LIG_TYR_ITIM	371	376	PF00017	0.605
LIG_TYR_ITIM	460	465	PF00017	0.560
LIG_WRC_WIRS_1	197	202	PF05994	0.480
LIG_WRC_WIRS_1	303	308	PF05994	0.634
LIG_WRC_WIRS_1	31	36	PF05994	0.408
MOD_CDC14_SPxK_1	486	489	PF00782	0.640
MOD_CDK_SPxK_1	483	489	PF00069	0.641
MOD_CDK_SPxxK_3	401	408	PF00069	0.643
MOD_CK1_1	168	174	PF00069	0.626
MOD_CK1_1	196	202	PF00069	0.471
MOD_CK2_1	102	108	PF00069	0.507
MOD_CK2_1	14	20	PF00069	0.701
MOD_CK2_1	189	195	PF00069	0.628
MOD_CK2_1	84	90	PF00069	0.665
MOD_GlcNHglycan	120	123	PF01048	0.610
MOD_GlcNHglycan	156	159	PF01048	0.602
MOD_GlcNHglycan	17	20	PF01048	0.632
MOD_GlcNHglycan	171	174	PF01048	0.172
MOD_GlcNHglycan	217	220	PF01048	0.588
MOD_GlcNHglycan	483	486	PF01048	0.726
MOD_GlcNHglycan	78	81	PF01048	0.655
MOD_GlcNHglycan	82	85	PF01048	0.647
MOD_GSK3_1	165	172	PF00069	0.525
MOD_GSK3_1	189	196	PF00069	0.619
MOD_GSK3_1	273	280	PF00069	0.527
MOD_GSK3_1	387	394	PF00069	0.556
MOD_GSK3_1	39	46	PF00069	0.669
MOD_GSK3_1	479	486	PF00069	0.637
MOD_GSK3_1	76	83	PF00069	0.700
MOD_GSK3_1	98	105	PF00069	0.588
MOD_NEK2_1	100	105	PF00069	0.595
MOD_NEK2_1	107	112	PF00069	0.566
MOD_NEK2_1	154	159	PF00069	0.598
MOD_NEK2_1	188	193	PF00069	0.420
MOD_NEK2_1	203	208	PF00069	0.150
MOD_NEK2_1	220	225	PF00069	0.355
MOD_NEK2_1	30	35	PF00069	0.447
MOD_NEK2_1	338	343	PF00069	0.667
MOD_NEK2_1	381	386	PF00069	0.497
MOD_NEK2_1	424	429	PF00069	0.366
MOD_NEK2_1	434	439	PF00069	0.548
MOD_NEK2_1	488	493	PF00069	0.674
MOD_NEK2_2	39	44	PF00069	0.565
MOD_PIKK_1	246	252	PF00454	0.569
MOD_PIKK_1	84	90	PF00454	0.636
MOD_PKA_2	118	124	PF00069	0.612
MOD_PKA_2	168	174	PF00069	0.653
MOD_PKA_2	43	49	PF00069	0.647
MOD_PKA_2	434	440	PF00069	0.659
MOD_Plk_1	107	113	PF00069	0.694
MOD_Plk_1	424	430	PF00069	0.480
MOD_Plk_2-3	108	114	PF00069	0.653
MOD_Plk_4	282	288	PF00069	0.537
MOD_Plk_4	329	335	PF00069	0.559
MOD_Plk_4	359	365	PF00069	0.555
MOD_Plk_4	424	430	PF00069	0.408
MOD_ProDKin_1	401	407	PF00069	0.636
MOD_ProDKin_1	483	489	PF00069	0.724
MOD_ProDKin_1	50	56	PF00069	0.667
MOD_ProDKin_1	91	97	PF00069	0.644
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.685
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.480
TRG_ENDOCYTIC_2	138	141	PF00928	0.567
TRG_ENDOCYTIC_2	179	182	PF00928	0.408
TRG_ENDOCYTIC_2	269	272	PF00928	0.456
TRG_ENDOCYTIC_2	373	376	PF00928	0.517
TRG_ENDOCYTIC_2	382	385	PF00928	0.442
TRG_ENDOCYTIC_2	406	409	PF00928	0.537
TRG_ENDOCYTIC_2	462	465	PF00928	0.577
TRG_ER_diArg_1	407	410	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y0	Leptomonas seymouri	62%	96%
A0A1X0P8I4	Trypanosomatidae	38%	100%
A0A422P255	Trypanosoma rangeli	37%	100%
A4HNS5	Leishmania braziliensis	80%	100%
A4ICR9	Leishmania infantum	100%	100%
D0A2N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q211	Leishmania major	93%	100%
V5BZX2	Trypanosoma cruzi	38%	100%