Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IIQ7_LEIDO

TriTrypDb:

LdBPK_342820.1 , LdCL_340036300 , LDHU3_34.4820

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A0A3Q8IIQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.491
CLV_MEL_PAP_1	235	241	PF00089	0.455
CLV_NRD_NRD_1	106	108	PF00675	0.710
CLV_NRD_NRD_1	113	115	PF00675	0.595
CLV_NRD_NRD_1	218	220	PF00675	0.466
CLV_NRD_NRD_1	279	281	PF00675	0.601
CLV_NRD_NRD_1	31	33	PF00675	0.627
CLV_NRD_NRD_1	360	362	PF00675	0.479
CLV_NRD_NRD_1	414	416	PF00675	0.422
CLV_PCSK_FUR_1	111	115	PF00082	0.579
CLV_PCSK_KEX2_1	106	108	PF00082	0.674
CLV_PCSK_KEX2_1	113	115	PF00082	0.643
CLV_PCSK_KEX2_1	218	220	PF00082	0.459
CLV_PCSK_KEX2_1	279	281	PF00082	0.523
CLV_PCSK_KEX2_1	31	33	PF00082	0.647
CLV_PCSK_KEX2_1	360	362	PF00082	0.479
CLV_PCSK_PC7_1	356	362	PF00082	0.432
CLV_PCSK_SKI1_1	371	375	PF00082	0.489
DEG_APCC_DBOX_1	355	363	PF00400	0.424
DEG_SCF_FBW7_1	150	156	PF00400	0.661
DOC_CKS1_1	150	155	PF01111	0.721
DOC_MAPK_gen_1	106	112	PF00069	0.533
DOC_MAPK_gen_1	218	229	PF00069	0.415
DOC_MAPK_gen_1	279	285	PF00069	0.490
DOC_MAPK_gen_1	360	367	PF00069	0.448
DOC_MAPK_MEF2A_6	330	338	PF00069	0.453
DOC_PIKK_1	68	76	PF02985	0.607
DOC_USP7_MATH_1	169	173	PF00917	0.698
DOC_WW_Pin1_4	123	128	PF00397	0.610
DOC_WW_Pin1_4	140	145	PF00397	0.601
DOC_WW_Pin1_4	149	154	PF00397	0.729
DOC_WW_Pin1_4	160	165	PF00397	0.601
DOC_WW_Pin1_4	261	266	PF00397	0.583
DOC_WW_Pin1_4	268	273	PF00397	0.605
DOC_WW_Pin1_4	37	42	PF00397	0.571
DOC_WW_Pin1_4	385	390	PF00397	0.472
LIG_14-3-3_CanoR_1	106	112	PF00244	0.524
LIG_14-3-3_CanoR_1	121	129	PF00244	0.469
LIG_14-3-3_CanoR_1	137	145	PF00244	0.558
LIG_14-3-3_CanoR_1	15	22	PF00244	0.543
LIG_14-3-3_CanoR_1	155	164	PF00244	0.548
LIG_14-3-3_CanoR_1	279	283	PF00244	0.578
LIG_14-3-3_CanoR_1	330	334	PF00244	0.420
LIG_14-3-3_CanoR_1	397	402	PF00244	0.499
LIG_14-3-3_CanoR_1	403	407	PF00244	0.417
LIG_Actin_WH2_2	282	298	PF00022	0.551
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_DLG_GKlike_1	397	405	PF00625	0.415
LIG_FHA_1	145	151	PF00498	0.738
LIG_FHA_1	197	203	PF00498	0.578
LIG_FHA_1	286	292	PF00498	0.471
LIG_FHA_1	372	378	PF00498	0.372
LIG_FHA_2	126	132	PF00498	0.630
LIG_FHA_2	137	143	PF00498	0.611
LIG_FHA_2	179	185	PF00498	0.641
LIG_FHA_2	64	70	PF00498	0.584
LIG_FHA_2	79	85	PF00498	0.487
LIG_LIR_Gen_1	10	16	PF02991	0.640
LIG_LIR_Gen_1	281	290	PF02991	0.529
LIG_LIR_Nem_3	10	14	PF02991	0.645
LIG_LIR_Nem_3	281	285	PF02991	0.545
LIG_MYND_1	261	265	PF01753	0.520
LIG_SH2_STAP1	145	149	PF00017	0.566
LIG_SH2_STAP1	300	304	PF00017	0.422
LIG_SH2_STAT3	200	203	PF00017	0.541
LIG_SH2_STAT5	200	203	PF00017	0.492
LIG_SH2_STAT5	220	223	PF00017	0.399
LIG_SH2_STAT5	358	361	PF00017	0.488
LIG_SH3_3	259	265	PF00018	0.741
LIG_SUMO_SIM_par_1	288	294	PF11976	0.593
LIG_SUMO_SIM_par_1	363	368	PF11976	0.431
LIG_SUMO_SIM_par_1	46	53	PF11976	0.595
LIG_TRAF2_1	189	192	PF00917	0.613
LIG_TRAF2_1	81	84	PF00917	0.576
LIG_WRC_WIRS_1	251	256	PF05994	0.549
MOD_CDC14_SPxK_1	276	279	PF00782	0.528
MOD_CDK_SPxK_1	149	155	PF00069	0.570
MOD_CDK_SPxK_1	268	274	PF00069	0.545
MOD_CDK_SPxxK_3	273	280	PF00069	0.617
MOD_CK1_1	123	129	PF00069	0.713
MOD_CK1_1	151	157	PF00069	0.693
MOD_CK1_1	402	408	PF00069	0.370
MOD_CK2_1	178	184	PF00069	0.722
MOD_CK2_1	78	84	PF00069	0.607
MOD_Cter_Amidation	277	280	PF01082	0.574
MOD_GlcNHglycan	157	160	PF01048	0.653
MOD_GlcNHglycan	164	167	PF01048	0.624
MOD_GlcNHglycan	170	174	PF01048	0.613
MOD_GlcNHglycan	231	234	PF01048	0.450
MOD_GlcNHglycan	305	309	PF01048	0.466
MOD_GlcNHglycan	366	370	PF01048	0.485
MOD_GSK3_1	136	143	PF00069	0.642
MOD_GSK3_1	144	151	PF00069	0.620
MOD_GSK3_1	243	250	PF00069	0.597
MOD_GSK3_1	281	288	PF00069	0.542
MOD_GSK3_1	365	372	PF00069	0.347
MOD_GSK3_1	397	404	PF00069	0.436
MOD_GSK3_1	60	67	PF00069	0.621
MOD_GSK3_1	74	81	PF00069	0.516
MOD_N-GLC_1	369	374	PF02516	0.375
MOD_N-GLC_1	74	79	PF02516	0.586
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	14	19	PF00069	0.510
MOD_NEK2_1	247	252	PF00069	0.555
MOD_NEK2_1	338	343	PF00069	0.400
MOD_NEK2_1	365	370	PF00069	0.425
MOD_NEK2_1	384	389	PF00069	0.264
MOD_NEK2_1	401	406	PF00069	0.396
MOD_PIKK_1	1	7	PF00454	0.613
MOD_PIKK_1	86	92	PF00454	0.511
MOD_PKA_2	105	111	PF00069	0.529
MOD_PKA_2	120	126	PF00069	0.459
MOD_PKA_2	136	142	PF00069	0.620
MOD_PKA_2	14	20	PF00069	0.533
MOD_PKA_2	154	160	PF00069	0.565
MOD_PKA_2	229	235	PF00069	0.437
MOD_PKA_2	237	243	PF00069	0.478
MOD_PKA_2	278	284	PF00069	0.501
MOD_PKA_2	329	335	PF00069	0.418
MOD_PKA_2	396	402	PF00069	0.450
MOD_Plk_1	369	375	PF00069	0.377
MOD_Plk_1	74	80	PF00069	0.628
MOD_Plk_1	9	15	PF00069	0.559
MOD_Plk_4	125	131	PF00069	0.563
MOD_Plk_4	196	202	PF00069	0.623
MOD_Plk_4	243	249	PF00069	0.528
MOD_Plk_4	285	291	PF00069	0.496
MOD_Plk_4	329	335	PF00069	0.491
MOD_ProDKin_1	123	129	PF00069	0.613
MOD_ProDKin_1	140	146	PF00069	0.601
MOD_ProDKin_1	149	155	PF00069	0.731
MOD_ProDKin_1	160	166	PF00069	0.600
MOD_ProDKin_1	261	267	PF00069	0.585
MOD_ProDKin_1	268	274	PF00069	0.606
MOD_ProDKin_1	37	43	PF00069	0.567
MOD_ProDKin_1	385	391	PF00069	0.464
TRG_DiLeu_BaEn_4	192	198	PF01217	0.570
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.397
TRG_ER_diArg_1	110	113	PF00400	0.566
TRG_ER_diArg_1	218	220	PF00400	0.453
TRG_ER_diArg_1	30	32	PF00400	0.604
TRG_ER_diArg_1	359	361	PF00400	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBH6	Leptomonas seymouri	44%	100%
A4HB18	Leishmania braziliensis	68%	100%
A4IA75	Leishmania infantum	100%	100%
E9B588	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2P5	Leishmania major	90%	100%