Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIQ6_LEIDO

TriTrypDb:

LdBPK_150890.1 , LdCL_150014400 , LDHU3_15.1140

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.576
CLV_C14_Caspase3-7	570	574	PF00656	0.520
CLV_C14_Caspase3-7	647	651	PF00656	0.739
CLV_C14_Caspase3-7	798	802	PF00656	0.634
CLV_NRD_NRD_1	174	176	PF00675	0.597
CLV_NRD_NRD_1	198	200	PF00675	0.594
CLV_NRD_NRD_1	206	208	PF00675	0.535
CLV_NRD_NRD_1	214	216	PF00675	0.545
CLV_NRD_NRD_1	278	280	PF00675	0.698
CLV_NRD_NRD_1	391	393	PF00675	0.607
CLV_NRD_NRD_1	478	480	PF00675	0.659
CLV_NRD_NRD_1	53	55	PF00675	0.739
CLV_NRD_NRD_1	542	544	PF00675	0.527
CLV_PCSK_KEX2_1	174	176	PF00082	0.584
CLV_PCSK_KEX2_1	206	208	PF00082	0.555
CLV_PCSK_KEX2_1	216	218	PF00082	0.625
CLV_PCSK_KEX2_1	278	280	PF00082	0.698
CLV_PCSK_KEX2_1	478	480	PF00082	0.659
CLV_PCSK_KEX2_1	52	54	PF00082	0.737
CLV_PCSK_KEX2_1	542	544	PF00082	0.535
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.573
CLV_PCSK_SKI1_1	199	203	PF00082	0.537
CLV_PCSK_SKI1_1	338	342	PF00082	0.627
CLV_PCSK_SKI1_1	405	409	PF00082	0.578
CLV_PCSK_SKI1_1	469	473	PF00082	0.650
CLV_PCSK_SKI1_1	593	597	PF00082	0.651
CLV_PCSK_SKI1_1	610	614	PF00082	0.669
CLV_PCSK_SKI1_1	624	628	PF00082	0.665
CLV_PCSK_SKI1_1	820	824	PF00082	0.579
DEG_APCC_DBOX_1	198	206	PF00400	0.662
DEG_APCC_DBOX_1	337	345	PF00400	0.680
DEG_SCF_FBW7_1	245	251	PF00400	0.756
DEG_SPOP_SBC_1	236	240	PF00917	0.681
DEG_SPOP_SBC_1	7	11	PF00917	0.762
DOC_CKS1_1	245	250	PF01111	0.756
DOC_CKS1_1	805	810	PF01111	0.652
DOC_CYCLIN_RxL_1	196	203	PF00134	0.551
DOC_CYCLIN_RxL_1	402	412	PF00134	0.515
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.523
DOC_MAPK_gen_1	768	775	PF00069	0.749
DOC_PP1_RVXF_1	643	649	PF00149	0.736
DOC_PP2B_LxvP_1	30	33	PF13499	0.699
DOC_PP2B_LxvP_1	633	636	PF13499	0.723
DOC_PP2B_LxvP_1	741	744	PF13499	0.670
DOC_PP4_FxxP_1	665	668	PF00568	0.727
DOC_USP7_MATH_1	108	112	PF00917	0.704
DOC_USP7_MATH_1	190	194	PF00917	0.609
DOC_USP7_MATH_1	248	252	PF00917	0.776
DOC_USP7_MATH_1	305	309	PF00917	0.764
DOC_USP7_MATH_1	314	318	PF00917	0.672
DOC_USP7_MATH_1	409	413	PF00917	0.578
DOC_USP7_MATH_1	481	485	PF00917	0.568
DOC_USP7_MATH_1	58	62	PF00917	0.771
DOC_USP7_MATH_1	628	632	PF00917	0.717
DOC_USP7_MATH_1	637	641	PF00917	0.595
DOC_USP7_MATH_1	64	68	PF00917	0.636
DOC_USP7_MATH_1	666	670	PF00917	0.697
DOC_USP7_MATH_1	675	679	PF00917	0.674
DOC_USP7_MATH_1	683	687	PF00917	0.636
DOC_USP7_MATH_1	7	11	PF00917	0.743
DOC_USP7_MATH_1	727	731	PF00917	0.727
DOC_USP7_MATH_1	774	778	PF00917	0.599
DOC_USP7_MATH_2	113	119	PF00917	0.753
DOC_USP7_UBL2_3	200	204	PF12436	0.660
DOC_WW_Pin1_4	13	18	PF00397	0.728
DOC_WW_Pin1_4	239	244	PF00397	0.810
DOC_WW_Pin1_4	291	296	PF00397	0.737
DOC_WW_Pin1_4	394	399	PF00397	0.769
DOC_WW_Pin1_4	435	440	PF00397	0.610
DOC_WW_Pin1_4	60	65	PF00397	0.846
DOC_WW_Pin1_4	638	643	PF00397	0.666
DOC_WW_Pin1_4	671	676	PF00397	0.705
DOC_WW_Pin1_4	679	684	PF00397	0.719
DOC_WW_Pin1_4	70	75	PF00397	0.524
DOC_WW_Pin1_4	783	788	PF00397	0.716
DOC_WW_Pin1_4	804	809	PF00397	0.643
LIG_14-3-3_CanoR_1	104	113	PF00244	0.604
LIG_14-3-3_CanoR_1	134	139	PF00244	0.587
LIG_14-3-3_CanoR_1	326	330	PF00244	0.644
LIG_14-3-3_CanoR_1	346	350	PF00244	0.618
LIG_14-3-3_CanoR_1	363	373	PF00244	0.508
LIG_14-3-3_CanoR_1	392	401	PF00244	0.697
LIG_14-3-3_CanoR_1	528	534	PF00244	0.590
LIG_14-3-3_CanoR_1	59	64	PF00244	0.782
LIG_14-3-3_CanoR_1	645	649	PF00244	0.740
LIG_14-3-3_CanoR_1	655	662	PF00244	0.605
LIG_14-3-3_CanoR_1	677	682	PF00244	0.728
LIG_14-3-3_CanoR_1	68	76	PF00244	0.575
LIG_14-3-3_CanoR_1	793	800	PF00244	0.721
LIG_APCC_ABBAyCdc20_2	469	475	PF00400	0.663
LIG_BIR_III_4	20	24	PF00653	0.826
LIG_CaM_IQ_9	470	485	PF13499	0.485
LIG_EVH1_2	32	36	PF00568	0.703
LIG_FHA_1	196	202	PF00498	0.538
LIG_FHA_1	240	246	PF00498	0.753
LIG_FHA_1	260	266	PF00498	0.757
LIG_FHA_1	269	275	PF00498	0.675
LIG_FHA_1	376	382	PF00498	0.642
LIG_FHA_1	700	706	PF00498	0.632
LIG_FHA_2	245	251	PF00498	0.718
LIG_FHA_2	318	324	PF00498	0.594
LIG_FHA_2	365	371	PF00498	0.649
LIG_FHA_2	594	600	PF00498	0.662
LIG_FHA_2	645	651	PF00498	0.739
LIG_FHA_2	655	661	PF00498	0.608
LIG_FHA_2	796	802	PF00498	0.595
LIG_LIR_Apic_2	663	668	PF02991	0.777
LIG_LIR_Apic_2	786	791	PF02991	0.751
LIG_LIR_Gen_1	147	154	PF02991	0.563
LIG_LIR_LC3C_4	631	635	PF02991	0.592
LIG_LIR_Nem_3	147	152	PF02991	0.572
LIG_LIR_Nem_3	352	356	PF02991	0.501
LIG_LIR_Nem_3	816	822	PF02991	0.573
LIG_Pex14_1	183	187	PF04695	0.665
LIG_Pex14_1	815	819	PF04695	0.582
LIG_RPA_C_Fungi	177	189	PF08784	0.584
LIG_SH2_CRK	353	357	PF00017	0.501
LIG_SH2_STAT3	160	163	PF00017	0.548
LIG_SH3_3	26	32	PF00018	0.704
LIG_SH3_3	271	277	PF00018	0.712
LIG_SH3_3	370	376	PF00018	0.815
LIG_SH3_3	631	637	PF00018	0.623
LIG_SH3_3	719	725	PF00018	0.739
LIG_SH3_3	732	738	PF00018	0.660
LIG_SH3_3	802	808	PF00018	0.663
LIG_SUMO_SIM_anti_2	584	590	PF11976	0.558
LIG_SUMO_SIM_anti_2	730	736	PF11976	0.577
LIG_SUMO_SIM_par_1	150	156	PF11976	0.546
LIG_SUMO_SIM_par_1	406	412	PF11976	0.620
LIG_TRAF2_1	518	521	PF00917	0.543
LIG_TRAF2_1	814	817	PF00917	0.567
LIG_UBA3_1	201	210	PF00899	0.650
MOD_CDC14_SPxK_1	674	677	PF00782	0.807
MOD_CDK_SPxK_1	671	677	PF00069	0.710
MOD_CDK_SPxxK_3	638	645	PF00069	0.628
MOD_CDK_SPxxK_3	804	811	PF00069	0.635
MOD_CK1_1	107	113	PF00069	0.773
MOD_CK1_1	13	19	PF00069	0.738
MOD_CK1_1	193	199	PF00069	0.661
MOD_CK1_1	229	235	PF00069	0.753
MOD_CK1_1	238	244	PF00069	0.704
MOD_CK1_1	259	265	PF00069	0.753
MOD_CK1_1	317	323	PF00069	0.709
MOD_CK1_1	325	331	PF00069	0.556
MOD_CK1_1	345	351	PF00069	0.693
MOD_CK1_1	362	368	PF00069	0.530
MOD_CK1_1	397	403	PF00069	0.667
MOD_CK1_1	433	439	PF00069	0.770
MOD_CK1_1	6	12	PF00069	0.734
MOD_CK1_1	66	72	PF00069	0.803
MOD_CK1_1	684	690	PF00069	0.703
MOD_CK1_1	712	718	PF00069	0.711
MOD_CK2_1	317	323	PF00069	0.596
MOD_CK2_1	409	415	PF00069	0.631
MOD_CK2_1	542	548	PF00069	0.537
MOD_CK2_1	593	599	PF00069	0.651
MOD_Cter_Amidation	390	393	PF01082	0.567
MOD_GlcNHglycan	10	13	PF01048	0.807
MOD_GlcNHglycan	106	109	PF01048	0.626
MOD_GlcNHglycan	110	113	PF01048	0.676
MOD_GlcNHglycan	142	145	PF01048	0.631
MOD_GlcNHglycan	232	235	PF01048	0.792
MOD_GlcNHglycan	250	253	PF01048	0.753
MOD_GlcNHglycan	309	312	PF01048	0.810
MOD_GlcNHglycan	411	414	PF01048	0.696
MOD_GlcNHglycan	432	435	PF01048	0.722
MOD_GlcNHglycan	457	460	PF01048	0.774
MOD_GlcNHglycan	483	486	PF01048	0.665
MOD_GlcNHglycan	5	8	PF01048	0.771
MOD_GlcNHglycan	544	547	PF01048	0.529
MOD_GlcNHglycan	630	633	PF01048	0.654
MOD_GlcNHglycan	662	665	PF01048	0.809
MOD_GlcNHglycan	712	715	PF01048	0.773
MOD_GlcNHglycan	718	721	PF01048	0.751
MOD_GlcNHglycan	725	728	PF01048	0.784
MOD_GlcNHglycan	762	767	PF01048	0.834
MOD_GlcNHglycan	77	80	PF01048	0.828
MOD_GlcNHglycan	94	97	PF01048	0.747
MOD_GSK3_1	104	111	PF00069	0.788
MOD_GSK3_1	191	198	PF00069	0.592
MOD_GSK3_1	226	233	PF00069	0.749
MOD_GSK3_1	235	242	PF00069	0.702
MOD_GSK3_1	244	251	PF00069	0.598
MOD_GSK3_1	287	294	PF00069	0.680
MOD_GSK3_1	3	10	PF00069	0.730
MOD_GSK3_1	314	321	PF00069	0.703
MOD_GSK3_1	392	399	PF00069	0.680
MOD_GSK3_1	429	436	PF00069	0.670
MOD_GSK3_1	538	545	PF00069	0.647
MOD_GSK3_1	59	66	PF00069	0.793
MOD_GSK3_1	624	631	PF00069	0.722
MOD_GSK3_1	667	674	PF00069	0.721
MOD_GSK3_1	675	682	PF00069	0.698
MOD_GSK3_1	708	715	PF00069	0.812
MOD_GSK3_1	723	730	PF00069	0.604
MOD_GSK3_1	789	796	PF00069	0.704
MOD_LATS_1	102	108	PF00433	0.612
MOD_LATS_1	57	63	PF00433	0.771
MOD_N-GLC_1	243	248	PF02516	0.649
MOD_N-GLC_1	287	292	PF02516	0.693
MOD_N-GLC_1	359	364	PF02516	0.649
MOD_N-GLC_1	502	507	PF02516	0.511
MOD_N-GLC_1	593	598	PF02516	0.653
MOD_N-GLC_1	92	97	PF02516	0.703
MOD_NEK2_1	344	349	PF00069	0.447
MOD_NEK2_1	386	391	PF00069	0.628
MOD_NEK2_1	430	435	PF00069	0.705
MOD_NEK2_1	526	531	PF00069	0.648
MOD_NEK2_1	581	586	PF00069	0.568
MOD_NEK2_1	710	715	PF00069	0.763
MOD_PIKK_1	502	508	PF00454	0.513
MOD_PIKK_1	581	587	PF00454	0.515
MOD_PKA_1	392	398	PF00069	0.581
MOD_PKA_1	542	548	PF00069	0.537
MOD_PKA_2	229	235	PF00069	0.769
MOD_PKA_2	325	331	PF00069	0.641
MOD_PKA_2	345	351	PF00069	0.658
MOD_PKA_2	362	368	PF00069	0.524
MOD_PKA_2	529	535	PF00069	0.576
MOD_PKA_2	542	548	PF00069	0.558
MOD_PKA_2	58	64	PF00069	0.772
MOD_PKA_2	644	650	PF00069	0.760
MOD_PKA_2	654	660	PF00069	0.607
MOD_PKA_2	67	73	PF00069	0.550
MOD_PKB_1	390	398	PF00069	0.574
MOD_Plk_1	287	293	PF00069	0.697
MOD_Plk_1	502	508	PF00069	0.513
MOD_Plk_4	287	293	PF00069	0.658
MOD_Plk_4	345	351	PF00069	0.618
MOD_Plk_4	416	422	PF00069	0.613
MOD_Plk_4	548	554	PF00069	0.548
MOD_Plk_4	728	734	PF00069	0.711
MOD_Plk_4	736	742	PF00069	0.667
MOD_ProDKin_1	13	19	PF00069	0.726
MOD_ProDKin_1	239	245	PF00069	0.811
MOD_ProDKin_1	291	297	PF00069	0.736
MOD_ProDKin_1	394	400	PF00069	0.768
MOD_ProDKin_1	435	441	PF00069	0.612
MOD_ProDKin_1	60	66	PF00069	0.846
MOD_ProDKin_1	638	644	PF00069	0.667
MOD_ProDKin_1	671	677	PF00069	0.710
MOD_ProDKin_1	679	685	PF00069	0.714
MOD_ProDKin_1	70	76	PF00069	0.527
MOD_ProDKin_1	783	789	PF00069	0.717
MOD_ProDKin_1	804	810	PF00069	0.638
MOD_SUMO_for_1	507	510	PF00179	0.659
MOD_SUMO_for_1	568	571	PF00179	0.555
MOD_SUMO_rev_2	619	626	PF00179	0.724
TRG_DiLeu_BaEn_1	287	292	PF01217	0.746
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.528
TRG_ENDOCYTIC_2	149	152	PF00928	0.562
TRG_ENDOCYTIC_2	353	356	PF00928	0.498
TRG_ER_diArg_1	161	164	PF00400	0.552
TRG_ER_diArg_1	173	175	PF00400	0.563
TRG_ER_diArg_1	205	207	PF00400	0.559
TRG_ER_diArg_1	214	217	PF00400	0.615
TRG_ER_diArg_1	277	279	PF00400	0.702
TRG_ER_diArg_1	52	54	PF00400	0.727
TRG_NLS_Bipartite_1	199	219	PF00514	0.619
TRG_NLS_MonoExtN_4	214	219	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C2	Leptomonas seymouri	32%	89%
A4H856	Leishmania braziliensis	54%	97%
A4HWI1	Leishmania infantum	99%	100%
E9AQ82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
Q4QFA0	Leishmania major	87%	100%