Pre-RNA processing PIH1/Nop17, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIQ5_LEIDO

TriTrypDb:

LdBPK_354400.1 , LdCL_350049100 , LDHU3_35.5820

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.652
CLV_C14_Caspase3-7	358	362	PF00656	0.482
CLV_NRD_NRD_1	181	183	PF00675	0.336
CLV_NRD_NRD_1	349	351	PF00675	0.338
CLV_NRD_NRD_1	411	413	PF00675	0.248
CLV_NRD_NRD_1	468	470	PF00675	0.519
CLV_NRD_NRD_1	480	482	PF00675	0.388
CLV_NRD_NRD_1	520	522	PF00675	0.482
CLV_NRD_NRD_1	557	559	PF00675	0.587
CLV_PCSK_KEX2_1	181	183	PF00082	0.360
CLV_PCSK_KEX2_1	311	313	PF00082	0.598
CLV_PCSK_KEX2_1	349	351	PF00082	0.300
CLV_PCSK_KEX2_1	468	470	PF00082	0.569
CLV_PCSK_KEX2_1	480	482	PF00082	0.604
CLV_PCSK_KEX2_1	50	52	PF00082	0.508
CLV_PCSK_KEX2_1	520	522	PF00082	0.484
CLV_PCSK_KEX2_1	599	601	PF00082	0.729
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.598
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.596
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.639
CLV_PCSK_PC7_1	345	351	PF00082	0.336
CLV_PCSK_SKI1_1	297	301	PF00082	0.505
CLV_PCSK_SKI1_1	438	442	PF00082	0.580
CLV_PCSK_SKI1_1	629	633	PF00082	0.533
CLV_PCSK_SKI1_1	68	72	PF00082	0.298
DEG_APCC_KENBOX_2	319	323	PF00400	0.355
DEG_Kelch_Keap1_1	372	377	PF01344	0.401
DEG_Nend_UBRbox_3	1	3	PF02207	0.548
DOC_CYCLIN_RxL_1	626	635	PF00134	0.516
DOC_MAPK_gen_1	157	166	PF00069	0.427
DOC_MAPK_gen_1	409	419	PF00069	0.471
DOC_MAPK_MEF2A_6	412	421	PF00069	0.453
DOC_MAPK_RevD_3	334	350	PF00069	0.536
DOC_PP1_RVXF_1	204	211	PF00149	0.536
DOC_PP2B_LxvP_1	331	334	PF13499	0.498
DOC_PP4_FxxP_1	87	90	PF00568	0.545
DOC_USP7_MATH_1	23	27	PF00917	0.400
DOC_USP7_MATH_1	242	246	PF00917	0.741
DOC_USP7_MATH_1	273	277	PF00917	0.667
DOC_USP7_MATH_1	295	299	PF00917	0.467
DOC_USP7_MATH_1	369	373	PF00917	0.479
DOC_USP7_MATH_1	489	493	PF00917	0.457
DOC_USP7_MATH_1	594	598	PF00917	0.739
DOC_USP7_UBL2_3	211	215	PF12436	0.461
DOC_USP7_UBL2_3	409	413	PF12436	0.442
DOC_WW_Pin1_4	281	286	PF00397	0.652
DOC_WW_Pin1_4	387	392	PF00397	0.555
DOC_WW_Pin1_4	570	575	PF00397	0.763
DOC_WW_Pin1_4	582	587	PF00397	0.762
LIG_14-3-3_CanoR_1	140	150	PF00244	0.536
LIG_14-3-3_CanoR_1	412	417	PF00244	0.484
LIG_14-3-3_CanoR_1	480	484	PF00244	0.426
LIG_14-3-3_CanoR_1	600	609	PF00244	0.544
LIG_Clathr_ClatBox_1	631	635	PF01394	0.517
LIG_DLG_GKlike_1	412	419	PF00625	0.496
LIG_FHA_1	285	291	PF00498	0.684
LIG_FHA_1	328	334	PF00498	0.525
LIG_FHA_1	412	418	PF00498	0.555
LIG_FHA_1	579	585	PF00498	0.640
LIG_FHA_2	269	275	PF00498	0.647
LIG_FHA_2	336	342	PF00498	0.473
LIG_FHA_2	358	364	PF00498	0.418
LIG_FHA_2	432	438	PF00498	0.578
LIG_FHA_2	439	445	PF00498	0.526
LIG_FHA_2	614	620	PF00498	0.551
LIG_GBD_Chelix_1	543	551	PF00786	0.334
LIG_IBAR_NPY_1	316	318	PF08397	0.434
LIG_KLC1_Yacidic_2	352	357	PF13176	0.473
LIG_LIR_Apic_2	136	142	PF02991	0.442
LIG_LIR_Gen_1	14	24	PF02991	0.466
LIG_LIR_Gen_1	390	400	PF02991	0.538
LIG_LIR_Nem_3	14	19	PF02991	0.468
LIG_LIR_Nem_3	177	183	PF02991	0.442
LIG_LIR_Nem_3	203	208	PF02991	0.547
LIG_LIR_Nem_3	390	395	PF02991	0.538
LIG_Pex14_2	16	20	PF04695	0.385
LIG_PTB_Apo_2	10	17	PF02174	0.409
LIG_PTB_Apo_2	204	211	PF02174	0.455
LIG_PTB_Apo_2	313	320	PF02174	0.460
LIG_SH2_CRK	139	143	PF00017	0.536
LIG_SH2_CRK	162	166	PF00017	0.442
LIG_SH2_SRC	332	335	PF00017	0.526
LIG_SH2_STAP1	162	166	PF00017	0.457
LIG_SH2_STAP1	305	309	PF00017	0.543
LIG_SH2_STAT5	318	321	PF00017	0.454
LIG_SH2_STAT5	332	335	PF00017	0.442
LIG_SH2_STAT5	355	358	PF00017	0.442
LIG_SH2_STAT5	410	413	PF00017	0.536
LIG_SH2_STAT5	483	486	PF00017	0.418
LIG_SH2_STAT5	546	549	PF00017	0.411
LIG_SH2_STAT5	630	633	PF00017	0.504
LIG_SH3_3	262	268	PF00018	0.660
LIG_SH3_3	420	426	PF00018	0.444
LIG_TRAF2_1	454	457	PF00917	0.514
LIG_UBA3_1	416	420	PF00899	0.322
MOD_CK1_1	196	202	PF00069	0.373
MOD_CK1_1	250	256	PF00069	0.738
MOD_CK1_1	276	282	PF00069	0.633
MOD_CK1_1	372	378	PF00069	0.249
MOD_CK1_1	387	393	PF00069	0.276
MOD_CK1_1	572	578	PF00069	0.720
MOD_CK1_1	582	588	PF00069	0.589
MOD_CK1_1	602	608	PF00069	0.648
MOD_CK2_1	335	341	PF00069	0.279
MOD_CK2_1	357	363	PF00069	0.246
MOD_CK2_1	39	45	PF00069	0.525
MOD_CK2_1	438	444	PF00069	0.592
MOD_CK2_1	479	485	PF00069	0.443
MOD_CK2_1	613	619	PF00069	0.643
MOD_GlcNHglycan	244	247	PF01048	0.629
MOD_GlcNHglycan	25	28	PF01048	0.600
MOD_GlcNHglycan	274	278	PF01048	0.796
MOD_GlcNHglycan	371	374	PF01048	0.448
MOD_GlcNHglycan	381	384	PF01048	0.324
MOD_GlcNHglycan	386	389	PF01048	0.309
MOD_GlcNHglycan	487	490	PF01048	0.571
MOD_GlcNHglycan	491	494	PF01048	0.600
MOD_GlcNHglycan	560	563	PF01048	0.710
MOD_GlcNHglycan	581	584	PF01048	0.716
MOD_GSK3_1	238	245	PF00069	0.705
MOD_GSK3_1	273	280	PF00069	0.686
MOD_GSK3_1	387	394	PF00069	0.416
MOD_GSK3_1	485	492	PF00069	0.575
MOD_GSK3_1	566	573	PF00069	0.778
MOD_GSK3_1	578	585	PF00069	0.738
MOD_LATS_1	310	316	PF00433	0.527
MOD_N-GLC_1	485	490	PF02516	0.543
MOD_N-GLC_2	109	111	PF02516	0.279
MOD_NEK2_1	327	332	PF00069	0.343
MOD_NEK2_1	39	44	PF00069	0.654
MOD_NEK2_1	612	617	PF00069	0.641
MOD_NEK2_2	335	340	PF00069	0.355
MOD_PIKK_1	247	253	PF00454	0.713
MOD_PIKK_1	426	432	PF00454	0.630
MOD_PIKK_1	602	608	PF00454	0.779
MOD_PIKK_1	613	619	PF00454	0.613
MOD_PK_1	524	530	PF00069	0.482
MOD_PKA_1	412	418	PF00069	0.382
MOD_PKA_1	558	564	PF00069	0.617
MOD_PKA_1	599	605	PF00069	0.549
MOD_PKA_2	221	227	PF00069	0.279
MOD_PKA_2	411	417	PF00069	0.318
MOD_PKA_2	479	485	PF00069	0.428
MOD_PKA_2	599	605	PF00069	0.549
MOD_PKB_1	220	228	PF00069	0.275
MOD_PKB_1	556	564	PF00069	0.602
MOD_Plk_1	485	491	PF00069	0.551
MOD_Plk_2-3	357	363	PF00069	0.371
MOD_Plk_2-3	479	485	PF00069	0.447
MOD_Plk_2-3	549	555	PF00069	0.536
MOD_Plk_4	412	418	PF00069	0.355
MOD_ProDKin_1	281	287	PF00069	0.653
MOD_ProDKin_1	387	393	PF00069	0.438
MOD_ProDKin_1	570	576	PF00069	0.762
MOD_ProDKin_1	582	588	PF00069	0.763
MOD_SUMO_for_1	290	293	PF00179	0.618
MOD_SUMO_for_1	49	52	PF00179	0.600
MOD_SUMO_for_1	563	566	PF00179	0.639
MOD_SUMO_rev_2	402	411	PF00179	0.357
TRG_DiLeu_BaEn_2	178	184	PF01217	0.322
TRG_ENDOCYTIC_2	162	165	PF00928	0.298
TRG_ER_diArg_1	180	182	PF00400	0.410
TRG_ER_diArg_1	220	223	PF00400	0.279
TRG_ER_diArg_1	349	351	PF00400	0.351
TRG_ER_diArg_1	520	523	PF00400	0.487
TRG_ER_diArg_1	555	558	PF00400	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6F3	Leptomonas seymouri	62%	100%
A0A1X0P509	Trypanosomatidae	46%	100%
A0A422NU93	Trypanosoma rangeli	47%	100%
A4HNA2	Leishmania braziliensis	80%	100%
A4IBX3	Leishmania infantum	99%	100%
C9ZYN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AFR0	Leishmania major	94%	100%
E9B6W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
V5BT79	Trypanosoma cruzi	47%	100%