Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IIP6_LEIDO

TriTrypDb:

LdBPK_354210.1 , LdCL_350047200 , LDHU3_35.5430

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IIP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.717
CLV_NRD_NRD_1	142	144	PF00675	0.443
CLV_NRD_NRD_1	214	216	PF00675	0.530
CLV_NRD_NRD_1	219	221	PF00675	0.498
CLV_NRD_NRD_1	293	295	PF00675	0.517
CLV_PCSK_KEX2_1	142	144	PF00082	0.392
CLV_PCSK_KEX2_1	214	216	PF00082	0.447
CLV_PCSK_KEX2_1	293	295	PF00082	0.517
CLV_PCSK_SKI1_1	167	171	PF00082	0.406
CLV_PCSK_SKI1_1	214	218	PF00082	0.440
CLV_PCSK_SKI1_1	89	93	PF00082	0.339
DEG_APCC_DBOX_1	166	174	PF00400	0.587
DEG_APCC_DBOX_1	228	236	PF00400	0.723
DEG_APCC_DBOX_1	298	306	PF00400	0.612
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DOC_CDC14_PxL_1	96	104	PF14671	0.491
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.589
DOC_MAPK_DCC_7	54	64	PF00069	0.646
DOC_MAPK_gen_1	142	149	PF00069	0.624
DOC_MAPK_MEF2A_6	142	149	PF00069	0.594
DOC_MAPK_MEF2A_6	50	59	PF00069	0.657
DOC_PP1_RVXF_1	87	93	PF00149	0.339
DOC_PP2B_LxvP_1	111	114	PF13499	0.477
DOC_PP2B_LxvP_1	97	100	PF13499	0.690
DOC_USP7_MATH_1	208	212	PF00917	0.616
DOC_USP7_MATH_1	216	220	PF00917	0.675
DOC_USP7_MATH_1	250	254	PF00917	0.678
DOC_USP7_MATH_1	256	260	PF00917	0.634
DOC_WW_Pin1_4	122	127	PF00397	0.730
DOC_WW_Pin1_4	39	44	PF00397	0.677
LIG_14-3-3_CanoR_1	134	139	PF00244	0.684
LIG_14-3-3_CanoR_1	192	196	PF00244	0.619
LIG_14-3-3_CanoR_1	29	34	PF00244	0.641
LIG_APCC_ABBA_1	82	87	PF00400	0.339
LIG_BRCT_BRCA1_1	171	175	PF00533	0.632
LIG_BRCT_BRCA1_1	302	306	PF00533	0.628
LIG_deltaCOP1_diTrp_1	80	85	PF00928	0.385
LIG_FHA_1	126	132	PF00498	0.677
LIG_FHA_1	133	139	PF00498	0.605
LIG_FHA_1	181	187	PF00498	0.578
LIG_FHA_1	208	214	PF00498	0.670
LIG_FHA_1	249	255	PF00498	0.723
LIG_FHA_1	287	293	PF00498	0.703
LIG_FHA_1	29	35	PF00498	0.748
LIG_FHA_1	68	74	PF00498	0.442
LIG_FHA_2	261	267	PF00498	0.713
LIG_FHA_2	51	57	PF00498	0.681
LIG_LIR_Apic_2	95	101	PF02991	0.481
LIG_LIR_Gen_1	106	116	PF02991	0.596
LIG_LIR_Gen_1	19	26	PF02991	0.279
LIG_LIR_Gen_1	194	199	PF02991	0.586
LIG_LIR_Nem_3	106	111	PF02991	0.596
LIG_LIR_Nem_3	11	15	PF02991	0.314
LIG_LIR_Nem_3	19	23	PF02991	0.322
LIG_LIR_Nem_3	194	198	PF02991	0.589
LIG_LIR_Nem_3	80	85	PF02991	0.295
LIG_Pex14_1	81	85	PF04695	0.466
LIG_SH2_CRK	108	112	PF00017	0.479
LIG_SH2_CRK	195	199	PF00017	0.612
LIG_SH2_CRK	94	98	PF00017	0.339
LIG_SH2_NCK_1	195	199	PF00017	0.586
LIG_SH2_SRC	98	101	PF00017	0.647
LIG_SH2_STAP1	108	112	PF00017	0.479
LIG_SH2_STAP1	195	199	PF00017	0.572
LIG_SH2_STAP1	20	24	PF00017	0.283
LIG_SH2_STAP1	94	98	PF00017	0.339
LIG_SH2_STAT5	15	18	PF00017	0.344
LIG_SH2_STAT5	154	157	PF00017	0.672
LIG_SH2_STAT5	94	97	PF00017	0.339
LIG_SH3_3	35	41	PF00018	0.634
LIG_SUMO_SIM_par_1	6	11	PF11976	0.466
LIG_SUMO_SIM_par_1	64	70	PF11976	0.339
LIG_TRAF2_1	103	106	PF00917	0.597
LIG_WRC_WIRS_1	9	14	PF05994	0.387
MOD_CDK_SPxxK_3	122	129	PF00069	0.720
MOD_CK1_1	125	131	PF00069	0.615
MOD_CK1_1	258	264	PF00069	0.712
MOD_CK1_1	42	48	PF00069	0.797
MOD_CK2_1	216	222	PF00069	0.570
MOD_CK2_1	276	282	PF00069	0.724
MOD_CK2_1	50	56	PF00069	0.690
MOD_GlcNHglycan	189	192	PF01048	0.561
MOD_GlcNHglycan	224	229	PF01048	0.473
MOD_GlcNHglycan	244	247	PF01048	0.501
MOD_GlcNHglycan	278	281	PF01048	0.598
MOD_GlcNHglycan	282	285	PF01048	0.474
MOD_GlcNHglycan	302	305	PF01048	0.425
MOD_GSK3_1	180	187	PF00069	0.622
MOD_GSK3_1	250	257	PF00069	0.670
MOD_GSK3_1	276	283	PF00069	0.693
MOD_GSK3_1	28	35	PF00069	0.659
MOD_N-GLC_1	152	157	PF02516	0.445
MOD_NEK2_1	1	6	PF00069	0.459
MOD_NEK2_1	16	21	PF00069	0.383
MOD_NEK2_1	180	185	PF00069	0.594
MOD_NEK2_1	254	259	PF00069	0.659
MOD_NEK2_1	260	265	PF00069	0.685
MOD_NEK2_1	268	273	PF00069	0.737
MOD_NEK2_1	67	72	PF00069	0.508
MOD_NEK2_1	8	13	PF00069	0.313
MOD_NEK2_1	92	97	PF00069	0.339
MOD_PKA_2	187	193	PF00069	0.684
MOD_PKA_2	28	34	PF00069	0.648
MOD_Plk_1	155	161	PF00069	0.613
MOD_Plk_4	134	140	PF00069	0.658
MOD_Plk_4	250	256	PF00069	0.655
MOD_Plk_4	29	35	PF00069	0.724
MOD_Plk_4	72	78	PF00069	0.466
MOD_Plk_4	8	14	PF00069	0.401
MOD_Plk_4	92	98	PF00069	0.183
MOD_ProDKin_1	122	128	PF00069	0.728
MOD_ProDKin_1	39	45	PF00069	0.680
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.594
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.454
TRG_ENDOCYTIC_2	108	111	PF00928	0.485
TRG_ENDOCYTIC_2	15	18	PF00928	0.344
TRG_ENDOCYTIC_2	195	198	PF00928	0.588
TRG_ENDOCYTIC_2	20	23	PF00928	0.340
TRG_ENDOCYTIC_2	94	97	PF00928	0.339
TRG_ER_diArg_1	141	143	PF00400	0.590
TRG_ER_diArg_1	213	215	PF00400	0.728
TRG_ER_diArg_1	292	294	PF00400	0.722
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X0	Leptomonas seymouri	54%	99%
A4HN86	Leishmania braziliensis	62%	100%
A4IBV4	Leishmania infantum	99%	100%
E9AFP1	Leishmania major	85%	100%
E9B6U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%