Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IIP4_LEIDO

TriTrypDb:

LdBPK_150660.1 , LdCL_150011700 , LDHU3_15.0820

Length:

956

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.692
CLV_C14_Caspase3-7	239	243	PF00656	0.773
CLV_C14_Caspase3-7	468	472	PF00656	0.726
CLV_NRD_NRD_1	135	137	PF00675	0.781
CLV_NRD_NRD_1	174	176	PF00675	0.727
CLV_NRD_NRD_1	308	310	PF00675	0.655
CLV_NRD_NRD_1	694	696	PF00675	0.604
CLV_NRD_NRD_1	871	873	PF00675	0.744
CLV_PCSK_FUR_1	868	872	PF00082	0.767
CLV_PCSK_KEX2_1	135	137	PF00082	0.684
CLV_PCSK_KEX2_1	174	176	PF00082	0.731
CLV_PCSK_KEX2_1	307	309	PF00082	0.586
CLV_PCSK_KEX2_1	694	696	PF00082	0.604
CLV_PCSK_KEX2_1	870	872	PF00082	0.813
CLV_PCSK_SKI1_1	231	235	PF00082	0.701
CLV_PCSK_SKI1_1	297	301	PF00082	0.627
CLV_PCSK_SKI1_1	369	373	PF00082	0.769
CLV_PCSK_SKI1_1	819	823	PF00082	0.635
CLV_PCSK_SKI1_1	938	942	PF00082	0.704
DEG_Nend_UBRbox_2	1	3	PF02207	0.802
DEG_SPOP_SBC_1	114	118	PF00917	0.607
DEG_SPOP_SBC_1	13	17	PF00917	0.735
DEG_SPOP_SBC_1	288	292	PF00917	0.833
DEG_SPOP_SBC_1	463	467	PF00917	0.771
DEG_SPOP_SBC_1	60	64	PF00917	0.694
DOC_CKS1_1	266	271	PF01111	0.632
DOC_CKS1_1	610	615	PF01111	0.716
DOC_CKS1_1	653	658	PF01111	0.695
DOC_USP7_MATH_1	114	118	PF00917	0.772
DOC_USP7_MATH_1	236	240	PF00917	0.776
DOC_USP7_MATH_1	243	247	PF00917	0.698
DOC_USP7_MATH_1	280	284	PF00917	0.733
DOC_USP7_MATH_1	286	290	PF00917	0.722
DOC_USP7_MATH_1	314	318	PF00917	0.698
DOC_USP7_MATH_1	343	347	PF00917	0.798
DOC_USP7_MATH_1	462	466	PF00917	0.852
DOC_USP7_MATH_1	48	52	PF00917	0.817
DOC_USP7_MATH_1	585	589	PF00917	0.741
DOC_USP7_MATH_1	60	64	PF00917	0.653
DOC_USP7_MATH_1	743	747	PF00917	0.636
DOC_USP7_MATH_1	823	827	PF00917	0.787
DOC_USP7_MATH_1	830	834	PF00917	0.778
DOC_USP7_MATH_1	845	849	PF00917	0.683
DOC_USP7_MATH_1	889	893	PF00917	0.724
DOC_USP7_MATH_1	9	13	PF00917	0.824
DOC_USP7_MATH_1	92	96	PF00917	0.834
DOC_USP7_MATH_1	947	951	PF00917	0.737
DOC_USP7_MATH_2	171	177	PF00917	0.629
DOC_WW_Pin1_4	100	105	PF00397	0.728
DOC_WW_Pin1_4	106	111	PF00397	0.738
DOC_WW_Pin1_4	14	19	PF00397	0.814
DOC_WW_Pin1_4	265	270	PF00397	0.632
DOC_WW_Pin1_4	282	287	PF00397	0.590
DOC_WW_Pin1_4	418	423	PF00397	0.838
DOC_WW_Pin1_4	457	462	PF00397	0.758
DOC_WW_Pin1_4	569	574	PF00397	0.647
DOC_WW_Pin1_4	588	593	PF00397	0.688
DOC_WW_Pin1_4	609	614	PF00397	0.717
DOC_WW_Pin1_4	649	654	PF00397	0.717
DOC_WW_Pin1_4	75	80	PF00397	0.776
DOC_WW_Pin1_4	915	920	PF00397	0.723
LIG_14-3-3_CanoR_1	112	120	PF00244	0.585
LIG_14-3-3_CanoR_1	174	183	PF00244	0.749
LIG_14-3-3_CanoR_1	297	304	PF00244	0.664
LIG_14-3-3_CanoR_1	307	313	PF00244	0.562
LIG_14-3-3_CanoR_1	316	325	PF00244	0.475
LIG_14-3-3_CanoR_1	351	360	PF00244	0.634
LIG_14-3-3_CanoR_1	750	760	PF00244	0.806
LIG_14-3-3_CanoR_1	896	901	PF00244	0.803
LIG_14-3-3_CanoR_1	912	919	PF00244	0.702
LIG_AP2alpha_2	928	930	PF02296	0.684
LIG_APCC_ABBA_1	187	192	PF00400	0.629
LIG_BIR_III_2	166	170	PF00653	0.767
LIG_BRCT_BRCA1_1	229	233	PF00533	0.717
LIG_BRCT_BRCA1_1	645	649	PF00533	0.645
LIG_CSL_BTD_1	582	585	PF09270	0.818
LIG_DLG_GKlike_1	643	650	PF00625	0.645
LIG_eIF4E_1	229	235	PF01652	0.698
LIG_FHA_1	34	40	PF00498	0.814
LIG_FHA_1	458	464	PF00498	0.761
LIG_FHA_1	491	497	PF00498	0.713
LIG_FHA_1	755	761	PF00498	0.693
LIG_FHA_1	79	85	PF00498	0.824
LIG_FHA_1	795	801	PF00498	0.740
LIG_FHA_1	806	812	PF00498	0.643
LIG_FHA_1	847	853	PF00498	0.741
LIG_FHA_1	939	945	PF00498	0.803
LIG_FHA_2	266	272	PF00498	0.634
LIG_FHA_2	298	304	PF00498	0.647
LIG_FHA_2	370	376	PF00498	0.746
LIG_FHA_2	466	472	PF00498	0.730
LIG_FHA_2	858	864	PF00498	0.747
LIG_FHA_2	916	922	PF00498	0.714
LIG_GBD_Chelix_1	688	696	PF00786	0.599
LIG_LIR_Apic_2	254	258	PF02991	0.698
LIG_LIR_Gen_1	26	35	PF02991	0.750
LIG_LIR_Gen_1	578	585	PF02991	0.720
LIG_LIR_Nem_3	26	32	PF02991	0.709
LIG_LIR_Nem_3	513	517	PF02991	0.683
LIG_LIR_Nem_3	578	584	PF02991	0.722
LIG_LIR_Nem_3	67	71	PF02991	0.807
LIG_LIR_Nem_3	927	933	PF02991	0.678
LIG_NRBOX	413	419	PF00104	0.725
LIG_SH2_GRB2like	630	633	PF00017	0.741
LIG_SH2_NCK_1	697	701	PF00017	0.653
LIG_SH2_PTP2	255	258	PF00017	0.700
LIG_SH2_SRC	255	258	PF00017	0.700
LIG_SH2_STAP1	630	634	PF00017	0.739
LIG_SH2_STAP1	88	92	PF00017	0.720
LIG_SH2_STAT3	144	147	PF00017	0.718
LIG_SH2_STAT5	255	258	PF00017	0.700
LIG_SH2_STAT5	29	32	PF00017	0.740
LIG_SH2_STAT5	452	455	PF00017	0.753
LIG_SH2_STAT5	88	91	PF00017	0.722
LIG_SH2_STAT5	924	927	PF00017	0.707
LIG_SH3_1	768	774	PF00018	0.721
LIG_SH3_1	788	794	PF00018	0.512
LIG_SH3_3	322	328	PF00018	0.784
LIG_SH3_3	451	457	PF00018	0.756
LIG_SH3_3	607	613	PF00018	0.801
LIG_SH3_3	650	656	PF00018	0.771
LIG_SH3_3	73	79	PF00018	0.815
LIG_SH3_3	768	774	PF00018	0.726
LIG_SH3_3	788	794	PF00018	0.691
LIG_SH3_3	81	87	PF00018	0.695
LIG_SH3_3	835	841	PF00018	0.754
LIG_TRAF2_1	372	375	PF00917	0.637
LIG_TRAF2_1	918	921	PF00917	0.709
LIG_WRC_WIRS_1	605	610	PF05994	0.811
MOD_CDC14_SPxK_1	109	112	PF00782	0.735
MOD_CDK_SPK_2	100	105	PF00069	0.809
MOD_CDK_SPK_2	265	270	PF00069	0.632
MOD_CDK_SPK_2	588	593	PF00069	0.749
MOD_CDK_SPxK_1	106	112	PF00069	0.748
MOD_CDK_SPxxK_3	100	107	PF00069	0.787
MOD_CK1_1	103	109	PF00069	0.712
MOD_CK1_1	116	122	PF00069	0.685
MOD_CK1_1	12	18	PF00069	0.712
MOD_CK1_1	20	26	PF00069	0.720
MOD_CK1_1	278	284	PF00069	0.741
MOD_CK1_1	289	295	PF00069	0.726
MOD_CK1_1	346	352	PF00069	0.741
MOD_CK1_1	355	361	PF00069	0.658
MOD_CK1_1	41	47	PF00069	0.791
MOD_CK1_1	465	471	PF00069	0.856
MOD_CK1_1	507	513	PF00069	0.688
MOD_CK1_1	51	57	PF00069	0.668
MOD_CK1_1	588	594	PF00069	0.709
MOD_CK1_1	620	626	PF00069	0.713
MOD_CK1_1	64	70	PF00069	0.641
MOD_CK1_1	641	647	PF00069	0.795
MOD_CK1_1	652	658	PF00069	0.672
MOD_CK1_1	78	84	PF00069	0.678
MOD_CK1_1	832	838	PF00069	0.795
MOD_CK2_1	265	271	PF00069	0.631
MOD_CK2_1	297	303	PF00069	0.657
MOD_CK2_1	369	375	PF00069	0.658
MOD_CK2_1	857	863	PF00069	0.745
MOD_CK2_1	915	921	PF00069	0.720
MOD_Cter_Amidation	868	871	PF01082	0.766
MOD_GlcNHglycan	11	14	PF01048	0.791
MOD_GlcNHglycan	238	241	PF01048	0.759
MOD_GlcNHglycan	242	246	PF01048	0.728
MOD_GlcNHglycan	357	360	PF01048	0.729
MOD_GlcNHglycan	426	429	PF01048	0.763
MOD_GlcNHglycan	431	434	PF01048	0.714
MOD_GlcNHglycan	436	439	PF01048	0.701
MOD_GlcNHglycan	443	446	PF01048	0.656
MOD_GlcNHglycan	45	48	PF01048	0.793
MOD_GlcNHglycan	488	491	PF01048	0.655
MOD_GlcNHglycan	53	56	PF01048	0.734
MOD_GlcNHglycan	561	564	PF01048	0.797
MOD_GlcNHglycan	619	622	PF01048	0.734
MOD_GlcNHglycan	63	66	PF01048	0.587
MOD_GlcNHglycan	643	646	PF01048	0.784
MOD_GlcNHglycan	698	701	PF01048	0.634
MOD_GlcNHglycan	754	757	PF01048	0.702
MOD_GlcNHglycan	764	767	PF01048	0.672
MOD_GlcNHglycan	812	815	PF01048	0.769
MOD_GlcNHglycan	832	835	PF01048	0.832
MOD_GlcNHglycan	863	867	PF01048	0.806
MOD_GlcNHglycan	891	894	PF01048	0.767
MOD_GSK3_1	114	121	PF00069	0.783
MOD_GSK3_1	17	24	PF00069	0.710
MOD_GSK3_1	223	230	PF00069	0.800
MOD_GSK3_1	278	285	PF00069	0.763
MOD_GSK3_1	288	295	PF00069	0.682
MOD_GSK3_1	308	315	PF00069	0.504
MOD_GSK3_1	316	323	PF00069	0.639
MOD_GSK3_1	33	40	PF00069	0.804
MOD_GSK3_1	342	349	PF00069	0.719
MOD_GSK3_1	441	448	PF00069	0.785
MOD_GSK3_1	486	493	PF00069	0.649
MOD_GSK3_1	49	56	PF00069	0.776
MOD_GSK3_1	506	513	PF00069	0.568
MOD_GSK3_1	569	576	PF00069	0.715
MOD_GSK3_1	584	591	PF00069	0.719
MOD_GSK3_1	60	67	PF00069	0.663
MOD_GSK3_1	620	627	PF00069	0.794
MOD_GSK3_1	641	648	PF00069	0.719
MOD_GSK3_1	729	736	PF00069	0.717
MOD_GSK3_1	739	746	PF00069	0.774
MOD_GSK3_1	819	826	PF00069	0.711
MOD_GSK3_1	830	837	PF00069	0.744
MOD_GSK3_1	9	16	PF00069	0.745
MOD_GSK3_1	907	914	PF00069	0.816
MOD_GSK3_1	924	931	PF00069	0.650
MOD_GSK3_1	943	950	PF00069	0.725
MOD_GSK3_1	99	106	PF00069	0.777
MOD_LATS_1	827	833	PF00433	0.635
MOD_N-GLC_1	352	357	PF02516	0.735
MOD_N-GLC_1	42	47	PF02516	0.732
MOD_N-GLC_1	424	429	PF02516	0.814
MOD_N-GLC_1	473	478	PF02516	0.662
MOD_N-GLC_1	559	564	PF02516	0.738
MOD_N-GLC_1	588	593	PF02516	0.714
MOD_N-GLC_1	857	862	PF02516	0.727
MOD_N-GLC_2	911	913	PF02516	0.749
MOD_NEK2_1	120	125	PF00069	0.681
MOD_NEK2_1	234	239	PF00069	0.707
MOD_NEK2_1	287	292	PF00069	0.795
MOD_NEK2_1	506	511	PF00069	0.816
MOD_NEK2_1	525	530	PF00069	0.504
MOD_NEK2_1	559	564	PF00069	0.742
MOD_NEK2_1	635	640	PF00069	0.753
MOD_NEK2_1	737	742	PF00069	0.710
MOD_PIKK_1	17	23	PF00454	0.811
MOD_PIKK_1	275	281	PF00454	0.798
MOD_PIKK_1	316	322	PF00454	0.797
MOD_PIKK_1	445	451	PF00454	0.705
MOD_PIKK_1	660	666	PF00454	0.739
MOD_PIKK_1	92	98	PF00454	0.735
MOD_PKA_1	174	180	PF00069	0.726
MOD_PKA_1	308	314	PF00069	0.761
MOD_PKA_2	173	179	PF00069	0.732
MOD_PKA_2	308	314	PF00069	0.761
MOD_PKA_2	520	526	PF00069	0.820
MOD_PKA_2	749	755	PF00069	0.722
MOD_PKA_2	895	901	PF00069	0.756
MOD_PKA_2	911	917	PF00069	0.748
MOD_PKB_1	870	878	PF00069	0.765
MOD_Plk_1	273	279	PF00069	0.849
MOD_Plk_1	34	40	PF00069	0.721
MOD_Plk_1	507	513	PF00069	0.691
MOD_Plk_4	224	230	PF00069	0.703
MOD_Plk_4	251	257	PF00069	0.710
MOD_Plk_4	320	326	PF00069	0.679
MOD_Plk_4	34	40	PF00069	0.814
MOD_Plk_4	413	419	PF00069	0.725
MOD_Plk_4	645	651	PF00069	0.729
MOD_Plk_4	733	739	PF00069	0.787
MOD_Plk_4	743	749	PF00069	0.671
MOD_Plk_4	834	840	PF00069	0.759
MOD_ProDKin_1	100	106	PF00069	0.730
MOD_ProDKin_1	14	20	PF00069	0.812
MOD_ProDKin_1	265	271	PF00069	0.631
MOD_ProDKin_1	282	288	PF00069	0.589
MOD_ProDKin_1	418	424	PF00069	0.837
MOD_ProDKin_1	457	463	PF00069	0.758
MOD_ProDKin_1	569	575	PF00069	0.647
MOD_ProDKin_1	588	594	PF00069	0.689
MOD_ProDKin_1	609	615	PF00069	0.719
MOD_ProDKin_1	649	655	PF00069	0.713
MOD_ProDKin_1	75	81	PF00069	0.778
MOD_ProDKin_1	915	921	PF00069	0.720
MOD_SUMO_rev_2	916	925	PF00179	0.713
TRG_DiLeu_BaEn_1	375	380	PF01217	0.538
TRG_DiLeu_BaEn_1	684	689	PF01217	0.674
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.695
TRG_ENDOCYTIC_2	29	32	PF00928	0.721
TRG_ENDOCYTIC_2	68	71	PF00928	0.815
TRG_ER_diArg_1	307	309	PF00400	0.744
TRG_ER_diArg_1	694	696	PF00400	0.704
TRG_ER_diArg_1	767	770	PF00400	0.697
TRG_ER_diArg_1	868	871	PF00400	0.827
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ58	Leptomonas seymouri	33%	100%
A4H836	Leishmania braziliensis	62%	97%
A4HWG1	Leishmania infantum	99%	100%
E9AQ61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	96%
Q4QFC2	Leishmania major	89%	100%