IPP_transferase/Zinc-finger_of_C2H2_type_putative /Pfam:PF01715/Pfam:PF12874

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

IPP transferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIN6_LEIDO

TriTrypDb:

LdBPK_290980.1 , LdCL_290015000 , LDHU3_29.1350

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIN6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006400	tRNA modification	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008033	tRNA processing	8	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	1
GO:0052381	tRNA dimethylallyltransferase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.609
CLV_NRD_NRD_1	12	14	PF00675	0.423
CLV_NRD_NRD_1	190	192	PF00675	0.559
CLV_NRD_NRD_1	210	212	PF00675	0.633
CLV_NRD_NRD_1	34	36	PF00675	0.343
CLV_NRD_NRD_1	80	82	PF00675	0.366
CLV_PCSK_KEX2_1	12	14	PF00082	0.415
CLV_PCSK_KEX2_1	183	185	PF00082	0.346
CLV_PCSK_KEX2_1	190	192	PF00082	0.559
CLV_PCSK_KEX2_1	210	212	PF00082	0.626
CLV_PCSK_KEX2_1	80	82	PF00082	0.366
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.346
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.685
CLV_PCSK_PC7_1	186	192	PF00082	0.544
CLV_PCSK_SKI1_1	191	195	PF00082	0.581
CLV_PCSK_SKI1_1	20	24	PF00082	0.259
CLV_PCSK_SKI1_1	3	7	PF00082	0.507
DEG_APCC_DBOX_1	185	193	PF00400	0.537
DEG_APCC_DBOX_1	19	27	PF00400	0.398
DEG_Nend_UBRbox_2	1	3	PF02207	0.391
DOC_CYCLIN_RxL_1	88	101	PF00134	0.627
DOC_MAPK_gen_1	12	18	PF00069	0.509
DOC_MAPK_gen_1	161	170	PF00069	0.323
DOC_MAPK_MEF2A_6	173	180	PF00069	0.531
DOC_PP2B_LxvP_1	206	209	PF13499	0.608
DOC_USP7_MATH_1	121	125	PF00917	0.622
DOC_USP7_MATH_1	38	42	PF00917	0.399
DOC_USP7_UBL2_3	32	36	PF12436	0.507
DOC_WW_Pin1_4	133	138	PF00397	0.558
LIG_14-3-3_CterR_2	211	215	PF00244	0.673
LIG_Actin_WH2_2	19	34	PF00022	0.463
LIG_BIR_III_2	120	124	PF00653	0.460
LIG_BRCT_BRCA1_1	51	55	PF00533	0.509
LIG_FHA_1	106	112	PF00498	0.542
LIG_FHA_1	133	139	PF00498	0.536
LIG_Integrin_isoDGR_2	33	35	PF01839	0.323
LIG_LIR_Gen_1	108	115	PF02991	0.587
LIG_LIR_Gen_1	50	55	PF02991	0.509
LIG_LIR_Nem_3	108	113	PF02991	0.586
LIG_LIR_Nem_3	50	54	PF02991	0.411
LIG_MLH1_MIPbox_1	51	55	PF16413	0.509
LIG_PCNA_PIPBox_1	126	135	PF02747	0.598
LIG_PCNA_TLS_4	3	10	PF02747	0.439
LIG_Pex14_2	110	114	PF04695	0.666
LIG_Pex14_2	51	55	PF04695	0.411
LIG_Rb_LxCxE_1	41	64	PF01857	0.411
LIG_SH2_STAT3	82	85	PF00017	0.352
LIG_SH3_3	134	140	PF00018	0.612
LIG_UBA3_1	145	149	PF00899	0.693
LIG_WRC_WIRS_1	129	134	PF05994	0.600
MOD_CK1_1	61	67	PF00069	0.391
MOD_CK2_1	156	162	PF00069	0.622
MOD_CK2_1	63	69	PF00069	0.419
MOD_CK2_1	99	105	PF00069	0.598
MOD_Cter_Amidation	33	36	PF01082	0.323
MOD_GlcNHglycan	42	45	PF01048	0.371
MOD_GSK3_1	121	128	PF00069	0.590
MOD_GSK3_1	49	56	PF00069	0.442
MOD_GSK3_1	58	65	PF00069	0.369
MOD_NEK2_1	132	137	PF00069	0.580
MOD_NEK2_1	141	146	PF00069	0.618
MOD_NEK2_1	97	102	PF00069	0.541
MOD_PIKK_1	156	162	PF00454	0.640
MOD_PIKK_1	49	55	PF00454	0.453
MOD_PKA_2	185	191	PF00069	0.532
MOD_Plk_1	49	55	PF00069	0.411
MOD_Plk_4	128	134	PF00069	0.594
MOD_Plk_4	141	147	PF00069	0.584
MOD_Plk_4	58	64	PF00069	0.439
MOD_ProDKin_1	133	139	PF00069	0.561
MOD_SUMO_rev_2	156	165	PF00179	0.559
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.411
TRG_ER_diArg_1	12	14	PF00400	0.419
TRG_ER_diArg_1	189	191	PF00400	0.552
TRG_ER_diArg_1	80	82	PF00400	0.411
TRG_ER_diLys_1	210	215	PF00400	0.806
TRG_NES_CRM1_1	4	19	PF08389	0.439
TRG_NLS_MonoCore_2	209	214	PF00514	0.688
TRG_NLS_MonoExtN_4	181	187	PF00514	0.546
TRG_NLS_MonoExtN_4	207	214	PF00514	0.674
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI4	Leptomonas seymouri	56%	100%
A4HHA1	Leishmania braziliensis	80%	100%
A4I4E7	Leishmania infantum	100%	100%
E9ADU7	Leishmania major	94%	100%
E9ALY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%