LeishMANIAdb
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Eukaryotic translation initiation factor 3 subunit L

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Eukaryotic translation initiation factor 3 subunit L
Gene product:
eukaryotic translation initiation factor 3 subunit l
Species:
Leishmania donovani
UniProt:
A0A3Q8IIN0_LEIDO
TriTrypDb:
LdBPK_360270.1 , LdCL_360007700 , LDHU3_36.0390
Length:
544

Annotations

Annotations by Jardim et al.

Translation, Eukaryotic translation initiation factor 3 subunit L

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005852 eukaryotic translation initiation factor 3 complex 2 12
GO:0016282 eukaryotic 43S preinitiation complex 4 6
GO:0032991 protein-containing complex 1 12
GO:0033290 eukaryotic 48S preinitiation complex 4 6
GO:0070993 translation preinitiation complex 3 6
GO:1990904 ribonucleoprotein complex 2 6
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Phosphorylation

Amastigote: 535, 536

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IIN0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIN0

Function

Biological processes
Term Name Level Count
GO:0001732 formation of cytoplasmic translation initiation complex 7 6
GO:0009987 cellular process 1 6
GO:0016043 cellular component organization 3 6
GO:0022607 cellular component assembly 4 6
GO:0022618 ribonucleoprotein complex assembly 6 6
GO:0043933 protein-containing complex organization 4 6
GO:0065003 protein-containing complex assembly 5 6
GO:0071826 ribonucleoprotein complex subunit organization 5 6
GO:0071840 cellular component organization or biogenesis 2 6
GO:0006413 translational initiation 3 1
GO:0008152 metabolic process 1 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 162 166 PF00656 0.415
CLV_C14_Caspase3-7 27 31 PF00656 0.485
CLV_C14_Caspase3-7 302 306 PF00656 0.521
CLV_MEL_PAP_1 229 235 PF00089 0.215
CLV_NRD_NRD_1 262 264 PF00675 0.223
CLV_NRD_NRD_1 272 274 PF00675 0.299
CLV_NRD_NRD_1 28 30 PF00675 0.486
CLV_NRD_NRD_1 306 308 PF00675 0.204
CLV_NRD_NRD_1 363 365 PF00675 0.215
CLV_NRD_NRD_1 472 474 PF00675 0.441
CLV_NRD_NRD_1 488 490 PF00675 0.454
CLV_NRD_NRD_1 496 498 PF00675 0.513
CLV_PCSK_KEX2_1 262 264 PF00082 0.223
CLV_PCSK_KEX2_1 272 274 PF00082 0.299
CLV_PCSK_KEX2_1 28 30 PF00082 0.486
CLV_PCSK_KEX2_1 363 365 PF00082 0.215
CLV_PCSK_KEX2_1 472 474 PF00082 0.460
CLV_PCSK_KEX2_1 487 489 PF00082 0.462
CLV_PCSK_KEX2_1 495 497 PF00082 0.511
CLV_PCSK_PC1ET2_1 472 474 PF00082 0.556
CLV_PCSK_PC1ET2_1 487 489 PF00082 0.554
CLV_PCSK_PC1ET2_1 495 497 PF00082 0.722
CLV_PCSK_PC7_1 24 30 PF00082 0.459
CLV_PCSK_PC7_1 492 498 PF00082 0.650
CLV_PCSK_SKI1_1 227 231 PF00082 0.220
CLV_PCSK_SKI1_1 263 267 PF00082 0.215
CLV_PCSK_SKI1_1 328 332 PF00082 0.241
CLV_PCSK_SKI1_1 337 341 PF00082 0.195
CLV_PCSK_SKI1_1 88 92 PF00082 0.261
DEG_APCC_DBOX_1 226 234 PF00400 0.415
DEG_SPOP_SBC_1 426 430 PF00917 0.415
DOC_CYCLIN_RxL_1 85 93 PF00134 0.271
DOC_CYCLIN_yClb5_NLxxxL_5 295 304 PF00134 0.415
DOC_CYCLIN_yClb5_NLxxxL_5 386 393 PF00134 0.415
DOC_MAPK_gen_1 200 207 PF00069 0.487
DOC_MAPK_gen_1 262 269 PF00069 0.457
DOC_MAPK_MEF2A_6 200 207 PF00069 0.476
DOC_MAPK_MEF2A_6 262 269 PF00069 0.415
DOC_MAPK_MEF2A_6 58 65 PF00069 0.403
DOC_PP2B_LxvP_1 339 342 PF13499 0.404
DOC_USP7_MATH_1 154 158 PF00917 0.525
DOC_USP7_MATH_1 533 537 PF00917 0.520
DOC_USP7_UBL2_3 456 460 PF12436 0.549
DOC_WW_Pin1_4 231 236 PF00397 0.514
DOC_WW_Pin1_4 332 337 PF00397 0.395
DOC_WW_Pin1_4 344 349 PF00397 0.395
LIG_14-3-3_CanoR_1 262 268 PF00244 0.446
LIG_Actin_WH2_2 446 461 PF00022 0.554
LIG_AP2alpha_1 327 331 PF02296 0.450
LIG_BIR_II_1 1 5 PF00653 0.616
LIG_BIR_III_4 101 105 PF00653 0.420
LIG_BRCT_BRCA1_1 257 261 PF00533 0.416
LIG_BRCT_BRCA1_1 334 338 PF00533 0.395
LIG_BRCT_BRCA1_1 429 433 PF00533 0.467
LIG_BRCT_BRCA1_1 446 450 PF00533 0.501
LIG_BRCT_BRCA1_1 535 539 PF00533 0.554
LIG_BRCT_BRCA1_1 68 72 PF00533 0.359
LIG_BRCT_BRCA1_1 82 86 PF00533 0.325
LIG_BRCT_BRCA1_2 82 88 PF00533 0.389
LIG_Clathr_ClatBox_1 393 397 PF01394 0.499
LIG_FHA_1 145 151 PF00498 0.447
LIG_FHA_1 186 192 PF00498 0.481
LIG_FHA_1 264 270 PF00498 0.499
LIG_FHA_1 299 305 PF00498 0.415
LIG_FHA_1 417 423 PF00498 0.481
LIG_FHA_1 533 539 PF00498 0.689
LIG_FHA_2 1 7 PF00498 0.494
LIG_FHA_2 106 112 PF00498 0.571
LIG_FHA_2 213 219 PF00498 0.415
LIG_FHA_2 319 325 PF00498 0.457
LIG_FHA_2 390 396 PF00498 0.421
LIG_FHA_2 462 468 PF00498 0.509
LIG_Integrin_isoDGR_2 270 272 PF01839 0.299
LIG_LIR_Apic_2 118 122 PF02991 0.499
LIG_LIR_Apic_2 148 154 PF02991 0.499
LIG_LIR_Gen_1 108 116 PF02991 0.424
LIG_LIR_Gen_1 128 137 PF02991 0.451
LIG_LIR_Gen_1 138 146 PF02991 0.465
LIG_LIR_Gen_1 14 22 PF02991 0.294
LIG_LIR_Gen_1 192 203 PF02991 0.565
LIG_LIR_Gen_1 209 219 PF02991 0.390
LIG_LIR_Gen_1 247 254 PF02991 0.404
LIG_LIR_Gen_1 281 292 PF02991 0.404
LIG_LIR_Gen_1 335 343 PF02991 0.395
LIG_LIR_Gen_1 39 50 PF02991 0.399
LIG_LIR_Gen_1 430 437 PF02991 0.499
LIG_LIR_Gen_1 79 90 PF02991 0.314
LIG_LIR_Nem_3 103 109 PF02991 0.254
LIG_LIR_Nem_3 128 133 PF02991 0.462
LIG_LIR_Nem_3 138 144 PF02991 0.465
LIG_LIR_Nem_3 14 19 PF02991 0.293
LIG_LIR_Nem_3 192 198 PF02991 0.536
LIG_LIR_Nem_3 209 214 PF02991 0.431
LIG_LIR_Nem_3 239 244 PF02991 0.410
LIG_LIR_Nem_3 247 251 PF02991 0.379
LIG_LIR_Nem_3 281 287 PF02991 0.449
LIG_LIR_Nem_3 324 330 PF02991 0.399
LIG_LIR_Nem_3 335 341 PF02991 0.394
LIG_LIR_Nem_3 39 45 PF02991 0.317
LIG_LIR_Nem_3 397 403 PF02991 0.457
LIG_LIR_Nem_3 430 436 PF02991 0.493
LIG_LIR_Nem_3 447 453 PF02991 0.374
LIG_LIR_Nem_3 59 63 PF02991 0.471
LIG_LIR_Nem_3 79 85 PF02991 0.271
LIG_NRBOX 202 208 PF00104 0.457
LIG_NRBOX 389 395 PF00104 0.499
LIG_PCNA_yPIPBox_3 166 174 PF02747 0.415
LIG_PCNA_yPIPBox_3 200 211 PF02747 0.427
LIG_Pex14_2 327 331 PF04695 0.401
LIG_REV1ctd_RIR_1 16 24 PF16727 0.314
LIG_SH2_CRK 141 145 PF00017 0.499
LIG_SH2_CRK 195 199 PF00017 0.560
LIG_SH2_CRK 211 215 PF00017 0.404
LIG_SH2_CRK 284 288 PF00017 0.457
LIG_SH2_CRK 400 404 PF00017 0.532
LIG_SH2_CRK 82 86 PF00017 0.240
LIG_SH2_GRB2like 382 385 PF00017 0.499
LIG_SH2_NCK_1 119 123 PF00017 0.499
LIG_SH2_NCK_1 195 199 PF00017 0.499
LIG_SH2_SRC 195 198 PF00017 0.415
LIG_SH2_SRC 303 306 PF00017 0.415
LIG_SH2_STAP1 109 113 PF00017 0.499
LIG_SH2_STAP1 38 42 PF00017 0.304
LIG_SH2_STAP1 82 86 PF00017 0.383
LIG_SH2_STAT3 38 41 PF00017 0.329
LIG_SH2_STAT3 524 527 PF00017 0.509
LIG_SH2_STAT5 248 251 PF00017 0.402
LIG_SH2_STAT5 286 289 PF00017 0.499
LIG_SH2_STAT5 303 306 PF00017 0.499
LIG_SH2_STAT5 378 381 PF00017 0.415
LIG_SH3_3 170 176 PF00018 0.400
LIG_SH3_3 94 100 PF00018 0.579
LIG_SUMO_SIM_anti_2 439 447 PF11976 0.434
LIG_SUMO_SIM_par_1 391 398 PF11976 0.401
LIG_TYR_ITIM 139 144 PF00017 0.499
LIG_TYR_ITIM 80 85 PF00017 0.322
LIG_UBA3_1 112 117 PF00899 0.415
LIG_UBA3_1 169 174 PF00899 0.499
LIG_UBA3_1 372 380 PF00899 0.499
LIG_UBA3_1 403 407 PF00899 0.415
LIG_UBA3_1 457 462 PF00899 0.417
LIG_WRC_WIRS_1 81 86 PF05994 0.249
MOD_CDC14_SPxK_1 347 350 PF00782 0.487
MOD_CDK_SPK_2 332 337 PF00069 0.395
MOD_CDK_SPxK_1 344 350 PF00069 0.487
MOD_CK1_1 212 218 PF00069 0.498
MOD_CK1_1 318 324 PF00069 0.471
MOD_CK1_1 344 350 PF00069 0.466
MOD_CK2_1 105 111 PF00069 0.481
MOD_CK2_1 212 218 PF00069 0.513
MOD_CK2_1 318 324 PF00069 0.426
MOD_CK2_1 389 395 PF00069 0.421
MOD_CK2_1 426 432 PF00069 0.415
MOD_CMANNOS 124 127 PF00535 0.204
MOD_Cter_Amidation 270 273 PF01082 0.299
MOD_GlcNHglycan 191 194 PF01048 0.273
MOD_GlcNHglycan 211 214 PF01048 0.186
MOD_GlcNHglycan 512 515 PF01048 0.739
MOD_GSK3_1 185 192 PF00069 0.499
MOD_GSK3_1 299 306 PF00069 0.509
MOD_GSK3_1 337 344 PF00069 0.499
MOD_N-GLC_1 298 303 PF02516 0.204
MOD_N-GLC_1 475 480 PF02516 0.440
MOD_N-GLC_1 93 98 PF02516 0.345
MOD_NEK2_1 37 42 PF00069 0.411
MOD_NEK2_1 389 394 PF00069 0.396
MOD_NEK2_1 475 480 PF00069 0.440
MOD_NEK2_1 80 85 PF00069 0.415
MOD_NEK2_2 236 241 PF00069 0.457
MOD_PIKK_1 37 43 PF00454 0.340
MOD_PIKK_1 461 467 PF00454 0.465
MOD_PKA_1 272 278 PF00069 0.404
MOD_PKA_2 272 278 PF00069 0.492
MOD_PKA_2 315 321 PF00069 0.499
MOD_Plk_1 154 160 PF00069 0.443
MOD_Plk_1 164 170 PF00069 0.457
MOD_Plk_1 298 304 PF00069 0.461
MOD_Plk_1 93 99 PF00069 0.467
MOD_Plk_4 135 141 PF00069 0.408
MOD_Plk_4 236 242 PF00069 0.400
MOD_Plk_4 299 305 PF00069 0.416
MOD_Plk_4 389 395 PF00069 0.404
MOD_Plk_4 80 86 PF00069 0.249
MOD_ProDKin_1 231 237 PF00069 0.514
MOD_ProDKin_1 332 338 PF00069 0.395
MOD_ProDKin_1 344 350 PF00069 0.395
TRG_DiLeu_BaEn_1 155 160 PF01217 0.432
TRG_DiLeu_BaLyEn_6 165 170 PF01217 0.400
TRG_DiLeu_LyEn_5 155 160 PF01217 0.499
TRG_ENDOCYTIC_2 109 112 PF00928 0.499
TRG_ENDOCYTIC_2 141 144 PF00928 0.499
TRG_ENDOCYTIC_2 16 19 PF00928 0.304
TRG_ENDOCYTIC_2 195 198 PF00928 0.573
TRG_ENDOCYTIC_2 211 214 PF00928 0.472
TRG_ENDOCYTIC_2 248 251 PF00928 0.405
TRG_ENDOCYTIC_2 284 287 PF00928 0.467
TRG_ENDOCYTIC_2 378 381 PF00928 0.415
TRG_ENDOCYTIC_2 400 403 PF00928 0.532
TRG_ENDOCYTIC_2 82 85 PF00928 0.287
TRG_ENDOCYTIC_2 87 90 PF00928 0.334
TRG_ER_diArg_1 261 263 PF00400 0.423
TRG_ER_diArg_1 272 274 PF00400 0.439
TRG_ER_diArg_1 362 364 PF00400 0.415
TRG_ER_diArg_1 408 411 PF00400 0.434
TRG_ER_diArg_1 496 498 PF00400 0.605
TRG_NES_CRM1_1 128 142 PF08389 0.404
TRG_NES_CRM1_1 371 383 PF08389 0.418
TRG_NLS_MonoExtN_4 492 499 PF00514 0.654
TRG_Pf-PMV_PEXEL_1 158 162 PF00026 0.299
TRG_Pf-PMV_PEXEL_1 411 416 PF00026 0.204

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDA7 Leptomonas seymouri 79% 100%
A0A0S4KNQ8 Bodo saltans 35% 100%
A0A1X0P8D7 Trypanosomatidae 53% 100%
A0A3R7KQY4 Trypanosoma rangeli 53% 100%
A1C690 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 23% 100%
A1DGW6 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 23% 100%
A2R7S7 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 23% 100%
A4HNN3 Leishmania braziliensis 97% 100%
A4ICW2 Leishmania infantum 100% 100%
A5A6M4 Pan troglodytes 25% 96%
A7SDW5 Nematostella vectensis 24% 100%
A8PHP4 Brugia malayi 22% 99%
A8X419 Caenorhabditis briggsae 24% 100%
A9VCY6 Monosiga brevicollis 24% 100%
B0WR18 Culex quinquefasciatus 22% 100%
B0XS74 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 23% 100%
B3M7W0 Drosophila ananassae 23% 100%
B3NH71 Drosophila erecta 23% 100%
B4GR63 Drosophila persimilis 24% 100%
B4HFJ3 Drosophila sechellia 23% 100%
B4IWN1 Drosophila grimshawi 23% 100%
B4KZ45 Drosophila mojavensis 23% 100%
B4LEJ0 Drosophila virilis 23% 100%
B4MX71 Drosophila willistoni 23% 100%
B4PG99 Drosophila yakuba 23% 100%
B4QR64 Drosophila simulans 23% 100%
D0A2I7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ASE2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
P0CN56 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 23% 86%
P0CN57 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 23% 86%
Q0CPA8 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 23% 100%
Q16FL6 Aedes aegypti 23% 100%
Q2M0S3 Drosophila pseudoobscura pseudoobscura 24% 100%
Q2U041 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 23% 100%
Q3ZCK1 Bos taurus 25% 96%
Q4PF85 Ustilago maydis (strain 521 / FGSC 9021) 22% 81%
Q4Q253 Leishmania major 98% 100%
Q4X1D2 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 100%
Q5B0H6 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 23% 100%
Q5F428 Gallus gallus 25% 96%
Q6CAE9 Yarrowia lipolytica (strain CLIB 122 / E 150) 24% 100%
Q6P878 Xenopus tropicalis 25% 97%
Q7Q5Y8 Anopheles gambiae 22% 100%
Q7T2A5 Danio rerio 25% 94%
Q8AVJ0 Xenopus laevis 24% 97%
Q8QZY1 Mus musculus 25% 96%
Q95QW0 Caenorhabditis elegans 24% 100%
Q9VTU4 Drosophila melanogaster 23% 100%
Q9Y262 Homo sapiens 25% 96%
V5BV76 Trypanosoma cruzi 53% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS