Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IIM3_LEIDO

TriTrypDb:

LdBPK_342380.1 , LdCL_340031400 , LDHU3_34.3940

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.469
CLV_C14_Caspase3-7	220	224	PF00656	0.414
CLV_C14_Caspase3-7	395	399	PF00656	0.663
CLV_C14_Caspase3-7	79	83	PF00656	0.502
CLV_NRD_NRD_1	101	103	PF00675	0.467
CLV_NRD_NRD_1	243	245	PF00675	0.439
CLV_NRD_NRD_1	27	29	PF00675	0.405
CLV_NRD_NRD_1	371	373	PF00675	0.657
CLV_NRD_NRD_1	418	420	PF00675	0.665
CLV_NRD_NRD_1	53	55	PF00675	0.407
CLV_PCSK_FUR_1	241	245	PF00082	0.443
CLV_PCSK_KEX2_1	101	103	PF00082	0.409
CLV_PCSK_KEX2_1	243	245	PF00082	0.439
CLV_PCSK_KEX2_1	371	373	PF00082	0.750
CLV_PCSK_KEX2_1	414	416	PF00082	0.611
CLV_PCSK_KEX2_1	418	420	PF00082	0.589
CLV_PCSK_KEX2_1	93	95	PF00082	0.464
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.611
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.428
CLV_PCSK_SKI1_1	205	209	PF00082	0.420
CLV_PCSK_SKI1_1	35	39	PF00082	0.506
CLV_PCSK_SKI1_1	411	415	PF00082	0.723
CLV_PCSK_SKI1_1	50	54	PF00082	0.363
CLV_PCSK_SKI1_1	518	522	PF00082	0.460
CLV_PCSK_SKI1_1	544	548	PF00082	0.551
CLV_PCSK_SKI1_1	93	97	PF00082	0.467
DEG_APCC_DBOX_1	292	300	PF00400	0.511
DEG_APCC_DBOX_1	49	57	PF00400	0.450
DEG_Nend_UBRbox_3	1	3	PF02207	0.512
DEG_SCF_FBW7_1	469	475	PF00400	0.574
DEG_SPOP_SBC_1	393	397	PF00917	0.678
DEG_SPOP_SBC_1	582	586	PF00917	0.531
DOC_CKS1_1	469	474	PF01111	0.579
DOC_CYCLIN_RxL_1	515	525	PF00134	0.457
DOC_CYCLIN_RxL_1	540	549	PF00134	0.481
DOC_MAPK_gen_1	150	160	PF00069	0.425
DOC_MAPK_gen_1	28	36	PF00069	0.389
DOC_MAPK_gen_1	320	328	PF00069	0.562
DOC_MAPK_MEF2A_6	153	162	PF00069	0.427
DOC_MAPK_MEF2A_6	29	38	PF00069	0.406
DOC_MIT_MIM_1	65	73	PF04212	0.439
DOC_PP1_RVXF_1	92	99	PF00149	0.411
DOC_USP7_MATH_1	122	126	PF00917	0.394
DOC_USP7_MATH_1	295	299	PF00917	0.481
DOC_USP7_MATH_1	373	377	PF00917	0.740
DOC_USP7_MATH_1	392	396	PF00917	0.778
DOC_USP7_MATH_1	472	476	PF00917	0.685
DOC_USP7_MATH_1	48	52	PF00917	0.446
DOC_USP7_MATH_1	582	586	PF00917	0.548
DOC_USP7_MATH_1	61	65	PF00917	0.333
DOC_USP7_UBL2_3	486	490	PF12436	0.550
DOC_WW_Pin1_4	341	346	PF00397	0.767
DOC_WW_Pin1_4	350	355	PF00397	0.634
DOC_WW_Pin1_4	468	473	PF00397	0.663
LIG_14-3-3_CanoR_1	243	248	PF00244	0.410
LIG_14-3-3_CanoR_1	262	267	PF00244	0.606
LIG_14-3-3_CanoR_1	322	329	PF00244	0.698
LIG_14-3-3_CanoR_1	339	345	PF00244	0.693
LIG_14-3-3_CanoR_1	374	383	PF00244	0.640
LIG_14-3-3_CanoR_1	418	425	PF00244	0.585
LIG_14-3-3_CanoR_1	47	53	PF00244	0.464
LIG_14-3-3_CanoR_1	54	63	PF00244	0.372
LIG_14-3-3_CanoR_1	550	555	PF00244	0.503
LIG_14-3-3_CanoR_1	69	74	PF00244	0.472
LIG_DLG_GKlike_1	69	77	PF00625	0.370
LIG_FHA_1	261	267	PF00498	0.439
LIG_FHA_1	3	9	PF00498	0.517
LIG_FHA_1	302	308	PF00498	0.524
LIG_FHA_1	31	37	PF00498	0.405
LIG_FHA_1	395	401	PF00498	0.681
LIG_FHA_1	441	447	PF00498	0.597
LIG_FHA_2	142	148	PF00498	0.476
LIG_FHA_2	452	458	PF00498	0.674
LIG_FHA_2	521	527	PF00498	0.551
LIG_GBD_Chelix_1	547	555	PF00786	0.434
LIG_LIR_Apic_2	42	48	PF02991	0.447
LIG_LIR_Gen_1	173	183	PF02991	0.484
LIG_LIR_Gen_1	187	198	PF02991	0.323
LIG_LIR_Gen_1	501	510	PF02991	0.487
LIG_LIR_Nem_3	108	114	PF02991	0.399
LIG_LIR_Nem_3	173	178	PF02991	0.474
LIG_LIR_Nem_3	187	193	PF02991	0.323
LIG_LIR_Nem_3	208	213	PF02991	0.542
LIG_LIR_Nem_3	327	331	PF02991	0.622
LIG_LIR_Nem_3	501	506	PF02991	0.486
LIG_LIR_Nem_3	67	73	PF02991	0.392
LIG_NRBOX	550	556	PF00104	0.444
LIG_Pex14_1	206	210	PF04695	0.415
LIG_Rb_LxCxE_1	494	515	PF01857	0.537
LIG_SH2_CRK	11	15	PF00017	0.511
LIG_SH2_CRK	190	194	PF00017	0.377
LIG_SH2_GRB2like	510	513	PF00017	0.549
LIG_SH2_NCK_1	175	179	PF00017	0.506
LIG_SH2_NCK_1	190	194	PF00017	0.317
LIG_SH2_STAP1	510	514	PF00017	0.466
LIG_SH2_STAT5	182	185	PF00017	0.412
LIG_SH2_STAT5	276	279	PF00017	0.537
LIG_SH2_STAT5	288	291	PF00017	0.390
LIG_SH2_STAT5	599	602	PF00017	0.694
LIG_SH3_3	328	334	PF00018	0.604
LIG_SH3_3	367	373	PF00018	0.786
LIG_SH3_3	466	472	PF00018	0.721
LIG_TRAF2_1	177	180	PF00917	0.417
LIG_TRAF2_1	18	21	PF00917	0.540
LIG_TRAF2_1	298	301	PF00917	0.517
LIG_TRAF2_1	523	526	PF00917	0.550
LIG_TYR_ITIM	188	193	PF00017	0.389
MOD_CDK_SPK_2	350	355	PF00069	0.650
MOD_CK1_1	139	145	PF00069	0.449
MOD_CK1_1	184	190	PF00069	0.430
MOD_CK1_1	191	197	PF00069	0.404
MOD_CK1_1	236	242	PF00069	0.488
MOD_CK1_1	363	369	PF00069	0.658
MOD_CK1_1	396	402	PF00069	0.655
MOD_CK1_1	417	423	PF00069	0.706
MOD_CK1_1	449	455	PF00069	0.692
MOD_CK1_1	463	469	PF00069	0.773
MOD_CK1_1	470	476	PF00069	0.592
MOD_CK1_1	539	545	PF00069	0.489
MOD_CK1_1	72	78	PF00069	0.461
MOD_CK2_1	151	157	PF00069	0.377
MOD_CK2_1	174	180	PF00069	0.401
MOD_CK2_1	232	238	PF00069	0.447
MOD_CK2_1	295	301	PF00069	0.517
MOD_CK2_1	396	402	PF00069	0.639
MOD_CK2_1	520	526	PF00069	0.546
MOD_CK2_1	61	67	PF00069	0.429
MOD_CK2_1	73	79	PF00069	0.388
MOD_GlcNHglycan	120	123	PF01048	0.389
MOD_GlcNHglycan	153	156	PF01048	0.479
MOD_GlcNHglycan	238	241	PF01048	0.431
MOD_GlcNHglycan	311	314	PF01048	0.682
MOD_GlcNHglycan	357	360	PF01048	0.665
MOD_GlcNHglycan	365	368	PF01048	0.670
MOD_GlcNHglycan	420	423	PF01048	0.684
MOD_GlcNHglycan	426	429	PF01048	0.670
MOD_GlcNHglycan	472	475	PF01048	0.647
MOD_GlcNHglycan	563	566	PF01048	0.684
MOD_GlcNHglycan	585	588	PF01048	0.687
MOD_GSK3_1	118	125	PF00069	0.472
MOD_GSK3_1	136	143	PF00069	0.322
MOD_GSK3_1	170	177	PF00069	0.449
MOD_GSK3_1	184	191	PF00069	0.398
MOD_GSK3_1	228	235	PF00069	0.502
MOD_GSK3_1	258	265	PF00069	0.510
MOD_GSK3_1	277	284	PF00069	0.319
MOD_GSK3_1	346	353	PF00069	0.706
MOD_GSK3_1	392	399	PF00069	0.684
MOD_GSK3_1	414	421	PF00069	0.657
MOD_GSK3_1	435	442	PF00069	0.600
MOD_GSK3_1	446	453	PF00069	0.565
MOD_GSK3_1	463	470	PF00069	0.631
MOD_GSK3_1	510	517	PF00069	0.469
MOD_GSK3_1	546	553	PF00069	0.513
MOD_GSK3_1	69	76	PF00069	0.418
MOD_N-GLC_1	572	577	PF02516	0.670
MOD_NEK2_1	140	145	PF00069	0.408
MOD_NEK2_1	151	156	PF00069	0.393
MOD_NEK2_1	170	175	PF00069	0.409
MOD_NEK2_1	183	188	PF00069	0.387
MOD_NEK2_1	303	308	PF00069	0.583
MOD_NEK2_1	424	429	PF00069	0.705
MOD_NEK2_1	436	441	PF00069	0.569
MOD_NEK2_1	450	455	PF00069	0.557
MOD_NEK2_1	546	551	PF00069	0.517
MOD_NEK2_1	73	78	PF00069	0.634
MOD_OFUCOSY	119	126	PF10250	0.329
MOD_PIKK_1	112	118	PF00454	0.481
MOD_PIKK_1	191	197	PF00454	0.456
MOD_PIKK_1	260	266	PF00454	0.434
MOD_PKA_1	243	249	PF00069	0.435
MOD_PKA_1	414	420	PF00069	0.656
MOD_PKA_1	54	60	PF00069	0.382
MOD_PKA_2	242	248	PF00069	0.432
MOD_PKA_2	321	327	PF00069	0.807
MOD_PKA_2	338	344	PF00069	0.700
MOD_PKA_2	363	369	PF00069	0.635
MOD_PKA_2	373	379	PF00069	0.672
MOD_PKA_2	414	420	PF00069	0.659
MOD_PKA_2	457	463	PF00069	0.623
MOD_PKA_2	539	545	PF00069	0.443
MOD_PKB_1	241	249	PF00069	0.438
MOD_PKB_1	372	380	PF00069	0.621
MOD_Plk_1	170	176	PF00069	0.498
MOD_Plk_1	178	184	PF00069	0.403
MOD_Plk_1	318	324	PF00069	0.578
MOD_Plk_1	601	607	PF00069	0.593
MOD_Plk_4	136	142	PF00069	0.510
MOD_Plk_4	178	184	PF00069	0.440
MOD_Plk_4	420	426	PF00069	0.568
MOD_Plk_4	492	498	PF00069	0.531
MOD_Plk_4	73	79	PF00069	0.607
MOD_ProDKin_1	341	347	PF00069	0.766
MOD_ProDKin_1	350	356	PF00069	0.633
MOD_ProDKin_1	468	474	PF00069	0.658
MOD_SUMO_for_1	354	357	PF00179	0.641
MOD_SUMO_rev_2	312	321	PF00179	0.565
MOD_SUMO_rev_2	501	511	PF00179	0.464
TRG_DiLeu_BaEn_4	20	26	PF01217	0.483
TRG_DiLeu_BaEn_4	501	507	PF01217	0.537
TRG_DiLeu_BaLyEn_6	547	552	PF01217	0.509
TRG_ENDOCYTIC_2	175	178	PF00928	0.384
TRG_ENDOCYTIC_2	190	193	PF00928	0.406
TRG_ENDOCYTIC_2	503	506	PF00928	0.499
TRG_ER_diArg_1	100	102	PF00400	0.472
TRG_ER_diArg_1	370	372	PF00400	0.685
TRG_NLS_MonoExtN_4	85	91	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ7	Leptomonas seymouri	46%	98%
A4HBI7	Leishmania braziliensis	66%	100%
A4IA31	Leishmania infantum	99%	100%
E9B546	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q2U0	Leishmania major	86%	100%