Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIL4_LEIDO

TriTrypDb:

LdBPK_353700.1 , LdCL_350042000 , LDHU3_35.4850

Length:

860

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.576
CLV_C14_Caspase3-7	671	675	PF00656	0.480
CLV_C14_Caspase3-7	704	708	PF00656	0.670
CLV_MEL_PAP_1	545	551	PF00089	0.549
CLV_NRD_NRD_1	187	189	PF00675	0.533
CLV_NRD_NRD_1	323	325	PF00675	0.660
CLV_NRD_NRD_1	370	372	PF00675	0.650
CLV_NRD_NRD_1	519	521	PF00675	0.691
CLV_NRD_NRD_1	614	616	PF00675	0.817
CLV_NRD_NRD_1	648	650	PF00675	0.593
CLV_NRD_NRD_1	656	658	PF00675	0.624
CLV_NRD_NRD_1	702	704	PF00675	0.580
CLV_PCSK_KEX2_1	187	189	PF00082	0.533
CLV_PCSK_KEX2_1	370	372	PF00082	0.650
CLV_PCSK_KEX2_1	519	521	PF00082	0.691
CLV_PCSK_KEX2_1	614	616	PF00082	0.825
CLV_PCSK_KEX2_1	648	650	PF00082	0.593
CLV_PCSK_KEX2_1	655	657	PF00082	0.634
CLV_PCSK_KEX2_1	702	704	PF00082	0.580
CLV_PCSK_KEX2_1	850	852	PF00082	0.562
CLV_PCSK_PC1ET2_1	850	852	PF00082	0.562
CLV_PCSK_PC7_1	651	657	PF00082	0.655
CLV_PCSK_SKI1_1	187	191	PF00082	0.590
CLV_PCSK_SKI1_1	232	236	PF00082	0.581
CLV_PCSK_SKI1_1	238	242	PF00082	0.556
CLV_PCSK_SKI1_1	493	497	PF00082	0.556
CLV_PCSK_SKI1_1	520	524	PF00082	0.682
DEG_APCC_DBOX_1	492	500	PF00400	0.607
DEG_SPOP_SBC_1	482	486	PF00917	0.640
DEG_SPOP_SBC_1	537	541	PF00917	0.566
DEG_SPOP_SBC_1	558	562	PF00917	0.604
DOC_CKS1_1	191	196	PF01111	0.634
DOC_CKS1_1	362	367	PF01111	0.567
DOC_CYCLIN_RxL_1	102	113	PF00134	0.486
DOC_CYCLIN_RxL_1	185	196	PF00134	0.594
DOC_CYCLIN_RxL_1	229	237	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	362	368	PF00134	0.654
DOC_CYCLIN_yCln2_LP_2	692	698	PF00134	0.592
DOC_MAPK_DCC_7	493	501	PF00069	0.560
DOC_MAPK_gen_1	848	858	PF00069	0.475
DOC_MAPK_MEF2A_6	493	501	PF00069	0.623
DOC_MAPK_MEF2A_6	799	808	PF00069	0.691
DOC_PP1_RVXF_1	186	193	PF00149	0.593
DOC_PP2B_LxvP_1	109	112	PF13499	0.470
DOC_PP2B_LxvP_1	468	471	PF13499	0.572
DOC_PP4_FxxP_1	98	101	PF00568	0.541
DOC_USP7_MATH_1	144	148	PF00917	0.624
DOC_USP7_MATH_1	174	178	PF00917	0.599
DOC_USP7_MATH_1	302	306	PF00917	0.646
DOC_USP7_MATH_1	313	317	PF00917	0.577
DOC_USP7_MATH_1	330	334	PF00917	0.511
DOC_USP7_MATH_1	344	348	PF00917	0.585
DOC_USP7_MATH_1	355	359	PF00917	0.576
DOC_USP7_MATH_1	366	370	PF00917	0.556
DOC_USP7_MATH_1	393	397	PF00917	0.635
DOC_USP7_MATH_1	443	447	PF00917	0.582
DOC_USP7_MATH_1	482	486	PF00917	0.651
DOC_USP7_MATH_1	527	531	PF00917	0.654
DOC_USP7_MATH_1	566	570	PF00917	0.596
DOC_USP7_MATH_1	65	69	PF00917	0.577
DOC_USP7_MATH_1	701	705	PF00917	0.664
DOC_USP7_MATH_1	75	79	PF00917	0.447
DOC_USP7_MATH_1	751	755	PF00917	0.724
DOC_USP7_MATH_1	836	840	PF00917	0.555
DOC_WW_Pin1_4	190	195	PF00397	0.633
DOC_WW_Pin1_4	214	219	PF00397	0.650
DOC_WW_Pin1_4	278	283	PF00397	0.544
DOC_WW_Pin1_4	308	313	PF00397	0.654
DOC_WW_Pin1_4	361	366	PF00397	0.581
DOC_WW_Pin1_4	415	420	PF00397	0.658
DOC_WW_Pin1_4	426	431	PF00397	0.578
DOC_WW_Pin1_4	484	489	PF00397	0.574
DOC_WW_Pin1_4	511	516	PF00397	0.634
DOC_WW_Pin1_4	52	57	PF00397	0.594
DOC_WW_Pin1_4	570	575	PF00397	0.653
DOC_WW_Pin1_4	598	603	PF00397	0.593
DOC_WW_Pin1_4	607	612	PF00397	0.556
DOC_WW_Pin1_4	632	637	PF00397	0.660
DOC_WW_Pin1_4	676	681	PF00397	0.540
DOC_WW_Pin1_4	697	702	PF00397	0.644
LIG_14-3-3_CanoR_1	126	133	PF00244	0.517
LIG_14-3-3_CanoR_1	210	218	PF00244	0.651
LIG_14-3-3_CanoR_1	251	259	PF00244	0.582
LIG_14-3-3_CanoR_1	332	341	PF00244	0.647
LIG_14-3-3_CanoR_1	483	488	PF00244	0.647
LIG_14-3-3_CanoR_1	519	525	PF00244	0.654
LIG_14-3-3_CanoR_1	548	556	PF00244	0.556
LIG_14-3-3_CanoR_1	62	68	PF00244	0.595
LIG_14-3-3_CanoR_1	648	654	PF00244	0.637
LIG_14-3-3_CanoR_1	655	663	PF00244	0.610
LIG_14-3-3_CanoR_1	668	676	PF00244	0.481
LIG_14-3-3_CanoR_1	697	701	PF00244	0.615
LIG_14-3-3_CanoR_1	851	857	PF00244	0.560
LIG_BRCT_BRCA1_1	280	284	PF00533	0.541
LIG_Clathr_ClatBox_1	80	84	PF01394	0.465
LIG_CSL_BTD_1	463	466	PF09270	0.650
LIG_FHA_1	101	107	PF00498	0.502
LIG_FHA_1	12	18	PF00498	0.470
LIG_FHA_1	164	170	PF00498	0.513
LIG_FHA_1	334	340	PF00498	0.646
LIG_FHA_1	36	42	PF00498	0.601
LIG_FHA_1	390	396	PF00498	0.656
LIG_FHA_1	401	407	PF00498	0.576
LIG_FHA_1	471	477	PF00498	0.645
LIG_FHA_1	485	491	PF00498	0.538
LIG_FHA_1	53	59	PF00498	0.491
LIG_FHA_1	595	601	PF00498	0.608
LIG_FHA_1	648	654	PF00498	0.631
LIG_FHA_1	762	768	PF00498	0.562
LIG_FHA_2	719	725	PF00498	0.534
LIG_FHA_2	838	844	PF00498	0.526
LIG_LIR_Apic_2	96	101	PF02991	0.532
LIG_LIR_Gen_1	18	27	PF02991	0.532
LIG_LIR_Gen_1	572	581	PF02991	0.529
LIG_LIR_Gen_1	6	16	PF02991	0.507
LIG_LIR_Gen_1	716	727	PF02991	0.529
LIG_LIR_Nem_3	103	107	PF02991	0.487
LIG_LIR_Nem_3	118	124	PF02991	0.390
LIG_LIR_Nem_3	18	22	PF02991	0.475
LIG_LIR_Nem_3	46	50	PF02991	0.593
LIG_LIR_Nem_3	550	556	PF02991	0.646
LIG_LIR_Nem_3	572	578	PF02991	0.562
LIG_LIR_Nem_3	6	11	PF02991	0.496
LIG_LIR_Nem_3	716	722	PF02991	0.526
LIG_LIR_Nem_3	814	819	PF02991	0.551
LIG_LYPXL_yS_3	47	50	PF13949	0.596
LIG_NRBOX	377	383	PF00104	0.636
LIG_Pex14_1	121	125	PF04695	0.465
LIG_RPA_C_Fungi	652	664	PF08784	0.621
LIG_SH2_CRK	104	108	PF00017	0.483
LIG_SH2_CRK	236	240	PF00017	0.533
LIG_SH2_CRK	575	579	PF00017	0.558
LIG_SH2_CRK	606	610	PF00017	0.646
LIG_SH2_CRK	74	78	PF00017	0.519
LIG_SH2_NCK_1	74	78	PF00017	0.519
LIG_SH2_PTP2	717	720	PF00017	0.514
LIG_SH2_SRC	553	556	PF00017	0.656
LIG_SH2_STAT5	108	111	PF00017	0.465
LIG_SH2_STAT5	34	37	PF00017	0.615
LIG_SH2_STAT5	588	591	PF00017	0.612
LIG_SH2_STAT5	669	672	PF00017	0.631
LIG_SH2_STAT5	717	720	PF00017	0.514
LIG_SH2_STAT5	785	788	PF00017	0.537
LIG_SH2_STAT5	845	848	PF00017	0.548
LIG_SH2_STAT5	852	855	PF00017	0.497
LIG_SH3_3	18	24	PF00018	0.557
LIG_SH3_3	191	197	PF00018	0.632
LIG_SH3_3	296	302	PF00018	0.615
LIG_SH3_3	309	315	PF00018	0.613
LIG_SH3_3	338	344	PF00018	0.642
LIG_SH3_3	370	376	PF00018	0.577
LIG_SH3_3	491	497	PF00018	0.622
LIG_SH3_3	695	701	PF00018	0.606
LIG_SH3_3	725	731	PF00018	0.506
LIG_SUMO_SIM_anti_2	802	809	PF11976	0.604
LIG_SUMO_SIM_par_1	336	342	PF11976	0.557
LIG_SUMO_SIM_par_1	78	84	PF11976	0.446
LIG_TRAF2_1	430	433	PF00917	0.565
LIG_TYR_ITIM	604	609	PF00017	0.639
LIG_TYR_ITIM	72	77	PF00017	0.511
LIG_WRC_WIRS_1	771	776	PF05994	0.538
LIG_WW_3	311	315	PF00397	0.623
LIG_WW_3	508	512	PF00397	0.672
MOD_CDC14_SPxK_1	311	314	PF00782	0.649
MOD_CDC14_SPxK_1	700	703	PF00782	0.561
MOD_CDK_SPK_2	426	431	PF00069	0.642
MOD_CDK_SPK_2	598	603	PF00069	0.611
MOD_CDK_SPK_2	697	702	PF00069	0.620
MOD_CDK_SPxK_1	308	314	PF00069	0.655
MOD_CDK_SPxK_1	697	703	PF00069	0.541
MOD_CDK_SPxxK_3	570	577	PF00069	0.652
MOD_CDK_SPxxK_3	607	614	PF00069	0.651
MOD_CK1_1	196	202	PF00069	0.570
MOD_CK1_1	214	220	PF00069	0.526
MOD_CK1_1	305	311	PF00069	0.669
MOD_CK1_1	33	39	PF00069	0.582
MOD_CK1_1	333	339	PF00069	0.595
MOD_CK1_1	394	400	PF00069	0.659
MOD_CK1_1	402	408	PF00069	0.601
MOD_CK1_1	418	424	PF00069	0.553
MOD_CK1_1	426	432	PF00069	0.600
MOD_CK1_1	547	553	PF00069	0.633
MOD_CK1_1	569	575	PF00069	0.654
MOD_CK1_1	598	604	PF00069	0.531
MOD_CK1_1	63	69	PF00069	0.592
MOD_CK1_1	632	638	PF00069	0.659
MOD_CK1_1	659	665	PF00069	0.639
MOD_CK2_1	216	222	PF00069	0.656
MOD_CK2_1	426	432	PF00069	0.628
MOD_CK2_1	548	554	PF00069	0.615
MOD_CK2_1	718	724	PF00069	0.528
MOD_CK2_1	76	82	PF00069	0.456
MOD_CK2_1	837	843	PF00069	0.528
MOD_Cter_Amidation	322	325	PF01082	0.667
MOD_Cter_Amidation	653	656	PF01082	0.656
MOD_DYRK1A_RPxSP_1	607	611	PF00069	0.582
MOD_DYRK1A_RPxSP_1	697	701	PF00069	0.615
MOD_GlcNHglycan	112	115	PF01048	0.502
MOD_GlcNHglycan	153	156	PF01048	0.602
MOD_GlcNHglycan	218	221	PF01048	0.653
MOD_GlcNHglycan	244	247	PF01048	0.608
MOD_GlcNHglycan	269	272	PF01048	0.595
MOD_GlcNHglycan	287	290	PF01048	0.561
MOD_GlcNHglycan	304	307	PF01048	0.545
MOD_GlcNHglycan	315	318	PF01048	0.596
MOD_GlcNHglycan	321	324	PF01048	0.558
MOD_GlcNHglycan	350	353	PF01048	0.561
MOD_GlcNHglycan	357	360	PF01048	0.646
MOD_GlcNHglycan	389	392	PF01048	0.610
MOD_GlcNHglycan	406	409	PF01048	0.607
MOD_GlcNHglycan	425	428	PF01048	0.523
MOD_GlcNHglycan	446	449	PF01048	0.674
MOD_GlcNHglycan	550	553	PF01048	0.615
MOD_GlcNHglycan	568	571	PF01048	0.533
MOD_GlcNHglycan	582	585	PF01048	0.496
MOD_GlcNHglycan	63	66	PF01048	0.595
MOD_GlcNHglycan	631	634	PF01048	0.671
MOD_GlcNHglycan	637	640	PF01048	0.604
MOD_GlcNHglycan	67	70	PF01048	0.559
MOD_GlcNHglycan	670	673	PF01048	0.484
MOD_GlcNHglycan	703	706	PF01048	0.621
MOD_GlcNHglycan	753	756	PF01048	0.643
MOD_GlcNHglycan	761	764	PF01048	0.576
MOD_GSK3_1	174	181	PF00069	0.622
MOD_GSK3_1	192	199	PF00069	0.522
MOD_GSK3_1	234	241	PF00069	0.594
MOD_GSK3_1	274	281	PF00069	0.645
MOD_GSK3_1	29	36	PF00069	0.611
MOD_GSK3_1	302	309	PF00069	0.659
MOD_GSK3_1	330	337	PF00069	0.602
MOD_GSK3_1	344	351	PF00069	0.574
MOD_GSK3_1	383	390	PF00069	0.629
MOD_GSK3_1	396	403	PF00069	0.562
MOD_GSK3_1	511	518	PF00069	0.691
MOD_GSK3_1	544	551	PF00069	0.593
MOD_GSK3_1	557	564	PF00069	0.491
MOD_GSK3_1	566	573	PF00069	0.582
MOD_GSK3_1	57	64	PF00069	0.595
MOD_GSK3_1	594	601	PF00069	0.608
MOD_GSK3_1	619	626	PF00069	0.665
MOD_GSK3_1	676	683	PF00069	0.540
MOD_GSK3_1	697	704	PF00069	0.652
MOD_GSK3_1	759	766	PF00069	0.649
MOD_N-GLC_1	355	360	PF02516	0.654
MOD_N-GLC_1	713	718	PF02516	0.468
MOD_N-GLC_1	837	842	PF02516	0.524
MOD_N-GLC_2	736	738	PF02516	0.442
MOD_NEK2_1	107	112	PF00069	0.470
MOD_NEK2_1	165	170	PF00069	0.576
MOD_NEK2_1	213	218	PF00069	0.634
MOD_NEK2_1	228	233	PF00069	0.537
MOD_NEK2_1	234	239	PF00069	0.593
MOD_NEK2_1	30	35	PF00069	0.559
MOD_NEK2_1	339	344	PF00069	0.642
MOD_NEK2_1	536	541	PF00069	0.555
MOD_NEK2_1	605	610	PF00069	0.581
MOD_NEK2_2	852	857	PF00069	0.558
MOD_PIKK_1	174	180	PF00454	0.623
MOD_PIKK_1	211	217	PF00454	0.633
MOD_PK_1	649	655	PF00069	0.568
MOD_PKA_1	656	662	PF00069	0.622
MOD_PKA_2	125	131	PF00069	0.505
MOD_PKA_2	135	141	PF00069	0.532
MOD_PKA_2	203	209	PF00069	0.661
MOD_PKA_2	228	234	PF00069	0.640
MOD_PKA_2	313	319	PF00069	0.601
MOD_PKA_2	331	337	PF00069	0.584
MOD_PKA_2	482	488	PF00069	0.636
MOD_PKA_2	547	553	PF00069	0.549
MOD_PKA_2	61	67	PF00069	0.597
MOD_PKA_2	647	653	PF00069	0.575
MOD_PKA_2	656	662	PF00069	0.583
MOD_PKA_2	696	702	PF00069	0.616
MOD_PKA_2	795	801	PF00069	0.635
MOD_PKB_1	451	459	PF00069	0.578
MOD_PKB_1	627	635	PF00069	0.669
MOD_PKB_1	655	663	PF00069	0.623
MOD_PKB_1	666	674	PF00069	0.531
MOD_PKB_1	759	767	PF00069	0.524
MOD_PKB_1	815	823	PF00069	0.539
MOD_Plk_1	17	23	PF00069	0.530
MOD_Plk_1	30	36	PF00069	0.535
MOD_Plk_1	339	345	PF00069	0.553
MOD_Plk_1	558	564	PF00069	0.614
MOD_Plk_1	713	719	PF00069	0.460
MOD_Plk_4	165	171	PF00069	0.601
MOD_Plk_4	334	340	PF00069	0.559
MOD_Plk_4	344	350	PF00069	0.514
MOD_Plk_4	418	424	PF00069	0.575
MOD_Plk_4	54	60	PF00069	0.596
MOD_Plk_4	680	686	PF00069	0.611
MOD_Plk_4	713	719	PF00069	0.547
MOD_Plk_4	76	82	PF00069	0.481
MOD_ProDKin_1	190	196	PF00069	0.632
MOD_ProDKin_1	214	220	PF00069	0.651
MOD_ProDKin_1	278	284	PF00069	0.547
MOD_ProDKin_1	308	314	PF00069	0.655
MOD_ProDKin_1	361	367	PF00069	0.581
MOD_ProDKin_1	415	421	PF00069	0.659
MOD_ProDKin_1	426	432	PF00069	0.576
MOD_ProDKin_1	484	490	PF00069	0.574
MOD_ProDKin_1	511	517	PF00069	0.635
MOD_ProDKin_1	52	58	PF00069	0.596
MOD_ProDKin_1	570	576	PF00069	0.653
MOD_ProDKin_1	598	604	PF00069	0.595
MOD_ProDKin_1	607	613	PF00069	0.559
MOD_ProDKin_1	632	638	PF00069	0.659
MOD_ProDKin_1	676	682	PF00069	0.540
MOD_ProDKin_1	697	703	PF00069	0.652
MOD_SUMO_for_1	430	433	PF00179	0.565
TRG_DiLeu_BaEn_1	357	362	PF01217	0.569
TRG_DiLeu_BaEn_1	740	745	PF01217	0.657
TRG_DiLeu_BaEn_1	802	807	PF01217	0.613
TRG_DiLeu_BaEn_4	740	746	PF01217	0.497
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.432
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.555
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.628
TRG_DiLeu_BaLyEn_6	801	806	PF01217	0.616
TRG_ENDOCYTIC_2	104	107	PF00928	0.481
TRG_ENDOCYTIC_2	47	50	PF00928	0.596
TRG_ENDOCYTIC_2	553	556	PF00928	0.656
TRG_ENDOCYTIC_2	575	578	PF00928	0.561
TRG_ENDOCYTIC_2	606	609	PF00928	0.645
TRG_ENDOCYTIC_2	717	720	PF00928	0.514
TRG_ENDOCYTIC_2	74	77	PF00928	0.520
TRG_ER_diArg_1	186	188	PF00400	0.534
TRG_ER_diArg_1	207	210	PF00400	0.609
TRG_ER_diArg_1	370	372	PF00400	0.650
TRG_ER_diArg_1	613	615	PF00400	0.828
TRG_ER_diArg_1	648	651	PF00400	0.614
TRG_ER_diArg_1	655	657	PF00400	0.609
TRG_ER_diArg_1	666	669	PF00400	0.515
TRG_ER_diArg_1	701	703	PF00400	0.572
TRG_ER_diArg_1	91	94	PF00400	0.488
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4IBQ4	Leishmania infantum	97%	100%
E9AFI9	Leishmania major	85%	100%
E9B6P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%