SNARE domain family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BET1-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIL2_LEIDO

TriTrypDb:

LdBPK_290660.1 , LdCL_290011300 , LDHU3_29.0930

Length:

139

Annotations

LeishMANIAdb annotations

A SNARE-like tail-anchored coil-coil protein required for ER-to-Golgi transport. Probably not GPI anchored due to reverse topology. Localization: Golgi (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIL2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.449
CLV_NRD_NRD_1	11	13	PF00675	0.493
CLV_NRD_NRD_1	66	68	PF00675	0.446
CLV_PCSK_KEX2_1	10	12	PF00082	0.495
CLV_PCSK_KEX2_1	66	68	PF00082	0.439
CLV_PCSK_SKI1_1	66	70	PF00082	0.429
DEG_MDM2_SWIB_1	115	123	PF02201	0.529
DEG_Nend_Nbox_1	1	3	PF02207	0.758
DOC_PP1_RVXF_1	107	113	PF00149	0.701
DOC_USP7_MATH_1	40	44	PF00917	0.718
DOC_USP7_MATH_1	68	72	PF00917	0.707
DOC_USP7_UBL2_3	70	74	PF12436	0.677
DOC_WW_Pin1_4	21	26	PF00397	0.739
LIG_14-3-3_CanoR_1	101	105	PF00244	0.617
LIG_14-3-3_CanoR_1	67	73	PF00244	0.649
LIG_14-3-3_CanoR_1	88	94	PF00244	0.622
LIG_BRCT_BRCA1_1	5	9	PF00533	0.641
LIG_FHA_1	44	50	PF00498	0.688
LIG_FHA_1	89	95	PF00498	0.621
LIG_LIR_Gen_1	114	123	PF02991	0.463
LIG_LIR_Gen_1	71	79	PF02991	0.708
LIG_NRP_CendR_1	137	139	PF00754	0.575
LIG_Pex14_2	115	119	PF04695	0.493
LIG_Pex14_2	124	128	PF04695	0.303
LIG_SH2_STAT5	133	136	PF00017	0.337
LIG_TRAF2_1	48	51	PF00917	0.637
LIG_TYR_ITIM	131	136	PF00017	0.312
LIG_UBA3_1	61	70	PF00899	0.670
MOD_CK1_1	24	30	PF00069	0.698
MOD_CK1_1	43	49	PF00069	0.666
MOD_GSK3_1	20	27	PF00069	0.667
MOD_GSK3_1	89	96	PF00069	0.609
MOD_NEK2_1	100	105	PF00069	0.586
MOD_NEK2_1	89	94	PF00069	0.571
MOD_NEK2_2	4	9	PF00069	0.639
MOD_NEK2_2	40	45	PF00069	0.674
MOD_PIKK_1	93	99	PF00454	0.553
MOD_PKA_2	100	106	PF00069	0.665
MOD_PKA_2	89	95	PF00069	0.676
MOD_Plk_4	4	10	PF00069	0.640
MOD_Plk_4	89	95	PF00069	0.621
MOD_ProDKin_1	21	27	PF00069	0.739
TRG_DiLeu_BaEn_1	53	58	PF01217	0.614
TRG_DiLeu_BaEn_1	81	86	PF01217	0.580
TRG_ENDOCYTIC_2	133	136	PF00928	0.312
TRG_ER_diArg_1	65	67	PF00400	0.644
TRG_ER_diArg_1	9	12	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG6	Leptomonas seymouri	67%	100%
A0A1X0NZJ5	Trypanosomatidae	45%	100%
A0A422NUM6	Trypanosoma rangeli	39%	100%
A4HH70	Leishmania braziliensis	81%	100%
A4I4B6	Leishmania infantum	98%	100%
C9ZL52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADR5	Leishmania major	94%	100%
E9AM15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O35623	Mus musculus	32%	100%
Q62896	Rattus norvegicus	32%	100%