NLI_interacting_factor-like_phosphatase_putative/ Pfam:PF03031

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIK2_LEIDO

TriTrypDb:

LdBPK_353570.1 , LdCL_350040700 , LDHU3_35.4690

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIK2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.658
CLV_NRD_NRD_1	466	468	PF00675	0.609
CLV_NRD_NRD_1	558	560	PF00675	0.536
CLV_NRD_NRD_1	81	83	PF00675	0.661
CLV_PCSK_KEX2_1	110	112	PF00082	0.695
CLV_PCSK_KEX2_1	123	125	PF00082	0.549
CLV_PCSK_KEX2_1	465	467	PF00082	0.610
CLV_PCSK_KEX2_1	558	560	PF00082	0.536
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.695
CLV_PCSK_PC7_1	461	467	PF00082	0.309
CLV_PCSK_SKI1_1	83	87	PF00082	0.596
DOC_CYCLIN_RxL_1	224	235	PF00134	0.581
DOC_MAPK_gen_1	123	131	PF00069	0.638
DOC_MAPK_gen_1	435	443	PF00069	0.385
DOC_MAPK_gen_1	82	88	PF00069	0.543
DOC_MAPK_MEF2A_6	286	295	PF00069	0.492
DOC_MAPK_MEF2A_6	380	389	PF00069	0.331
DOC_MAPK_MEF2A_6	522	530	PF00069	0.480
DOC_PP1_RVXF_1	550	557	PF00149	0.513
DOC_PP2B_PxIxI_1	382	388	PF00149	0.385
DOC_USP7_MATH_1	115	119	PF00917	0.602
DOC_USP7_MATH_1	454	458	PF00917	0.331
DOC_USP7_MATH_1	501	505	PF00917	0.616
DOC_USP7_UBL2_3	338	342	PF12436	0.385
DOC_WW_Pin1_4	161	166	PF00397	0.624
DOC_WW_Pin1_4	179	184	PF00397	0.500
DOC_WW_Pin1_4	197	202	PF00397	0.550
DOC_WW_Pin1_4	221	226	PF00397	0.606
DOC_WW_Pin1_4	267	272	PF00397	0.552
DOC_WW_Pin1_4	279	284	PF00397	0.372
DOC_WW_Pin1_4	417	422	PF00397	0.333
DOC_WW_Pin1_4	42	47	PF00397	0.639
DOC_WW_Pin1_4	53	58	PF00397	0.599
LIG_14-3-3_CanoR_1	116	121	PF00244	0.653
LIG_14-3-3_CanoR_1	123	129	PF00244	0.613
LIG_14-3-3_CanoR_1	13	21	PF00244	0.563
LIG_14-3-3_CanoR_1	143	148	PF00244	0.493
LIG_14-3-3_CanoR_1	202	209	PF00244	0.581
LIG_14-3-3_CanoR_1	477	486	PF00244	0.536
LIG_14-3-3_CanoR_1	489	498	PF00244	0.508
LIG_14-3-3_CanoR_1	539	547	PF00244	0.491
LIG_Actin_WH2_2	423	440	PF00022	0.254
LIG_BIR_III_2	206	210	PF00653	0.564
LIG_Clathr_ClatBox_1	128	132	PF01394	0.540
LIG_Clathr_ClatBox_1	352	356	PF01394	0.363
LIG_DLG_GKlike_1	124	131	PF00625	0.629
LIG_FHA_1	182	188	PF00498	0.667
LIG_FHA_1	21	27	PF00498	0.632
LIG_FHA_1	290	296	PF00498	0.385
LIG_FHA_1	302	308	PF00498	0.274
LIG_FHA_1	4	10	PF00498	0.541
LIG_FHA_1	438	444	PF00498	0.350
LIG_FHA_1	501	507	PF00498	0.751
LIG_FHA_1	523	529	PF00498	0.489
LIG_FHA_1	54	60	PF00498	0.643
LIG_FHA_2	232	238	PF00498	0.653
LIG_FHA_2	494	500	PF00498	0.607
LIG_LIR_Gen_1	348	358	PF02991	0.385
LIG_LIR_Gen_1	514	524	PF02991	0.572
LIG_LIR_Nem_3	102	107	PF02991	0.672
LIG_LIR_Nem_3	334	340	PF02991	0.347
LIG_LIR_Nem_3	348	353	PF02991	0.293
LIG_LIR_Nem_3	356	361	PF02991	0.311
LIG_LIR_Nem_3	381	385	PF02991	0.511
LIG_LIR_Nem_3	514	520	PF02991	0.602
LIG_MYND_1	161	165	PF01753	0.599
LIG_MYND_1	279	283	PF01753	0.431
LIG_MYND_1	46	50	PF01753	0.604
LIG_PCNA_TLS_4	344	351	PF02747	0.385
LIG_PCNA_yPIPBox_3	438	452	PF02747	0.385
LIG_PTB_Apo_2	271	278	PF02174	0.572
LIG_PTB_Apo_2	98	105	PF02174	0.571
LIG_PTB_Phospho_1	98	104	PF10480	0.571
LIG_RPA_C_Fungi	119	131	PF08784	0.553
LIG_SH2_CRK	104	108	PF00017	0.595
LIG_SH2_CRK	43	47	PF00017	0.542
LIG_SH2_CRK	455	459	PF00017	0.385
LIG_SH2_NCK_1	43	47	PF00017	0.520
LIG_SH2_STAP1	370	374	PF00017	0.385
LIG_SH2_STAT5	280	283	PF00017	0.484
LIG_SH2_STAT5	426	429	PF00017	0.309
LIG_SH2_STAT5	43	46	PF00017	0.562
LIG_SH3_3	22	28	PF00018	0.672
LIG_SH3_3	220	226	PF00018	0.550
LIG_SH3_3	304	310	PF00018	0.301
LIG_SH3_3	448	454	PF00018	0.385
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.681
LIG_SUMO_SIM_par_1	250	255	PF11976	0.484
LIG_SUMO_SIM_par_1	291	296	PF11976	0.385
LIG_SUMO_SIM_par_1	33	39	PF11976	0.520
LIG_SUMO_SIM_par_1	439	444	PF11976	0.385
LIG_SUMO_SIM_par_1	5	10	PF11976	0.520
LIG_TRAF2_1	233	236	PF00917	0.656
LIG_WRC_WIRS_1	546	551	PF05994	0.553
MOD_CDC14_SPxK_1	164	167	PF00782	0.625
MOD_CDC14_SPxK_1	224	227	PF00782	0.529
MOD_CDK_SPK_2	197	202	PF00069	0.581
MOD_CDK_SPxK_1	161	167	PF00069	0.624
MOD_CDK_SPxK_1	221	227	PF00069	0.531
MOD_CDK_SPxxK_3	279	286	PF00069	0.394
MOD_CDK_SPxxK_3	42	49	PF00069	0.545
MOD_CK1_1	119	125	PF00069	0.582
MOD_CK1_1	15	21	PF00069	0.644
MOD_CK1_1	215	221	PF00069	0.604
MOD_CK1_1	282	288	PF00069	0.410
MOD_CK1_1	331	337	PF00069	0.458
MOD_CK1_1	392	398	PF00069	0.585
MOD_CK1_1	493	499	PF00069	0.611
MOD_CK1_1	95	101	PF00069	0.610
MOD_CK2_1	231	237	PF00069	0.652
MOD_CK2_1	493	499	PF00069	0.650
MOD_CK2_1	538	544	PF00069	0.534
MOD_Cter_Amidation	108	111	PF01082	0.698
MOD_GlcNHglycan	107	110	PF01048	0.655
MOD_GlcNHglycan	145	148	PF01048	0.660
MOD_GlcNHglycan	17	20	PF01048	0.621
MOD_GlcNHglycan	172	176	PF01048	0.618
MOD_GlcNHglycan	333	336	PF01048	0.359
MOD_GlcNHglycan	394	397	PF01048	0.647
MOD_GlcNHglycan	492	495	PF01048	0.650
MOD_GSK3_1	115	122	PF00069	0.670
MOD_GSK3_1	149	156	PF00069	0.610
MOD_GSK3_1	191	198	PF00069	0.506
MOD_GSK3_1	227	234	PF00069	0.592
MOD_GSK3_1	297	304	PF00069	0.385
MOD_GSK3_1	3	10	PF00069	0.652
MOD_GSK3_1	327	334	PF00069	0.366
MOD_GSK3_1	95	102	PF00069	0.594
MOD_N-GLC_1	267	272	PF02516	0.552
MOD_N-GLC_1	99	104	PF02516	0.626
MOD_N-GLC_2	447	449	PF02516	0.309
MOD_NEK2_1	195	200	PF00069	0.659
MOD_NEK2_1	252	257	PF00069	0.503
MOD_NEK2_1	297	302	PF00069	0.385
MOD_NEK2_1	30	35	PF00069	0.619
MOD_NEK2_1	36	41	PF00069	0.580
MOD_NEK2_1	363	368	PF00069	0.520
MOD_NEK2_1	389	394	PF00069	0.535
MOD_NEK2_1	437	442	PF00069	0.385
MOD_NEK2_1	478	483	PF00069	0.700
MOD_NEK2_1	510	515	PF00069	0.646
MOD_NEK2_1	550	555	PF00069	0.560
MOD_NEK2_1	59	64	PF00069	0.607
MOD_NEK2_1	99	104	PF00069	0.672
MOD_NEK2_2	454	459	PF00069	0.331
MOD_PIKK_1	252	258	PF00454	0.482
MOD_PIKK_1	398	404	PF00454	0.586
MOD_PIKK_1	478	484	PF00454	0.533
MOD_PIKK_1	538	544	PF00454	0.480
MOD_PIKK_1	59	65	PF00454	0.608
MOD_PKA_1	123	129	PF00069	0.589
MOD_PKA_2	115	121	PF00069	0.637
MOD_PKA_2	12	18	PF00069	0.557
MOD_PKA_2	123	129	PF00069	0.610
MOD_PKA_2	142	148	PF00069	0.496
MOD_PKA_2	289	295	PF00069	0.385
MOD_PKA_2	437	443	PF00069	0.385
MOD_PKA_2	478	484	PF00069	0.533
MOD_PKA_2	538	544	PF00069	0.480
MOD_PKB_1	114	122	PF00069	0.606
MOD_Plk_1	297	303	PF00069	0.385
MOD_Plk_1	501	507	PF00069	0.700
MOD_Plk_1	522	528	PF00069	0.480
MOD_Plk_1	74	80	PF00069	0.676
MOD_Plk_1	99	105	PF00069	0.590
MOD_Plk_4	124	130	PF00069	0.628
MOD_Plk_4	227	233	PF00069	0.634
MOD_Plk_4	289	295	PF00069	0.385
MOD_Plk_4	297	303	PF00069	0.311
MOD_Plk_4	437	443	PF00069	0.254
MOD_Plk_4	522	528	PF00069	0.508
MOD_Plk_4	545	551	PF00069	0.555
MOD_ProDKin_1	161	167	PF00069	0.624
MOD_ProDKin_1	179	185	PF00069	0.499
MOD_ProDKin_1	197	203	PF00069	0.549
MOD_ProDKin_1	221	227	PF00069	0.606
MOD_ProDKin_1	267	273	PF00069	0.557
MOD_ProDKin_1	279	285	PF00069	0.377
MOD_ProDKin_1	417	423	PF00069	0.333
MOD_ProDKin_1	42	48	PF00069	0.641
MOD_ProDKin_1	53	59	PF00069	0.600
MOD_SUMO_for_1	166	169	PF00179	0.575
TRG_DiLeu_BaEn_1	523	528	PF01217	0.460
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.756
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.590
TRG_ENDOCYTIC_2	104	107	PF00928	0.619
TRG_ENDOCYTIC_2	337	340	PF00928	0.456
TRG_ENDOCYTIC_2	455	458	PF00928	0.385
TRG_ENDOCYTIC_2	517	520	PF00928	0.623
TRG_ER_diArg_1	465	467	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HN21	Leishmania braziliensis	59%	90%
A4IBP7	Leishmania infantum	99%	100%
E9AFH6	Leishmania major	88%	100%
E9B6N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%