NLI_interacting_factor-like_phosphatase_putative/ Pfam:PF03031

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIK2_LEIDO

TriTrypDb:

LdBPK_353570.1 , LdCL_350040700 , LDHU3_35.4690

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIK2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.658
CLV_NRD_NRD_1	466	468	PF00675	0.609
CLV_NRD_NRD_1	558	560	PF00675	0.536
CLV_NRD_NRD_1	81	83	PF00675	0.661
CLV_PCSK_KEX2_1	110	112	PF00082	0.695
CLV_PCSK_KEX2_1	123	125	PF00082	0.549
CLV_PCSK_KEX2_1	465	467	PF00082	0.610
CLV_PCSK_KEX2_1	558	560	PF00082	0.536
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.695
CLV_PCSK_PC7_1	461	467	PF00082	0.309

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4HN21	Leishmania braziliensis	59%	90%
A4IBP7	Leishmania infantum	99%	100%
E9AFH6	Leishmania major	88%	100%
E9B6N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%

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