LeishMANIAdb
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Metallophos domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Metallophos domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IIK0_LEIDO
TriTrypDb:
LdBPK_290450.1 * , LdCL_290009300 , LDHU3_29.0620
Length:
379

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 14, no: 13
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17

Expansion

Sequence features

A0A3Q8IIK0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIK0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 28
GO:0016787 hydrolase activity 2 28

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.328
CLV_NRD_NRD_1 16 18 PF00675 0.464
CLV_NRD_NRD_1 232 234 PF00675 0.551
CLV_NRD_NRD_1 347 349 PF00675 0.663
CLV_NRD_NRD_1 4 6 PF00675 0.521
CLV_PCSK_KEX2_1 232 234 PF00082 0.534
CLV_PCSK_KEX2_1 347 349 PF00082 0.663
CLV_PCSK_PC1ET2_1 347 349 PF00082 0.537
CLV_PCSK_SKI1_1 158 162 PF00082 0.281
CLV_PCSK_SKI1_1 316 320 PF00082 0.431
CLV_PCSK_SKI1_1 344 348 PF00082 0.671
DEG_APCC_KENBOX_2 288 292 PF00400 0.189
DOC_ANK_TNKS_1 85 92 PF00023 0.530
DOC_CKS1_1 373 378 PF01111 0.439
DOC_CKS1_1 47 52 PF01111 0.379
DOC_CKS1_1 68 73 PF01111 0.238
DOC_CYCLIN_RxL_1 178 186 PF00134 0.408
DOC_MAPK_gen_1 118 126 PF00069 0.389
DOC_MAPK_gen_1 287 296 PF00069 0.307
DOC_MAPK_gen_1 5 11 PF00069 0.543
DOC_MAPK_HePTP_8 286 298 PF00069 0.208
DOC_MAPK_MEF2A_6 119 128 PF00069 0.389
DOC_MAPK_MEF2A_6 289 298 PF00069 0.342
DOC_MAPK_MEF2A_6 316 324 PF00069 0.354
DOC_MAPK_RevD_3 335 350 PF00069 0.254
DOC_USP7_MATH_1 152 156 PF00917 0.499
DOC_USP7_MATH_1 335 339 PF00917 0.304
DOC_USP7_MATH_1 63 67 PF00917 0.350
DOC_USP7_UBL2_3 345 349 PF12436 0.331
DOC_WW_Pin1_4 257 262 PF00397 0.274
DOC_WW_Pin1_4 372 377 PF00397 0.411
DOC_WW_Pin1_4 46 51 PF00397 0.467
DOC_WW_Pin1_4 67 72 PF00397 0.253
LIG_14-3-3_CanoR_1 158 163 PF00244 0.509
LIG_14-3-3_CanoR_1 353 359 PF00244 0.423
LIG_14-3-3_CanoR_1 370 374 PF00244 0.354
LIG_14-3-3_CanoR_1 99 105 PF00244 0.557
LIG_Actin_WH2_2 90 107 PF00022 0.442
LIG_BIR_II_1 1 5 PF00653 0.565
LIG_BIR_III_1 1 5 PF00653 0.547
LIG_BIR_III_3 1 5 PF00653 0.547
LIG_BRCT_BRCA1_1 21 25 PF00533 0.389
LIG_Clathr_ClatBox_1 317 321 PF01394 0.265
LIG_eIF4E_1 177 183 PF01652 0.366
LIG_FHA_1 317 323 PF00498 0.380
LIG_FHA_1 35 41 PF00498 0.388
LIG_FHA_1 47 53 PF00498 0.389
LIG_FHA_2 373 379 PF00498 0.456
LIG_LIR_Apic_2 176 180 PF02991 0.523
LIG_LIR_Gen_1 334 343 PF02991 0.359
LIG_LIR_Nem_3 186 192 PF02991 0.471
LIG_LIR_Nem_3 22 28 PF02991 0.136
LIG_LIR_Nem_3 334 339 PF02991 0.351
LIG_PDZ_Class_1 374 379 PF00595 0.343
LIG_Pex14_2 34 38 PF04695 0.200
LIG_PTB_Apo_2 327 334 PF02174 0.217
LIG_PTB_Phospho_1 327 333 PF10480 0.220
LIG_SH2_PTP2 177 180 PF00017 0.457
LIG_SH2_PTP2 189 192 PF00017 0.457
LIG_SH2_SRC 177 180 PF00017 0.429
LIG_SH2_SRC 194 197 PF00017 0.501
LIG_SH2_STAP1 333 337 PF00017 0.363
LIG_SH2_STAT5 177 180 PF00017 0.468
LIG_SH2_STAT5 189 192 PF00017 0.472
LIG_SH2_STAT5 194 197 PF00017 0.463
LIG_SH2_STAT5 327 330 PF00017 0.380
LIG_SH2_STAT5 48 51 PF00017 0.516
LIG_SH3_3 133 139 PF00018 0.408
LIG_SH3_3 361 367 PF00018 0.289
LIG_SH3_3 65 71 PF00018 0.222
LIG_SUMO_SIM_anti_2 208 215 PF11976 0.573
LIG_SUMO_SIM_par_1 158 163 PF11976 0.408
LIG_SUMO_SIM_par_1 167 172 PF11976 0.373
LIG_SUMO_SIM_par_1 212 218 PF11976 0.439
LIG_SUMO_SIM_par_1 86 92 PF11976 0.481
LIG_TRFH_1 363 367 PF08558 0.256
LIG_UBA3_1 141 149 PF00899 0.452
LIG_WRC_WIRS_1 336 341 PF05994 0.231
MOD_CDC14_SPxK_1 3 6 PF00782 0.516
MOD_CDK_SPxxK_3 70 77 PF00069 0.213
MOD_CK2_1 351 357 PF00069 0.347
MOD_CK2_1 372 378 PF00069 0.423
MOD_GlcNHglycan 154 157 PF01048 0.311
MOD_GlcNHglycan 162 165 PF01048 0.292
MOD_GlcNHglycan 171 174 PF01048 0.207
MOD_GlcNHglycan 185 188 PF01048 0.268
MOD_GlcNHglycan 21 24 PF01048 0.208
MOD_GlcNHglycan 279 282 PF01048 0.530
MOD_GSK3_1 158 165 PF00069 0.357
MOD_GSK3_1 34 41 PF00069 0.404
MOD_GSK3_1 63 70 PF00069 0.341
MOD_N-GLC_1 183 188 PF02516 0.317
MOD_N-GLC_1 248 253 PF02516 0.452
MOD_NEK2_1 100 105 PF00069 0.450
MOD_NEK2_1 169 174 PF00069 0.498
MOD_NEK2_1 183 188 PF00069 0.455
MOD_NEK2_1 248 253 PF00069 0.291
MOD_NEK2_1 34 39 PF00069 0.364
MOD_NEK2_1 351 356 PF00069 0.361
MOD_PIKK_1 162 168 PF00454 0.396
MOD_PKA_2 100 106 PF00069 0.501
MOD_PKA_2 352 358 PF00069 0.426
MOD_PKA_2 369 375 PF00069 0.286
MOD_Plk_1 263 269 PF00069 0.336
MOD_Plk_4 263 269 PF00069 0.360
MOD_Plk_4 335 341 PF00069 0.363
MOD_Plk_4 34 40 PF00069 0.400
MOD_Plk_4 369 375 PF00069 0.375
MOD_ProDKin_1 257 263 PF00069 0.274
MOD_ProDKin_1 372 378 PF00069 0.412
MOD_ProDKin_1 46 52 PF00069 0.469
MOD_ProDKin_1 67 73 PF00069 0.253
MOD_SUMO_rev_2 146 150 PF00179 0.556
TRG_DiLeu_BaEn_1 140 145 PF01217 0.389
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.408
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.530
TRG_ENDOCYTIC_2 189 192 PF00928 0.526
TRG_ENDOCYTIC_2 202 205 PF00928 0.559
TRG_ENDOCYTIC_2 333 336 PF00928 0.311
TRG_NLS_MonoCore_2 346 351 PF00514 0.308
TRG_NLS_MonoExtC_3 343 348 PF00514 0.289
TRG_NLS_MonoExtN_4 341 348 PF00514 0.292

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V2 Leptomonas seymouri 30% 100%
A0A0N1P9R1 Leptomonas seymouri 26% 100%
A0A0S4JMN0 Bodo saltans 32% 94%
A0A0S4KJG1 Bodo saltans 27% 100%
A0A1X0NU01 Trypanosomatidae 27% 100%
A0A1X0NZX7 Trypanosomatidae 35% 85%
A0A1X0P2G6 Trypanosomatidae 29% 100%
A0A3Q8IBB4 Leishmania donovani 28% 100%
A0A3R7NTC0 Trypanosoma rangeli 27% 100%
A0A3S5IRW3 Trypanosoma rangeli 34% 92%
A0A3S7X3U9 Leishmania donovani 27% 100%
A4HCJ2 Leishmania braziliensis 29% 100%
A4HH45 Leishmania braziliensis 73% 100%
A4HIR7 Leishmania braziliensis 29% 100%
A4I008 Leishmania infantum 28% 100%
A4I498 Leishmania infantum 99% 100%
A4I612 Leishmania infantum 29% 100%
C9ZQ86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
C9ZRD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 85%
E9ADP5 Leishmania major 94% 100%
E9AM35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AVY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B1A3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
O74480 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
Q4Q6W1 Leishmania major 30% 100%
Q4QBJ8 Leishmania major 28% 100%
Q944L7 Arabidopsis thaliana 26% 97%
V5ARZ9 Trypanosoma cruzi 25% 100%
V5BPY7 Trypanosoma cruzi 33% 86%
V5BX32 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS