Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIJ0_LEIDO

TriTrypDb:

LdBPK_150070.1 , LdCL_150005600 , LDHU3_15.0100

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.660
CLV_C14_Caspase3-7	93	97	PF00656	0.587
CLV_MEL_PAP_1	121	127	PF00089	0.565
CLV_NRD_NRD_1	183	185	PF00675	0.798
CLV_NRD_NRD_1	284	286	PF00675	0.605
CLV_NRD_NRD_1	34	36	PF00675	0.577
CLV_NRD_NRD_1	354	356	PF00675	0.567
CLV_NRD_NRD_1	426	428	PF00675	0.542
CLV_PCSK_FUR_1	181	185	PF00082	0.743
CLV_PCSK_KEX2_1	183	185	PF00082	0.771
CLV_PCSK_KEX2_1	284	286	PF00082	0.602
CLV_PCSK_KEX2_1	34	36	PF00082	0.535
CLV_PCSK_KEX2_1	354	356	PF00082	0.584
CLV_PCSK_KEX2_1	426	428	PF00082	0.530
CLV_PCSK_PC7_1	350	356	PF00082	0.559
DEG_APCC_DBOX_1	123	131	PF00400	0.573
DEG_APCC_DBOX_1	425	433	PF00400	0.412
DOC_CYCLIN_RxL_1	390	401	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.692
DOC_MAPK_gen_1	354	361	PF00069	0.603
DOC_USP7_MATH_1	165	169	PF00917	0.765
DOC_USP7_MATH_1	172	176	PF00917	0.750
DOC_USP7_MATH_1	190	194	PF00917	0.596
DOC_USP7_MATH_1	198	202	PF00917	0.773
DOC_USP7_MATH_1	2	6	PF00917	0.658
DOC_USP7_MATH_1	219	223	PF00917	0.724
DOC_USP7_MATH_1	237	241	PF00917	0.743
DOC_USP7_MATH_1	461	465	PF00917	0.811
DOC_WW_Pin1_4	144	149	PF00397	0.711
DOC_WW_Pin1_4	161	166	PF00397	0.659
DOC_WW_Pin1_4	168	173	PF00397	0.786
DOC_WW_Pin1_4	210	215	PF00397	0.721
DOC_WW_Pin1_4	449	454	PF00397	0.623
LIG_14-3-3_CanoR_1	124	128	PF00244	0.574
LIG_14-3-3_CanoR_1	157	166	PF00244	0.635
LIG_14-3-3_CanoR_1	224	233	PF00244	0.721
LIG_14-3-3_CanoR_1	236	242	PF00244	0.714
LIG_14-3-3_CanoR_1	34	42	PF00244	0.640
LIG_14-3-3_CanoR_1	57	63	PF00244	0.569
LIG_eIF4E_1	443	449	PF01652	0.561
LIG_EVH1_1	414	418	PF00568	0.624
LIG_FHA_1	14	20	PF00498	0.639
LIG_FHA_1	153	159	PF00498	0.624
LIG_FHA_1	215	221	PF00498	0.679
LIG_FHA_1	256	262	PF00498	0.611
LIG_FHA_1	59	65	PF00498	0.686
LIG_FHA_2	240	246	PF00498	0.588
LIG_FHA_2	27	33	PF00498	0.513
LIG_FHA_2	71	77	PF00498	0.584
LIG_FHA_2	91	97	PF00498	0.427
LIG_IBAR_NPY_1	264	266	PF08397	0.622
LIG_LIR_Gen_1	90	95	PF02991	0.613
LIG_LIR_Nem_3	419	425	PF02991	0.593
LIG_LIR_Nem_3	90	94	PF02991	0.614
LIG_RPA_C_Fungi	350	362	PF08784	0.638
LIG_SH2_NCK_1	443	447	PF00017	0.564
LIG_SH2_STAP1	102	106	PF00017	0.600
LIG_SH2_STAT5	44	47	PF00017	0.591
LIG_SH3_3	109	115	PF00018	0.650
LIG_SH3_3	142	148	PF00018	0.729
LIG_SH3_3	179	185	PF00018	0.807
LIG_SH3_3	213	219	PF00018	0.681
LIG_SH3_3	410	416	PF00018	0.638
LIG_SH3_3	450	456	PF00018	0.630
LIG_SH3_3	61	67	PF00018	0.709
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.653
LIG_SUMO_SIM_par_1	444	452	PF11976	0.630
LIG_TRAF2_1	385	388	PF00917	0.677
LIG_TRAF2_1	398	401	PF00917	0.564
LIG_TRAF2_1	83	86	PF00917	0.645
LIG_WRC_WIRS_1	88	93	PF05994	0.575
MOD_CK1_1	164	170	PF00069	0.765
MOD_CK1_1	193	199	PF00069	0.760
MOD_CK1_1	223	229	PF00069	0.676
MOD_CK1_1	244	250	PF00069	0.665
MOD_CK1_1	46	52	PF00069	0.697
MOD_CK2_1	123	129	PF00069	0.739
MOD_CK2_1	144	150	PF00069	0.710
MOD_CK2_1	239	245	PF00069	0.601
MOD_CK2_1	341	347	PF00069	0.550
MOD_CK2_1	461	467	PF00069	0.741
MOD_CK2_1	72	78	PF00069	0.485
MOD_GlcNHglycan	108	111	PF01048	0.643
MOD_GlcNHglycan	159	162	PF01048	0.699
MOD_GlcNHglycan	200	203	PF01048	0.737
MOD_GlcNHglycan	254	258	PF01048	0.676
MOD_GlcNHglycan	422	425	PF01048	0.652
MOD_GlcNHglycan	444	447	PF01048	0.581
MOD_GlcNHglycan	49	52	PF01048	0.596
MOD_GSK3_1	13	20	PF00069	0.651
MOD_GSK3_1	152	159	PF00069	0.700
MOD_GSK3_1	161	168	PF00069	0.659
MOD_GSK3_1	172	179	PF00069	0.752
MOD_GSK3_1	190	197	PF00069	0.562
MOD_GSK3_1	210	217	PF00069	0.714
MOD_GSK3_1	219	226	PF00069	0.747
MOD_GSK3_1	237	244	PF00069	0.714
MOD_GSK3_1	374	381	PF00069	0.589
MOD_GSK3_1	43	50	PF00069	0.649
MOD_GSK3_1	72	79	PF00069	0.582
MOD_NEK2_1	13	18	PF00069	0.577
MOD_NEK2_1	220	225	PF00069	0.767
MOD_PIKK_1	176	182	PF00454	0.804
MOD_PKA_1	34	40	PF00069	0.573
MOD_PKA_2	123	129	PF00069	0.661
MOD_PKA_2	156	162	PF00069	0.718
MOD_PKA_2	191	197	PF00069	0.827
MOD_PKA_2	208	214	PF00069	0.772
MOD_PKA_2	223	229	PF00069	0.725
MOD_PKA_2	34	40	PF00069	0.602
MOD_PKA_2	374	380	PF00069	0.649
MOD_Plk_1	244	250	PF00069	0.605
MOD_Plk_2-3	123	129	PF00069	0.764
MOD_Plk_2-3	98	104	PF00069	0.566
MOD_Plk_4	87	93	PF00069	0.576
MOD_ProDKin_1	144	150	PF00069	0.710
MOD_ProDKin_1	161	167	PF00069	0.661
MOD_ProDKin_1	168	174	PF00069	0.787
MOD_ProDKin_1	210	216	PF00069	0.720
MOD_ProDKin_1	449	455	PF00069	0.628
MOD_SUMO_for_1	7	10	PF00179	0.619
TRG_DiLeu_BaEn_3	86	92	PF01217	0.603
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.580
TRG_ER_diArg_1	181	184	PF00400	0.822
TRG_ER_diArg_1	284	286	PF00400	0.503
TRG_ER_diArg_1	33	35	PF00400	0.571
TRG_ER_diArg_1	425	427	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C4	Leptomonas seymouri	40%	87%
A0A422NS55	Trypanosoma rangeli	31%	78%
A4H7X7	Leishmania braziliensis	64%	100%
A4HWA4	Leishmania infantum	100%	100%
C9ZNT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	87%
E9AQ04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QFH7	Leishmania major	89%	100%