Pentamidine resistance protein 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p-glycoprotein e (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8III5_LEIDO

TriTrypDb:

LdBPK_311290.1 , LdBPK_311300.1 , LdBPK_340690.1 , LdCL_310020000 , LDHU3_31.2160

Length:

1553

Annotations

LeishMANIAdb annotations

Multidrug resistance transporters, involved in active transport of various unidentified small-molecule substrates.. ABC transporters belonging to subfamily C.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 63

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	34
GO:0043226	organelle	2	1
GO:0043229	intracellular organelle	3	1
GO:0110165	cellular anatomical entity	1	34

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Expansion

Sequence features

A0A3Q8III5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0009987	cellular process	1	6
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0055085	transmembrane transport	2	6

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	34
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	34
GO:0005488	binding	1	34
GO:0005524	ATP binding	5	34
GO:0015399	primary active transmembrane transporter activity	4	34
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	34
GO:0022804	active transmembrane transporter activity	3	34
GO:0022857	transmembrane transporter activity	2	34

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.493
CLV_C14_Caspase3-7	488	492	PF00656	0.390
CLV_C14_Caspase3-7	664	668	PF00656	0.495
CLV_C14_Caspase3-7	699	703	PF00656	0.500
CLV_C14_Caspase3-7	774	778	PF00656	0.532
CLV_C14_Caspase3-7	846	850	PF00656	0.618
CLV_MEL_PAP_1	124	130	PF00089	0.312
CLV_NRD_NRD_1	116	118	PF00675	0.338
CLV_NRD_NRD_1	1372	1374	PF00675	0.355
CLV_NRD_NRD_1	1539	1541	PF00675	0.371

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0D1CZ63	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
A0A0N1IGL0	Leptomonas seymouri	33%	100%
A0A0S4ITB5	Bodo saltans	29%	100%
A0A0S4IXH5	Bodo saltans	39%	82%
A0A0S6XH62	Fungal sp. (strain No.11243)	25%	100%
A0A0U1LQE1	Talaromyces islandicus	28%	100%
A0A179H0T5	Purpureocillium lilacinum	26%	100%
A0A1U8QTJ9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	29%	100%
A0A1X0NPP4	Trypanosomatidae	37%	89%
A0A1X0PAJ0	Trypanosomatidae	26%	100%

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