Cardiolipin synthetase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cardiolipin synthetase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8III3_LEIDO

TriTrypDb:

LdBPK_341860.1 , LdCL_340026300 , LDHU3_34.3190

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8III3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8III3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016740	transferase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.649
CLV_C14_Caspase3-7	742	746	PF00656	0.562
CLV_NRD_NRD_1	180	182	PF00675	0.478
CLV_NRD_NRD_1	187	189	PF00675	0.428
CLV_NRD_NRD_1	22	24	PF00675	0.550
CLV_NRD_NRD_1	248	250	PF00675	0.358
CLV_NRD_NRD_1	314	316	PF00675	0.543
CLV_NRD_NRD_1	326	328	PF00675	0.485
CLV_NRD_NRD_1	353	355	PF00675	0.593
CLV_NRD_NRD_1	498	500	PF00675	0.566
CLV_NRD_NRD_1	505	507	PF00675	0.613
CLV_NRD_NRD_1	526	528	PF00675	0.524
CLV_NRD_NRD_1	572	574	PF00675	0.346
CLV_NRD_NRD_1	577	579	PF00675	0.289
CLV_NRD_NRD_1	589	591	PF00675	0.366
CLV_NRD_NRD_1	601	603	PF00675	0.353
CLV_PCSK_KEX2_1	107	109	PF00082	0.610
CLV_PCSK_KEX2_1	180	182	PF00082	0.431
CLV_PCSK_KEX2_1	186	188	PF00082	0.397
CLV_PCSK_KEX2_1	22	24	PF00082	0.550
CLV_PCSK_KEX2_1	240	242	PF00082	0.532
CLV_PCSK_KEX2_1	314	316	PF00082	0.567
CLV_PCSK_KEX2_1	326	328	PF00082	0.507
CLV_PCSK_KEX2_1	353	355	PF00082	0.581
CLV_PCSK_KEX2_1	498	500	PF00082	0.566
CLV_PCSK_KEX2_1	505	507	PF00082	0.613
CLV_PCSK_KEX2_1	518	520	PF00082	0.513
CLV_PCSK_KEX2_1	526	528	PF00082	0.480
CLV_PCSK_KEX2_1	577	579	PF00082	0.300
CLV_PCSK_KEX2_1	601	603	PF00082	0.332
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.610
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.423
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.605
CLV_PCSK_PC7_1	18	24	PF00082	0.534
CLV_PCSK_PC7_1	573	579	PF00082	0.377
CLV_PCSK_SKI1_1	156	160	PF00082	0.520
CLV_PCSK_SKI1_1	223	227	PF00082	0.446
CLV_PCSK_SKI1_1	249	253	PF00082	0.318
CLV_PCSK_SKI1_1	326	330	PF00082	0.586
CLV_PCSK_SKI1_1	37	41	PF00082	0.606
CLV_PCSK_SKI1_1	413	417	PF00082	0.563
CLV_PCSK_SKI1_1	470	474	PF00082	0.590
CLV_PCSK_SKI1_1	499	503	PF00082	0.605
CLV_PCSK_SKI1_1	506	510	PF00082	0.538
CLV_PCSK_SKI1_1	590	594	PF00082	0.283
DEG_COP1_1	532	539	PF00400	0.463
DEG_MDM2_SWIB_1	115	123	PF02201	0.359
DEG_MDM2_SWIB_1	148	155	PF02201	0.350
DOC_CDC14_PxL_1	525	533	PF14671	0.523
DOC_CKS1_1	581	586	PF01111	0.283
DOC_CYCLIN_RxL_1	246	255	PF00134	0.419
DOC_CYCLIN_RxL_1	587	594	PF00134	0.317
DOC_CYCLIN_RxL_1	709	720	PF00134	0.437
DOC_CYCLIN_RxL_1	8	17	PF00134	0.587
DOC_CYCLIN_yClb5_NLxxxL_5	670	679	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.618
DOC_MAPK_gen_1	246	254	PF00069	0.324
DOC_MAPK_gen_1	372	380	PF00069	0.520
DOC_MAPK_gen_1	573	581	PF00069	0.365
DOC_MAPK_gen_1	601	608	PF00069	0.362
DOC_MAPK_gen_1	631	639	PF00069	0.348
DOC_MAPK_gen_1	710	718	PF00069	0.393
DOC_MAPK_MEF2A_6	601	608	PF00069	0.317
DOC_MAPK_MEF2A_6	710	718	PF00069	0.428
DOC_PP1_RVXF_1	159	165	PF00149	0.400
DOC_PP1_RVXF_1	233	240	PF00149	0.506
DOC_PP1_RVXF_1	730	736	PF00149	0.356
DOC_USP7_MATH_1	147	151	PF00917	0.480
DOC_USP7_MATH_1	359	363	PF00917	0.622
DOC_USP7_MATH_1	421	425	PF00917	0.665
DOC_USP7_MATH_1	492	496	PF00917	0.557
DOC_USP7_MATH_1	80	84	PF00917	0.608
DOC_USP7_MATH_2	479	485	PF00917	0.532
DOC_WW_Pin1_4	110	115	PF00397	0.489
DOC_WW_Pin1_4	239	244	PF00397	0.434
DOC_WW_Pin1_4	4	9	PF00397	0.474
DOC_WW_Pin1_4	454	459	PF00397	0.562
DOC_WW_Pin1_4	475	480	PF00397	0.740
DOC_WW_Pin1_4	580	585	PF00397	0.283
DOC_WW_Pin1_4	746	751	PF00397	0.540
DOC_WW_Pin1_4	76	81	PF00397	0.676
LIG_14-3-3_CanoR_1	108	114	PF00244	0.605
LIG_14-3-3_CanoR_1	131	139	PF00244	0.435
LIG_14-3-3_CanoR_1	227	233	PF00244	0.492
LIG_14-3-3_CanoR_1	385	394	PF00244	0.629
LIG_14-3-3_CanoR_1	400	408	PF00244	0.682
LIG_14-3-3_CanoR_1	493	501	PF00244	0.624
LIG_14-3-3_CanoR_1	519	528	PF00244	0.528
LIG_14-3-3_CanoR_1	578	584	PF00244	0.283
LIG_14-3-3_CanoR_1	717	722	PF00244	0.364
LIG_14-3-3_CanoR_1	732	736	PF00244	0.419
LIG_AP2alpha_2	617	619	PF02296	0.283
LIG_APCC_ABBA_1	138	143	PF00400	0.435
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BIR_III_4	745	749	PF00653	0.548
LIG_BIR_III_4	87	91	PF00653	0.509
LIG_BRCT_BRCA1_1	111	115	PF00533	0.480
LIG_BRCT_BRCA1_1	60	64	PF00533	0.654
LIG_BRCT_BRCA1_1	719	723	PF00533	0.357
LIG_deltaCOP1_diTrp_1	617	622	PF00928	0.283
LIG_eIF4E_1	627	633	PF01652	0.317
LIG_eIF4E_1	724	730	PF01652	0.415
LIG_FHA_1	190	196	PF00498	0.335
LIG_FHA_1	207	213	PF00498	0.397
LIG_FHA_1	229	235	PF00498	0.497
LIG_FHA_1	323	329	PF00498	0.582
LIG_FHA_1	434	440	PF00498	0.621
LIG_FHA_1	520	526	PF00498	0.566
LIG_FHA_1	53	59	PF00498	0.544
LIG_FHA_1	531	537	PF00498	0.303
LIG_FHA_1	548	554	PF00498	0.349
LIG_FHA_1	587	593	PF00498	0.365
LIG_FHA_1	627	633	PF00498	0.317
LIG_FHA_1	650	656	PF00498	0.317
LIG_FHA_1	690	696	PF00498	0.377
LIG_FHA_1	717	723	PF00498	0.338
LIG_FHA_2	100	106	PF00498	0.587
LIG_FHA_2	111	117	PF00498	0.505
LIG_FHA_2	414	420	PF00498	0.799
LIG_FHA_2	425	431	PF00498	0.722
LIG_LIR_Apic_2	582	588	PF02991	0.283
LIG_LIR_Gen_1	116	127	PF02991	0.456
LIG_LIR_Gen_1	14	24	PF02991	0.522
LIG_LIR_Gen_1	149	158	PF02991	0.476
LIG_LIR_Gen_1	61	72	PF02991	0.477
LIG_LIR_Gen_1	656	665	PF02991	0.283
LIG_LIR_Gen_1	713	723	PF02991	0.376
LIG_LIR_Nem_3	116	122	PF02991	0.399
LIG_LIR_Nem_3	14	19	PF02991	0.519
LIG_LIR_Nem_3	149	155	PF02991	0.446
LIG_LIR_Nem_3	339	344	PF02991	0.612
LIG_LIR_Nem_3	61	67	PF02991	0.527
LIG_LIR_Nem_3	656	662	PF02991	0.283
LIG_LIR_Nem_3	713	718	PF02991	0.416
LIG_LIR_Nem_3	719	724	PF02991	0.372
LIG_LIR_Nem_3	734	738	PF02991	0.345
LIG_PCNA_yPIPBox_3	170	183	PF02747	0.434
LIG_Pex14_2	115	119	PF04695	0.365
LIG_Pex14_2	148	152	PF04695	0.381
LIG_PTB_Apo_2	553	560	PF02174	0.455
LIG_PTB_Apo_2	722	729	PF02174	0.431
LIG_PTB_Phospho_1	553	559	PF10480	0.446
LIG_REV1ctd_RIR_1	223	231	PF16727	0.500
LIG_RPA_C_Fungi	500	512	PF08784	0.608
LIG_RPA_C_Fungi	596	608	PF08784	0.317
LIG_SH2_CRK	724	728	PF00017	0.425
LIG_SH2_GRB2like	109	112	PF00017	0.506
LIG_SH2_NCK_1	27	31	PF00017	0.465
LIG_SH2_STAP1	47	51	PF00017	0.495
LIG_SH2_STAP1	521	525	PF00017	0.569
LIG_SH2_STAP1	562	566	PF00017	0.445
LIG_SH2_STAT3	562	565	PF00017	0.418
LIG_SH2_STAT3	640	643	PF00017	0.304
LIG_SH2_STAT5	167	170	PF00017	0.374
LIG_SH2_STAT5	232	235	PF00017	0.394
LIG_SH2_STAT5	27	30	PF00017	0.476
LIG_SH2_STAT5	270	273	PF00017	0.359
LIG_SH2_STAT5	521	524	PF00017	0.592
LIG_SH2_STAT5	542	545	PF00017	0.550
LIG_SH2_STAT5	586	589	PF00017	0.359
LIG_SH2_STAT5	627	630	PF00017	0.317
LIG_SH2_STAT5	95	98	PF00017	0.575
LIG_SH3_1	218	224	PF00018	0.459
LIG_SH3_3	134	140	PF00018	0.424
LIG_SH3_3	218	224	PF00018	0.459
LIG_SH3_3	285	291	PF00018	0.361
LIG_SH3_3	72	78	PF00018	0.653
LIG_SH3_3	741	747	PF00018	0.576
LIG_Sin3_3	593	600	PF02671	0.377
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.458
LIG_SUMO_SIM_par_1	250	255	PF11976	0.319
LIG_SUMO_SIM_par_1	651	657	PF11976	0.317
LIG_TRAF2_1	102	105	PF00917	0.464
LIG_TRAF2_1	343	346	PF00917	0.599
LIG_TYR_ITIM	722	727	PF00017	0.428
LIG_WRC_WIRS_1	735	740	PF05994	0.447
LIG_WRPW_2	222	225	PF00400	0.442
MOD_CDK_SPxxK_3	239	246	PF00069	0.380
MOD_CDK_SPxxK_3	4	11	PF00069	0.468
MOD_CK1_1	228	234	PF00069	0.463
MOD_CK1_1	386	392	PF00069	0.559
MOD_CK1_1	424	430	PF00069	0.568
MOD_CK1_1	461	467	PF00069	0.647
MOD_CK1_1	510	516	PF00069	0.548
MOD_CK1_1	612	618	PF00069	0.286
MOD_CK1_1	657	663	PF00069	0.284
MOD_CK1_1	68	74	PF00069	0.649
MOD_CK1_1	689	695	PF00069	0.348
MOD_CK1_1	76	82	PF00069	0.565
MOD_CK2_1	11	17	PF00069	0.591
MOD_CK2_1	413	419	PF00069	0.618
MOD_CK2_1	424	430	PF00069	0.738
MOD_CK2_1	475	481	PF00069	0.661
MOD_CK2_1	99	105	PF00069	0.660
MOD_CMANNOS	313	316	PF00535	0.541
MOD_CMANNOS	619	622	PF00535	0.283
MOD_Cter_Amidation	351	354	PF01082	0.628
MOD_GlcNHglycan	143	146	PF01048	0.434
MOD_GlcNHglycan	202	205	PF01048	0.512
MOD_GlcNHglycan	28	31	PF01048	0.608
MOD_GlcNHglycan	350	353	PF01048	0.652
MOD_GlcNHglycan	359	362	PF01048	0.643
MOD_GlcNHglycan	385	388	PF01048	0.546
MOD_GlcNHglycan	41	44	PF01048	0.513
MOD_GlcNHglycan	427	430	PF01048	0.779
MOD_GlcNHglycan	454	457	PF01048	0.725
MOD_GlcNHglycan	465	468	PF01048	0.644
MOD_GlcNHglycan	484	487	PF01048	0.684
MOD_GlcNHglycan	490	493	PF01048	0.574
MOD_GlcNHglycan	494	497	PF01048	0.506
MOD_GlcNHglycan	593	596	PF01048	0.454
MOD_GlcNHglycan	67	70	PF01048	0.688
MOD_GlcNHglycan	82	85	PF01048	0.665
MOD_GSK3_1	318	325	PF00069	0.558
MOD_GSK3_1	383	390	PF00069	0.545
MOD_GSK3_1	421	428	PF00069	0.664
MOD_GSK3_1	450	457	PF00069	0.800
MOD_GSK3_1	458	465	PF00069	0.687
MOD_GSK3_1	488	495	PF00069	0.677
MOD_GSK3_1	547	554	PF00069	0.370
MOD_GSK3_1	609	616	PF00069	0.283
MOD_GSK3_1	622	629	PF00069	0.283
MOD_GSK3_1	654	661	PF00069	0.287
MOD_GSK3_1	76	83	PF00069	0.657
MOD_LATS_1	517	523	PF00433	0.593
MOD_N-GLC_1	110	115	PF02516	0.445
MOD_N-GLC_1	200	205	PF02516	0.422
MOD_N-GLC_1	612	617	PF02516	0.377
MOD_NEK2_1	141	146	PF00069	0.430
MOD_NEK2_1	225	230	PF00069	0.436
MOD_NEK2_1	26	31	PF00069	0.593
MOD_NEK2_1	281	286	PF00069	0.338
MOD_NEK2_1	381	386	PF00069	0.589
MOD_NEK2_1	463	468	PF00069	0.686
MOD_NEK2_1	609	614	PF00069	0.289
MOD_NEK2_1	65	70	PF00069	0.698
MOD_NEK2_1	716	721	PF00069	0.352
MOD_NEK2_2	175	180	PF00069	0.365
MOD_NEK2_2	359	364	PF00069	0.623
MOD_NEK2_2	404	409	PF00069	0.608
MOD_PIKK_1	318	324	PF00454	0.584
MOD_PIKK_1	399	405	PF00454	0.660
MOD_PIKK_1	547	553	PF00454	0.359
MOD_PIKK_1	59	65	PF00454	0.546
MOD_PIKK_1	689	695	PF00454	0.377
MOD_PIKK_1	73	79	PF00454	0.447
MOD_PK_1	560	566	PF00069	0.379
MOD_PKA_2	130	136	PF00069	0.454
MOD_PKA_2	206	212	PF00069	0.490
MOD_PKA_2	281	287	PF00069	0.337
MOD_PKA_2	300	306	PF00069	0.285
MOD_PKA_2	399	405	PF00069	0.721
MOD_PKA_2	492	498	PF00069	0.721
MOD_PKA_2	510	516	PF00069	0.624
MOD_PKA_2	545	551	PF00069	0.333
MOD_PKA_2	716	722	PF00069	0.372
MOD_PKA_2	731	737	PF00069	0.500
MOD_PKB_1	558	566	PF00069	0.447
MOD_Plk_1	560	566	PF00069	0.366
MOD_Plk_4	11	17	PF00069	0.570
MOD_Plk_4	147	153	PF00069	0.467
MOD_Plk_4	163	169	PF00069	0.294
MOD_Plk_4	228	234	PF00069	0.495
MOD_Plk_4	376	382	PF00069	0.554
MOD_Plk_4	389	395	PF00069	0.676
MOD_Plk_4	439	445	PF00069	0.610
MOD_Plk_4	649	655	PF00069	0.290
MOD_Plk_4	717	723	PF00069	0.365
MOD_ProDKin_1	110	116	PF00069	0.486
MOD_ProDKin_1	239	245	PF00069	0.427
MOD_ProDKin_1	4	10	PF00069	0.475
MOD_ProDKin_1	454	460	PF00069	0.556
MOD_ProDKin_1	475	481	PF00069	0.742
MOD_ProDKin_1	580	586	PF00069	0.283
MOD_ProDKin_1	746	752	PF00069	0.545
MOD_ProDKin_1	76	82	PF00069	0.675
MOD_SUMO_rev_2	298	306	PF00179	0.441
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.377
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.354
TRG_ENDOCYTIC_2	222	225	PF00928	0.472
TRG_ENDOCYTIC_2	341	344	PF00928	0.634
TRG_ENDOCYTIC_2	47	50	PF00928	0.539
TRG_ENDOCYTIC_2	521	524	PF00928	0.575
TRG_ENDOCYTIC_2	724	727	PF00928	0.334
TRG_ER_diArg_1	179	181	PF00400	0.424
TRG_ER_diArg_1	186	188	PF00400	0.569
TRG_ER_diArg_1	205	208	PF00400	0.456
TRG_ER_diArg_1	22	24	PF00400	0.550
TRG_ER_diArg_1	313	315	PF00400	0.575
TRG_ER_diArg_1	326	328	PF00400	0.498
TRG_ER_diArg_1	332	335	PF00400	0.587
TRG_ER_diArg_1	353	355	PF00400	0.597
TRG_ER_diArg_1	366	369	PF00400	0.546
TRG_ER_diArg_1	497	499	PF00400	0.546
TRG_ER_diArg_1	525	527	PF00400	0.473
TRG_ER_diArg_1	543	546	PF00400	0.506
TRG_ER_diArg_1	577	579	PF00400	0.303
TRG_NES_CRM1_1	693	708	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC19	Leptomonas seymouri	68%	89%
A0A0S4J7Q2	Bodo saltans	42%	100%
A0A3R7MZ93	Trypanosoma rangeli	47%	100%
A4IAM8	Leishmania infantum	99%	100%
E9AI68	Leishmania braziliensis	82%	100%
E9B4Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2Z0	Leishmania major	93%	100%