Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIH8_LEIDO

TriTrypDb:

LdBPK_353290.1 , LdCL_350037900 , LDHU3_35.4340

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	598	602	PF00656	0.669
CLV_NRD_NRD_1	122	124	PF00675	0.529
CLV_NRD_NRD_1	23	25	PF00675	0.479
CLV_NRD_NRD_1	252	254	PF00675	0.415
CLV_NRD_NRD_1	261	263	PF00675	0.435
CLV_NRD_NRD_1	354	356	PF00675	0.487
CLV_NRD_NRD_1	437	439	PF00675	0.393
CLV_NRD_NRD_1	502	504	PF00675	0.532
CLV_NRD_NRD_1	588	590	PF00675	0.608
CLV_NRD_NRD_1	604	606	PF00675	0.670
CLV_NRD_NRD_1	705	707	PF00675	0.729
CLV_NRD_NRD_1	80	82	PF00675	0.470
CLV_PCSK_KEX2_1	122	124	PF00082	0.600
CLV_PCSK_KEX2_1	214	216	PF00082	0.540
CLV_PCSK_KEX2_1	23	25	PF00082	0.479
CLV_PCSK_KEX2_1	252	254	PF00082	0.428
CLV_PCSK_KEX2_1	261	263	PF00082	0.485
CLV_PCSK_KEX2_1	354	356	PF00082	0.500
CLV_PCSK_KEX2_1	426	428	PF00082	0.470
CLV_PCSK_KEX2_1	437	439	PF00082	0.337
CLV_PCSK_KEX2_1	501	503	PF00082	0.506
CLV_PCSK_KEX2_1	587	589	PF00082	0.568
CLV_PCSK_KEX2_1	604	606	PF00082	0.651
CLV_PCSK_KEX2_1	704	706	PF00082	0.781
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.540
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.475
CLV_PCSK_SKI1_1	110	114	PF00082	0.585
CLV_PCSK_SKI1_1	193	197	PF00082	0.494
CLV_PCSK_SKI1_1	390	394	PF00082	0.505
CLV_PCSK_SKI1_1	5	9	PF00082	0.602
CLV_PCSK_SKI1_1	629	633	PF00082	0.592
CLV_PCSK_SKI1_1	675	679	PF00082	0.714
CLV_PCSK_SKI1_1	88	92	PF00082	0.575
CLV_Separin_Metazoa	498	502	PF03568	0.376
CLV_Separin_Metazoa	578	582	PF03568	0.731
DEG_APCC_DBOX_1	141	149	PF00400	0.514
DEG_APCC_DBOX_1	190	198	PF00400	0.543
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DOC_CYCLIN_yClb5_NLxxxL_5	402	411	PF00134	0.468
DOC_MAPK_gen_1	261	269	PF00069	0.427
DOC_MAPK_gen_1	731	739	PF00069	0.628
DOC_USP7_MATH_1	115	119	PF00917	0.556
DOC_USP7_MATH_1	54	58	PF00917	0.549
DOC_USP7_MATH_1	599	603	PF00917	0.633
DOC_USP7_MATH_1	753	757	PF00917	0.607
DOC_USP7_MATH_1	759	763	PF00917	0.557
DOC_USP7_UBL2_3	106	110	PF12436	0.588
DOC_WW_Pin1_4	720	725	PF00397	0.639
DOC_WW_Pin1_4	743	748	PF00397	0.724
DOC_WW_Pin1_4	774	779	PF00397	0.712
LIG_14-3-3_CanoR_1	262	268	PF00244	0.487
LIG_14-3-3_CanoR_1	55	59	PF00244	0.573
LIG_14-3-3_CanoR_1	564	574	PF00244	0.585
LIG_14-3-3_CanoR_1	697	703	PF00244	0.806
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.444
LIG_Clathr_ClatBox_1	194	198	PF01394	0.546
LIG_deltaCOP1_diTrp_1	430	439	PF00928	0.393
LIG_deltaCOP1_diTrp_1	773	783	PF00928	0.694
LIG_eIF4E_1	574	580	PF01652	0.441
LIG_FHA_1	112	118	PF00498	0.551
LIG_FHA_1	324	330	PF00498	0.646
LIG_FHA_1	595	601	PF00498	0.633
LIG_FHA_1	782	788	PF00498	0.563
LIG_FHA_2	102	108	PF00498	0.553
LIG_FHA_2	163	169	PF00498	0.476
LIG_FHA_2	207	213	PF00498	0.557
LIG_FHA_2	333	339	PF00498	0.571
LIG_FHA_2	384	390	PF00498	0.544
LIG_FHA_2	596	602	PF00498	0.709
LIG_Integrin_isoDGR_2	640	642	PF01839	0.614
LIG_KLC1_Yacidic_2	224	229	PF13176	0.449
LIG_LIR_Apic_2	681	687	PF02991	0.679
LIG_LIR_Gen_1	171	180	PF02991	0.488
LIG_LIR_Gen_1	782	789	PF02991	0.606
LIG_LIR_Nem_3	171	175	PF02991	0.461
LIG_LIR_Nem_3	782	786	PF02991	0.604
LIG_NRBOX	86	92	PF00104	0.607
LIG_PCNA_PIPBox_1	294	303	PF02747	0.492
LIG_PCNA_yPIPBox_3	653	666	PF02747	0.651
LIG_Pex14_1	432	436	PF04695	0.387
LIG_RPA_C_Fungi	50	62	PF08784	0.452
LIG_SH2_GRB2like	574	577	PF00017	0.432
LIG_SH2_SRC	227	230	PF00017	0.424
LIG_SH2_STAP1	172	176	PF00017	0.537
LIG_SH2_STAP1	346	350	PF00017	0.594
LIG_SH2_STAT5	227	230	PF00017	0.424
LIG_SH2_STAT5	300	303	PF00017	0.498
LIG_SH3_2	724	729	PF14604	0.598
LIG_SH3_3	603	609	PF00018	0.737
LIG_SH3_3	684	690	PF00018	0.669
LIG_SH3_3	714	720	PF00018	0.670
LIG_SH3_3	721	727	PF00018	0.699
LIG_SUMO_SIM_anti_2	496	501	PF11976	0.375
LIG_TRAF2_1	209	212	PF00917	0.545
LIG_TRAF2_1	284	287	PF00917	0.504
LIG_TRAF2_1	302	305	PF00917	0.342
LIG_TRAF2_1	317	320	PF00917	0.484
LIG_TRAF2_1	419	422	PF00917	0.549
LIG_TRAF2_1	449	452	PF00917	0.488
LIG_WW_2	724	727	PF00397	0.593
MOD_CDC14_SPxK_1	746	749	PF00782	0.534
MOD_CDK_SPxK_1	743	749	PF00069	0.595
MOD_CK1_1	594	600	PF00069	0.555
MOD_CK1_1	766	772	PF00069	0.612
MOD_CK1_1	779	785	PF00069	0.733
MOD_CK2_1	162	168	PF00069	0.474
MOD_CK2_1	206	212	PF00069	0.526
MOD_CK2_1	31	37	PF00069	0.508
MOD_CK2_1	381	387	PF00069	0.425
MOD_CK2_1	40	46	PF00069	0.527
MOD_CK2_1	425	431	PF00069	0.454
MOD_CK2_1	769	775	PF00069	0.750
MOD_GlcNHglycan	117	120	PF01048	0.491
MOD_GlcNHglycan	184	187	PF01048	0.518
MOD_GlcNHglycan	32	36	PF01048	0.450
MOD_GlcNHglycan	413	417	PF01048	0.453
MOD_GlcNHglycan	614	617	PF01048	0.761
MOD_GlcNHglycan	620	623	PF01048	0.699
MOD_GlcNHglycan	636	639	PF01048	0.742
MOD_GlcNHglycan	662	665	PF01048	0.620
MOD_GlcNHglycan	778	781	PF01048	0.683
MOD_GlcNHglycan	93	97	PF01048	0.720
MOD_GSK3_1	111	118	PF00069	0.460
MOD_GSK3_1	140	147	PF00069	0.567
MOD_GSK3_1	421	428	PF00069	0.488
MOD_GSK3_1	591	598	PF00069	0.735
MOD_GSK3_1	660	667	PF00069	0.604
MOD_GSK3_1	754	761	PF00069	0.598
MOD_GSK3_1	787	794	PF00069	0.599
MOD_N-GLC_1	30	35	PF02516	0.575
MOD_N-GLC_1	763	768	PF02516	0.724
MOD_NEK2_1	197	202	PF00069	0.560
MOD_NEK2_1	246	251	PF00069	0.589
MOD_NEK2_1	378	383	PF00069	0.507
MOD_NEK2_1	461	466	PF00069	0.538
MOD_NEK2_1	666	671	PF00069	0.603
MOD_NEK2_1	678	683	PF00069	0.669
MOD_NEK2_1	792	797	PF00069	0.632
MOD_PIKK_1	162	168	PF00454	0.582
MOD_PIKK_1	206	212	PF00454	0.544
MOD_PIKK_1	378	384	PF00454	0.556
MOD_PIKK_1	395	401	PF00454	0.395
MOD_PIKK_1	40	46	PF00454	0.506
MOD_PIKK_1	519	525	PF00454	0.536
MOD_PIKK_1	565	571	PF00454	0.606
MOD_PIKK_1	763	769	PF00454	0.625
MOD_PIKK_1	793	799	PF00454	0.600
MOD_PKA_2	263	269	PF00069	0.565
MOD_PKA_2	40	46	PF00069	0.616
MOD_PKA_2	54	60	PF00069	0.493
MOD_PKA_2	612	618	PF00069	0.744
MOD_PKA_2	698	704	PF00069	0.746
MOD_PKA_2	730	736	PF00069	0.738
MOD_Plk_1	197	203	PF00069	0.472
MOD_Plk_1	246	252	PF00069	0.475
MOD_Plk_1	412	418	PF00069	0.519
MOD_Plk_1	421	427	PF00069	0.467
MOD_Plk_1	709	715	PF00069	0.620
MOD_Plk_1	763	769	PF00069	0.655
MOD_Plk_4	144	150	PF00069	0.508
MOD_Plk_4	197	203	PF00069	0.470
MOD_ProDKin_1	720	726	PF00069	0.641
MOD_ProDKin_1	743	749	PF00069	0.728
MOD_ProDKin_1	774	780	PF00069	0.711
MOD_SUMO_for_1	284	287	PF00179	0.498
MOD_SUMO_for_1	62	65	PF00179	0.501
MOD_SUMO_rev_2	32	40	PF00179	0.462
MOD_SUMO_rev_2	65	71	PF00179	0.571
TRG_DiLeu_BaEn_1	144	149	PF01217	0.494
TRG_DiLeu_BaEn_1	190	195	PF01217	0.542
TRG_DiLeu_BaEn_1	237	242	PF01217	0.534
TRG_DiLeu_BaEn_4	131	137	PF01217	0.637
TRG_DiLeu_LyEn_5	190	195	PF01217	0.542
TRG_DiLeu_LyEn_5	237	242	PF01217	0.463
TRG_ENDOCYTIC_2	172	175	PF00928	0.539
TRG_ENDOCYTIC_2	574	577	PF00928	0.489
TRG_ER_diArg_1	121	123	PF00400	0.521
TRG_ER_diArg_1	22	24	PF00400	0.475
TRG_ER_diArg_1	261	264	PF00400	0.596
TRG_ER_diArg_1	436	438	PF00400	0.390
TRG_ER_diArg_1	500	503	PF00400	0.464
TRG_ER_diArg_1	587	589	PF00400	0.657
TRG_ER_diArg_1	604	606	PF00400	0.654
TRG_ER_diArg_1	703	706	PF00400	0.772
TRG_ER_diArg_1	739	742	PF00400	0.679
TRG_NES_CRM1_1	456	471	PF08389	0.512
TRG_NES_CRM1_1	554	569	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	473	478	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJW5	Leptomonas seymouri	59%	82%
A0A0S4IKJ1	Bodo saltans	30%	100%
A0A1X0P6F2	Trypanosomatidae	34%	92%
A0A422MWV3	Trypanosoma rangeli	33%	95%
A4HMZ1	Leishmania braziliensis	79%	100%
A4IBL5	Leishmania infantum	100%	100%
C9ZZ25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	92%
E9AFE8	Leishmania major	92%	100%
E9B6K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BCX8	Trypanosoma cruzi	33%	95%