Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF501), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIH7_LEIDO

TriTrypDb:

LdBPK_343510.1 , LdCL_340044500 , LDHU3_34.5750

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIH7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.380
CLV_PCSK_KEX2_1	204	206	PF00082	0.485
CLV_PCSK_KEX2_1	5	7	PF00082	0.629
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.581
CLV_PCSK_SKI1_1	117	121	PF00082	0.296
CLV_PCSK_SKI1_1	280	284	PF00082	0.431
DOC_CYCLIN_RxL_1	114	121	PF00134	0.272
DOC_MAPK_gen_1	27	36	PF00069	0.476
DOC_MAPK_MEF2A_6	280	288	PF00069	0.403
DOC_PP1_RVXF_1	239	246	PF00149	0.332
DOC_PP4_FxxP_1	245	248	PF00568	0.440
DOC_USP7_MATH_1	146	150	PF00917	0.385
DOC_USP7_MATH_1	171	175	PF00917	0.385
DOC_WW_Pin1_4	118	123	PF00397	0.367
LIG_14-3-3_CanoR_1	204	209	PF00244	0.421
LIG_14-3-3_CanoR_1	216	225	PF00244	0.331
LIG_14-3-3_CanoR_1	241	246	PF00244	0.394
LIG_14-3-3_CanoR_1	280	285	PF00244	0.395
LIG_14-3-3_CanoR_1	6	12	PF00244	0.557
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_Clathr_ClatBox_1	285	289	PF01394	0.375
LIG_FHA_1	221	227	PF00498	0.400
LIG_FHA_1	281	287	PF00498	0.472
LIG_FHA_1	58	64	PF00498	0.325
LIG_FHA_2	35	41	PF00498	0.441
LIG_Integrin_isoDGR_2	54	56	PF01839	0.300
LIG_Integrin_isoDGR_2	57	59	PF01839	0.282
LIG_LIR_Apic_2	244	248	PF02991	0.416
LIG_LIR_Gen_1	215	226	PF02991	0.443
LIG_LIR_Nem_3	13	19	PF02991	0.561
LIG_LIR_Nem_3	215	221	PF02991	0.448
LIG_LIR_Nem_3	235	240	PF02991	0.485
LIG_Pex14_2	128	132	PF04695	0.291
LIG_Pex14_2	221	225	PF04695	0.353
LIG_PTB_Apo_2	239	246	PF02174	0.417
LIG_SH2_NCK_1	19	23	PF00017	0.557
LIG_SH2_PTP2	179	182	PF00017	0.398
LIG_SH2_SRC	19	22	PF00017	0.576
LIG_SH2_STAP1	112	116	PF00017	0.291
LIG_SH2_STAP1	19	23	PF00017	0.557
LIG_SH2_STAT5	179	182	PF00017	0.304
LIG_SH3_3	165	171	PF00018	0.367
LIG_SH3_3	244	250	PF00018	0.455
LIG_SUMO_SIM_par_1	283	289	PF11976	0.525
LIG_TYR_ITIM	177	182	PF00017	0.397
MOD_CK1_1	219	225	PF00069	0.470
MOD_CK2_1	34	40	PF00069	0.447
MOD_GlcNHglycan	8	11	PF01048	0.617
MOD_GlcNHglycan	91	94	PF01048	0.324
MOD_GSK3_1	204	211	PF00069	0.580
MOD_GSK3_1	212	219	PF00069	0.397
MOD_N-GLC_1	241	246	PF02516	0.393
MOD_NEK2_1	212	217	PF00069	0.407
MOD_NEK2_1	34	39	PF00069	0.442
MOD_NEK2_1	47	52	PF00069	0.221
MOD_NEK2_1	68	73	PF00069	0.291
MOD_PIKK_1	265	271	PF00454	0.437
MOD_PKA_1	204	210	PF00069	0.363
MOD_PKA_1	5	11	PF00069	0.610
MOD_PKA_2	204	210	PF00069	0.401
MOD_PKA_2	5	11	PF00069	0.610
MOD_Plk_1	212	218	PF00069	0.423
MOD_Plk_1	241	247	PF00069	0.384
MOD_Plk_4	171	177	PF00069	0.385
MOD_Plk_4	280	286	PF00069	0.329
MOD_Plk_4	63	69	PF00069	0.291
MOD_ProDKin_1	118	124	PF00069	0.367
MOD_SUMO_rev_2	2	7	PF00179	0.612
TRG_ENDOCYTIC_2	179	182	PF00928	0.338
TRG_ER_diArg_1	204	206	PF00400	0.380
TRG_ER_diArg_1	292	295	PF00400	0.469
TRG_NLS_MonoExtN_4	295	301	PF00514	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T1	Leptomonas seymouri	58%	100%
A0A422N2V1	Trypanosoma rangeli	40%	100%
A4HB91	Leishmania braziliensis	74%	100%
A4IAD9	Leishmania infantum	99%	100%
C9ZLV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B5G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2H2	Leishmania major	88%	100%