Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIG9_LEIDO

TriTrypDb:

LdBPK_354830.1 , LdCL_350053300 , LDHU3_35.6350

Length:

354

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A0A3Q8IIG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIG9

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	15
GO:0006457	protein folding	2	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009987	cellular process	1	15
GO:0018193	peptidyl-amino acid modification	5	15
GO:0018208	peptidyl-proline modification	6	15
GO:0019538	protein metabolic process	3	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	15
GO:0003824	catalytic activity	1	15
GO:0016853	isomerase activity	2	15
GO:0016859	cis-trans isomerase activity	3	15
GO:0140096	catalytic activity, acting on a protein	2	15
GO:0005488	binding	1	1
GO:0016018	cyclosporin A binding	4	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	296	298	PF00675	0.466
CLV_PCSK_KEX2_1	17	19	PF00082	0.353
CLV_PCSK_KEX2_1	205	207	PF00082	0.565
CLV_PCSK_KEX2_1	296	298	PF00082	0.438
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.333
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.562
CLV_PCSK_SKI1_1	20	24	PF00082	0.339
CLV_PCSK_SKI1_1	232	236	PF00082	0.484
CLV_PCSK_SKI1_1	289	293	PF00082	0.435
CLV_PCSK_SKI1_1	350	354	PF00082	0.538
DOC_MAPK_gen_1	15	25	PF00069	0.352
DOC_MAPK_MEF2A_6	17	25	PF00069	0.395
DOC_MAPK_MEF2A_6	277	286	PF00069	0.565
DOC_PP1_RVXF_1	133	140	PF00149	0.357
DOC_PP4_FxxP_1	98	101	PF00568	0.337
DOC_USP7_MATH_1	209	213	PF00917	0.469
DOC_USP7_MATH_1	225	229	PF00917	0.541
DOC_USP7_UBL2_3	335	339	PF12436	0.465
DOC_WW_Pin1_4	152	157	PF00397	0.461
DOC_WW_Pin1_4	196	201	PF00397	0.520
DOC_WW_Pin1_4	27	32	PF00397	0.337
LIG_14-3-3_CanoR_1	144	150	PF00244	0.352
LIG_14-3-3_CanoR_1	277	283	PF00244	0.560
LIG_APCC_ABBA_1	23	28	PF00400	0.357
LIG_APCC_ABBA_1	86	91	PF00400	0.337
LIG_BIR_III_2	176	180	PF00653	0.641
LIG_BIR_III_4	306	310	PF00653	0.544
LIG_BRCT_BRCA1_1	119	123	PF00533	0.357
LIG_FHA_1	277	283	PF00498	0.522
LIG_FHA_1	297	303	PF00498	0.280
LIG_FHA_1	326	332	PF00498	0.497
LIG_FHA_1	81	87	PF00498	0.353
LIG_LIR_Apic_2	95	101	PF02991	0.337
LIG_LIR_Gen_1	24	31	PF02991	0.347
LIG_LIR_Gen_1	4	12	PF02991	0.411
LIG_LIR_Gen_1	62	71	PF02991	0.366
LIG_LIR_Nem_3	188	193	PF02991	0.517
LIG_LIR_Nem_3	24	29	PF02991	0.369
LIG_LIR_Nem_3	35	40	PF02991	0.390
LIG_LIR_Nem_3	4	10	PF02991	0.502
LIG_LIR_Nem_3	62	66	PF02991	0.366
LIG_MLH1_MIPbox_1	119	123	PF16413	0.357
LIG_PTB_Apo_2	215	222	PF02174	0.428
LIG_PTB_Phospho_1	220	226	PF10480	0.563
LIG_REV1ctd_RIR_1	292	301	PF16727	0.406
LIG_RPA_C_Fungi	292	304	PF08784	0.364
LIG_SH2_GRB2like	239	242	PF00017	0.542
LIG_SH2_SRC	7	10	PF00017	0.333
LIG_SH2_STAP1	226	230	PF00017	0.432
LIG_SH2_STAP1	233	237	PF00017	0.386
LIG_SH2_STAT3	239	242	PF00017	0.473
LIG_SH2_STAT5	239	242	PF00017	0.455
LIG_SH2_STAT5	5	8	PF00017	0.468
LIG_SH3_3	188	194	PF00018	0.520
LIG_TRAF2_1	179	182	PF00917	0.558
MOD_CDK_SPK_2	27	32	PF00069	0.352
MOD_CK2_1	225	231	PF00069	0.600
MOD_Cter_Amidation	45	48	PF01082	0.392
MOD_GlcNHglycan	103	107	PF01048	0.489
MOD_GlcNHglycan	227	230	PF01048	0.541
MOD_GSK3_1	123	130	PF00069	0.392
MOD_GSK3_1	278	285	PF00069	0.595
MOD_GSK3_1	325	332	PF00069	0.550
MOD_GSK3_1	80	87	PF00069	0.378
MOD_N-GLC_1	117	122	PF02516	0.366
MOD_N-GLC_1	80	85	PF02516	0.363
MOD_N-GLC_1	96	101	PF02516	0.223
MOD_NEK2_1	122	127	PF00069	0.372
MOD_NEK2_1	8	13	PF00069	0.354
MOD_NEK2_2	145	150	PF00069	0.352
MOD_NEK2_2	209	214	PF00069	0.431
MOD_NEK2_2	84	89	PF00069	0.357
MOD_PIKK_1	117	123	PF00454	0.357
MOD_PIKK_1	312	318	PF00454	0.451
MOD_PKA_1	296	302	PF00069	0.456
MOD_PKA_2	276	282	PF00069	0.524
MOD_PKA_2	296	302	PF00069	0.294
MOD_Plk_1	8	14	PF00069	0.430
MOD_Plk_1	96	102	PF00069	0.438
MOD_Plk_2-3	182	188	PF00069	0.662
MOD_Plk_4	84	90	PF00069	0.357
MOD_ProDKin_1	152	158	PF00069	0.461
MOD_ProDKin_1	196	202	PF00069	0.520
MOD_ProDKin_1	27	33	PF00069	0.337
MOD_SUMO_for_1	16	19	PF00179	0.333
MOD_SUMO_rev_2	198	207	PF00179	0.620
MOD_SUMO_rev_2	247	257	PF00179	0.492
MOD_SUMO_rev_2	281	291	PF00179	0.567
TRG_ENDOCYTIC_2	5	8	PF00928	0.468
TRG_ER_diArg_1	295	297	PF00400	0.434
TRG_ER_diLys_1	350	354	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAQ4	Leptomonas seymouri	83%	100%
A0A0S4JAB5	Bodo saltans	58%	99%
A0A1X0P563	Trypanosomatidae	65%	100%
A0A3Q8IPW3	Leishmania donovani	30%	100%
A0A3R7RE54	Trypanosoma rangeli	44%	100%
A0A3S5H7U6	Leishmania donovani	53%	100%
A0A3S7X325	Leishmania donovani	32%	100%
A0A3S7XB52	Leishmania donovani	40%	100%
A0A422P185	Trypanosoma rangeli	65%	100%
A4H8P7	Leishmania braziliensis	33%	100%
A4HCL8	Leishmania braziliensis	45%	100%
A4HHU7	Leishmania braziliensis	33%	100%
A4HNE1	Leishmania braziliensis	87%	100%
A4I4Z7	Leishmania infantum	32%	100%
A4I935	Leishmania infantum	53%	100%
A4IC14	Leishmania infantum	100%	100%
A4IDA1	Leishmania infantum	40%	100%
C9ZYI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AFV2	Leishmania major	96%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B705	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P0C1I1	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	48%	97%
P0CP80	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	40%	94%
P0CP81	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	40%	94%
P26882	Bos taurus	45%	96%
P47103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	90%
P53691	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	95%
Q08752	Homo sapiens	46%	96%
Q11004	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	99%
Q2U0E0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	43%	95%
Q4HXF6	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	45%	95%
Q4P0V4	Ustilago maydis (strain 521 / FGSC 9021)	40%	89%
Q4Q1A6	Leishmania major	40%	100%
Q4Q7V7	Leishmania major	32%	100%
Q4WIF3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	94%
Q5ACI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	96%
Q5B4E7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	42%	95%
Q5U8Z7	Amanita muscaria	41%	95%
Q6BXZ7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	44%	96%
Q6CBP4	Yarrowia lipolytica (strain CLIB 122 / E 150)	41%	96%
Q6CL78	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	43%	95%
Q6DGG0	Rattus norvegicus	44%	96%
Q6FNU6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	42%	95%
Q75A33	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	96%
Q9C566	Arabidopsis thaliana	42%	98%
Q9CR16	Mus musculus	44%	96%
Q9P3X9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	94%
V5B2A0	Trypanosoma cruzi	45%	100%
V5D7H4	Trypanosoma cruzi	63%	100%