Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIF7_LEIDO

TriTrypDb:

LdBPK_354600.1 , LdCL_350051100 , LDHU3_35.6050

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.589
CLV_NRD_NRD_1	307	309	PF00675	0.641
CLV_NRD_NRD_1	445	447	PF00675	0.652
CLV_NRD_NRD_1	543	545	PF00675	0.657
CLV_NRD_NRD_1	558	560	PF00675	0.753
CLV_NRD_NRD_1	76	78	PF00675	0.521
CLV_PCSK_KEX2_1	306	308	PF00082	0.607
CLV_PCSK_KEX2_1	419	421	PF00082	0.653
CLV_PCSK_KEX2_1	445	447	PF00082	0.652
CLV_PCSK_KEX2_1	543	545	PF00082	0.655
CLV_PCSK_KEX2_1	76	78	PF00082	0.468
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.604
CLV_PCSK_SKI1_1	183	187	PF00082	0.456
CLV_PCSK_SKI1_1	401	405	PF00082	0.511
CLV_PCSK_SKI1_1	537	541	PF00082	0.615
CLV_PCSK_SKI1_1	606	610	PF00082	0.520
DEG_APCC_DBOX_1	307	315	PF00400	0.511
DEG_APCC_DBOX_1	390	398	PF00400	0.484
DEG_APCC_DBOX_1	543	551	PF00400	0.653
DEG_SPOP_SBC_1	374	378	PF00917	0.519
DEG_SPOP_SBC_1	513	517	PF00917	0.580
DOC_CYCLIN_RxL_1	602	612	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	88	94	PF00134	0.540
DOC_MAPK_gen_1	306	314	PF00069	0.530
DOC_MAPK_gen_1	691	700	PF00069	0.550
DOC_MAPK_MEF2A_6	307	316	PF00069	0.499
DOC_MAPK_MEF2A_6	691	700	PF00069	0.519
DOC_MAPK_NFAT4_5	693	701	PF00069	0.511
DOC_MAPK_RevD_3	404	420	PF00069	0.511
DOC_PP1_RVXF_1	84	90	PF00149	0.503
DOC_PP4_FxxP_1	226	229	PF00568	0.417
DOC_PP4_FxxP_1	539	542	PF00568	0.531
DOC_USP7_MATH_1	112	116	PF00917	0.758
DOC_USP7_MATH_1	218	222	PF00917	0.499
DOC_USP7_MATH_1	301	305	PF00917	0.763
DOC_USP7_MATH_1	348	352	PF00917	0.534
DOC_USP7_MATH_1	373	377	PF00917	0.521
DOC_USP7_MATH_1	482	486	PF00917	0.559
DOC_USP7_MATH_1	512	516	PF00917	0.680
DOC_USP7_MATH_1	524	528	PF00917	0.620
DOC_USP7_MATH_1	572	576	PF00917	0.784
DOC_WW_Pin1_4	329	334	PF00397	0.754
DOC_WW_Pin1_4	538	543	PF00397	0.744
DOC_WW_Pin1_4	564	569	PF00397	0.771
DOC_WW_Pin1_4	578	583	PF00397	0.645
DOC_WW_Pin1_4	635	640	PF00397	0.503
DOC_WW_Pin1_4	649	654	PF00397	0.503
LIG_14-3-3_CanoR_1	685	694	PF00244	0.489
LIG_Actin_WH2_2	168	185	PF00022	0.504
LIG_Actin_WH2_2	390	407	PF00022	0.495
LIG_AP2alpha_1	661	665	PF02296	0.458
LIG_BIR_III_2	212	216	PF00653	0.516
LIG_BRCT_BRCA1_1	526	530	PF00533	0.630
LIG_BRCT_BRCA1_1	633	637	PF00533	0.472
LIG_Clathr_ClatBox_1	468	472	PF01394	0.392
LIG_CtBP_PxDLS_1	70	76	PF00389	0.563
LIG_EH1_1	172	180	PF00400	0.464
LIG_eIF4E_1	78	84	PF01652	0.609
LIG_FHA_1	117	123	PF00498	0.752
LIG_FHA_1	134	140	PF00498	0.260
LIG_FHA_1	157	163	PF00498	0.502
LIG_FHA_1	376	382	PF00498	0.529
LIG_FHA_1	488	494	PF00498	0.574
LIG_FHA_1	515	521	PF00498	0.568
LIG_FHA_1	578	584	PF00498	0.712
LIG_FHA_1	676	682	PF00498	0.438
LIG_FHA_1	83	89	PF00498	0.495
LIG_FHA_2	103	109	PF00498	0.741
LIG_FHA_2	152	158	PF00498	0.622
LIG_FHA_2	24	30	PF00498	0.649
LIG_FHA_2	590	596	PF00498	0.671
LIG_FHA_2	687	693	PF00498	0.610
LIG_Integrin_isoDGR_2	422	424	PF01839	0.512
LIG_IRF3_LxIS_1	402	407	PF10401	0.373
LIG_LIR_Gen_1	247	257	PF02991	0.561
LIG_LIR_Gen_1	310	321	PF02991	0.455
LIG_LIR_Gen_1	464	471	PF02991	0.449
LIG_LIR_Gen_1	509	518	PF02991	0.708
LIG_LIR_Gen_1	527	536	PF02991	0.672
LIG_LIR_LC3C_4	622	625	PF02991	0.508
LIG_LIR_Nem_3	247	252	PF02991	0.518
LIG_LIR_Nem_3	310	316	PF02991	0.435
LIG_LIR_Nem_3	464	468	PF02991	0.470
LIG_LIR_Nem_3	509	513	PF02991	0.743
LIG_LIR_Nem_3	527	533	PF02991	0.631
LIG_NRBOX	696	702	PF00104	0.503
LIG_NRBOX	83	89	PF00104	0.502
LIG_PCNA_PIPBox_1	219	228	PF02747	0.490
LIG_PCNA_yPIPBox_3	424	436	PF02747	0.661
LIG_Pex14_1	359	363	PF04695	0.513
LIG_Pex14_2	657	661	PF04695	0.484
LIG_SH2_CRK	249	253	PF00017	0.553
LIG_SH2_STAT5	393	396	PF00017	0.533
LIG_SH2_STAT5	658	661	PF00017	0.532
LIG_SH3_3	212	218	PF00018	0.527
LIG_SH3_3	31	37	PF00018	0.640
LIG_SH3_3	565	571	PF00018	0.738
LIG_SH3_3	630	636	PF00018	0.486
LIG_SH3_3	88	94	PF00018	0.441
LIG_Sin3_3	621	628	PF02671	0.575
LIG_SUMO_SIM_anti_2	156	164	PF11976	0.561
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.499
LIG_SUMO_SIM_par_1	131	136	PF11976	0.497
LIG_SUMO_SIM_par_1	467	473	PF11976	0.401
LIG_TRAF2_1	439	442	PF00917	0.567
LIG_UBA3_1	696	704	PF00899	0.537
MOD_CDC14_SPxK_1	541	544	PF00782	0.544
MOD_CDK_SPK_2	538	543	PF00069	0.496
MOD_CDK_SPxK_1	538	544	PF00069	0.538
MOD_CK1_1	102	108	PF00069	0.789
MOD_CK1_1	128	134	PF00069	0.595
MOD_CK1_1	167	173	PF00069	0.560
MOD_CK1_1	247	253	PF00069	0.584
MOD_CK1_1	270	276	PF00069	0.730
MOD_CK1_1	283	289	PF00069	0.600
MOD_CK1_1	376	382	PF00069	0.510
MOD_CK1_1	449	455	PF00069	0.614
MOD_CK1_1	516	522	PF00069	0.691
MOD_CK1_1	564	570	PF00069	0.818
MOD_CK1_1	576	582	PF00069	0.689
MOD_CK1_1	586	592	PF00069	0.709
MOD_CK1_1	7	13	PF00069	0.691
MOD_CK2_1	102	108	PF00069	0.720
MOD_CK2_1	23	29	PF00069	0.650
MOD_CK2_1	589	595	PF00069	0.664
MOD_GlcNHglycan	110	113	PF01048	0.672
MOD_GlcNHglycan	116	119	PF01048	0.674
MOD_GlcNHglycan	189	192	PF01048	0.662
MOD_GlcNHglycan	196	199	PF01048	0.736
MOD_GlcNHglycan	257	260	PF01048	0.722
MOD_GlcNHglycan	272	275	PF01048	0.589
MOD_GlcNHglycan	288	291	PF01048	0.749
MOD_GlcNHglycan	299	302	PF01048	0.656
MOD_GlcNHglycan	316	319	PF01048	0.340
MOD_GlcNHglycan	336	339	PF01048	0.728
MOD_GlcNHglycan	406	409	PF01048	0.530
MOD_GlcNHglycan	472	475	PF01048	0.484
MOD_GlcNHglycan	484	487	PF01048	0.573
MOD_GlcNHglycan	55	58	PF01048	0.418
MOD_GlcNHglycan	9	12	PF01048	0.745
MOD_GSK3_1	108	115	PF00069	0.691
MOD_GSK3_1	18	25	PF00069	0.657
MOD_GSK3_1	231	238	PF00069	0.551
MOD_GSK3_1	244	251	PF00069	0.528
MOD_GSK3_1	297	304	PF00069	0.699
MOD_GSK3_1	325	332	PF00069	0.665
MOD_GSK3_1	373	380	PF00069	0.594
MOD_GSK3_1	508	515	PF00069	0.663
MOD_GSK3_1	572	579	PF00069	0.734
MOD_GSK3_1	585	592	PF00069	0.639
MOD_GSK3_1	631	638	PF00069	0.491
MOD_GSK3_1	681	688	PF00069	0.545
MOD_N-GLC_1	102	107	PF02516	0.797
MOD_N-GLC_1	235	240	PF02516	0.616
MOD_N-GLC_1	446	451	PF02516	0.644
MOD_N-GLC_1	513	518	PF02516	0.738
MOD_N-GLC_1	583	588	PF02516	0.725
MOD_N-GLC_2	341	343	PF02516	0.667
MOD_NEK2_1	252	257	PF00069	0.668
MOD_NEK2_1	296	301	PF00069	0.773
MOD_NEK2_1	312	317	PF00069	0.429
MOD_NEK2_1	395	400	PF00069	0.481
MOD_NEK2_1	4	9	PF00069	0.753
MOD_NEK2_1	404	409	PF00069	0.519
MOD_NEK2_1	415	420	PF00069	0.292
MOD_NEK2_1	573	578	PF00069	0.750
MOD_NEK2_1	609	614	PF00069	0.448
MOD_NEK2_1	623	628	PF00069	0.390
MOD_NEK2_1	681	686	PF00069	0.556
MOD_NEK2_2	686	691	PF00069	0.593
MOD_PIKK_1	396	402	PF00454	0.594
MOD_PIKK_1	422	428	PF00454	0.645
MOD_PIKK_1	449	455	PF00454	0.718
MOD_PIKK_1	487	493	PF00454	0.572
MOD_PIKK_1	545	551	PF00454	0.659
MOD_PIKK_1	71	77	PF00454	0.564
MOD_PK_1	5	11	PF00069	0.652
MOD_PKA_2	404	410	PF00069	0.487
MOD_Plk_1	156	162	PF00069	0.489
MOD_Plk_1	167	173	PF00069	0.524
MOD_Plk_1	531	537	PF00069	0.563
MOD_Plk_1	583	589	PF00069	0.697
MOD_Plk_1	595	601	PF00069	0.587
MOD_Plk_4	128	134	PF00069	0.561
MOD_Plk_4	18	24	PF00069	0.778
MOD_Plk_4	218	224	PF00069	0.443
MOD_Plk_4	244	250	PF00069	0.497
MOD_Plk_4	377	383	PF00069	0.593
MOD_Plk_4	668	674	PF00069	0.582
MOD_ProDKin_1	329	335	PF00069	0.755
MOD_ProDKin_1	538	544	PF00069	0.747
MOD_ProDKin_1	564	570	PF00069	0.772
MOD_ProDKin_1	578	584	PF00069	0.645
MOD_ProDKin_1	635	641	PF00069	0.509
MOD_ProDKin_1	649	655	PF00069	0.505
MOD_SUMO_rev_2	234	239	PF00179	0.574
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.541
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.479
TRG_ENDOCYTIC_2	249	252	PF00928	0.590
TRG_ENDOCYTIC_2	658	661	PF00928	0.532
TRG_ER_diArg_1	306	308	PF00400	0.618
TRG_ER_diArg_1	542	544	PF00400	0.608
TRG_ER_diArg_1	76	78	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN1	Leptomonas seymouri	53%	98%
A0A1X0P552	Trypanosomatidae	29%	100%
A4HNC0	Leishmania braziliensis	72%	100%
A4IBZ3	Leishmania infantum	100%	100%
C9ZYL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AFT0	Leishmania major	90%	100%
E9B6Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%