Kinesin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinesin, putative

Gene product:

kinesin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIF6_LEIDO

TriTrypDb:

LdBPK_341640.1 , LdCL_340022700 , LDHU3_34.2480

Length:

1068

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	1
GO:0005929	cilium	4	1
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IIF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIF6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005524	ATP binding	5	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8
GO:0016787	hydrolase activity	2	6
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	605	609	PF00656	0.487
CLV_C14_Caspase3-7	654	658	PF00656	0.629
CLV_NRD_NRD_1	15	17	PF00675	0.628
CLV_NRD_NRD_1	168	170	PF00675	0.341
CLV_NRD_NRD_1	414	416	PF00675	0.356
CLV_NRD_NRD_1	612	614	PF00675	0.492
CLV_NRD_NRD_1	764	766	PF00675	0.637
CLV_NRD_NRD_1	806	808	PF00675	0.622
CLV_NRD_NRD_1	817	819	PF00675	0.626
CLV_PCSK_FUR_1	274	278	PF00082	0.321
CLV_PCSK_KEX2_1	1006	1008	PF00082	0.547
CLV_PCSK_KEX2_1	1058	1060	PF00082	0.558
CLV_PCSK_KEX2_1	15	17	PF00082	0.622
CLV_PCSK_KEX2_1	276	278	PF00082	0.298
CLV_PCSK_KEX2_1	414	416	PF00082	0.353
CLV_PCSK_KEX2_1	6	8	PF00082	0.578
CLV_PCSK_KEX2_1	612	614	PF00082	0.483
CLV_PCSK_KEX2_1	677	679	PF00082	0.677
CLV_PCSK_KEX2_1	816	818	PF00082	0.586
CLV_PCSK_KEX2_1	824	826	PF00082	0.544
CLV_PCSK_KEX2_1	829	831	PF00082	0.511
CLV_PCSK_PC1ET2_1	1006	1008	PF00082	0.547
CLV_PCSK_PC1ET2_1	1058	1060	PF00082	0.558
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.289
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.343
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.578
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.677
CLV_PCSK_PC1ET2_1	824	826	PF00082	0.563
CLV_PCSK_PC1ET2_1	829	831	PF00082	0.563
CLV_PCSK_PC7_1	825	831	PF00082	0.565
CLV_PCSK_SKI1_1	1035	1039	PF00082	0.552
CLV_PCSK_SKI1_1	311	315	PF00082	0.293
CLV_PCSK_SKI1_1	380	384	PF00082	0.293
CLV_PCSK_SKI1_1	397	401	PF00082	0.293
CLV_PCSK_SKI1_1	449	453	PF00082	0.293
CLV_PCSK_SKI1_1	931	935	PF00082	0.530
DEG_APCC_DBOX_1	355	363	PF00400	0.327
DEG_APCC_DBOX_1	624	632	PF00400	0.447
DEG_ODPH_VHL_1	767	780	PF01847	0.614
DEG_SPOP_SBC_1	728	732	PF00917	0.601
DEG_SPOP_SBC_1	769	773	PF00917	0.592
DEG_SPOP_SBC_1	994	998	PF00917	0.621
DOC_ANK_TNKS_1	276	283	PF00023	0.292
DOC_ANK_TNKS_1	764	771	PF00023	0.626
DOC_CKS1_1	34	39	PF01111	0.606
DOC_CKS1_1	844	849	PF01111	0.530
DOC_MAPK_gen_1	380	388	PF00069	0.293
DOC_MAPK_gen_1	414	420	PF00069	0.313
DOC_MAPK_gen_1	440	448	PF00069	0.294
DOC_MAPK_gen_1	89	97	PF00069	0.243
DOC_MAPK_MEF2A_6	61	70	PF00069	0.407
DOC_PP1_RVXF_1	16	23	PF00149	0.582
DOC_PP1_RVXF_1	283	289	PF00149	0.293
DOC_PP2B_LxvP_1	752	755	PF13499	0.541
DOC_USP7_MATH_1	1053	1057	PF00917	0.543
DOC_USP7_MATH_1	163	167	PF00917	0.418
DOC_USP7_MATH_1	25	29	PF00917	0.590
DOC_USP7_MATH_1	255	259	PF00917	0.305
DOC_USP7_MATH_1	401	405	PF00917	0.278
DOC_USP7_MATH_1	43	47	PF00917	0.484
DOC_USP7_MATH_1	523	527	PF00917	0.502
DOC_USP7_MATH_1	669	673	PF00917	0.638
DOC_USP7_MATH_1	691	695	PF00917	0.596
DOC_USP7_MATH_1	704	708	PF00917	0.573
DOC_USP7_MATH_1	714	718	PF00917	0.613
DOC_USP7_MATH_1	721	725	PF00917	0.546
DOC_USP7_MATH_1	728	732	PF00917	0.546
DOC_USP7_MATH_1	769	773	PF00917	0.582
DOC_USP7_MATH_1	81	85	PF00917	0.295
DOC_USP7_MATH_1	860	864	PF00917	0.691
DOC_USP7_MATH_1	979	983	PF00917	0.656
DOC_USP7_UBL2_3	100	104	PF12436	0.273
DOC_USP7_UBL2_3	673	677	PF12436	0.562
DOC_USP7_UBL2_3	824	828	PF12436	0.560
DOC_WW_Pin1_4	27	32	PF00397	0.553
DOC_WW_Pin1_4	303	308	PF00397	0.293
DOC_WW_Pin1_4	33	38	PF00397	0.592
DOC_WW_Pin1_4	462	467	PF00397	0.335
DOC_WW_Pin1_4	662	667	PF00397	0.514
DOC_WW_Pin1_4	746	751	PF00397	0.665
DOC_WW_Pin1_4	759	764	PF00397	0.639
DOC_WW_Pin1_4	786	791	PF00397	0.580
DOC_WW_Pin1_4	843	848	PF00397	0.530
DOC_WW_Pin1_4	9	14	PF00397	0.635
DOC_WW_Pin1_4	973	978	PF00397	0.617
LIG_14-3-3_CanoR_1	201	207	PF00244	0.263
LIG_14-3-3_CanoR_1	228	232	PF00244	0.310
LIG_14-3-3_CanoR_1	331	341	PF00244	0.302
LIG_14-3-3_CanoR_1	560	569	PF00244	0.535
LIG_14-3-3_CanoR_1	726	734	PF00244	0.636
LIG_14-3-3_CanoR_1	862	867	PF00244	0.563
LIG_14-3-3_CanoR_1	877	884	PF00244	0.545
LIG_14-3-3_CanoR_1	993	1001	PF00244	0.642
LIG_Actin_WH2_2	902	917	PF00022	0.516
LIG_APCC_ABBA_1	339	344	PF00400	0.293
LIG_BRCT_BRCA1_1	46	50	PF00533	0.524
LIG_BRCT_BRCA1_1	788	792	PF00533	0.587
LIG_CSL_BTD_1	21	24	PF09270	0.527
LIG_eIF4E_1	908	914	PF01652	0.508
LIG_FHA_1	15	21	PF00498	0.656
LIG_FHA_1	238	244	PF00498	0.278
LIG_FHA_1	338	344	PF00498	0.282
LIG_FHA_1	388	394	PF00498	0.341
LIG_FHA_1	432	438	PF00498	0.306
LIG_FHA_1	443	449	PF00498	0.390
LIG_FHA_1	456	462	PF00498	0.341
LIG_FHA_1	473	479	PF00498	0.341
LIG_FHA_1	496	502	PF00498	0.446
LIG_FHA_1	561	567	PF00498	0.552
LIG_FHA_1	685	691	PF00498	0.625
LIG_FHA_1	83	89	PF00498	0.333
LIG_FHA_1	885	891	PF00498	0.542
LIG_FHA_1	995	1001	PF00498	0.619
LIG_FHA_2	122	128	PF00498	0.335
LIG_FHA_2	203	209	PF00498	0.263
LIG_FHA_2	216	222	PF00498	0.291
LIG_FHA_2	560	566	PF00498	0.574
LIG_FHA_2	739	745	PF00498	0.620
LIG_FHA_2	77	83	PF00498	0.267
LIG_FHA_2	850	856	PF00498	0.487
LIG_FHA_2	887	893	PF00498	0.524
LIG_Integrin_RGD_1	7	9	PF01839	0.633
LIG_LIR_Apic_2	1038	1044	PF02991	0.616
LIG_LIR_Apic_2	841	847	PF02991	0.540
LIG_LIR_Apic_2	855	860	PF02991	0.517
LIG_LIR_Gen_1	1015	1025	PF02991	0.568
LIG_LIR_Gen_1	123	132	PF02991	0.479
LIG_LIR_Gen_1	598	605	PF02991	0.418
LIG_LIR_Nem_3	1015	1020	PF02991	0.579
LIG_LIR_Nem_3	123	128	PF02991	0.479
LIG_LIR_Nem_3	230	235	PF02991	0.337
LIG_LIR_Nem_3	312	318	PF02991	0.321
LIG_LIR_Nem_3	598	603	PF02991	0.417
LIG_LIR_Nem_3	60	66	PF02991	0.400
LIG_LIR_Nem_3	851	856	PF02991	0.488
LIG_LIR_Nem_3	954	959	PF02991	0.462
LIG_MYND_1	750	754	PF01753	0.554
LIG_NRBOX	443	449	PF00104	0.341
LIG_NRP_CendR_1	1066	1068	PF00754	0.549
LIG_PCNA_PIPBox_1	320	329	PF02747	0.293
LIG_PCNA_yPIPBox_3	236	244	PF02747	0.293
LIG_PCNA_yPIPBox_3	593	606	PF02747	0.490
LIG_Pex14_2	227	231	PF04695	0.341
LIG_Rb_pABgroove_1	189	197	PF01858	0.341
LIG_SH2_CRK	600	604	PF00017	0.416
LIG_SH2_CRK	844	848	PF00017	0.546
LIG_SH2_CRK	857	861	PF00017	0.534
LIG_SH2_CRK	956	960	PF00017	0.476
LIG_SH2_SRC	342	345	PF00017	0.341
LIG_SH2_SRC	908	911	PF00017	0.510
LIG_SH2_STAP1	1028	1032	PF00017	0.522
LIG_SH2_STAP1	840	844	PF00017	0.534
LIG_SH2_STAP1	853	857	PF00017	0.494
LIG_SH2_STAT3	1028	1031	PF00017	0.590
LIG_SH2_STAT3	840	843	PF00017	0.624
LIG_SH2_STAT3	856	859	PF00017	0.475
LIG_SH2_STAT5	225	228	PF00017	0.293
LIG_SH2_STAT5	342	345	PF00017	0.301
LIG_SH2_STAT5	470	473	PF00017	0.309
LIG_SH2_STAT5	908	911	PF00017	0.510
LIG_SH3_1	1047	1053	PF00018	0.624
LIG_SH3_1	71	77	PF00018	0.292
LIG_SH3_3	1047	1053	PF00018	0.602
LIG_SH3_3	71	77	PF00018	0.292
LIG_SH3_3	731	737	PF00018	0.635
LIG_SH3_3	748	754	PF00018	0.522
LIG_SH3_3	757	763	PF00018	0.642
LIG_SH3_3	868	874	PF00018	0.601
LIG_SH3_3	972	978	PF00018	0.620
LIG_SH3_3	988	994	PF00018	0.558
LIG_SUMO_SIM_anti_2	357	363	PF11976	0.293
LIG_SUMO_SIM_anti_2	626	633	PF11976	0.436
LIG_SxIP_EBH_1	993	1006	PF03271	0.634
LIG_TRAF2_1	51	54	PF00917	0.476
LIG_TRAF2_1	683	686	PF00917	0.612
LIG_UBA3_1	314	321	PF00899	0.341
LIG_UBA3_1	392	397	PF00899	0.293
LIG_WRC_WIRS_1	122	127	PF05994	0.335
LIG_WW_3	12	16	PF00397	0.653
LIG_WW_3	547	551	PF00397	0.517
MOD_CDC14_SPxK_1	12	15	PF00782	0.566
MOD_CDC14_SPxK_1	762	765	PF00782	0.641
MOD_CDK_SPxK_1	759	765	PF00069	0.641
MOD_CDK_SPxK_1	9	15	PF00069	0.610
MOD_CDK_SPxxK_3	462	469	PF00069	0.335
MOD_CDK_SPxxK_3	759	766	PF00069	0.629
MOD_CDK_SPxxK_3	9	16	PF00069	0.652
MOD_CK1_1	1012	1018	PF00069	0.753
MOD_CK1_1	151	157	PF00069	0.341
MOD_CK1_1	258	264	PF00069	0.335
MOD_CK1_1	332	338	PF00069	0.341
MOD_CK1_1	35	41	PF00069	0.603
MOD_CK1_1	357	363	PF00069	0.293
MOD_CK1_1	442	448	PF00069	0.410
MOD_CK1_1	456	462	PF00069	0.341
MOD_CK1_1	555	561	PF00069	0.554
MOD_CK1_1	729	735	PF00069	0.647
MOD_CK1_1	771	777	PF00069	0.533
MOD_CK1_1	973	979	PF00069	0.630
MOD_CK1_1	982	988	PF00069	0.601
MOD_CK2_1	121	127	PF00069	0.283
MOD_CK2_1	202	208	PF00069	0.263
MOD_CK2_1	303	309	PF00069	0.309
MOD_CK2_1	523	529	PF00069	0.573
MOD_CK2_1	713	719	PF00069	0.559
MOD_CK2_1	936	942	PF00069	0.536
MOD_Cter_Amidation	1004	1007	PF01082	0.553
MOD_Cter_Amidation	814	817	PF01082	0.584
MOD_GlcNHglycan	1014	1017	PF01048	0.593
MOD_GlcNHglycan	150	153	PF01048	0.341
MOD_GlcNHglycan	26	30	PF01048	0.586
MOD_GlcNHglycan	263	266	PF01048	0.259
MOD_GlcNHglycan	315	318	PF01048	0.341
MOD_GlcNHglycan	37	40	PF01048	0.558
MOD_GlcNHglycan	377	380	PF01048	0.308
MOD_GlcNHglycan	403	406	PF01048	0.315
MOD_GlcNHglycan	46	49	PF01048	0.551
MOD_GlcNHglycan	693	697	PF01048	0.607
MOD_GlcNHglycan	705	709	PF01048	0.533
MOD_GlcNHglycan	715	719	PF01048	0.578
MOD_GlcNHglycan	972	975	PF01048	0.645
MOD_GlcNHglycan	979	982	PF01048	0.618
MOD_GlcNHglycan	985	988	PF01048	0.587
MOD_GSK3_1	202	209	PF00069	0.251
MOD_GSK3_1	223	230	PF00069	0.293
MOD_GSK3_1	255	262	PF00069	0.372
MOD_GSK3_1	371	378	PF00069	0.283
MOD_GSK3_1	397	404	PF00069	0.306
MOD_GSK3_1	548	555	PF00069	0.612
MOD_GSK3_1	973	980	PF00069	0.654
MOD_GSK3_1	982	989	PF00069	0.693
MOD_N-GLC_1	1033	1038	PF02516	0.611
MOD_N-GLC_1	354	359	PF02516	0.243
MOD_N-GLC_1	388	393	PF02516	0.347
MOD_N-GLC_1	662	667	PF02516	0.650
MOD_N-GLC_1	786	791	PF02516	0.599
MOD_N-GLC_1	936	941	PF02516	0.539
MOD_N-GLC_1	994	999	PF02516	0.628
MOD_N-GLC_2	535	537	PF02516	0.509
MOD_NEK2_1	1010	1015	PF00069	0.606
MOD_NEK2_1	139	144	PF00069	0.311
MOD_NEK2_1	227	232	PF00069	0.293
MOD_NEK2_1	243	248	PF00069	0.414
MOD_NEK2_1	260	265	PF00069	0.438
MOD_NEK2_1	313	318	PF00069	0.284
MOD_NEK2_1	575	580	PF00069	0.612
MOD_NEK2_1	684	689	PF00069	0.578
MOD_NEK2_1	713	718	PF00069	0.576
MOD_NEK2_1	727	732	PF00069	0.591
MOD_NEK2_1	893	898	PF00069	0.530
MOD_NEK2_2	1053	1058	PF00069	0.502
MOD_NEK2_2	337	342	PF00069	0.341
MOD_PIKK_1	163	169	PF00454	0.312
MOD_PIKK_1	7	13	PF00454	0.578
MOD_PIKK_1	860	866	PF00454	0.583
MOD_PK_1	776	782	PF00069	0.545
MOD_PKA_1	823	829	PF00069	0.540
MOD_PKA_2	14	20	PF00069	0.631
MOD_PKA_2	227	233	PF00069	0.306
MOD_PKA_2	243	249	PF00069	0.414
MOD_PKA_2	330	336	PF00069	0.303
MOD_PKA_2	439	445	PF00069	0.342
MOD_PKA_2	559	565	PF00069	0.609
MOD_PKA_2	669	675	PF00069	0.652
MOD_PKA_2	802	808	PF00069	0.616
MOD_PKA_2	876	882	PF00069	0.626
MOD_PKA_2	937	943	PF00069	0.521
MOD_PKB_1	1049	1057	PF00069	0.523
MOD_Plk_1	223	229	PF00069	0.323
MOD_Plk_1	357	363	PF00069	0.293
MOD_Plk_1	388	394	PF00069	0.347
MOD_Plk_1	495	501	PF00069	0.506
MOD_Plk_1	684	690	PF00069	0.608
MOD_Plk_1	793	799	PF00069	0.609
MOD_Plk_2-3	215	221	PF00069	0.292
MOD_Plk_4	139	145	PF00069	0.310
MOD_Plk_4	202	208	PF00069	0.273
MOD_Plk_4	227	233	PF00069	0.341
MOD_Plk_4	357	363	PF00069	0.293
MOD_Plk_4	388	394	PF00069	0.342
MOD_Plk_4	442	448	PF00069	0.339
MOD_Plk_4	456	462	PF00069	0.320
MOD_Plk_4	474	480	PF00069	0.341
MOD_Plk_4	496	502	PF00069	0.477
MOD_Plk_4	523	529	PF00069	0.532
MOD_Plk_4	575	581	PF00069	0.456
MOD_Plk_4	909	915	PF00069	0.506
MOD_ProDKin_1	27	33	PF00069	0.554
MOD_ProDKin_1	303	309	PF00069	0.293
MOD_ProDKin_1	462	468	PF00069	0.335
MOD_ProDKin_1	662	668	PF00069	0.517
MOD_ProDKin_1	746	752	PF00069	0.666
MOD_ProDKin_1	759	765	PF00069	0.641
MOD_ProDKin_1	786	792	PF00069	0.584
MOD_ProDKin_1	843	849	PF00069	0.529
MOD_ProDKin_1	9	15	PF00069	0.637
MOD_ProDKin_1	973	979	PF00069	0.614
MOD_SUMO_for_1	294	297	PF00179	0.283
MOD_SUMO_for_1	512	515	PF00179	0.428
MOD_SUMO_rev_2	654	662	PF00179	0.663
TRG_DiLeu_BaEn_1	368	373	PF01217	0.293
TRG_DiLeu_BaEn_4	507	513	PF01217	0.402
TRG_ENDOCYTIC_2	519	522	PF00928	0.441
TRG_ENDOCYTIC_2	600	603	PF00928	0.415
TRG_ENDOCYTIC_2	956	959	PF00928	0.469
TRG_ER_diArg_1	1046	1049	PF00400	0.649
TRG_ER_diArg_1	14	16	PF00400	0.691
TRG_ER_diArg_1	284	287	PF00400	0.322
TRG_ER_diArg_1	422	425	PF00400	0.290
TRG_ER_diArg_1	65	68	PF00400	0.381
TRG_ER_diArg_1	70	73	PF00400	0.341
TRG_ER_diArg_1	816	818	PF00400	0.602
TRG_NLS_MonoExtN_4	676	681	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	682	686	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	931	935	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	946	950	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMQ7	Leptomonas seymouri	54%	99%
A4H7S0	Leishmania braziliensis	65%	100%
A4HCT2	Leishmania braziliensis	28%	100%
A4I9W6	Leishmania infantum	99%	100%
E9B4X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q348	Leishmania major	91%	100%