IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIE7_LEIDO

TriTrypDb:

LdBPK_310800.1 , LdCL_310013800 , LDHU3_31.1330

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.533
CLV_NRD_NRD_1	123	125	PF00675	0.448
CLV_PCSK_KEX2_1	191	193	PF00082	0.466
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.454
CLV_PCSK_SKI1_1	104	108	PF00082	0.521
CLV_PCSK_SKI1_1	111	115	PF00082	0.483
CLV_PCSK_SKI1_1	117	121	PF00082	0.436
CLV_PCSK_SKI1_1	124	128	PF00082	0.352
CLV_PCSK_SKI1_1	183	187	PF00082	0.457
DOC_MAPK_gen_1	157	164	PF00069	0.487
DOC_PP4_FxxP_1	7	10	PF00568	0.571
DOC_USP7_MATH_1	115	119	PF00917	0.526
DOC_USP7_MATH_1	138	142	PF00917	0.546
DOC_USP7_MATH_1	160	164	PF00917	0.436
DOC_USP7_MATH_1	22	26	PF00917	0.445
DOC_USP7_MATH_1	53	57	PF00917	0.506
DOC_USP7_UBL2_3	103	107	PF12436	0.564
DOC_WW_Pin1_4	297	302	PF00397	0.766
LIG_14-3-3_CanoR_1	230	234	PF00244	0.610
LIG_14-3-3_CanoR_1	283	289	PF00244	0.613
LIG_Actin_WH2_2	88	105	PF00022	0.506
LIG_AP2alpha_1	171	175	PF02296	0.484
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BRCT_BRCA1_1	47	51	PF00533	0.473
LIG_BRCT_BRCA1_1	55	59	PF00533	0.492
LIG_CaM_IQ_9	161	176	PF13499	0.326
LIG_FHA_1	200	206	PF00498	0.473
LIG_FHA_2	207	213	PF00498	0.524
LIG_FHA_2	58	64	PF00498	0.488
LIG_LIR_Apic_2	6	10	PF02991	0.583
LIG_LIR_Gen_1	172	182	PF02991	0.479
LIG_LIR_Gen_1	48	59	PF02991	0.478
LIG_LIR_Nem_3	118	123	PF02991	0.473
LIG_LIR_Nem_3	172	178	PF02991	0.454
LIG_LIR_Nem_3	25	29	PF02991	0.565
LIG_LIR_Nem_3	48	54	PF02991	0.473
LIG_Pex14_2	171	175	PF04695	0.443
LIG_Rb_LxCxE_1	216	235	PF01857	0.392
LIG_SH2_CRK	87	91	PF00017	0.473
LIG_SH2_SRC	67	70	PF00017	0.505
LIG_SH2_STAT5	193	196	PF00017	0.467
LIG_SH2_STAT5	67	70	PF00017	0.503
LIG_SH3_3	92	98	PF00018	0.462
LIG_SUMO_SIM_anti_2	243	249	PF11976	0.398
LIG_TRAF2_1	214	217	PF00917	0.507
LIG_TRAF2_2	10	15	PF00917	0.528
LIG_TRFH_1	254	258	PF08558	0.555
LIG_UBA3_1	33	38	PF00899	0.537
LIG_WRC_WIRS_1	23	28	PF05994	0.512
LIG_WW_3	292	296	PF00397	0.603
MOD_CK1_1	149	155	PF00069	0.519
MOD_CK1_1	243	249	PF00069	0.577
MOD_CK1_1	273	279	PF00069	0.667
MOD_CK1_1	286	292	PF00069	0.707
MOD_CK2_1	102	108	PF00069	0.549
MOD_CK2_1	115	121	PF00069	0.487
MOD_CK2_1	211	217	PF00069	0.459
MOD_CK2_1	229	235	PF00069	0.362
MOD_CK2_1	57	63	PF00069	0.596
MOD_CK2_1	74	80	PF00069	0.445
MOD_GlcNHglycan	116	120	PF01048	0.429
MOD_GlcNHglycan	26	29	PF01048	0.450
MOD_GSK3_1	24	31	PF00069	0.417
MOD_GSK3_1	282	289	PF00069	0.736
MOD_GSK3_1	297	304	PF00069	0.644
MOD_GSK3_1	53	60	PF00069	0.542
MOD_N-GLC_1	183	188	PF02516	0.571
MOD_NEK2_1	102	107	PF00069	0.463
MOD_NEK2_1	144	149	PF00069	0.507
MOD_NEK2_1	40	45	PF00069	0.514
MOD_PIKK_1	248	254	PF00454	0.531
MOD_PKA_2	229	235	PF00069	0.518
MOD_PKA_2	282	288	PF00069	0.746
MOD_Plk_1	115	121	PF00069	0.610
MOD_Plk_1	243	249	PF00069	0.665
MOD_Plk_2-3	74	80	PF00069	0.379
MOD_Plk_4	200	206	PF00069	0.486
MOD_Plk_4	229	235	PF00069	0.578
MOD_Plk_4	243	249	PF00069	0.589
MOD_ProDKin_1	297	303	PF00069	0.767
MOD_SUMO_for_1	113	116	PF00179	0.524
TRG_DiLeu_BaEn_4	216	222	PF01217	0.533
TRG_ENDOCYTIC_2	193	196	PF00928	0.472
TRG_ENDOCYTIC_2	87	90	PF00928	0.499
TRG_ER_diArg_1	294	297	PF00400	0.616
TRG_NLS_MonoExtN_4	122	128	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	24%	71%
A0A0N0P3S1	Leptomonas seymouri	59%	68%
A0A0N0P4S1	Leptomonas seymouri	23%	100%
A0A1X0NK28	Trypanosomatidae	38%	76%
A0A3Q8IG21	Leishmania donovani	93%	100%
A0A3S7WQB3	Leishmania donovani	25%	74%
A4H6C6	Leishmania braziliensis	23%	100%
A4HJ56	Leishmania braziliensis	66%	100%
A4HTM7	Leishmania infantum	25%	74%
A4I6H9	Leishmania infantum	92%	100%
E9AHL0	Leishmania infantum	98%	100%
E9AMG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	74%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q6H8	Leishmania major	81%	100%
Q4Q6I6	Leishmania major	78%	99%
Q4QI82	Leishmania major	24%	100%