Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIE6_LEIDO

TriTrypDb:

LdBPK_354370.1 , LdCL_350048800 , LDHU3_35.5790

Length:

249

Annotations

LeishMANIAdb annotations

A very conserved protein restricted to Kinetoplastids, protentially involved in coiled-coil interactions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.456
CLV_NRD_NRD_1	181	183	PF00675	0.385
CLV_NRD_NRD_1	230	232	PF00675	0.450
CLV_NRD_NRD_1	25	27	PF00675	0.718
CLV_NRD_NRD_1	76	78	PF00675	0.671
CLV_PCSK_KEX2_1	180	182	PF00082	0.427
CLV_PCSK_KEX2_1	2	4	PF00082	0.655
CLV_PCSK_KEX2_1	230	232	PF00082	0.452
CLV_PCSK_KEX2_1	246	248	PF00082	0.452
CLV_PCSK_KEX2_1	25	27	PF00082	0.718
CLV_PCSK_KEX2_1	75	77	PF00082	0.671
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.408
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.726
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.424
CLV_PCSK_PC7_1	226	232	PF00082	0.448
CLV_PCSK_SKI1_1	150	154	PF00082	0.393
CLV_PCSK_SKI1_1	181	185	PF00082	0.453
CLV_Separin_Metazoa	157	161	PF03568	0.647
CLV_Separin_Metazoa	72	76	PF03568	0.467
DEG_APCC_DBOX_1	149	157	PF00400	0.601
DEG_Nend_UBRbox_1	1	4	PF02207	0.479
DEG_SPOP_SBC_1	185	189	PF00917	0.493
DOC_MAPK_gen_1	160	167	PF00069	0.639
DOC_MAPK_gen_1	180	186	PF00069	0.476
DOC_MAPK_gen_1	75	82	PF00069	0.459
DOC_MAPK_MEF2A_6	109	116	PF00069	0.309
DOC_USP7_MATH_1	185	189	PF00917	0.629
DOC_USP7_MATH_1	64	68	PF00917	0.556
LIG_14-3-3_CanoR_1	230	236	PF00244	0.664
LIG_14-3-3_CanoR_1	3	8	PF00244	0.466
LIG_FHA_1	119	125	PF00498	0.389
LIG_FHA_1	147	153	PF00498	0.601
LIG_FHA_1	211	217	PF00498	0.652
LIG_FHA_1	84	90	PF00498	0.446
LIG_FHA_1	92	98	PF00498	0.419
LIG_FHA_2	56	62	PF00498	0.524
LIG_FHA_2	66	72	PF00498	0.490
LIG_LIR_Nem_3	99	104	PF02991	0.413
LIG_Pex14_2	103	107	PF04695	0.410
LIG_SH2_PTP2	90	93	PF00017	0.421
LIG_SH2_SRC	90	93	PF00017	0.438
LIG_SH2_STAP1	27	31	PF00017	0.521
LIG_SH2_STAT3	174	177	PF00017	0.609
LIG_SH2_STAT5	235	238	PF00017	0.650
LIG_SH2_STAT5	90	93	PF00017	0.410
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.636
LIG_SUMO_SIM_par_1	78	83	PF11976	0.498
LIG_TRAF2_1	59	62	PF00917	0.438
LIG_TRAF2_1	69	72	PF00917	0.549
LIG_UBA3_1	152	161	PF00899	0.707
LIG_WW_3	72	76	PF00397	0.529
MOD_CK1_1	83	89	PF00069	0.449
MOD_CK2_1	151	157	PF00069	0.611
MOD_CK2_1	186	192	PF00069	0.609
MOD_CK2_1	55	61	PF00069	0.522
MOD_CK2_1	65	71	PF00069	0.557
MOD_GlcNHglycan	16	19	PF01048	0.729
MOD_GSK3_1	127	134	PF00069	0.703
MOD_N-GLC_1	83	88	PF02516	0.643
MOD_NEK2_1	118	123	PF00069	0.297
MOD_NEK2_1	184	189	PF00069	0.509
MOD_NEK2_1	82	87	PF00069	0.447
MOD_PIKK_1	118	124	PF00454	0.297
MOD_PIKK_1	133	139	PF00454	0.644
MOD_PIKK_1	229	235	PF00454	0.653
MOD_PK_1	3	9	PF00069	0.439
MOD_PKA_1	2	8	PF00069	0.453
MOD_PKA_2	127	133	PF00069	0.705
MOD_PKA_2	2	8	PF00069	0.478
MOD_PKA_2	207	213	PF00069	0.660
MOD_PKA_2	229	235	PF00069	0.665
MOD_Plk_2-3	151	157	PF00069	0.611
MOD_Plk_2-3	192	198	PF00069	0.708
MOD_Plk_4	3	9	PF00069	0.548
MOD_Plk_4	96	102	PF00069	0.415
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.631
TRG_ENDOCYTIC_2	101	104	PF00928	0.413
TRG_ER_diArg_1	25	27	PF00400	0.459
TRG_ER_diArg_1	74	77	PF00400	0.553
TRG_ER_diLys_1	244	249	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X4	Leptomonas seymouri	78%	98%
A0A0S4KGJ1	Bodo saltans	66%	100%
A0A1X0P6H7	Trypanosomatidae	83%	95%
A0A422NU86	Trypanosoma rangeli	75%	98%
A4HN99	Leishmania braziliensis	83%	99%
A4IBX0	Leishmania infantum	100%	100%
C9ZYN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	98%
E9AFQ7	Leishmania major	96%	100%
E9B6W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DUI0	Trypanosoma cruzi	81%	100%