Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIE5_LEIDO

TriTrypDb:

LdBPK_283050.1 , LdCL_280035900 , LDHU3_28.4070

Length:

944

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	521	525	PF00656	0.558
CLV_NRD_NRD_1	122	124	PF00675	0.647
CLV_NRD_NRD_1	307	309	PF00675	0.718
CLV_NRD_NRD_1	320	322	PF00675	0.565
CLV_NRD_NRD_1	367	369	PF00675	0.630
CLV_NRD_NRD_1	425	427	PF00675	0.668
CLV_NRD_NRD_1	492	494	PF00675	0.645
CLV_NRD_NRD_1	710	712	PF00675	0.639
CLV_NRD_NRD_1	719	721	PF00675	0.634
CLV_NRD_NRD_1	805	807	PF00675	0.486
CLV_NRD_NRD_1	846	848	PF00675	0.576
CLV_PCSK_FUR_1	305	309	PF00082	0.642
CLV_PCSK_FUR_1	423	427	PF00082	0.588
CLV_PCSK_KEX2_1	122	124	PF00082	0.647
CLV_PCSK_KEX2_1	307	309	PF00082	0.672
CLV_PCSK_KEX2_1	319	321	PF00082	0.656
CLV_PCSK_KEX2_1	367	369	PF00082	0.630
CLV_PCSK_KEX2_1	425	427	PF00082	0.668
CLV_PCSK_KEX2_1	492	494	PF00082	0.633
CLV_PCSK_KEX2_1	538	540	PF00082	0.759
CLV_PCSK_KEX2_1	710	712	PF00082	0.712
CLV_PCSK_KEX2_1	719	721	PF00082	0.634
CLV_PCSK_KEX2_1	846	848	PF00082	0.576
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.759
CLV_PCSK_SKI1_1	164	168	PF00082	0.501
CLV_PCSK_SKI1_1	237	241	PF00082	0.663
CLV_PCSK_SKI1_1	248	252	PF00082	0.575
CLV_PCSK_SKI1_1	308	312	PF00082	0.739
CLV_PCSK_SKI1_1	385	389	PF00082	0.744
CLV_PCSK_SKI1_1	426	430	PF00082	0.689
CLV_PCSK_SKI1_1	467	471	PF00082	0.690
CLV_PCSK_SKI1_1	535	539	PF00082	0.750
CLV_PCSK_SKI1_1	711	715	PF00082	0.578
CLV_PCSK_SKI1_1	719	723	PF00082	0.572
CLV_PCSK_SKI1_1	858	862	PF00082	0.732
DEG_APCC_DBOX_1	327	335	PF00400	0.716
DEG_APCC_DBOX_1	471	479	PF00400	0.693
DEG_APCC_DBOX_1	934	942	PF00400	0.639
DEG_Nend_UBRbox_4	1	3	PF02207	0.622
DEG_SPOP_SBC_1	310	314	PF00917	0.486
DEG_SPOP_SBC_1	571	575	PF00917	0.718
DOC_AGCK_PIF_1	272	277	PF00069	0.649
DOC_ANK_TNKS_1	448	455	PF00023	0.437
DOC_CYCLIN_RxL_1	245	252	PF00134	0.716
DOC_CYCLIN_RxL_1	35	46	PF00134	0.584
DOC_MAPK_gen_1	164	174	PF00069	0.671
DOC_MAPK_gen_1	367	375	PF00069	0.633
DOC_MAPK_gen_1	492	498	PF00069	0.659
DOC_MAPK_gen_1	755	764	PF00069	0.732
DOC_MAPK_MEF2A_6	167	176	PF00069	0.698
DOC_MAPK_MEF2A_6	755	762	PF00069	0.729
DOC_MAPK_MEF2A_6	902	910	PF00069	0.706
DOC_MAPK_NFAT4_5	755	763	PF00069	0.670
DOC_PP1_RVXF_1	148	155	PF00149	0.651
DOC_PP1_RVXF_1	930	937	PF00149	0.706
DOC_PP2B_LxvP_1	760	763	PF13499	0.735
DOC_PP2B_LxvP_1	98	101	PF13499	0.519
DOC_USP7_MATH_1	177	181	PF00917	0.598
DOC_USP7_MATH_1	215	219	PF00917	0.818
DOC_USP7_MATH_1	268	272	PF00917	0.642
DOC_USP7_MATH_1	310	314	PF00917	0.740
DOC_USP7_MATH_1	362	366	PF00917	0.592
DOC_USP7_MATH_1	387	391	PF00917	0.746
DOC_USP7_MATH_1	418	422	PF00917	0.752
DOC_USP7_MATH_1	444	448	PF00917	0.653
DOC_USP7_MATH_1	518	522	PF00917	0.684
DOC_USP7_MATH_1	553	557	PF00917	0.711
DOC_USP7_MATH_1	562	566	PF00917	0.778
DOC_USP7_MATH_1	570	574	PF00917	0.595
DOC_USP7_MATH_1	606	610	PF00917	0.796
DOC_USP7_MATH_1	763	767	PF00917	0.664
DOC_USP7_MATH_1	825	829	PF00917	0.681
DOC_WW_Pin1_4	213	218	PF00397	0.758
DOC_WW_Pin1_4	278	283	PF00397	0.621
DOC_WW_Pin1_4	516	521	PF00397	0.681
DOC_WW_Pin1_4	522	527	PF00397	0.594
DOC_WW_Pin1_4	765	770	PF00397	0.749
DOC_WW_Pin1_4	8	13	PF00397	0.677
LIG_14-3-3_CanoR_1	202	208	PF00244	0.718
LIG_14-3-3_CanoR_1	286	292	PF00244	0.669
LIG_14-3-3_CanoR_1	305	315	PF00244	0.446
LIG_14-3-3_CanoR_1	367	376	PF00244	0.665
LIG_14-3-3_CanoR_1	492	498	PF00244	0.705
LIG_14-3-3_CanoR_1	510	514	PF00244	0.462
LIG_14-3-3_CanoR_1	585	593	PF00244	0.536
LIG_14-3-3_CanoR_1	696	703	PF00244	0.576
LIG_14-3-3_CanoR_1	757	763	PF00244	0.681
LIG_Actin_WH2_2	394	409	PF00022	0.541
LIG_APCC_ABBAyCdc20_2	426	432	PF00400	0.689
LIG_CaM_IQ_9	142	158	PF13499	0.602
LIG_Clathr_ClatBox_1	913	917	PF01394	0.719
LIG_deltaCOP1_diTrp_1	420	427	PF00928	0.648
LIG_deltaCOP1_diTrp_1	842	850	PF00928	0.694
LIG_eIF4E_1	235	241	PF01652	0.722
LIG_FHA_1	140	146	PF00498	0.727
LIG_FHA_1	26	32	PF00498	0.616
LIG_FHA_1	310	316	PF00498	0.619
LIG_FHA_1	375	381	PF00498	0.626
LIG_FHA_1	44	50	PF00498	0.590
LIG_FHA_1	720	726	PF00498	0.517
LIG_FHA_1	780	786	PF00498	0.614
LIG_FHA_1	857	863	PF00498	0.729
LIG_FHA_1	929	935	PF00498	0.702
LIG_FHA_2	369	375	PF00498	0.733
LIG_FHA_2	60	66	PF00498	0.631
LIG_FHA_2	611	617	PF00498	0.801
LIG_FHA_2	629	635	PF00498	0.567
LIG_LIR_Gen_1	267	277	PF02991	0.646
LIG_LIR_Gen_1	377	386	PF02991	0.624
LIG_LIR_Gen_1	503	514	PF02991	0.722
LIG_LIR_Gen_1	643	653	PF02991	0.616
LIG_LIR_Gen_1	810	816	PF02991	0.642
LIG_LIR_Gen_1	887	898	PF02991	0.499
LIG_LIR_Nem_3	180	184	PF02991	0.651
LIG_LIR_Nem_3	267	272	PF02991	0.687
LIG_LIR_Nem_3	364	369	PF02991	0.686
LIG_LIR_Nem_3	377	381	PF02991	0.594
LIG_LIR_Nem_3	503	509	PF02991	0.714
LIG_LIR_Nem_3	643	648	PF02991	0.607
LIG_LIR_Nem_3	810	814	PF02991	0.649
LIG_LIR_Nem_3	871	877	PF02991	0.704
LIG_LIR_Nem_3	887	893	PF02991	0.448
LIG_MAD2	212	220	PF02301	0.634
LIG_MYND_1	765	769	PF01753	0.750
LIG_PCNA_yPIPBox_3	391	402	PF02747	0.542
LIG_Rb_pABgroove_1	229	237	PF01858	0.635
LIG_SH2_CRK	181	185	PF00017	0.653
LIG_SH2_CRK	378	382	PF00017	0.618
LIG_SH2_CRK	506	510	PF00017	0.731
LIG_SH2_CRK	645	649	PF00017	0.636
LIG_SH2_NCK_1	378	382	PF00017	0.719
LIG_SH2_PTP2	262	265	PF00017	0.512
LIG_SH2_SRC	242	245	PF00017	0.709
LIG_SH2_SRC	504	507	PF00017	0.510
LIG_SH2_SRC	926	929	PF00017	0.713
LIG_SH2_STAP1	235	239	PF00017	0.596
LIG_SH2_STAP1	376	380	PF00017	0.607
LIG_SH2_STAP1	504	508	PF00017	0.660
LIG_SH2_STAP1	926	930	PF00017	0.703
LIG_SH2_STAT3	137	140	PF00017	0.642
LIG_SH2_STAT3	235	238	PF00017	0.508
LIG_SH2_STAT3	369	372	PF00017	0.697
LIG_SH2_STAT3	641	644	PF00017	0.643
LIG_SH2_STAT5	262	265	PF00017	0.719
LIG_SH2_STAT5	278	281	PF00017	0.492
LIG_SH2_STAT5	323	326	PF00017	0.554
LIG_SH2_STAT5	376	379	PF00017	0.627
LIG_SH2_STAT5	629	632	PF00017	0.695
LIG_SH2_STAT5	645	648	PF00017	0.549
LIG_SH2_STAT5	877	880	PF00017	0.707
LIG_SH2_STAT5	898	901	PF00017	0.631
LIG_SH3_3	183	189	PF00018	0.530
LIG_SH3_3	205	211	PF00018	0.765
LIG_SH3_3	214	220	PF00018	0.754
LIG_SH3_3	260	266	PF00018	0.695
LIG_SH3_3	276	282	PF00018	0.571
LIG_SUMO_SIM_par_1	858	863	PF11976	0.731
LIG_TRAF2_1	488	491	PF00917	0.647
LIG_TRAF2_1	499	502	PF00917	0.700
LIG_TRAF2_1	596	599	PF00917	0.705
LIG_UBA3_1	878	883	PF00899	0.710
MOD_CDK_SPxK_1	8	14	PF00069	0.800
MOD_CDK_SPxxK_3	522	529	PF00069	0.562
MOD_CDK_SPxxK_3	765	772	PF00069	0.748
MOD_CK1_1	565	571	PF00069	0.843
MOD_CK1_1	609	615	PF00069	0.760
MOD_CK1_1	8	14	PF00069	0.749
MOD_CK1_1	824	830	PF00069	0.598
MOD_CK1_1	886	892	PF00069	0.703
MOD_CK2_1	193	199	PF00069	0.672
MOD_CK2_1	59	65	PF00069	0.594
MOD_CK2_1	593	599	PF00069	0.651
MOD_CK2_1	610	616	PF00069	0.694
MOD_CK2_1	765	771	PF00069	0.670
MOD_CK2_1	799	805	PF00069	0.709
MOD_Cter_Amidation	844	847	PF01082	0.574
MOD_GlcNHglycan	205	208	PF01048	0.652
MOD_GlcNHglycan	266	269	PF01048	0.642
MOD_GlcNHglycan	338	341	PF01048	0.626
MOD_GlcNHglycan	345	349	PF01048	0.618
MOD_GlcNHglycan	350	355	PF01048	0.607
MOD_GlcNHglycan	607	611	PF01048	0.770
MOD_GlcNHglycan	692	696	PF01048	0.720
MOD_GlcNHglycan	7	10	PF01048	0.798
MOD_GlcNHglycan	823	826	PF01048	0.653
MOD_GSK3_1	264	271	PF00069	0.642
MOD_GSK3_1	306	313	PF00069	0.672
MOD_GSK3_1	330	337	PF00069	0.634
MOD_GSK3_1	4	11	PF00069	0.660
MOD_GSK3_1	518	525	PF00069	0.687
MOD_GSK3_1	594	601	PF00069	0.760
MOD_GSK3_1	606	613	PF00069	0.642
MOD_GSK3_1	624	631	PF00069	0.723
MOD_GSK3_1	729	736	PF00069	0.657
MOD_GSK3_1	821	828	PF00069	0.587
MOD_GSK3_1	868	875	PF00069	0.567
MOD_GSK3_1	882	889	PF00069	0.623
MOD_LATS_1	881	887	PF00433	0.706
MOD_N-GLC_2	528	530	PF02516	0.569
MOD_NEK2_1	311	316	PF00069	0.705
MOD_NEK2_1	334	339	PF00069	0.711
MOD_NEK2_1	402	407	PF00069	0.752
MOD_NEK2_1	509	514	PF00069	0.664
MOD_NEK2_1	628	633	PF00069	0.503
MOD_NEK2_1	663	668	PF00069	0.749
MOD_NEK2_1	729	734	PF00069	0.717
MOD_NEK2_1	758	763	PF00069	0.642
MOD_NEK2_2	362	367	PF00069	0.509
MOD_PIKK_1	17	23	PF00454	0.688
MOD_PIKK_1	368	374	PF00454	0.695
MOD_PIKK_1	491	497	PF00454	0.660
MOD_PIKK_1	518	524	PF00454	0.781
MOD_PIKK_1	584	590	PF00454	0.598
MOD_PIKK_1	594	600	PF00454	0.644
MOD_PIKK_1	733	739	PF00454	0.643
MOD_PKA_1	719	725	PF00069	0.518
MOD_PKA_2	306	312	PF00069	0.572
MOD_PKA_2	491	497	PF00069	0.737
MOD_PKA_2	509	515	PF00069	0.446
MOD_PKA_2	584	590	PF00069	0.530
MOD_PKA_2	59	65	PF00069	0.704
MOD_PKA_2	663	669	PF00069	0.674
MOD_PKA_2	719	725	PF00069	0.541
MOD_Plk_1	444	450	PF00069	0.515
MOD_Plk_1	886	892	PF00069	0.703
MOD_Plk_2-3	193	199	PF00069	0.566
MOD_Plk_4	376	382	PF00069	0.621
MOD_Plk_4	624	630	PF00069	0.652
MOD_Plk_4	886	892	PF00069	0.636
MOD_ProDKin_1	213	219	PF00069	0.760
MOD_ProDKin_1	278	284	PF00069	0.618
MOD_ProDKin_1	516	522	PF00069	0.681
MOD_ProDKin_1	765	771	PF00069	0.748
MOD_ProDKin_1	8	14	PF00069	0.682
MOD_SUMO_for_1	537	540	PF00179	0.755
MOD_SUMO_rev_2	222	231	PF00179	0.746
MOD_SUMO_rev_2	447	457	PF00179	0.509
TRG_DiLeu_BaEn_4	65	71	PF01217	0.700
TRG_DiLeu_BaEn_4	680	686	PF01217	0.728
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.713
TRG_ENDOCYTIC_2	181	184	PF00928	0.648
TRG_ENDOCYTIC_2	262	265	PF00928	0.512
TRG_ENDOCYTIC_2	378	381	PF00928	0.620
TRG_ENDOCYTIC_2	506	509	PF00928	0.727
TRG_ENDOCYTIC_2	645	648	PF00928	0.629
TRG_ENDOCYTIC_2	890	893	PF00928	0.517
TRG_ENDOCYTIC_2	898	901	PF00928	0.569
TRG_ER_diArg_1	305	308	PF00400	0.659
TRG_ER_diArg_1	318	321	PF00400	0.588
TRG_ER_diArg_1	366	368	PF00400	0.629
TRG_ER_diArg_1	422	425	PF00400	0.637
TRG_ER_diArg_1	56	59	PF00400	0.570
TRG_ER_diArg_1	719	721	PF00400	0.565
TRG_ER_diArg_1	755	758	PF00400	0.662
TRG_ER_diArg_1	781	784	PF00400	0.707
TRG_ER_diArg_1	921	924	PF00400	0.720
TRG_ER_diArg_1	940	943	PF00400	0.411
TRG_NES_CRM1_1	897	912	PF08389	0.588
TRG_NES_CRM1_1	933	944	PF08389	0.642
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	858	863	PF00026	0.731

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC11	Leptomonas seymouri	32%	100%
A4HGY6	Leishmania braziliensis	69%	100%
A4I418	Leishmania infantum	99%	100%
E9B0A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7X9	Leishmania major	88%	100%