SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IIE1_LEIDO

TriTrypDb:

LdBPK_352770.1 , LdCL_350032600 , LDHU3_35.3520

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.685
CLV_C14_Caspase3-7	345	349	PF00656	0.576
CLV_NRD_NRD_1	12	14	PF00675	0.644
CLV_NRD_NRD_1	173	175	PF00675	0.659
CLV_NRD_NRD_1	225	227	PF00675	0.690
CLV_NRD_NRD_1	298	300	PF00675	0.687
CLV_NRD_NRD_1	421	423	PF00675	0.559
CLV_NRD_NRD_1	446	448	PF00675	0.486
CLV_NRD_NRD_1	451	453	PF00675	0.518
CLV_NRD_NRD_1	584	586	PF00675	0.572
CLV_NRD_NRD_1	66	68	PF00675	0.706
CLV_PCSK_FUR_1	443	447	PF00082	0.517
CLV_PCSK_KEX2_1	224	226	PF00082	0.696
CLV_PCSK_KEX2_1	298	300	PF00082	0.687
CLV_PCSK_KEX2_1	421	423	PF00082	0.559
CLV_PCSK_KEX2_1	445	447	PF00082	0.515
CLV_PCSK_KEX2_1	714	716	PF00082	0.653
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.696
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.653
CLV_PCSK_SKI1_1	144	148	PF00082	0.666
CLV_PCSK_SKI1_1	339	343	PF00082	0.516
CLV_PCSK_SKI1_1	379	383	PF00082	0.453
CLV_PCSK_SKI1_1	447	451	PF00082	0.496
CLV_PCSK_SKI1_1	453	457	PF00082	0.489
CLV_PCSK_SKI1_1	501	505	PF00082	0.777
CLV_PCSK_SKI1_1	57	61	PF00082	0.646
CLV_PCSK_SKI1_1	621	625	PF00082	0.671
CLV_PCSK_SKI1_1	635	639	PF00082	0.504
CLV_PCSK_SKI1_1	715	719	PF00082	0.652
DEG_APCC_KENBOX_2	109	113	PF00400	0.704
DEG_Nend_Nbox_1	1	3	PF02207	0.565
DEG_SCF_FBW7_1	180	187	PF00400	0.655
DEG_SPOP_SBC_1	128	132	PF00917	0.715
DEG_SPOP_SBC_1	371	375	PF00917	0.568
DOC_CKS1_1	488	493	PF01111	0.647
DOC_CYCLIN_yClb1_LxF_4	31	36	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.665
DOC_MAPK_gen_1	33	40	PF00069	0.578
DOC_PP1_RVXF_1	31	37	PF00149	0.524
DOC_PP1_RVXF_1	577	584	PF00149	0.570
DOC_PP2B_LxvP_1	147	150	PF13499	0.644
DOC_PP2B_LxvP_1	38	41	PF13499	0.682
DOC_PP2B_LxvP_1	59	62	PF13499	0.664
DOC_PP2B_LxvP_1	637	640	PF13499	0.702
DOC_PP2B_LxvP_1	657	660	PF13499	0.374
DOC_PP2B_LxvP_1	77	80	PF13499	0.639
DOC_PP4_FxxP_1	404	407	PF00568	0.583
DOC_PP4_FxxP_1	658	661	PF00568	0.592
DOC_USP7_MATH_1	117	121	PF00917	0.737
DOC_USP7_MATH_1	126	130	PF00917	0.670
DOC_USP7_MATH_1	217	221	PF00917	0.693
DOC_USP7_MATH_1	239	243	PF00917	0.712
DOC_USP7_MATH_1	275	279	PF00917	0.691
DOC_USP7_MATH_1	371	375	PF00917	0.617
DOC_USP7_MATH_1	62	66	PF00917	0.693
DOC_USP7_MATH_1	685	689	PF00917	0.552
DOC_USP7_MATH_1	752	756	PF00917	0.645
DOC_USP7_MATH_2	491	497	PF00917	0.651
DOC_USP7_UBL2_3	33	37	PF12436	0.529
DOC_WW_Pin1_4	121	126	PF00397	0.769
DOC_WW_Pin1_4	180	185	PF00397	0.713
DOC_WW_Pin1_4	487	492	PF00397	0.647
DOC_WW_Pin1_4	566	571	PF00397	0.628
DOC_WW_Pin1_4	621	626	PF00397	0.633
DOC_WW_Pin1_4	733	738	PF00397	0.808
DOC_WW_Pin1_4	765	770	PF00397	0.647
LIG_14-3-3_CanoR_1	119	128	PF00244	0.768
LIG_14-3-3_CanoR_1	144	150	PF00244	0.664
LIG_14-3-3_CanoR_1	16	23	PF00244	0.626
LIG_14-3-3_CanoR_1	57	62	PF00244	0.655
LIG_APCC_ABBA_1	380	385	PF00400	0.475
LIG_APCC_ABBAyCdc20_2	379	385	PF00400	0.452
LIG_APCC_ABBAyCdc20_2	540	546	PF00400	0.559
LIG_BIR_III_4	554	558	PF00653	0.557
LIG_BRCT_BRCA1_1	434	438	PF00533	0.559
LIG_CaM_IQ_9	608	623	PF13499	0.676
LIG_CtBP_PxDLS_1	218	224	PF00389	0.671
LIG_DCNL_PONY_1	1	4	PF03556	0.545
LIG_FHA_1	141	147	PF00498	0.704
LIG_FHA_1	175	181	PF00498	0.707
LIG_FHA_1	23	29	PF00498	0.682
LIG_FHA_1	49	55	PF00498	0.688
LIG_FHA_1	58	64	PF00498	0.617
LIG_FHA_1	612	618	PF00498	0.531
LIG_FHA_1	634	640	PF00498	0.618
LIG_FHA_2	40	46	PF00498	0.699
LIG_FHA_2	488	494	PF00498	0.647
LIG_FHA_2	554	560	PF00498	0.592
LIG_FHA_2	641	647	PF00498	0.694
LIG_FHA_2	685	691	PF00498	0.519
LIG_LIR_Apic_2	402	407	PF02991	0.499
LIG_LIR_Apic_2	655	661	PF02991	0.577
LIG_LIR_Gen_1	435	444	PF02991	0.546
LIG_LIR_Gen_1	546	555	PF02991	0.604
LIG_LIR_Gen_1	671	681	PF02991	0.571
LIG_LIR_Nem_3	310	314	PF02991	0.537
LIG_LIR_Nem_3	405	411	PF02991	0.496
LIG_LIR_Nem_3	435	441	PF02991	0.521
LIG_LIR_Nem_3	546	550	PF02991	0.587
LIG_LIR_Nem_3	669	673	PF02991	0.541
LIG_LIR_Nem_3	708	713	PF02991	0.689
LIG_LYPXL_yS_3	311	314	PF13949	0.539
LIG_NRBOX	435	441	PF00104	0.555
LIG_SH2_CRK	173	177	PF00017	0.700
LIG_SH2_CRK	408	412	PF00017	0.411
LIG_SH2_NCK_1	97	101	PF00017	0.674
LIG_SH2_SRC	645	648	PF00017	0.562
LIG_SH2_STAP1	355	359	PF00017	0.455
LIG_SH2_STAP1	645	649	PF00017	0.510
LIG_SH2_STAP1	670	674	PF00017	0.544
LIG_SH2_STAT5	428	431	PF00017	0.490
LIG_SH2_STAT5	454	457	PF00017	0.489
LIG_SH2_STAT5	610	613	PF00017	0.591
LIG_SH2_STAT5	673	676	PF00017	0.557
LIG_SH3_3	122	128	PF00018	0.749
LIG_SH3_3	152	158	PF00018	0.823
LIG_SH3_3	17	23	PF00018	0.581
LIG_SH3_3	243	249	PF00018	0.758
LIG_SH3_3	250	256	PF00018	0.815
LIG_SH3_3	658	664	PF00018	0.595
LIG_SH3_3	725	731	PF00018	0.761
LIG_SH3_CIN85_PxpxPR_1	744	749	PF14604	0.648
LIG_Sin3_3	231	238	PF02671	0.623
LIG_TRAF2_1	736	739	PF00917	0.713
LIG_UBA3_1	580	586	PF00899	0.568
LIG_WW_3	124	128	PF00397	0.653
LIG_WW_3	248	252	PF00397	0.693
MOD_CDK_SPK_2	765	770	PF00069	0.647
MOD_CDK_SPxK_1	121	127	PF00069	0.664
MOD_CDK_SPxK_1	180	186	PF00069	0.655
MOD_CDK_SPxxK_3	487	494	PF00069	0.648
MOD_CDK_SPxxK_3	566	573	PF00069	0.550
MOD_CDK_SPxxK_3	621	628	PF00069	0.632
MOD_CK1_1	129	135	PF00069	0.779
MOD_CK1_1	140	146	PF00069	0.674
MOD_CK1_1	194	200	PF00069	0.742
MOD_CK1_1	39	45	PF00069	0.695
MOD_CK1_1	487	493	PF00069	0.648
MOD_CK1_1	589	595	PF00069	0.614
MOD_CK1_1	666	672	PF00069	0.545
MOD_CK1_1	757	763	PF00069	0.652
MOD_CK2_1	128	134	PF00069	0.717
MOD_CK2_1	371	377	PF00069	0.605
MOD_CK2_1	487	493	PF00069	0.648
MOD_CK2_1	553	559	PF00069	0.590
MOD_CK2_1	684	690	PF00069	0.512
MOD_CK2_1	733	739	PF00069	0.810
MOD_CK2_1	747	753	PF00069	0.587
MOD_CK2_1	83	89	PF00069	0.638
MOD_Cter_Amidation	11	14	PF01082	0.640
MOD_GlcNHglycan	147	150	PF01048	0.825
MOD_GlcNHglycan	17	20	PF01048	0.570
MOD_GlcNHglycan	273	276	PF01048	0.703
MOD_GlcNHglycan	315	318	PF01048	0.460
MOD_GlcNHglycan	495	498	PF01048	0.677
MOD_GlcNHglycan	526	529	PF01048	0.630
MOD_GlcNHglycan	687	690	PF01048	0.592
MOD_GlcNHglycan	70	73	PF01048	0.680
MOD_GlcNHglycan	85	88	PF01048	0.648
MOD_GlcNHglycan	9	12	PF01048	0.638
MOD_GlcNHglycan	96	100	PF01048	0.684
MOD_GSK3_1	115	122	PF00069	0.752
MOD_GSK3_1	145	152	PF00069	0.803
MOD_GSK3_1	180	187	PF00069	0.776
MOD_GSK3_1	271	278	PF00069	0.704
MOD_GSK3_1	357	364	PF00069	0.427
MOD_GSK3_1	385	392	PF00069	0.482
MOD_GSK3_1	463	470	PF00069	0.663
MOD_GSK3_1	471	478	PF00069	0.643
MOD_GSK3_1	57	64	PF00069	0.663
MOD_GSK3_1	754	761	PF00069	0.789
MOD_GSK3_1	83	90	PF00069	0.669
MOD_N-GLC_1	137	142	PF02516	0.724
MOD_N-GLC_1	371	376	PF02516	0.559
MOD_N-GLC_1	468	473	PF02516	0.704
MOD_N-GLC_1	504	509	PF02516	0.587
MOD_N-GLC_1	566	571	PF02516	0.644
MOD_N-GLC_2	203	205	PF02516	0.658
MOD_N-GLC_2	227	229	PF02516	0.601
MOD_NEK2_1	210	215	PF00069	0.765
MOD_NEK2_1	271	276	PF00069	0.692
MOD_NEK2_1	36	41	PF00069	0.640
MOD_NEK2_1	389	394	PF00069	0.493
MOD_NEK2_1	467	472	PF00069	0.724
MOD_NEK2_1	517	522	PF00069	0.632
MOD_NEK2_1	524	529	PF00069	0.588
MOD_NEK2_1	553	558	PF00069	0.629
MOD_NEK2_2	62	67	PF00069	0.695
MOD_NEK2_2	640	645	PF00069	0.591
MOD_PIKK_1	137	143	PF00454	0.814
MOD_PIKK_1	254	260	PF00454	0.689
MOD_PKA_1	174	180	PF00069	0.696
MOD_PKA_1	298	304	PF00069	0.671
MOD_PKA_2	126	132	PF00069	0.728
MOD_PKA_2	134	140	PF00069	0.743
MOD_PKA_2	15	21	PF00069	0.607
MOD_PKA_2	298	304	PF00069	0.671
MOD_PKA_2	389	395	PF00069	0.438
MOD_PKA_2	461	467	PF00069	0.541
MOD_Plk_1	184	190	PF00069	0.653
MOD_Plk_1	350	356	PF00069	0.473
MOD_Plk_1	384	390	PF00069	0.427
MOD_Plk_1	424	430	PF00069	0.500
MOD_Plk_1	515	521	PF00069	0.562
MOD_Plk_1	645	651	PF00069	0.560
MOD_Plk_1	752	758	PF00069	0.675
MOD_Plk_2-3	747	753	PF00069	0.647
MOD_Plk_4	217	223	PF00069	0.772
MOD_Plk_4	298	304	PF00069	0.669
MOD_Plk_4	310	316	PF00069	0.387
MOD_Plk_4	589	595	PF00069	0.614
MOD_Plk_4	633	639	PF00069	0.648
MOD_Plk_4	640	646	PF00069	0.590
MOD_Plk_4	669	675	PF00069	0.551
MOD_ProDKin_1	121	127	PF00069	0.772
MOD_ProDKin_1	180	186	PF00069	0.713
MOD_ProDKin_1	487	493	PF00069	0.648
MOD_ProDKin_1	566	572	PF00069	0.625
MOD_ProDKin_1	621	627	PF00069	0.629
MOD_ProDKin_1	733	739	PF00069	0.810
MOD_SUMO_rev_2	185	193	PF00179	0.789
MOD_SUMO_rev_2	316	322	PF00179	0.489
MOD_SUMO_rev_2	39	48	PF00179	0.696
MOD_SUMO_rev_2	487	496	PF00179	0.601
MOD_SUMO_rev_2	631	637	PF00179	0.579
TRG_Cilium_Arf4_1	766	770	PF00025	0.702
TRG_DiLeu_BaEn_4	424	430	PF01217	0.579
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.572
TRG_ENDOCYTIC_2	311	314	PF00928	0.480
TRG_ENDOCYTIC_2	383	386	PF00928	0.476
TRG_ENDOCYTIC_2	401	404	PF00928	0.528
TRG_ENDOCYTIC_2	408	411	PF00928	0.546
TRG_ENDOCYTIC_2	673	676	PF00928	0.561
TRG_ER_diArg_1	420	422	PF00400	0.537
TRG_ER_diArg_1	445	447	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	701	705	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	749	753	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGC9	Leptomonas seymouri	55%	96%
A4HMT9	Leishmania braziliensis	69%	98%
A4IBE0	Leishmania infantum	99%	100%
E9AF96	Leishmania major	56%	100%
E9B6F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%