Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IID6_LEIDO

TriTrypDb:

LdBPK_141000.1 , LdCL_140015700 , LDHU3_14.1270

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IID6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IID6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.643
CLV_C14_Caspase3-7	398	402	PF00656	0.585
CLV_C14_Caspase3-7	511	515	PF00656	0.635
CLV_NRD_NRD_1	270	272	PF00675	0.604
CLV_NRD_NRD_1	517	519	PF00675	0.679
CLV_NRD_NRD_1	524	526	PF00675	0.660
CLV_PCSK_FUR_1	268	272	PF00082	0.596
CLV_PCSK_FUR_1	522	526	PF00082	0.701
CLV_PCSK_KEX2_1	270	272	PF00082	0.604
CLV_PCSK_KEX2_1	521	523	PF00082	0.697
CLV_PCSK_KEX2_1	524	526	PF00082	0.674
CLV_PCSK_KEX2_1	95	97	PF00082	0.562
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.697
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.562
CLV_PCSK_SKI1_1	322	326	PF00082	0.552
CLV_PCSK_SKI1_1	344	348	PF00082	0.622
CLV_PCSK_SKI1_1	96	100	PF00082	0.552
DEG_Nend_Nbox_1	1	3	PF02207	0.796
DEG_SCF_FBW7_1	469	475	PF00400	0.600
DEG_SCF_FBW7_1	64	71	PF00400	0.680
DEG_SCF_TRCP1_1	643	649	PF00400	0.597
DEG_SPOP_SBC_1	251	255	PF00917	0.629
DEG_SPOP_SBC_1	570	574	PF00917	0.594
DOC_CKS1_1	351	356	PF01111	0.662
DOC_CKS1_1	37	42	PF01111	0.536
DOC_CKS1_1	379	384	PF01111	0.622
DOC_CKS1_1	469	474	PF01111	0.599
DOC_CKS1_1	703	708	PF01111	0.620
DOC_CYCLIN_RxL_1	93	103	PF00134	0.584
DOC_MAPK_DCC_7	278	288	PF00069	0.588
DOC_MAPK_gen_1	95	101	PF00069	0.554
DOC_PP2B_LxvP_1	510	513	PF13499	0.667
DOC_PP2B_LxvP_1	544	547	PF13499	0.704
DOC_PP2B_LxvP_1	774	777	PF13499	0.624
DOC_PP2B_PxIxI_1	59	65	PF00149	0.642
DOC_PP4_FxxP_1	351	354	PF00568	0.592
DOC_PP4_FxxP_1	703	706	PF00568	0.618
DOC_PP4_MxPP_1	843	846	PF00568	0.617
DOC_USP7_MATH_1	106	110	PF00917	0.599
DOC_USP7_MATH_1	143	147	PF00917	0.679
DOC_USP7_MATH_1	250	254	PF00917	0.624
DOC_USP7_MATH_1	364	368	PF00917	0.663
DOC_USP7_MATH_1	4	8	PF00917	0.630
DOC_USP7_MATH_1	450	454	PF00917	0.613
DOC_USP7_MATH_1	472	476	PF00917	0.610
DOC_USP7_MATH_1	537	541	PF00917	0.692
DOC_USP7_MATH_1	560	564	PF00917	0.639
DOC_USP7_MATH_1	571	575	PF00917	0.546
DOC_USP7_MATH_1	601	605	PF00917	0.567
DOC_USP7_MATH_1	613	617	PF00917	0.529
DOC_USP7_MATH_1	650	654	PF00917	0.633
DOC_USP7_MATH_1	767	771	PF00917	0.571
DOC_USP7_MATH_1	812	816	PF00917	0.649
DOC_USP7_MATH_1	817	821	PF00917	0.624
DOC_WW_Pin1_4	151	156	PF00397	0.700
DOC_WW_Pin1_4	186	191	PF00397	0.659
DOC_WW_Pin1_4	208	213	PF00397	0.636
DOC_WW_Pin1_4	218	223	PF00397	0.563
DOC_WW_Pin1_4	238	243	PF00397	0.515
DOC_WW_Pin1_4	278	283	PF00397	0.647
DOC_WW_Pin1_4	288	293	PF00397	0.585
DOC_WW_Pin1_4	327	332	PF00397	0.671
DOC_WW_Pin1_4	33	38	PF00397	0.664
DOC_WW_Pin1_4	336	341	PF00397	0.615
DOC_WW_Pin1_4	346	351	PF00397	0.517
DOC_WW_Pin1_4	378	383	PF00397	0.666
DOC_WW_Pin1_4	468	473	PF00397	0.597
DOC_WW_Pin1_4	64	69	PF00397	0.681
DOC_WW_Pin1_4	646	651	PF00397	0.657
DOC_WW_Pin1_4	652	657	PF00397	0.625
DOC_WW_Pin1_4	660	665	PF00397	0.544
DOC_WW_Pin1_4	702	707	PF00397	0.619
DOC_WW_Pin1_4	754	759	PF00397	0.611
DOC_WW_Pin1_4	828	833	PF00397	0.599
LIG_14-3-3_CanoR_1	23	30	PF00244	0.616
LIG_14-3-3_CanoR_1	333	340	PF00244	0.621
LIG_14-3-3_CanoR_1	449	455	PF00244	0.540
LIG_14-3-3_CanoR_1	96	102	PF00244	0.590
LIG_BIR_III_2	103	107	PF00653	0.583
LIG_BRCT_BRCA1_1	572	576	PF00533	0.571
LIG_Clathr_ClatBox_1	295	299	PF01394	0.572
LIG_deltaCOP1_diTrp_1	739	747	PF00928	0.557
LIG_EVH1_1	544	548	PF00568	0.705
LIG_FHA_1	129	135	PF00498	0.638
LIG_FHA_1	253	259	PF00498	0.638
LIG_FHA_1	37	43	PF00498	0.698
LIG_FHA_1	586	592	PF00498	0.550
LIG_FHA_1	68	74	PF00498	0.651
LIG_FHA_2	181	187	PF00498	0.636
LIG_FHA_2	209	215	PF00498	0.631
LIG_FHA_2	270	276	PF00498	0.596
LIG_FHA_2	437	443	PF00498	0.599
LIG_FHA_2	469	475	PF00498	0.624
LIG_FHA_2	493	499	PF00498	0.629
LIG_FHA_2	509	515	PF00498	0.549
LIG_FHA_2	556	562	PF00498	0.607
LIG_FHA_2	88	94	PF00498	0.567
LIG_IBAR_NPY_1	59	61	PF08397	0.660
LIG_KLC1_Yacidic_2	181	186	PF13176	0.607
LIG_LIR_Apic_2	181	187	PF02991	0.632
LIG_LIR_Apic_2	349	354	PF02991	0.591
LIG_LIR_Apic_2	540	546	PF02991	0.708
LIG_LIR_Gen_1	159	170	PF02991	0.679
LIG_LIR_Gen_1	577	587	PF02991	0.586
LIG_LIR_Gen_1	594	603	PF02991	0.478
LIG_LIR_Gen_1	740	751	PF02991	0.563
LIG_LIR_Nem_3	277	283	PF02991	0.640
LIG_LIR_Nem_3	573	579	PF02991	0.605
LIG_LIR_Nem_3	594	600	PF02991	0.554
LIG_LIR_Nem_3	739	745	PF02991	0.583
LIG_MYND_1	170	174	PF01753	0.617
LIG_Pex14_1	216	220	PF04695	0.594
LIG_Pex14_1	741	745	PF04695	0.587
LIG_Pex14_2	743	747	PF04695	0.590
LIG_PROFILIN_1	545	551	PF00235	0.656
LIG_SH2_CRK	335	339	PF00017	0.627
LIG_SH2_CRK	43	47	PF00017	0.684
LIG_SH2_CRK	580	584	PF00017	0.574
LIG_SH2_CRK	587	591	PF00017	0.519
LIG_SH2_NCK_1	335	339	PF00017	0.598
LIG_SH2_PTP2	61	64	PF00017	0.674
LIG_SH2_PTP2	745	748	PF00017	0.559
LIG_SH2_SRC	184	187	PF00017	0.630
LIG_SH2_SRC	543	546	PF00017	0.708
LIG_SH2_STAP1	244	248	PF00017	0.602
LIG_SH2_STAP1	580	584	PF00017	0.574
LIG_SH2_STAP1	587	591	PF00017	0.519
LIG_SH2_STAT3	102	105	PF00017	0.586
LIG_SH2_STAT3	393	396	PF00017	0.624
LIG_SH2_STAT3	484	487	PF00017	0.656
LIG_SH2_STAT5	184	187	PF00017	0.630
LIG_SH2_STAT5	335	338	PF00017	0.599
LIG_SH2_STAT5	543	546	PF00017	0.708
LIG_SH2_STAT5	587	590	PF00017	0.552
LIG_SH2_STAT5	61	64	PF00017	0.819
LIG_SH2_STAT5	666	669	PF00017	0.677
LIG_SH2_STAT5	745	748	PF00017	0.589
LIG_SH2_STAT5	810	813	PF00017	0.553
LIG_SH3_1	184	190	PF00018	0.637
LIG_SH3_1	542	548	PF00018	0.708
LIG_SH3_3	184	190	PF00018	0.637
LIG_SH3_3	328	334	PF00018	0.666
LIG_SH3_3	337	343	PF00018	0.625
LIG_SH3_3	34	40	PF00018	0.539
LIG_SH3_3	415	421	PF00018	0.661
LIG_SH3_3	466	472	PF00018	0.656
LIG_SH3_3	542	548	PF00018	0.708
LIG_SH3_3	551	557	PF00018	0.631
LIG_SH3_3	679	685	PF00018	0.652
LIG_SH3_3	826	832	PF00018	0.628
LIG_SH3_3	841	847	PF00018	0.576
LIG_TRAF2_2	638	643	PF00917	0.603
LIG_WRC_WIRS_1	98	103	PF05994	0.552
LIG_WW_1	354	357	PF00397	0.651
LIG_WW_1	851	854	PF00397	0.615
LIG_WW_3	353	357	PF00397	0.582
MOD_CDC14_SPxK_1	330	333	PF00782	0.688
MOD_CDC14_SPxK_1	339	342	PF00782	0.612
MOD_CDK_SPK_2	468	473	PF00069	0.597
MOD_CDK_SPxK_1	327	333	PF00069	0.676
MOD_CDK_SPxK_1	336	342	PF00069	0.616
MOD_CDK_SPxK_1	350	356	PF00069	0.523
MOD_CDK_SPxxK_3	378	385	PF00069	0.592
MOD_CK1_1	109	115	PF00069	0.623
MOD_CK1_1	146	152	PF00069	0.704
MOD_CK1_1	204	210	PF00069	0.657
MOD_CK1_1	221	227	PF00069	0.520
MOD_CK1_1	306	312	PF00069	0.622
MOD_CK1_1	367	373	PF00069	0.612
MOD_CK1_1	384	390	PF00069	0.539
MOD_CK1_1	422	428	PF00069	0.613
MOD_CK1_1	45	51	PF00069	0.721
MOD_CK1_1	5	11	PF00069	0.668
MOD_CK1_1	508	514	PF00069	0.647
MOD_CK1_1	657	663	PF00069	0.598
MOD_CK1_1	669	675	PF00069	0.552
MOD_CK1_1	770	776	PF00069	0.570
MOD_CK2_1	180	186	PF00069	0.639
MOD_CK2_1	208	214	PF00069	0.634
MOD_CK2_1	306	312	PF00069	0.594
MOD_CK2_1	371	377	PF00069	0.663
MOD_CK2_1	436	442	PF00069	0.574
MOD_CK2_1	468	474	PF00069	0.599
MOD_CK2_1	673	679	PF00069	0.583
MOD_CK2_1	87	93	PF00069	0.572
MOD_DYRK1A_RPxSP_1	828	832	PF00069	0.598
MOD_GlcNHglycan	131	134	PF01048	0.600
MOD_GlcNHglycan	20	23	PF01048	0.645
MOD_GlcNHglycan	223	226	PF01048	0.617
MOD_GlcNHglycan	26	29	PF01048	0.624
MOD_GlcNHglycan	4	7	PF01048	0.659
MOD_GlcNHglycan	405	408	PF01048	0.622
MOD_GlcNHglycan	430	433	PF01048	0.610
MOD_GlcNHglycan	465	468	PF01048	0.673
MOD_GlcNHglycan	478	481	PF01048	0.582
MOD_GlcNHglycan	561	565	PF01048	0.663
MOD_GlcNHglycan	573	576	PF01048	0.551
MOD_GlcNHglycan	615	618	PF01048	0.567
MOD_GlcNHglycan	634	637	PF01048	0.574
MOD_GlcNHglycan	643	646	PF01048	0.593
MOD_GlcNHglycan	669	672	PF01048	0.671
MOD_GlcNHglycan	673	676	PF01048	0.618
MOD_GlcNHglycan	729	732	PF01048	0.586
MOD_GlcNHglycan	780	783	PF01048	0.613
MOD_GlcNHglycan	814	817	PF01048	0.610
MOD_GlcNHglycan	819	822	PF01048	0.593
MOD_GlcNHglycan	82	85	PF01048	0.651
MOD_GSK3_1	146	153	PF00069	0.704
MOD_GSK3_1	204	211	PF00069	0.626
MOD_GSK3_1	250	257	PF00069	0.640
MOD_GSK3_1	274	281	PF00069	0.601
MOD_GSK3_1	282	289	PF00069	0.537
MOD_GSK3_1	304	311	PF00069	0.658
MOD_GSK3_1	346	353	PF00069	0.680
MOD_GSK3_1	367	374	PF00069	0.682
MOD_GSK3_1	377	384	PF00069	0.609
MOD_GSK3_1	391	398	PF00069	0.557
MOD_GSK3_1	45	52	PF00069	0.617
MOD_GSK3_1	459	466	PF00069	0.652
MOD_GSK3_1	468	475	PF00069	0.599
MOD_GSK3_1	5	12	PF00069	0.686
MOD_GSK3_1	64	71	PF00069	0.731
MOD_GSK3_1	641	648	PF00069	0.671
MOD_GSK3_1	650	657	PF00069	0.592
MOD_GSK3_1	667	674	PF00069	0.511
MOD_GSK3_1	750	757	PF00069	0.570
MOD_GSK3_1	772	779	PF00069	0.625
MOD_N-GLC_1	208	213	PF02516	0.592
MOD_N-GLC_1	49	54	PF02516	0.669
MOD_NEK2_1	107	112	PF00069	0.648
MOD_NEK2_1	2	7	PF00069	0.655
MOD_NEK2_1	310	315	PF00069	0.669
MOD_NEK2_1	365	370	PF00069	0.668
MOD_NEK2_1	391	396	PF00069	0.572
MOD_NEK2_1	42	47	PF00069	0.822
MOD_NEK2_1	667	672	PF00069	0.672
MOD_NEK2_1	9	14	PF00069	0.623
MOD_NEK2_2	537	542	PF00069	0.696
MOD_PIKK_1	365	371	PF00454	0.672
MOD_PIKK_1	419	425	PF00454	0.618
MOD_PIKK_1	443	449	PF00454	0.589
MOD_PIKK_1	555	561	PF00454	0.641
MOD_PIKK_1	9	15	PF00454	0.686
MOD_PKA_2	146	152	PF00069	0.704
MOD_PKA_2	269	275	PF00069	0.626
MOD_PKA_2	384	390	PF00069	0.585
MOD_PKA_2	9	15	PF00069	0.686
MOD_PKB_1	342	350	PF00069	0.613
MOD_Plk_1	107	113	PF00069	0.620
MOD_Plk_1	180	186	PF00069	0.606
MOD_Plk_1	49	55	PF00069	0.638
MOD_Plk_1	505	511	PF00069	0.604
MOD_Plk_1	68	74	PF00069	0.681
MOD_Plk_4	172	178	PF00069	0.602
MOD_Plk_4	654	660	PF00069	0.663
MOD_Plk_4	68	74	PF00069	0.666
MOD_Plk_4	737	743	PF00069	0.550
MOD_Plk_4	97	103	PF00069	0.582
MOD_ProDKin_1	151	157	PF00069	0.699
MOD_ProDKin_1	186	192	PF00069	0.660
MOD_ProDKin_1	208	214	PF00069	0.634
MOD_ProDKin_1	218	224	PF00069	0.565
MOD_ProDKin_1	238	244	PF00069	0.515
MOD_ProDKin_1	278	284	PF00069	0.643
MOD_ProDKin_1	288	294	PF00069	0.581
MOD_ProDKin_1	327	333	PF00069	0.676
MOD_ProDKin_1	33	39	PF00069	0.662
MOD_ProDKin_1	336	342	PF00069	0.616
MOD_ProDKin_1	346	352	PF00069	0.514
MOD_ProDKin_1	378	384	PF00069	0.664
MOD_ProDKin_1	468	474	PF00069	0.599
MOD_ProDKin_1	64	70	PF00069	0.680
MOD_ProDKin_1	646	652	PF00069	0.659
MOD_ProDKin_1	660	666	PF00069	0.546
MOD_ProDKin_1	702	708	PF00069	0.619
MOD_ProDKin_1	754	760	PF00069	0.611
MOD_ProDKin_1	828	834	PF00069	0.598
MOD_SUMO_rev_2	624	634	PF00179	0.630
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.580
TRG_ENDOCYTIC_2	162	165	PF00928	0.690
TRG_ENDOCYTIC_2	335	338	PF00928	0.628
TRG_ENDOCYTIC_2	43	46	PF00928	0.800
TRG_ENDOCYTIC_2	579	582	PF00928	0.587
TRG_ENDOCYTIC_2	587	590	PF00928	0.511
TRG_ENDOCYTIC_2	61	64	PF00928	0.798
TRG_ER_diArg_1	268	271	PF00400	0.595
TRG_ER_diArg_1	522	525	PF00400	0.699
TRG_NLS_MonoCore_2	517	522	PF00514	0.685
TRG_NLS_MonoCore_2	526	531	PF00514	0.629
TRG_NLS_MonoExtC_3	517	522	PF00514	0.695
TRG_NLS_MonoExtN_4	518	525	PF00514	0.694
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7P7	Leishmania braziliensis	61%	99%
A4HW36	Leishmania infantum	97%	100%
E9APT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	93%
Q4QFP1	Leishmania major	84%	99%